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3S3W
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STRUCTURE OF CHICKEN ACID-SENSING ION CHANNEL 1 AT 2.6 A RESOLUTION AND PH 7.5
Descriptor:Amiloride-sensitive cation channel 2, neuronal, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Dawson, R.J.P., Benz, J., Stohler, P., Tetaz, T., Joseph, C., Huber, S., Schmid, G., Huegin, D., Pflimlin, P., Trube, G., Rudolph, M.G., Hennig, M., Ruf, A.
Deposit date:2011-05-18
Release date:2012-05-23
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure of the Acid-sensing ion channel 1 in complex with the gating modifier Psalmotoxin 1.
Nat Commun, 3, 2012
3S3X
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STRUCTURE OF CHICKEN ACID-SENSING ION CHANNEL 1 AT 3.0 A RESOLUTION IN COMPLEX WITH PSALMOTOXIN
Descriptor:Amiloride-sensitive cation channel 2, neuronal, Psalmotoxin-1, ...
Authors:Dawson, R.J.P., Benz, J., Stohler, P., Tetaz, T., Joseph, C., Huber, S., Schmid, G., Huegin, D., Pflimlin, P., Trube, G., Rudolph, M.G., Hennig, M., Ruf, A.
Deposit date:2011-05-18
Release date:2012-05-23
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.99 Å)
Cite:Structure of the Acid-sensing ion channel 1 in complex with the gating modifier Psalmotoxin 1.
Nat Commun, 3, 2012
4MJO
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HUMAN LIVER FRUCTOSE-1,6-BISPHOSPHATASE(D-FRUCTOSE-1,6-BISPHOSPHATE, 1-PHOSPHOHYDROLASE) (E.C.3.1.3.11) COMPLEXED WITH THE ALLOSTERIC INHIBITOR 3
Descriptor:Fructose-1,6-bisphosphatase 1, N-({4-bromo-6-[(methylcarbamoyl)amino]pyridin-2-yl}carbamoyl)-5-(2-methoxyethyl)-4-methylthiophene-2-sulfonamide
Authors:Ruf, A., Joseph, C., Tetaz, T., Benz, J.
Deposit date:2013-09-04
Release date:2013-11-06
Last modified:2018-04-25
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Determination of protein-ligand binding constants of a cooperatively regulated tetrameric enzyme using electrospray mass spectrometry.
Acs Chem.Biol., 9, 2014
5LDZ
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QUADRUPLE SPACE GROUP AMBIGUITY DUE TO ROTATIONAL AND TRANSLATIONAL NON-CRYSTALLOGRAPHIC SYMMETRY IN HUMAN LIVER FRUCTOSE-1,6-BISPHOSPHATASE
Descriptor:Fructose-1,6-bisphosphatase 1, ZINC ION, SULFATE ION, ...
Authors:Ruf, A., Tetaz, T., Schott, B., Joseph, C., Rudolph, M.G.
Deposit date:2016-06-29
Release date:2016-10-26
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Quadruple space-group ambiguity owing to rotational and translational noncrystallographic symmetry in human liver fructose-1,6-bisphosphatase.
Acta Crystallogr D Struct Biol, 72, 2016
5PZQ
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HUMAN LIVER FRUCTOSE-1,6-BISPHOSPHATASE 1 (FRUCTOSE 1,6-BISPHOSPHATE 1-PHOSPHATASE, E.C.3.1.3.11) COMPLEXED WITH THE ALLOSTERIC INHIBITOR 2-(4-METHOXYPHENYL)FURAN-3,4-DICARBOXYLIC ACID
Descriptor:Fructose-1,6-bisphosphatase 1, 2-(4-methoxyphenyl)furan-3,4-dicarboxylic acid
Authors:Ruf, A., Joseph, C., Alker, A., Banner, D., Tetaz, T., Benz, J., Kuhn, B., Rudolph, M., Yang, H., Shao, C., Burley, S.K.
Deposit date:2017-04-16
Release date:2019-01-09
Last modified:2019-01-16
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Human liver fructose-1,6-bisphosphatase 1 (fructose 1,6-bisphosphate 1-phosphatase, E.C.3.1.3.11) complexed with the allosteric inhibitor 2-(4-methoxyphenyl)furan-3,4-dicarboxylic acid
To be published
5PZR
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HUMAN LIVER FRUCTOSE-1,6-BISPHOSPHATASE 1 (FRUCTOSE 1,6-BISPHOSPHATE 1-PHOSPHATASE, E.C.3.1.3.11) COMPLEXED WITH THE ALLOSTERIC INHIBITOR 1-(3-CHLOROPHENYL)SULFONYL-3-[3-[3-[(3-CHLOROPHENYL)SULFONYLCARBAMOYLAMINO]PROPOXY]PROPYL]UREA
Descriptor:Fructose-1,6-bisphosphatase 1, N,N'-{oxybis[(propane-3,1-diyl)carbamoyl]}bis(3-chlorobenzene-1-sulfonamide)
Authors:Ruf, A., Joseph, C., Alker, A., Banner, D., Tetaz, T., Benz, J., Kuhn, B., Rudolph, M., Yang, H., Shao, C., Burley, S.K.
Deposit date:2017-04-11
Release date:2019-01-09
Last modified:2019-01-16
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Human liver fructose-1,6-bisphosphatase 1 (fructose 1,6-bisphosphate 1-phosphatase, E.C.3.1.3.11) complexed with the allosteric inhibitor 1-(3-chlorophenyl)sulfonyl-3-[3-[3-[(3-chlorophenyl)sulfonylcarbamoylamino]propoxy]propyl]urea
To be published
5PZS
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HUMAN LIVER FRUCTOSE-1,6-BISPHOSPHATASE 1 (FRUCTOSE 1,6-BISPHOSPHATE 1-PHOSPHATASE, E.C.3.1.3.11) COMPLEXED WITH THE ALLOSTERIC INHIBITOR 1-(3-CHLOROPHENYL)SULFONYL-3-[6-[(3-CHLOROPHENYL)SULFONYLCARBAMOYLAMINO]HEXYL]UREA
Descriptor:Fructose-1,6-bisphosphatase 1, N,N'-(hexane-1,6-diyldicarbamoyl)bis(3-chlorobenzene-1-sulfonamide)
Authors:Ruf, A., Joseph, C., Alker, A., Banner, D., Tetaz, T., Benz, J., Kuhn, B., Rudolph, M., Yang, H., Shao, C., Burley, S.K.
Deposit date:2017-04-11
Release date:2019-01-09
Last modified:2019-01-16
Method:X-RAY DIFFRACTION (2.368 Å)
Cite:Human liver fructose-1,6-bisphosphatase 1 (fructose 1,6-bisphosphate 1-phosphatase, E.C.3.1.3.11) complexed with the allosteric inhibitor 1-(3-chlorophenyl)sulfonyl-3-[6-[(3-chlorophenyl)sulfonylcarbamoylamino]hexyl]urea
To be published
5PZT
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HUMAN LIVER FRUCTOSE-1,6-BISPHOSPHATASE 1 (FRUCTOSE 1,6-BISPHOSPHATE 1-PHOSPHATASE, E.C.3.1.3.11) COMPLEXED WITH THE ALLOSTERIC INHIBITOR 1-(5-BROMO-1,3-THIAZOL-2-YL)-3-(3-ETHYL-4-PHENYLPHENYL)SULFONYLUREA
Descriptor:Fructose-1,6-bisphosphatase 1, N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-2-ethyl[1,1'-biphenyl]-4-sulfonamide
Authors:Ruf, A., Joseph, C., Alker, A., Banner, D., Tetaz, T., Benz, J., Kuhn, B., Rudolph, M., Yang, H., Shao, C., Burley, S.K.
Deposit date:2017-04-18
Release date:2019-01-09
Last modified:2019-01-16
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Human liver fructose-1,6-bisphosphatase 1 (fructose 1,6-bisphosphate 1-phosphatase, E.C.3.1.3.11) complexed with the allosteric inhibitor 1-(5-bromo-1,3-thiazol-2-yl)-3-(3-ethyl-4-phenylphenyl)sulfonylurea
To be published
5PZU
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HUMAN LIVER FRUCTOSE-1,6-BISPHOSPHATASE 1 (FRUCTOSE 1,6-BISPHOSPHATE 1-PHOSPHATASE, E.C.3.1.3.11) COMPLEXED WITH THE ALLOSTERIC INHIBITOR [5-[2-AMINO-5-(2-METHYLPROPYL)-1,3-THIAZOL-4-YL]FURAN-2-YL]PHOSPHONIC ACID
Descriptor:Fructose-1,6-bisphosphatase 1, {5-[2-amino-5-(2-methylpropyl)-1,3-thiazol-4-yl]furan-2-yl}phosphonic acid
Authors:Ruf, A., Joseph, C., Alker, A., Banner, D., Tetaz, T., Benz, J., Kuhn, B., Rudolph, M., Yang, H., Shao, C., Burley, S.K.
Deposit date:2017-04-18
Release date:2019-01-09
Last modified:2019-01-16
Method:X-RAY DIFFRACTION (1.901 Å)
Cite:Human liver fructose-1,6-bisphosphatase 1 (fructose 1,6-bisphosphate 1-phosphatase, E.C.3.1.3.11) complexed with the allosteric inhibitor [5-[2-amino-5-(2-methylpropyl)-1,3-thiazol-4-yl]furan-2-yl]phosphonic acid
To be published
5PZV
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HUMAN LIVER FRUCTOSE-1,6-BISPHOSPHATASE 1 (FRUCTOSE 1,6-BISPHOSPHATE 1-PHOSPHATASE, E.C.3.1.3.11) COMPLEXED WITH THE ALLOSTERIC INHIBITOR 1-(4-BROMOPYRIDIN-2-YL)-3-(4-CHLOROPHENYL)SULFONYLUREA
Descriptor:Fructose-1,6-bisphosphatase 1, N-[(4-bromopyridin-2-yl)carbamoyl]-4-chlorobenzene-1-sulfonamide
Authors:Ruf, A., Joseph, C., Alker, A., Banner, D., Tetaz, T., Benz, J., Kuhn, B., Rudolph, M., Yang, H., Shao, C., Burley, S.K.
Deposit date:2017-04-11
Release date:2019-01-09
Last modified:2019-01-16
Method:X-RAY DIFFRACTION (2 Å)
Cite:Human liver fructose-1,6-bisphosphatase 1 (fructose 1,6-bisphosphate 1-phosphatase, E.C.3.1.3.11) complexed with the allosteric inhibitor 1-(4-bromopyridin-2-yl)-3-(4-chlorophenyl)sulfonylurea
To be published
5PZW
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HUMAN LIVER FRUCTOSE-1,6-BISPHOSPHATASE 1 (FRUCTOSE 1,6-BISPHOSPHATE 1-PHOSPHATASE, E.C.3.1.3.11) COMPLEXED WITH THE ALLOSTERIC INHIBITOR 1-(3-CHLOROPHENYL)SULFONYL-3-[5-[(3-CHLOROPHENYL)SULFONYLCARBAMOYLAMINO]PENTYL]UREA
Descriptor:Fructose-1,6-bisphosphatase 1, N,N'-(pentane-1,5-diyldicarbamoyl)bis(3-chlorobenzene-1-sulfonamide), AMINOIMIDAZOLE 4-CARBOXAMIDE RIBONUCLEOTIDE
Authors:Ruf, A., Joseph, C., Alker, A., Banner, D., Tetaz, T., Benz, J., Kuhn, B., Rudolph, M., Yang, H., Shao, C., Burley, S.K.
Deposit date:2017-04-16
Release date:2019-01-09
Last modified:2019-01-16
Method:X-RAY DIFFRACTION (2 Å)
Cite:Human liver fructose-1,6-bisphosphatase 1 (fructose 1,6-bisphosphate 1-phosphatase, E.C.3.1.3.11) complexed with the allosteric inhibitor 1-(3-chlorophenyl)sulfonyl-3-[5-[(3-chlorophenyl)sulfonylcarbamoylamino]pentyl]urea
To be published
5PZX
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HUMAN LIVER FRUCTOSE-1,6-BISPHOSPHATASE 1 (FRUCTOSE 1,6-BISPHOSPHATE 1-PHOSPHATASE, E.C.3.1.3.11) COMPLEXED WITH THE ALLOSTERIC INHIBITOR 1-(5-BROMO-1,3-THIAZOL-2-YL)-3-[4-METHOXY-3-(2-METHYLPROPYL)PHENYL]SULFONYLUREA
Descriptor:Fructose-1,6-bisphosphatase 1, N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-4-methoxy-3-(2-methylpropyl)benzene-1-sulfonamide
Authors:Ruf, A., Joseph, C., Alker, A., Banner, D., Tetaz, T., Benz, J., Kuhn, B., Rudolph, M., Yang, H., Shao, C., Burley, S.K.
Deposit date:2017-04-18
Release date:2019-01-09
Last modified:2019-01-16
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Human liver fructose-1,6-bisphosphatase 1 (fructose 1,6-bisphosphate 1-phosphatase, E.C.3.1.3.11) complexed with the allosteric inhibitor 1-(5-bromo-1,3-thiazol-2-yl)-3-[4-methoxy-3-(2-methylpropyl)phenyl]sulfonylurea
To be published
5PZY
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HUMAN LIVER FRUCTOSE-1,6-BISPHOSPHATASE 1 (FRUCTOSE 1,6-BISPHOSPHATE 1-PHOSPHATASE, E.C.3.1.3.11) COMPLEXED WITH THE ALLOSTERIC INHIBITOR 1-(5-BROMO-1,3-THIAZOL-2-YL)-3-(2-CHLOROPHENYL)SULFONYLUREA
Descriptor:Fructose-1,6-bisphosphatase 1, N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-2-chlorobenzene-1-sulfonamide
Authors:Ruf, A., Joseph, C., Alker, A., Banner, D., Tetaz, T., Benz, J., Kuhn, B., Rudolph, M., Yang, H., Shao, C., Burley, S.K.
Deposit date:2017-04-18
Release date:2019-01-09
Last modified:2019-01-16
Method:X-RAY DIFFRACTION (2.21 Å)
Cite:Human liver fructose-1,6-bisphosphatase 1 (fructose 1,6-bisphosphate 1-phosphatase, E.C.3.1.3.11) complexed with the allosteric inhibitor 1-(5-bromo-1,3-thiazol-2-yl)-3-(2-chlorophenyl)sulfonylurea
To be published
5PZZ
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HUMAN LIVER FRUCTOSE-1,6-BISPHOSPHATASE 1 (FRUCTOSE 1,6-BISPHOSPHATE 1-PHOSPHATASE, E.C.3.1.3.11) COMPLEXED WITH THE ALLOSTERIC INHIBITOR 1-(5-BROMO-1,3-THIAZOL-2-YL)-3-(3,4-DICHLOROPHENYL)SULFONYLUREA
Descriptor:Fructose-1,6-bisphosphatase 1, N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-3,4-dichlorobenzene-1-sulfonamide
Authors:Ruf, A., Joseph, C., Alker, A., Banner, D., Tetaz, T., Benz, J., Kuhn, B., Rudolph, M., Yang, H., Shao, C., Burley, S.K.
Deposit date:2017-04-28
Release date:2019-01-09
Last modified:2019-01-16
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Human liver fructose-1,6-bisphosphatase 1 (fructose 1,6-bisphosphate 1-phosphatase, E.C.3.1.3.11) complexed with the allosteric inhibitor 1-(5-bromo-1,3-thiazol-2-yl)-3-(3,4-dichlorophenyl)sulfonylurea
To be published
5Q00
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HUMAN LIVER FRUCTOSE-1,6-BISPHOSPHATASE 1 (FRUCTOSE 1,6-BISPHOSPHATE 1-PHOSPHATASE, E.C.3.1.3.11) COMPLEXED WITH THE ALLOSTERIC INHIBITOR 2-[3-[(5-BROMO-1,3-THIAZOL-2-YL)CARBAMOYLSULFAMOYL]-1-METHYLINDOL-7-YL]OXYACETAMIDE
Descriptor:Fructose-1,6-bisphosphatase 1, 2-[(3-{[(5-bromo-1,3-thiazol-2-yl)carbamoyl]sulfamoyl}-1-methyl-1H-indol-7-yl)oxy]acetamide
Authors:Ruf, A., Joseph, C., Alker, A., Banner, D., Tetaz, T., Benz, J., Kuhn, B., Rudolph, M., Yang, H., Shao, C., Burley, S.K.
Deposit date:2017-04-18
Release date:2019-01-16
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Human liver fructose-1,6-bisphosphatase 1 (fructose 1,6-bisphosphate 1-phosphatase, E.C.3.1.3.11) complexed with the allosteric inhibitor 2-[3-[(5-bromo-1,3-thiazol-2-yl)carbamoylsulfamoyl]-1-methylindol-7-yl]oxyacetamide
To be published
5Q01
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HUMAN LIVER FRUCTOSE-1,6-BISPHOSPHATASE 1 (FRUCTOSE 1,6-BISPHOSPHATE 1-PHOSPHATASE, E.C.3.1.3.11) COMPLEXED WITH THE ALLOSTERIC INHIBITOR 1-(5-BROMO-1,3-THIAZOL-2-YL)-3-[4-(4,5-DICHLORO-2-METHYLPYRAZOL-3-YL)OXYPHENYL]SULFONYLUREA
Descriptor:Fructose-1,6-bisphosphatase 1, N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-4-[(3,4-dichloro-1-methyl-1H-pyrazol-5-yl)oxy]benzene-1-sulfonamide
Authors:Ruf, A., Joseph, C., Alker, A., Banner, D., Tetaz, T., Benz, J., Kuhn, B., Rudolph, M., Yang, H., Shao, C., Burley, S.K.
Deposit date:2017-04-18
Release date:2019-01-09
Last modified:2019-01-16
Method:X-RAY DIFFRACTION (2.603 Å)
Cite:Human liver fructose-1,6-bisphosphatase 1 (fructose 1,6-bisphosphate 1-phosphatase, E.C.3.1.3.11) complexed with the allosteric inhibitor 1-(5-bromo-1,3-thiazol-2-yl)-3-[4-(4,5-dichloro-2-methylpyrazol-3-yl)oxyphenyl]sulfonylurea
To be published
5Q02
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HUMAN LIVER FRUCTOSE-1,6-BISPHOSPHATASE 1 (FRUCTOSE 1,6-BISPHOSPHATE 1-PHOSPHATASE, E.C.3.1.3.11) COMPLEXED WITH THE ALLOSTERIC INHIBITOR 1-(5-BROMO-1,3-THIAZOL-2-YL)-3-[5-(1,2-OXAZOL-3-YL)THIOPHEN-2-YL]SULFONYLUREA
Descriptor:Fructose-1,6-bisphosphatase 1, N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-5-(1,2-oxazol-3-yl)thiophene-2-sulfonamide
Authors:Ruf, A., Joseph, C., Alker, A., Banner, D., Tetaz, T., Benz, J., Kuhn, B., Rudolph, M., Yang, H., Shao, C., Burley, S.K.
Deposit date:2017-04-18
Release date:2019-01-09
Last modified:2019-01-16
Method:X-RAY DIFFRACTION (2.095 Å)
Cite:Human liver fructose-1,6-bisphosphatase 1 (fructose 1,6-bisphosphate 1-phosphatase, E.C.3.1.3.11) complexed with the allosteric inhibitor 1-(5-bromo-1,3-thiazol-2-yl)-3-[5-(1,2-oxazol-3-yl)thiophen-2-yl]sulfonylurea
To be published
5Q03
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HUMAN LIVER FRUCTOSE-1,6-BISPHOSPHATASE 1 (FRUCTOSE 1,6-BISPHOSPHATE 1-PHOSPHATASE, E.C.3.1.3.11) COMPLEXED WITH THE ALLOSTERIC INHIBITOR 1-(5-BROMO-1,3-THIAZOL-2-YL)-3-[5-(2-METHYLPROPYL)THIOPHEN-2-YL]SULFONYLUREA
Descriptor:Fructose-1,6-bisphosphatase 1, N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-5-(2-methylpropyl)thiophene-2-sulfonamide
Authors:Ruf, A., Joseph, C., Alker, A., Banner, D., Tetaz, T., Benz, J., Kuhn, B., Rudolph, M., Yang, H., Shao, C., Burley, S.K.
Deposit date:2017-04-18
Release date:2019-01-09
Last modified:2019-01-16
Method:X-RAY DIFFRACTION (2.31 Å)
Cite:Human liver fructose-1,6-bisphosphatase 1 (fructose 1,6-bisphosphate 1-phosphatase, E.C.3.1.3.11) complexed with the allosteric inhibitor 1-(5-bromo-1,3-thiazol-2-yl)-3-[5-(2-methylpropyl)thiophen-2-yl]sulfonylurea
To be published
5Q04
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HUMAN LIVER FRUCTOSE-1,6-BISPHOSPHATASE 1 (FRUCTOSE 1,6-BISPHOSPHATE 1-PHOSPHATASE, E.C.3.1.3.11) COMPLEXED WITH THE ALLOSTERIC INHIBITOR 1-(4-BROMO-5-CHLOROTHIOPHEN-2-YL)SULFONYL-3-(5-BROMO-1,3-THIAZOL-2-YL)UREA
Descriptor:Fructose-1,6-bisphosphatase 1, 4-bromo-N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-5-chlorothiophene-2-sulfonamide
Authors:Ruf, A., Joseph, C., Alker, A., Banner, D., Tetaz, T., Benz, J., Kuhn, B., Rudolph, M., Yang, H., Shao, C., Burley, S.K.
Deposit date:2017-04-18
Release date:2019-01-09
Last modified:2019-01-16
Method:X-RAY DIFFRACTION (2.502 Å)
Cite:Human liver fructose-1,6-bisphosphatase 1 (fructose 1,6-bisphosphate 1-phosphatase, E.C.3.1.3.11) complexed with the allosteric inhibitor 1-(4-bromo-5-chlorothiophen-2-yl)sulfonyl-3-(5-bromo-1,3-thiazol-2-yl)urea
To be published
5Q05
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HUMAN LIVER FRUCTOSE-1,6-BISPHOSPHATASE 1 (FRUCTOSE 1,6-BISPHOSPHATE 1-PHOSPHATASE, E.C.3.1.3.11) COMPLEXED WITH THE ALLOSTERIC INHIBITOR 1-(5-BROMO-1,3-THIAZOL-2-YL)-3-[5-(2-METHOXYETHYL)-4-METHYLTHIOPHEN-2-YL]SULFONYLUREA
Descriptor:Fructose-1,6-bisphosphatase 1, N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-5-(2-methoxyethyl)-4-methylthiophene-2-sulfonamide
Authors:Ruf, A., Joseph, C., Alker, A., Banner, D., Tetaz, T., Benz, J., Kuhn, B., Rudolph, M., Yang, H., Shao, C., Burley, S.K.
Deposit date:2017-04-20
Release date:2019-01-09
Last modified:2019-01-16
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Human liver fructose-1,6-bisphosphatase 1 (fructose 1,6-bisphosphate 1-phosphatase, E.C.3.1.3.11) complexed with the allosteric inhibitor 1-(5-bromo-1,3-thiazol-2-yl)-3-[5-(2-methoxyethyl)-4-methylthiophen-2-yl]sulfonylurea
To be published
5Q06
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HUMAN LIVER FRUCTOSE-1,6-BISPHOSPHATASE 1 (FRUCTOSE 1,6-BISPHOSPHATE 1-PHOSPHATASE, E.C.3.1.3.11) COMPLEXED WITH THE ALLOSTERIC INHIBITOR 1-(5-BROMO-1,3-THIAZOL-2-YL)-3-[4-(2-METHYL-1,3-THIAZOL-4-YL)PHENYL]SULFONYLUREA
Descriptor:Fructose-1,6-bisphosphatase 1, N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-4-(2-methyl-1,3-thiazol-4-yl)benzene-1-sulfonamide
Authors:Ruf, A., Joseph, C., Alker, A., Banner, D., Tetaz, T., Benz, J., Kuhn, B., Rudolph, M., Yang, H., Shao, C., Burley, S.K.
Deposit date:2017-04-18
Release date:2019-01-09
Last modified:2019-01-16
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Human liver fructose-1,6-bisphosphatase 1 (fructose 1,6-bisphosphate 1-phosphatase, E.C.3.1.3.11) complexed with the allosteric inhibitor 1-(5-bromo-1,3-thiazol-2-yl)-3-[4-(2-methyl-1,3-thiazol-4-yl)phenyl]sulfonylurea
To be published
5Q07
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HUMAN LIVER FRUCTOSE-1,6-BISPHOSPHATASE 1 (FRUCTOSE 1,6-BISPHOSPHATE 1-PHOSPHATASE, E.C.3.1.3.11) COMPLEXED WITH THE ALLOSTERIC INHIBITOR 1-(4-BROMO-6-MORPHOLIN-4-YLPYRIDIN-2-YL)-3-[5-(2-METHOXYETHYL)-4-METHYLTHIOPHEN-2-YL]SULFONYLUREA
Descriptor:Fructose-1,6-bisphosphatase 1, N-{[4-bromo-6-(morpholin-4-yl)pyridin-2-yl]carbamoyl}-5-(2-methoxyethyl)-4-methylthiophene-2-sulfonamide
Authors:Ruf, A., Joseph, C., Alker, A., Banner, D., Tetaz, T., Benz, J., Kuhn, B., Rudolph, M., Yang, H., Shao, C., Burley, S.K.
Deposit date:2017-04-16
Release date:2019-01-09
Last modified:2019-01-16
Method:X-RAY DIFFRACTION (2.424 Å)
Cite:Human liver fructose-1,6-bisphosphatase 1 (fructose 1,6-bisphosphate 1-phosphatase, E.C.3.1.3.11) complexed with the allosteric inhibitor 1-(4-bromo-6-morpholin-4-ylpyridin-2-yl)-3-[5-(2-methoxyethyl)-4-methylthiophen-2-yl]sulfonylurea
To be published
5Q08
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HUMAN LIVER FRUCTOSE-1,6-BISPHOSPHATASE 1 (FRUCTOSE 1,6-BISPHOSPHATE 1-PHOSPHATASE, E.C.3.1.3.11) COMPLEXED WITH THE ALLOSTERIC INHIBITOR 1-(1-BENZOTHIOPHEN-3-YLSULFONYL)-3-(5-BROMO-1,3-THIAZOL-2-YL)UREA
Descriptor:Fructose-1,6-bisphosphatase 1, N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-1-benzothiophene-3-sulfonamide
Authors:Ruf, A., Joseph, C., Alker, A., Banner, D., Tetaz, T., Benz, J., Kuhn, B., Rudolph, M., Yang, H., Shao, C., Burley, S.K.
Deposit date:2017-04-18
Release date:2019-01-09
Last modified:2019-01-16
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Human liver fructose-1,6-bisphosphatase 1 (fructose 1,6-bisphosphate 1-phosphatase, E.C.3.1.3.11) complexed with the allosteric inhibitor 1-(1-benzothiophen-3-ylsulfonyl)-3-(5-bromo-1,3-thiazol-2-yl)urea
To be published
5Q09
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HUMAN LIVER FRUCTOSE-1,6-BISPHOSPHATASE 1 (FRUCTOSE 1,6-BISPHOSPHATE 1-PHOSPHATASE, E.C.3.1.3.11) COMPLEXED WITH THE ALLOSTERIC INHIBITOR 1-[4-BROMO-6-(CARBAMOYLAMINO)PYRIDIN-2-YL]-3-[5-(2-METHOXYETHYL)-4-METHYLTHIOPHEN-2-YL]SULFONYLUREA
Descriptor:Fructose-1,6-bisphosphatase 1, N-{[4-bromo-6-(carbamoylamino)pyridin-2-yl]carbamoyl}-5-(2-methoxyethyl)-4-methylthiophene-2-sulfonamide
Authors:Ruf, A., Joseph, C., Alker, A., Banner, D., Tetaz, T., Benz, J., Kuhn, B., Rudolph, M., Yang, H., Shao, C., Burley, S.K.
Deposit date:2017-04-16
Release date:2019-01-09
Last modified:2019-01-16
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Human liver fructose-1,6-bisphosphatase 1 (fructose 1,6-bisphosphate 1-phosphatase, E.C.3.1.3.11) complexed with the allosteric inhibitor 1-[4-bromo-6-(carbamoylamino)pyridin-2-yl]-3-[5-(2-methoxyethyl)-4-methylthiophen-2-yl]sulfonylurea
To be published
5Q0A
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HUMAN LIVER FRUCTOSE-1,6-BISPHOSPHATASE 1 (FRUCTOSE 1,6-BISPHOSPHATE 1-PHOSPHATASE, E.C.3.1.3.11) COMPLEXED WITH THE ALLOSTERIC INHIBITOR 1-(5-CYANOPYRAZIN-2-YL)-3-[3-(DIFLUOROMETHOXY)PHENYL]SULFONYLUREA
Descriptor:Fructose-1,6-bisphosphatase 1, N-[(5-cyanopyrazin-2-yl)carbamoyl]-3-(difluoromethoxy)benzene-1-sulfonamide
Authors:Ruf, A., Joseph, C., Alker, A., Banner, D., Tetaz, T., Benz, J., Kuhn, B., Rudolph, M., Yang, H., Shao, C., Burley, S.K.
Deposit date:2017-04-11
Release date:2019-01-09
Last modified:2019-01-16
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Human liver fructose-1,6-bisphosphatase 1 (fructose 1,6-bisphosphate 1-phosphatase, E.C.3.1.3.11) complexed with the allosteric inhibitor 1-(5-cyanopyrazin-2-yl)-3-[3-(difluoromethoxy)phenyl]sulfonylurea
To be published
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