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1BSV
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GDP-FUCOSE SYNTHETASE FROM ESCHERICHIA COLI COMPLEX WITH NADPH
Descriptor:PROTEIN (GDP-FUCOSE SYNTHETASE), NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Somers, W.S., Stahl, M.L., Sullivan, F.X.
Deposit date:1998-08-31
Release date:1999-08-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:GDP-fucose synthetase from Escherichia coli: structure of a unique member of the short-chain dehydrogenase/reductase family that catalyzes two distinct reactions at the same active site.
Structure, 6, 1998
1DB3
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E.COLI GDP-MANNOSE 4,6-DEHYDRATASE
Descriptor:GDP-MANNOSE 4,6-DEHYDRATASE
Authors:Somoza, J.R., Menon, S., Somers, W.S., Sullivan, F.X.
Deposit date:1999-11-02
Release date:1999-11-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural and kinetic analysis of Escherichia coli GDP-mannose 4,6 dehydratase provides insights into the enzyme's catalytic mechanism and regulation by GDP-fucose.
Structure Fold.Des., 8, 2000
1FXS
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GDP-FUCOSE SYNTHETASE FROM ESCHERICHIA COLI COMPLEX WITH NADP
Descriptor:PROTEIN (GDP-FUCOSE SYNTHETASE), NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Somers, W.S., Stahl, M.L., Sullivan, F.X.
Deposit date:1998-09-01
Release date:1999-08-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:GDP-fucose synthetase from Escherichia coli: structure of a unique member of the short-chain dehydrogenase/reductase family that catalyzes two distinct reactions at the same active site.
Structure, 6, 1998
1GFS
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GDP-FUCOSE SYNTHETASE FROM E. COLI
Descriptor:GDP-FUCOSE SYNTHETASE
Authors:Somers, W.S., Stahl, M.L., Sullivan, F.X.
Deposit date:1998-08-17
Release date:1999-08-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:GDP-fucose synthetase from Escherichia coli: structure of a unique member of the short-chain dehydrogenase/reductase family that catalyzes two distinct reactions at the same active site.
Structure, 6, 1998
1KAM
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STRUCTURE OF BACILLUS SUBTILIS NICOTINIC ACID MONONUCLEOTIDE ADENYLYL TRANSFERASE
Descriptor:NICOTINATE-NUCLEOTIDE ADENYLYLTRANSFERASE
Authors:Olland, A.M., Underwood, K.W., Czerwinski, R.M., Lo, M.C., Aulabaugh, A., Bard, J., Stahl, M.L., Somers, W.S., Sullivan, F.X., Chopra, R.
Deposit date:2001-11-02
Release date:2002-07-12
Last modified:2014-11-12
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Identification, characterization, and crystal structure of Bacillus subtilis nicotinic acid mononucleotide adenylyltransferase.
J.Biol.Chem., 277, 2002
1KAQ
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STRUCTURE OF BACILLUS SUBTILIS NICOTINIC ACID MONONUCLEOTIDE ADENYLYL TRANSFERASE
Descriptor:NICOTINATE-NUCLEOTIDE ADENYLYLTRANSFERASE, NICOTINIC ACID ADENINE DINUCLEOTIDE
Authors:Olland, A.M., Underwood, K.W., Czerwinski, R.M., Lo, M.C., Aulabaugh, A., Bard, J., Stahl, M.L., Somers, W.S., Sullivan, F.X., Chopra, R.
Deposit date:2001-11-02
Release date:2002-07-12
Last modified:2014-11-19
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Identification, characterization, and crystal structure of Bacillus subtilis nicotinic acid mononucleotide adenylyltransferase.
J.Biol.Chem., 277, 2002
6E0E
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CRYSTAL STRUCTURE OF GLUCOKINASE IN COMPLEX WITH COMPOUND 6
Descriptor:Glucokinase, ALPHA-D-GLUCOSE, 2-({2-[(4-methyl-1,3-thiazol-2-yl)amino]pyridin-3-yl}oxy)benzonitrile
Authors:Hinklin, R.J., Baer, B.R., Boyd, S.A., Chicarelli, M.D., Condroski, K.R., DeWolf, W.E., Fischer, J., Frank, M., Hingorani, G.P., Lee, P.A., Neitzel, N.A., Pratt, S.A., Singh, A., Sullivan, F.X., Turner, T., Voegtli, W.C., Wallace, E.M., Williams, L., Aicher, T.D.
Deposit date:2018-07-06
Release date:2019-07-10
Last modified:2020-01-22
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Discovery and preclinical development of AR453588 as an anti-diabetic glucokinase activator.
Bioorg.Med.Chem., 28, 2020
6E0I
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CRYSTAL STRUCTURE OF GLUCOKINASE IN COMPLEX WITH COMPOUND 72
Descriptor:Glucokinase, ALPHA-D-GLUCOSE, DIMETHYL SULFOXIDE, ...
Authors:Hinklin, R.J., Baer, B.R., Boyd, S.A., Chicarelli, M.D., Condroski, K.R., DeWolf, W.E., Fischer, J., Frank, M., Hingorani, G.P., Lee, P.A., Neitzel, N.A., Pratt, S.A., Singh, A., Sullivan, F.X., Turner, T., Voegtli, W.C., Wallace, E.M., Williams, L., Aicher, T.D.
Deposit date:2018-07-06
Release date:2019-07-10
Last modified:2020-01-22
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Discovery and preclinical development of AR453588 as an anti-diabetic glucokinase activator.
Bioorg.Med.Chem., 28, 2020
6USX
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IDENTIFICATION OF THE CLINICAL DEVELOPMENT CANDIDATE MRTX849, A COVALENT KRASG12C INHIBITOR FOR THE TREATMENT OF CANCER
Descriptor:GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Vigers, G.P., Smith, D.J.
Deposit date:2019-10-28
Release date:2020-04-22
Method:X-RAY DIFFRACTION (2.27 Å)
Cite:Identification of the Clinical Development CandidateMRTX849, a Covalent KRASG12CInhibitor for the Treatment of Cancer.
J.Med.Chem., 2020
6USZ
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IDENTIFICATION OF THE CLINICAL DEVELOPMENT CANDIDATE MRTX849, A COVALENT KRASG12C INHIBITOR FOR THE TREATMENT OF CANCER
Descriptor:GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Vigers, G.P., Smith, D.J.
Deposit date:2019-10-28
Release date:2020-04-22
Method:X-RAY DIFFRACTION (2.03 Å)
Cite:Identification of the Clinical Development CandidateMRTX849, a Covalent KRASG12CInhibitor for the Treatment of Cancer.
J.Med.Chem., 2020
6UT0
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IDENTIFICATION OF THE CLINICAL DEVELOPMENT CANDIDATE MRTX849, A COVALENT KRASG12C INHIBITOR FOR THE TREATMENT OF CANCER
Descriptor:GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Vigers, G.P., Smith, D.J.
Deposit date:2019-10-29
Release date:2020-04-22
Method:X-RAY DIFFRACTION (1.94 Å)
Cite:Identification of the Clinical Development CandidateMRTX849, a Covalent KRASG12CInhibitor for the Treatment of Cancer.
J.Med.Chem., 2020