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2W5Y
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BINARY COMPLEX OF THE MIXED LINEAGE LEUKAEMIA (MLL1) SET DOMAIN WITH THE COFACTOR PRODUCT S-ADENOSYLHOMOCYSTEINE.
Descriptor:HISTONE-LYSINE N-METHYLTRANSFERASE HRX, ZINC ION, S-ADENOSYL-L-HOMOCYSTEINE
Authors:Southall, S.M., Wong, P.S., Odho, Z., Roe, S.M., WIlson, J.R.
Deposit date:2008-12-15
Release date:2009-02-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural Basis for the Requirement of Additional Factors for Mll1 Set Domain Activity and Recognition of Epigenetic Marks.
Mol.Cell, 33, 2009
2W5Z
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TERNARY COMPLEX OF THE MIXED LINEAGE LEUKAEMIA (MLL1) SET DOMAIN WITH THE COFACTOR PRODUCT S-ADENOSYLHOMOCYSTEINE AND HISTONE PEPTIDE.
Descriptor:HISTONE-LYSINE N-METHYLTRANSFERASE HRX, HISTONE PEPTIDE, ZINC ION, ...
Authors:Southall, S.M., Wong, P.S., Odho, Z., Roe, S.M., Wilson, J.R.
Deposit date:2008-12-15
Release date:2009-02-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural Basis for the Requirement of Additional Factors for Mll1 Set Domain Activity and Recognition of Epigenetic Marks.
Mol.Cell, 33, 2009
2G8S
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CRYSTAL STRUCTURE OF THE SOLUBLE ALDOSE SUGAR DEHYDROGENASE (ASD) FROM ESCHERICHIA COLI IN THE APO-FORM
Descriptor:Glucose/sorbosone dehydrogenases, CALCIUM ION, PHOSPHATE ION, ...
Authors:Southall, S.M., Doel, J.J., Richardson, D.J., Oubrie, A.
Deposit date:2006-03-03
Release date:2006-08-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Soluble Aldose Sugar Dehydrogenase from Escherichia coli: A HIGHLY EXPOSED ACTIVE SITE CONFERRING BROAD SUBSTRATE SPECIFICITY.
J.Biol.Chem., 281, 2006
3DAS
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STRUCTURE OF THE PQQ-BOUND FORM OF ALDOSE SUGAR DEHYDROGENASE (ADH) FROM STREPTOMYCES COELICOLOR
Descriptor:Putative oxidoreductase, ALPHA-L-ARABINOSE, CALCIUM ION, ...
Authors:Southall, S.M., Doel, J.J., Oubrie, A., Richardson, D.J.
Deposit date:2008-05-30
Release date:2009-06-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structural and Enzymatic Characterization of a Thermostable PQQ-dependent Soluble Aldose Sugar Dehydrogenase
To be Published
4AU7
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THE STRUCTURE OF THE SUV4-20H2 TERNARY COMPLEX WITH HISTONE H4
Descriptor:HISTONE-LYSINE N-METHYLTRANSFERASE SUV420H2, HISTONE H4 PEPTIDE, S-ADENOSYL-L-HOMOCYSTEINE, ...
Authors:Southall, S.M., Cronin, N.B., Wilson, J.R.
Deposit date:2012-05-14
Release date:2013-05-22
Last modified:2014-01-15
Method:X-RAY DIFFRACTION (2.07 Å)
Cite:A Novel Route to Product Specificity in the Suv4-20 Family of Histone H4K20 Methyltransferases.
Nucleic Acids Res., 42, 2014
4BUP
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A NOVEL ROUTE TO PRODUCT SPECIFICITY IN THE SUV4-20 FAMILY OF HISTONE H4K20 METHYLTRANSFERASES
Descriptor:HISTONE-LYSINE N-METHYLTRANSFERASE SUV420H1, ZINC ION, S-ADENOSYLMETHIONINE, ...
Authors:Southall, S.M., Cronin, N.B., Wilson, J.R.
Deposit date:2013-06-21
Release date:2013-10-02
Last modified:2014-01-15
Method:X-RAY DIFFRACTION (2.166 Å)
Cite:A Novel Route to Product Specificity in the Suv4-20 Family of Histone H4K20 Methyltransferases.
Nucleic Acids Res., 42, 2014
2XL2
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WDR5 IN COMPLEX WITH AN RBBP5 PEPTIDE RECRUITED TO NOVEL SITE
Descriptor:WD REPEAT-CONTAINING PROTEIN 5, RETINOBLASTOMA-BINDING PROTEIN 5, GLYCEROL
Authors:Odho, Z., Southall, S.M., Wilson, J.R.
Deposit date:2010-07-19
Release date:2010-08-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Characterisation of a Novel Wdr5 Binding Site that Recruits Rbbp5 Through a Conserved Motif and Enhances Methylation of H3K4 by Mll1.
J.Biol.Chem., 285, 2010
2XL3
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WDR5 IN COMPLEX WITH AN RBBP5 PEPTIDE AND HISTONE H3 PEPTIDE
Descriptor:WD REPEAT-CONTAINING PROTEIN 5, RETINOBLASTOMA-BINDING PROTEIN 5, HISTONE H3.1, ...
Authors:Odho, Z., Southall, S.M., Wilson, J.R.
Deposit date:2010-07-19
Release date:2010-08-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Characterisation of a Novel Wdr5 Binding Site that Recruits Rbbp5 Through a Conserved Motif and Enhances Methylation of H3K4 by Mll1.
J.Biol.Chem., 285, 2010
5EE7
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CRYSTAL STRUCTURE OF THE HUMAN GLUCAGON RECEPTOR (GCGR) IN COMPLEX WITH THE ANTAGONIST MK-0893
Descriptor:Glucagon receptor,Endolysin,Glucagon receptor, 3-[[4-[(1~{S})-1-[3-[3,5-bis(chloranyl)phenyl]-5-(6-methoxynaphthalen-2-yl)pyrazol-1-yl]ethyl]phenyl]carbonylamino]propanoic acid, OLEIC ACID, ...
Authors:Jazayeri, A., Dore, A.S., Lamb, D., Krishnamurthy, H., Southall, S.M., Baig, A.H., Bortolato, A., Koglin, M., Robertson, N.J., Errey, J.C., Andrews, S.P., Brown, A.J.H., Cooke, R.M., Weir, M., Marshall, F.H.
Deposit date:2015-10-22
Release date:2016-04-20
Last modified:2016-05-18
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Extra-helical binding site of a glucagon receptor antagonist.
Nature, 533, 2016