Author results

1CC0
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CRYSTAL STRUCTURE OF THE RHOA.GDP-RHOGDI COMPLEX
Descriptor:transforming protein rhoA, rho GDP dissociation inhibitor alpha, MAGNESIUM ION, ...
Authors:Longenecker, K.L., Read, P., Derewenda, U., Dauter, Z., Garrard, S., Walker, L., Somlyo, A.V., Somlyo, A.P., Nakamoto, R.K., Derewenda, Z.S.
Deposit date:1999-03-03
Release date:2000-01-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (5 Å)
Cite:How RhoGDI binds Rho.
Acta Crystallogr.,Sect.D, 55, 1999
1FHG
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HIGH RESOLUTION REFINEMENT OF TELOKIN
Descriptor:TELOKIN
Authors:Tomchick, D.R., Minor, W., Kiyatkin, A., Lewinski, K., Somlyo, A.V., Somlyo, A.P.
Deposit date:2000-08-01
Release date:2000-08-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:X-ray structure determination of telokin, the C-terminal domain of myosin light chain kinase, at 2.8 A resolution.
J.Mol.Biol., 227, 1992
1FTN
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CRYSTAL STRUCTURE OF THE HUMAN RHOA/GDP COMPLEX
Descriptor:TRANSFORMING PROTEIN RHOA (H12), MAGNESIUM ION, GUANOSINE-5'-DIPHOSPHATE
Authors:Wei, Y., Zhang, Y., Derewenda, U., Liu, X., Minor, W., Nakamoto, R.K., Somlyo, A.V., Somlyo, A.P., Derewenda, Z.S.
Deposit date:1997-03-13
Release date:1998-03-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure of RhoA-GDP and its functional implications.
Nat.Struct.Biol., 4, 1997
1XCG
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CRYSTAL STRUCTURE OF HUMAN RHOA IN COMPLEX WITH DH/PH FRAGMENT OF PDZRHOGEF
Descriptor:Rho guanine nucleotide exchange factor 11, Transforming protein RhoA
Authors:Derewenda, U., Oleksy, A., Stevenson, A.S., Korczynska, J., Dauter, Z., Somlyo, A.P., Otlewski, J., Somlyo, A.V., Derewenda, Z.S.
Deposit date:2004-09-01
Release date:2004-12-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:The crystal structure of RhoA in complex with the DH/PH fragment of PDZRhoGEF, an activator of the Ca(2+) sensitization pathway in smooth muscle
Structure, 12, 2004
3T06
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CRYSTAL STRUCTURE OF THE DH/PH FRAGMENT OF PDZRHOGEF WITH N-TERMINAL REGULATORY ELEMENTS IN COMPLEX WITH HUMAN RHOA
Descriptor:Rho guanine nucleotide exchange factor 11, Transforming protein RhoA
Authors:Bielnicki, J.A., Derewenda, U., Derewenda, Z.S.
Deposit date:2011-07-19
Release date:2011-08-03
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.84 Å)
Cite:Insights into the Molecular Activation Mechanism of the RhoA-specific Guanine Nucleotide Exchange Factor, PDZRhoGEF.
J.Biol.Chem., 286, 2011
3MSX
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CRYSTAL STRUCTURE OF RHOA.GDP.MGF3 IN COMPLEX WITH GAP DOMAIN OF ARHGAP20
Descriptor:Transforming protein RhoA, Rho GTPase-activating protein 20, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Utepbergenov, D., Cooper, D.R., Derewenda, U., Derewenda, Z.S.
Deposit date:2010-04-29
Release date:2011-03-16
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Mechanism of molecular specificity of RhoGAP domains towards small GTPases of RhoA family.
To be Published
4GUE
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STRUCTURE OF N-TERMINAL KINASE DOMAIN OF RSK2 WITH FLAVONOID GLYCOSIDE QUERCITRIN
Descriptor:Ribosomal protein S6 kinase alpha-3, 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4-oxo-4H-chromen-3-yl 6-deoxy-alpha-L-mannopyranoside, MAGNESIUM ION, ...
Authors:Derewenda, U., Utepbergenov, D., Szukalska, G., Derewenda, Z.S.
Deposit date:2012-08-29
Release date:2013-01-30
Last modified:2013-03-27
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Identification of quercitrin as an inhibitor of the p90 S6 ribosomal kinase (RSK): structure of its complex with the N-terminal domain of RSK2 at 1.8 A resolution.
Acta Crystallogr.,Sect.D, 69, 2013
5IRC
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P190A GAP DOMAIN COMPLEX WITH RHOA
Descriptor:Rho GTPase-activating protein 35, Transforming protein RhoA, CHLORIDE ION, ...
Authors:Derewenda, U., Derewenda, Z.
Deposit date:2016-03-12
Release date:2016-08-17
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (1.72 Å)
Cite:Deciphering the Molecular and Functional Basis of RHOGAP Family Proteins: A SYSTEMATIC APPROACH TOWARD SELECTIVE INACTIVATION OF RHO FAMILY PROTEINS.
J.Biol.Chem., 291, 2016