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1GUH
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BU of 1guh by Molmil
Structure determination and refinement of human alpha class glutathione transferase A1-1, and a comparison with the MU and PI class enzymes
Descriptor: GLUTATHIONE S-TRANSFERASE A1-1, S-BENZYL-GLUTATHIONE
Authors:Sinning, I, Kleywegt, G.J, Jones, T.A.
Deposit date:1993-02-24
Release date:1993-10-31
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure determination and refinement of human alpha class glutathione transferase A1-1, and a comparison with the Mu and Pi class enzymes.
J.Mol.Biol., 232, 1993
1SUR
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BU of 1sur by Molmil
PHOSPHO-ADENYLYL-SULFATE REDUCTASE
Descriptor: PAPS REDUCTASE
Authors:Sinning, I, Savage, H.
Deposit date:1998-04-01
Release date:1999-05-11
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of phosphoadenylyl sulphate (PAPS) reductase: a new family of adenine nucleotide alpha hydrolases.
Structure, 5, 1997
4V7F
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BU of 4v7f by Molmil
Arx1 pre-60S particle.
Descriptor: 25S ribosomal RNA, 5.8S ribosomal RNA, 5S ribosomal RNA, ...
Authors:Leidig, C, Thoms, M, Holdermann, I, Bradatsch, B, Berninghausen, O, Bange, G, Sinning, I, Hurt, E, Beckmann, R.
Deposit date:2013-12-10
Release date:2014-07-09
Last modified:2024-02-28
Method:ELECTRON MICROSCOPY (8.7 Å)
Cite:60S ribosome biogenesis requires rotation of the 5S ribonucleoprotein particle.
Nat Commun, 5, 2014
2ABW
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BU of 2abw by Molmil
Glutaminase subunit of the plasmodial PLP synthase (Vitamin B6 biosynthesis)
Descriptor: Pdx2 protein, TETRAETHYLENE GLYCOL
Authors:Gengenbacher, M, Fitzpatrick, T.B, Raschle, T, Flicker, K, Sinning, I, Mueller, S, Macheroux, P, Tews, I, Kappes, B.
Deposit date:2005-07-17
Release date:2006-01-10
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.62 Å)
Cite:Vitamin B6 Biosynthesis by the Malaria Parasite Plasmodium falciparum: Biochemical and structural insights
J.Biol.Chem., 281, 2006
1GSF
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BU of 1gsf by Molmil
GLUTATHIONE TRANSFERASE A1-1 COMPLEXED WITH ETHACRYNIC ACID
Descriptor: ETHACRYNIC ACID, GLUTATHIONE TRANSFERASE A1-1
Authors:L'Hermite, G, Sinning, I, Cameron, A.D, Jones, T.A.
Deposit date:1995-06-09
Release date:1995-09-15
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural analysis of human alpha-class glutathione transferase A1-1 in the apo-form and in complexes with ethacrynic acid and its glutathione conjugate.
Structure, 3, 1995
8CR1
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BU of 8cr1 by Molmil
Homo sapiens Get1/Get2 heterotetramer in complex with a Get3 dimer
Descriptor: ATPase ASNA1, Guided entry of tail-anchored proteins factor CAMLG,Guided entry of tail-anchored proteins factor 1,GET2-GET1, ZINC ION
Authors:McDowell, M.A, Heimes, M, Wild, K, Sinning, I.
Deposit date:2023-03-07
Release date:2023-11-29
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:The GET insertase exhibits conformational plasticity and induces membrane thinning.
Nat Commun, 14, 2023
4D2Q
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BU of 4d2q by Molmil
Negative-stain electron microscopy of E. coli ClpB mutant E432A (BAP form bound to ClpP)
Descriptor: CLPB
Authors:Carroni, M, Kummer, E, Oguchi, Y, Clare, D.K, Wendler, P, Sinning, I, Kopp, J, Mogk, A, Bukau, B, Saibil, H.R.
Deposit date:2014-05-12
Release date:2014-06-04
Last modified:2017-08-23
Method:ELECTRON MICROSCOPY (18 Å)
Cite:Head-to-Tail Interactions of the Coiled-Coil Domains Regulate Clpb Activity and Cooperation with Hsp70 in Protein Disaggregation.
Elife, 3, 2014
4D2X
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BU of 4d2x by Molmil
Negative-stain electron microscopy of E. coli ClpB of Y503D hyperactive mutant (BAP form bound to ClpP)
Descriptor: CHAPERONE PROTEIN CLPB
Authors:Carroni, M, Kummer, E, Oguchi, Y, Clare, D.K, Wendler, P, Sinning, I, Kopp, J, Mogk, A, Bukau, B, Saibil, H.R.
Deposit date:2014-05-13
Release date:2014-06-04
Last modified:2019-01-23
Method:ELECTRON MICROSCOPY (20 Å)
Cite:Head-to-Tail Interactions of the Coiled-Coil Domains Regulate Clpb Activity and Cooperation with Hsp70 in Protein Disaggregation.
Elife, 3, 2014
5M43
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BU of 5m43 by Molmil
Crystal structure of Yvh1 phosphatase domain from Chaetomium thermophilum
Descriptor: GLYCEROL, NITRATE ION, Putative uncharacterized protein
Authors:Ahmed, Y.L, Sinning, I.
Deposit date:2016-10-18
Release date:2016-11-30
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.646 Å)
Cite:Interaction network of the ribosome assembly machinery from a eukaryotic thermophile.
Protein Sci., 26, 2017
5MB9
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BU of 5mb9 by Molmil
Crystal structure of the eukaryotic ribosome associated complex (RAC), a unique Hsp70/Hsp40 pair
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, GLYCEROL, MAGNESIUM ION, ...
Authors:Gumiero, A, Weyer, F.A, Valentin Gese, G, Lapouge, K, Sinning, I.
Deposit date:2016-11-07
Release date:2016-12-28
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structural insights into a unique Hsp70-Hsp40 interaction in the eukaryotic ribosome-associated complex.
Nat. Struct. Mol. Biol., 24, 2017
1QZW
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BU of 1qzw by Molmil
Crystal structure of the complete core of archaeal SRP and implications for inter-domain communication
Descriptor: 7S RNA, Signal recognition 54 kDa protein
Authors:Rosendal, K.R, Wild, K, Montoya, G, Sinning, I.
Deposit date:2003-09-18
Release date:2003-11-18
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (4.1 Å)
Cite:Crystal structure of the complete core of archaeal signal recognition particle and implications for interdomain communication
Proc.Natl.Acad.Sci.USA, 100, 2003
1QZX
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BU of 1qzx by Molmil
Crystal structure of the complete core of archaeal SRP and implications for inter-domain communication
Descriptor: Signal recognition 54 kDa protein
Authors:Rosendal, K.R, Wild, K, Montoya, G, Sinning, I.
Deposit date:2003-09-18
Release date:2003-11-18
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (4 Å)
Cite:Crystal structure of the complete core of archaeal signal recognition particle and implications for interdomain communication
Proc.Natl.Acad.Sci.USA, 100, 2003
8CR2
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BU of 8cr2 by Molmil
Homo sapiens Get1/Get2 heterotetramer (a3' deletion variant) in complex with a Get3 dimer
Descriptor: ATPase ASNA1, Guided entry of tail-anchored proteins factor CAMLG,Guided entry of tail-anchored proteins factor 1, ZINC ION
Authors:McDowell, M.A, Heimes, M, Wild, K, Sinning, I.
Deposit date:2023-03-07
Release date:2023-11-29
Method:ELECTRON MICROSCOPY (4.2 Å)
Cite:The GET insertase exhibits conformational plasticity and induces membrane thinning.
Nat Commun, 14, 2023
8CQZ
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BU of 8cqz by Molmil
Homo sapiens Get3 in complex with the Get1 cytoplasmic domain
Descriptor: ATPase ASNA1, Guided entry of tail-anchored proteins factor 1
Authors:McDowell, M.A, Heimes, M, Wild, K, Saar, D, Sinning, I.
Deposit date:2023-03-07
Release date:2023-11-29
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:The GET insertase exhibits conformational plasticity and induces membrane thinning.
Nat Commun, 14, 2023
9FPZ
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BU of 9fpz by Molmil
Human NatA-MAP2 80S ribosome complex
Descriptor: 28S rRNA (300-MER, fragments), 5.8S rRNA (58-MER), ...
Authors:Klein, M.A, Wild, K, Sinning, I.
Deposit date:2024-06-14
Release date:2024-07-03
Method:ELECTRON MICROSCOPY (2.69 Å)
Cite:Multi-protein assemblies orchestrate enzymatic processing of the nascent chain on the 80S ribosome
To Be Published
9FQ0
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BU of 9fq0 by Molmil
Human NatA-NAC-MAP1 80S ribosome complex
Descriptor: 28S rRNA, 5.8S rRNA, 60S ribosomal protein L19, ...
Authors:Klein, M.A, Wild, K, Sinning, I.
Deposit date:2024-06-14
Release date:2024-07-03
Last modified:2024-07-17
Method:ELECTRON MICROSCOPY (4.67 Å)
Cite:Multi-protein assemblies orchestrate enzymatic processing of the nascent chain on the 80S ribosome
To Be Published
6Y31
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BU of 6y31 by Molmil
NG domain of human SRP54 T117 deletion mutant
Descriptor: Signal recognition particle 54 kDa protein
Authors:Juaire, K.D, Lapouge, K, Becker, M.M.M, Kotova, I, Haas, M, Carapito, R, Wild, K, Bahram, S, Sinning, I.
Deposit date:2020-02-17
Release date:2020-09-23
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (4.001 Å)
Cite:Structural and Functional Impact of SRP54 Mutations Causing Severe Congenital Neutropenia.
Structure, 29, 2021
6Y32
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BU of 6y32 by Molmil
Structure of the GTPase heterodimer of human SRP54 and SRalpha
Descriptor: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, SULFATE ION, ...
Authors:Juaire, K.D, Becker, M.M.M, Wild, K, Sinning, I.
Deposit date:2020-02-17
Release date:2020-09-23
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural and Functional Impact of SRP54 Mutations Causing Severe Congenital Neutropenia.
Structure, 29, 2021
1SMB
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BU of 1smb by Molmil
Crystal Structure of Golgi-Associated PR-1 protein
Descriptor: 17kD fetal brain protein
Authors:Serrano, R.L, Kuhn, A, Hendricks, A, Helms, J.B, Sinning, I, Groves, M.R.
Deposit date:2004-03-08
Release date:2004-09-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Structural analysis of the human Golgi-associated plant pathogenesis related protein GAPR-1 implicates dimerization as a regulatory mechanism
J.Mol.Biol., 339, 2004
1MHN
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BU of 1mhn by Molmil
High resolution crystal structure of the SMN Tudor domain
Descriptor: Survival motor neuron protein
Authors:Sprangers, R, Groves, M.R, Sinning, I, Sattler, M.
Deposit date:2002-08-20
Release date:2003-03-25
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:High Resolution X-ray and NMR Structures of the SMN Tudor Domain: conformational variation in the binding site for symmetrically dimethylated arginine residues
J.Mol.Biol., 327, 2003
5TKY
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BU of 5tky by Molmil
Crystal structure of the co-translational Hsp70 chaperone Ssb in the ATP-bound, open conformation
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Putative uncharacterized protein
Authors:Gumiero, A, Gese, G.V, Weyer, F.A, Lapouge, K, Sinning, I.
Deposit date:2016-10-10
Release date:2016-11-16
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Interaction of the cotranslational Hsp70 Ssb with ribosomal proteins and rRNA depends on its lid domain.
Nat Commun, 7, 2016
1Y10
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BU of 1y10 by Molmil
Mycobacterial adenylyl cyclase Rv1264, holoenzyme, inhibited state
Descriptor: CALCIUM ION, Hypothetical protein Rv1264/MT1302, PENTAETHYLENE GLYCOL
Authors:Tews, I, Findeisen, F, Sinning, I, Schultz, A, Schultz, J.E, Linder, J.U.
Deposit date:2004-11-16
Release date:2005-05-24
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The structure of a pH-sensing mycobacterial adenylyl cyclase holoenzyme
Science, 308, 2005
1Y11
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BU of 1y11 by Molmil
Mycobacterial adenylyl cyclase Rv1264, holoenzyme, active state
Descriptor: GLYCEROL, Hypothetical protein Rv1264/MT1302, PENTAETHYLENE GLYCOL, ...
Authors:Tews, I, Findeisen, F, Sinning, I, Schultz, A, Schultz, J.E, Linder, J.U.
Deposit date:2004-11-16
Release date:2005-05-24
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:The structure of a pH-sensing mycobacterial adenylyl cyclase holoenzyme
Science, 308, 2005
4WJS
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BU of 4wjs by Molmil
Crystal structure of Rsa4 from Chaetomium thermophilum
Descriptor: Rsa4
Authors:Holdermann, I, Bassler, J, Hurt, E, Sinning, I.
Deposit date:2014-10-01
Release date:2014-11-19
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:A network of assembly factors is involved in remodeling rRNA elements during preribosome maturation.
J.Cell Biol., 207, 2014
4WJV
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BU of 4wjv by Molmil
Crystal structure of Rsa4 in complex with the Nsa2 binding peptide
Descriptor: Maltose-binding periplasmic protein, Ribosome assembly protein 4, Ribosome biogenesis protein NSA2, ...
Authors:Holdermann, I, Paternoga, H, Bassler, J, Hurt, E, Sinning, I.
Deposit date:2014-10-01
Release date:2014-11-19
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:A network of assembly factors is involved in remodeling rRNA elements during preribosome maturation.
J.Cell Biol., 207, 2014

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