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7CBP
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CRYOEM STRUCTURE OF ZIKA VIRUS WITH FAB AT 4.1 ANGSTROM
Descriptor:Small envelope protein M, Envelope protein E, Fab Heavy chain, ...
Authors:Tyagi, A., Ahmed, T., Shi, J., Bhushan, S.
Deposit date:2020-06-13
Release date:2020-07-08
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:A complex between the Zika virion and the Fab of a broadly cross-reactive neutralizing monoclonal antibody revealed by cryo-EM and single particle analysis at 4.1 angstrom resolution.
J Struct Biol X, 4, 2020
7C2T
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HELICAL RECONSTRUCTION OF ZIKA VIRUS COMPLEXED WITH FAB C10
Descriptor:envelope protein, M protein, Heavy chain from Fab C10, ...
Authors:Morrone, S., Chew, S.V., Lim, X.N., Ng, T.S., Kostyuchenko, V.A., Zhang, S., Lok, S.M.
Deposit date:2020-05-09
Release date:2020-07-08
Method:ELECTRON MICROSCOPY (9.4 Å)
Cite:High flavivirus structural plasticity demonstrated by a non-spherical morphological variant.
Nat Commun, 11, 2020
7C2S
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HELICAL RECONSTRUCTION OF DENGUE VIRUS SEROTYPE 3 COMPLEXED WITH FAB C10
Descriptor:envelope protein, Heavy chain of Fab C10, light chain of Fab C10
Authors:Morrone, S., Chew, S.V., Lim, X.N., Ng, T.S., Kostyuchenko, V.A., Zhang, S., Lok, S.M.
Deposit date:2020-05-09
Release date:2020-07-08
Method:ELECTRON MICROSCOPY (10.4 Å)
Cite:High flavivirus structural plasticity demonstrated by a non-spherical morphological variant.
Nat Commun, 11, 2020
7C17
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THE CRYO-EM STRUCTURE OF E. COLI CUER TRANSCRIPTION ACTIVATION COMPLEX WITH FULLY DUPLEX PROMOTER DNA
Descriptor:DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Fang, C.L., Zhang, Y.
Deposit date:2020-05-02
Release date:2020-09-30
Last modified:2020-10-14
Method:ELECTRON MICROSCOPY (4.22 Å)
Cite:CueR activates transcription through a DNA distortion mechanism.
Nat.Chem.Biol., 2020
7BUF
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CRYO-EM STRUCTURE OF DENGUE VIRUS SEROTYPE 2 COMPLEXED WITH SIGN-3C IGG
Descriptor:SIgN-3C IgG heavy chain, SIgN-3C IgG light chain, Dengue virus serotype 2 E protein, ...
Authors:Zhang, S., Chew, S.V., Lim, X.N., Ng, T.S., Kostyuchenko, V.A., Lok, S.M.
Deposit date:2020-04-06
Release date:2020-05-13
Method:ELECTRON MICROSCOPY (6.1 Å)
Cite:A Human Antibody Neutralizes Different Flaviviruses by Using Different Mechanisms.
Cell Rep, 31, 2020
7BUE
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CRYO-EM STRUCTURE OF DENGUE VIRUS SEROTYPE 2 COMPLEXED WITH FAB SIGN-3C AT PH 5.0
Descriptor:SIgN-3C Fab heavy chain, SIgN-3C Fab light chain, Dengue serotype 2 E protein ectodomain
Authors:Zhang, S., Chew, S.V., Lim, X.N., Ng, T.S., Kostyuchenko, V.A., Lok, S.M.
Deposit date:2020-04-06
Release date:2020-05-13
Method:ELECTRON MICROSCOPY (7.8 Å)
Cite:A Human Antibody Neutralizes Different Flaviviruses by Using Different Mechanisms.
Cell Rep, 31, 2020
7BUD
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CRYO-EM STRUCTURE OF DENGUE VIRUS SEROTYPE 2 COMPLEXED WITH FAB SIGN-3C AT PH 8.0
Descriptor:SIgN-3C Fab heavy chain, SIgN-3C Fab light chain, Dengue virus serotype 2 E protein, ...
Authors:Zhang, S., Chew, S.V., Lim, X.N., Ng, T.S., Kostyuchenko, V.A., Lok, S.M.
Deposit date:2020-04-06
Release date:2020-05-13
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (4.5 Å)
Cite:A Human Antibody Neutralizes Different Flaviviruses by Using Different Mechanisms.
Cell Rep, 31, 2020
7BUB
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CRYO-EM STRUCTURE OF DENGUE VIRUS SEROTYPE 2 COMPLEXED WITH FAB SIGN-3C AT PH 6.5
Descriptor:SIgN-3C Fab heavy chain, SIgN-3C Fab light chain, Dengue virus serotype2 E protein, ...
Authors:Zhang, S., Chew, S.V., Lim, X.N., Ng, T.S., Kostyuchenko, V.A., Lok, S.M.
Deposit date:2020-04-06
Release date:2020-05-13
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (4.2 Å)
Cite:A Human Antibody Neutralizes Different Flaviviruses by Using Different Mechanisms.
Cell Rep, 31, 2020
7BUA
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CRYO-EM STRUCTURE OF ZIKA VIRUS COMPLEXED WITH FAB SIGN-3C AT PH 8.0
Descriptor:Genome polyprotein, zika virus M protein, SIgN-3C Fab heavy chain, ...
Authors:Zhang, S., Chew, S.V., Lim, X.N., Ng, T.S., Kostyuchenko, V.A., Lok, S.M.
Deposit date:2020-04-06
Release date:2020-05-13
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (4.8 Å)
Cite:A Human Antibody Neutralizes Different Flaviviruses by Using Different Mechanisms.
Cell Rep, 31, 2020
7BU8
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CRYO-EM STRUCTURE OF ZIKA VIRUS COMPLEXED WITH FAB SIGN-3C AT PH 6.5
Descriptor:Genome polyprotein, Zika virus M protein, SIgN-3C Fab heavy chain, ...
Authors:Zhang, S., Chew, S.V., Lim, X.N., Ng, T.S., Kostyuchenko, V.A., Lok, S.M.
Deposit date:2020-04-05
Release date:2020-05-13
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:A Human Antibody Neutralizes Different Flaviviruses by Using Different Mechanisms.
Cell Rep, 31, 2020
6ZDJ
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STRUCTURE OF THE NATIVE FULL-LENGTH HIV-1 CAPSID PROTEIN IN COMPLEX WITH CYCLOPHILIN A FROM HELICAL ASSEMBLY (-13,10)
Descriptor:Gag protein, Peptidyl-prolyl cis-trans isomerase A
Authors:Ni, T., Gerard, S., Zhao, G., Ning, J., Zhang, P.
Deposit date:2020-06-14
Release date:2020-08-19
Last modified:2020-09-16
Method:ELECTRON MICROSCOPY (5.8 Å)
Cite:Intrinsic curvature of the HIV-1 CA hexamer underlies capsid topology and interaction with cyclophilin A.
Nat.Struct.Mol.Biol., 27, 2020
6Y9Z
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STRUCTURE OF THE NATIVE FULL-LENGTH HIV-1 CAPSID PROTEIN IN COMPLEX WITH CYCLOPHILIN A FROM HELICAL ASSEMBLY (-13,9)
Descriptor:Gag-Pol polyprotein, Peptidyl-prolyl cis-trans isomerase A
Authors:Ni, T., Gerard, S., Zhao, G., Ning, J., Zhang, P.
Deposit date:2020-03-10
Release date:2020-08-19
Last modified:2020-09-16
Method:ELECTRON MICROSCOPY (4.8 Å)
Cite:Intrinsic curvature of the HIV-1 CA hexamer underlies capsid topology and interaction with cyclophilin A.
Nat.Struct.Mol.Biol., 27, 2020
6Y9Y
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STRUCTURE OF THE NATIVE FULL-LENGTH HIV-1 CAPSID PROTEIN IN COMPLEX WITH CYCLOPHILIN A FROM HELICAL ASSEMBLY (-7,13)
Descriptor:Gag-Pol polyprotein, Peptidyl-prolyl cis-trans isomerase A
Authors:Ni, T., Gerard, S., Zhao, G., Ning, J., Zhang, P.
Deposit date:2020-03-10
Release date:2020-08-19
Last modified:2020-09-16
Method:ELECTRON MICROSCOPY (6.1 Å)
Cite:Intrinsic curvature of the HIV-1 CA hexamer underlies capsid topology and interaction with cyclophilin A.
Nat.Struct.Mol.Biol., 27, 2020
6Y9X
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STRUCTURE OF THE NATIVE FULL-LENGTH HIV-1 CAPSID PROTEIN IN COMPLEX WITH CYCLOPHILIN A FROM HELICAL ASSEMBLY (-13,7)
Descriptor:Gag-Pol polyprotein, Peptidyl-prolyl cis-trans isomerase A
Authors:Ni, T., Gerard, S., Zhao, G., Ning, J., Zhang, P.
Deposit date:2020-03-10
Release date:2020-08-19
Last modified:2020-09-16
Method:ELECTRON MICROSCOPY (4.4 Å)
Cite:Intrinsic curvature of the HIV-1 CA hexamer underlies capsid topology and interaction with cyclophilin A.
Nat.Struct.Mol.Biol., 27, 2020
6Y9W
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STRUCTURE OF THE NATIVE FULL-LENGTH HIV-1 CAPSID PROTEIN IN COMPLEX WITH CYCLOPHILIN A FROM HELICAL ASSEMBLY (-13,8)
Descriptor:Gag-Pol polyprotein, Peptidyl-prolyl cis-trans isomerase A
Authors:Ni, T., Gerard, S., Zhao, G., Ning, J., Zhang, P.
Deposit date:2020-03-10
Release date:2020-08-19
Last modified:2020-09-16
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Intrinsic curvature of the HIV-1 CA hexamer underlies capsid topology and interaction with cyclophilin A.
Nat.Struct.Mol.Biol., 27, 2020
6Y9V
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STRUCTURE OF THE NATIVE FULL-LENGTH HIV-1 CAPSID PROTEIN IN COMPLEX WITH CYCLOPHILIN A FROM HELICAL ASSEMBLY (-8,13)
Descriptor:Gag-Pol polyprotein, Peptidyl-prolyl cis-trans isomerase A
Authors:Ni, T., Gerard, S., Zhao, G., Ning, J., Zhang, P.
Deposit date:2020-03-10
Release date:2020-08-19
Last modified:2020-09-16
Method:ELECTRON MICROSCOPY (6.9 Å)
Cite:Intrinsic curvature of the HIV-1 CA hexamer underlies capsid topology and interaction with cyclophilin A.
Nat.Struct.Mol.Biol., 27, 2020
6U28
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CRYSTAL STRUCTURE OF 1918 NS1-ED W187A IN COMPLEX WITH THE P85-BETA-ISH2 DOMAIN OF HUMAN PI3K
Descriptor:Non-structural protein 1, Phosphatidylinositol 3-kinase regulatory subunit beta
Authors:Cho, J.H., Zhao, B., Savage, N., Li, P.
Deposit date:2019-08-19
Release date:2020-04-22
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Molecular recognition of a host protein by NS1 of pandemic and seasonal influenza A viruses.
Proc.Natl.Acad.Sci.USA, 117, 2020
6T9O
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CRYOEM STRUCTURE OF HUMAN POLYCYSTIN-2/PKD2 IN UDM SUPPLEMENTED WITH PI(3,5)P2
Descriptor:Polycystin-2, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Wang, Q., Pike, A.C.W., Grieben, M., Baronina, A., Nasrallah, C., Shintre, C., Edwards, A.M., Arrowsmith, C.H., Bountra, C., Carpenter, E.P., Structural Genomics Consortium (SGC)
Deposit date:2019-10-28
Release date:2019-11-20
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (3.39 Å)
Cite:Lipid Interactions of a Ciliary Membrane TRP Channel: Simulation and Structural Studies of Polycystin-2.
Structure, 28, 2020
6T9N
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CRYOEM STRUCTURE OF HUMAN POLYCYSTIN-2/PKD2 IN UDM SUPPLEMENTED WITH PI(4,5)P2
Descriptor:Polycystin-2, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL, ...
Authors:Wang, Q., Pike, A.C.W., Grieben, M., Baronina, A., Nasrallah, C., Shintre, C., Edwards, A.M., Arrowsmith, C.H., Bountra, C., Carpenter, E.P., Structural Genomics Consortium (SGC)
Deposit date:2019-10-28
Release date:2019-11-20
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (2.96 Å)
Cite:Lipid Interactions of a Ciliary Membrane TRP Channel: Simulation and Structural Studies of Polycystin-2.
Structure, 28, 2020
6OX7
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THE COMPLEX OF 1918 NS1-ED AND THE ISH2 DOMAIN OF THE HUMAN P85BETA SUBUNIT OF PI3K
Descriptor:Non-structural protein 1, Phosphatidylinositol 3-kinase regulatory subunit beta
Authors:Shen, Q., Zhao, B., Li, P., Cho, J.H.
Deposit date:2019-05-13
Release date:2020-04-22
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Molecular recognition of a host protein by NS1 of pandemic and seasonal influenza A viruses.
Proc.Natl.Acad.Sci.USA, 117, 2020
6MS7
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PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA LIGAND BINDING DOMAIN IN COMPLEX WITH A NOVEL SELECTIVE PPAR-GAMMA MODULATOR VSP-77
Descriptor:Peroxisome proliferator-activated receptor gamma, PGC1 LXXLL motif, {[(1S)-1-(4-chlorophenyl)octyl]oxy}acetic acid
Authors:Yi, W., Jiang, H., Zhou, X.E., Shi, J., Zhao, G., Zhang, X., Sun, Y., Suino-Powell, K., Li, J., Li, J., Melcher, K., Xu, H.E.
Deposit date:2018-10-16
Release date:2019-10-23
Last modified:2020-04-15
Method:X-RAY DIFFRACTION (1.43 Å)
Cite:Identification and structural insight of an effective PPAR gamma modulator with improved therapeutic index for anti-diabetic drug discovery.
Chem Sci, 11, 2020
6MNL
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NMR SOLUTION STRUCTURES OF SECOND BROMODOMAIN OF BRD4 WITH FOXO3A PEPTIDE
Descriptor:FOXO3a peptide, Bromodomain-containing protein 4
Authors:Zeng, L., Zhou, M.-M.
Deposit date:2018-10-02
Release date:2018-10-31
Last modified:2018-12-19
Method:SOLUTION NMR
Cite:Targeting the BRD4/FOXO3a/CDK6 axis sensitizes AKT inhibition in luminal breast cancer.
Nat Commun, 9, 2018
6MIE
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SOLUTION NMR STRUCTURE OF THE KCNQ1 VOLTAGE-SENSING DOMAIN
Descriptor:Potassium voltage-gated channel subfamily KQT member 1
Authors:Taylor, K.C., Kuenze, G., Smith, J.A., Meiler, J., McFeeters, R.L., Sanders, C.R.
Deposit date:2018-09-19
Release date:2020-03-04
Last modified:2020-03-11
Method:SOLUTION NMR
Cite:Structure and physiological function of the human KCNQ1 channel voltage sensor intermediate state.
Elife, 9, 2020
6M6C
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CRYOEM STRUCTURE OF THERMUS THERMOPHILUS RNA POLYMERASE ELONGATION COMPLEX
Descriptor:DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Shi, J., Wen, A., Feng, Y.
Deposit date:2020-03-14
Release date:2020-10-14
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Structural basis of Mfd-dependent transcription termination.
Nucleic Acids Res., 2020
6M6B
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CRYO-EM STRUCTURE OF THERMUS THERMOPHILUS MFD IN COMPLEX WITH RNA POLYMERASE AND ATP-GAMMA-S
Descriptor:DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Shi, J., Wen, A., Feng, Y.
Deposit date:2020-03-14
Release date:2020-10-14
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Structural basis of Mfd-dependent transcription termination.
Nucleic Acids Res., 2020
170172
数据于2020-10-21公开中