2KXW
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4RJD
| TFP bound in alternate orientations to calcium-saturated Calmodulin C-Domains | Descriptor: | 10-[3-(4-METHYL-PIPERAZIN-1-YL)-PROPYL]-2-TRIFLUOROMETHYL-10H-PHENOTHIAZINE, CALCIUM ION, CHLORIDE ION, ... | Authors: | Feldkamp, M.D, Gakhar, L, Pandey, N, Shea, M.A. | Deposit date: | 2014-10-08 | Release date: | 2015-08-26 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Opposing orientations of the anti-psychotic drug trifluoperazine selected by alternate conformations of M144 in calmodulin. Proteins, 83, 2015
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6BUT
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3IFK
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3B32
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2M5E
| Structure of the C-domain of Calcium-saturated Calmodulin bound to the IQ motif of NaV1.2 | Descriptor: | CALCIUM ION, Calmodulin, Sodium channel protein type 2 subunit alpha | Authors: | Fowler, C.A, Feldkamp, M.D, Yu, L, Shea, M.A. | Deposit date: | 2013-02-21 | Release date: | 2014-07-23 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Calcium triggers reversal of calmodulin on nested anti-parallel sites in the IQ motif of the neuronal voltage-dependent sodium channel NaV1.2. Biophys. Chem., 224, 2017
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2HQW
| Crystal Structure of Ca2+/Calmodulin bound to NMDA Receptor NR1C1 peptide | Descriptor: | CALCIUM ION, Calmodulin, Glutamate NMDA receptor subunit zeta 1 | Authors: | Akyol, Z, Gakhar, L, Sorensen, B.R, Hell, J.H, Shea, M.A. | Deposit date: | 2006-07-19 | Release date: | 2007-11-13 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | The NMDA Receptor NR1 C1 Region Bound to Calmodulin: Structural Insights into Functional Differences between Homologous Domains. Structure, 15, 2007
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5VEB
| Crystal structure of a Fab binding to extracellular domain 5 of Cadherin-6 | Descriptor: | 2-acetamido-2-deoxy-alpha-D-galactopyranose, Cadherin-6, anti-CDH6 Fab heavy chain, ... | Authors: | Zhu, X, Bialucha, C.U, London, A, Clark, K, Hu, T. | Deposit date: | 2017-04-04 | Release date: | 2017-06-07 | Last modified: | 2024-04-24 | Method: | X-RAY DIFFRACTION (2.34 Å) | Cite: | Discovery and Optimization of HKT288, a Cadherin-6-Targeting ADC for the Treatment of Ovarian and Renal Cancers. Cancer Discov, 7, 2017
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