Author results

3TCP
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CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF THE PROTO-ONCOGENE TYROSINE-PROTEIN KINASE MER IN COMPLEX WITH INHIBITOR UNC569
Descriptor:Tyrosine-protein kinase Mer, 1-[(trans-4-aminocyclohexyl)methyl]-N-butyl-3-(4-fluorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-6-amine, CHLORIDE ION, ...
Authors:Liu, J., Yang, C., Simpson, C., DeRyckere, D., Van Deusen, A., Miley, M., Kireev, D.B., Norris-Drouin, J., Sather, S., Hunter, D., Patel, H.S., Janzen, W.P., Machius, M., Johnson, G., Earp, H.S., Graham, D.K., Frye, S., Wang, X.
Deposit date:2011-08-09
Release date:2012-06-20
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.69 Å)
Cite:Discovery of Novel Small Molecule Mer Kinase Inhibitors for the Treatment of Pediatric Acute Lymphoblastic Leukemia.
ACS Med Chem Lett, 3, 2012
4M3Q
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CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF THE PROTO-ONCOGENE TYROSINE-PROTEIN KINASE MER IN COMPLEX WITH INHIBITOR UNC1917
Descriptor:Tyrosine-protein kinase Mer, CHLORIDE ION, MAGNESIUM ION, ...
Authors:Zhang, W., Zhang, D., Stashko, M.A., DeRyckere, D., Hunter, D., Kireev, D.B., Miley, M., Cummings, C., Lee, M., Norris-Drouin, J., Stewart, W.M., Sather, S., Zhou, Y., Kirkpatrick, G., Machius, M., Janzen, W.P., Earp, H.S., Graham, D.K., Frye, S., Wang, X.
Deposit date:2013-08-06
Release date:2013-11-27
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.718 Å)
Cite:Pseudo-Cyclization through Intramolecular Hydrogen Bond Enables Discovery of Pyridine Substituted Pyrimidines as New Mer Kinase Inhibitors.
J.Med.Chem., 56, 2013
4MH7
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CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF THE PROTO-ONCOGENE TYROSINE-PROTEIN KINASE MER IN COMPLEX WITH INHIBITOR UNC1896
Descriptor:Tyrosine-protein kinase Mer, CHLORIDE ION, MAGNESIUM ION, ...
Authors:Zhang, W., McIver, A., Stashko, M.A., Deryckere, D., Branchford, B.R., Hunter, D., Kireev, D.B., Miley, M.J., Norris-Drouin, J., Stewart, W.M., Lee, M., Sather, S., Zhou, Y., DiPaola, J.A., Machius, M., Janzen, W.P., Earp, H.S., Graham, D.K., Frye, S., Wang, X.
Deposit date:2013-08-29
Release date:2014-05-21
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.51 Å)
Cite:Discovery of Mer specific tyrosine kinase inhibitors for the treatment and prevention of thrombosis.
J.Med.Chem., 56, 2013
4MHA
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CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF THE PROTO-ONCOGENE TYROSINE-PROTEIN KINASE MER IN COMPLEX WITH INHIBITOR UNC1817
Descriptor:Tyrosine-protein kinase Mer, CHLORIDE ION, 2-(butylamino)-4-[(trans-4-hydroxycyclohexyl)amino]-N-(4-sulfamoylbenzyl)pyrimidine-5-carboxamide, ...
Authors:Zhang, W., Mciver, A., Stashko, M.A., Deryckere, D., Branchford, B.R., Hunter, D., Kireev, D.B., Miley, D.B.M., Norris-Drouin, J., Stewart, W.M., Lee, M., Sather, S., Zhou, Y., Dipaola, J.A., Machius, M., Janzen, W.P., Earp, H.S., Graham, D.K., Frye, S., Wang, X.
Deposit date:2013-08-29
Release date:2014-05-21
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.59 Å)
Cite:Discovery of Mer specific tyrosine kinase inhibitors for the treatment and prevention of thrombosis.
J.Med.Chem., 56, 2013