Author results

1JBU
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COAGULATION FACTOR VII ZYMOGEN (EGF2/PROTEASE) IN COMPLEX WITH INHIBITORY EXOSITE PEPTIDE A-183
Descriptor:COAGULATION FACTOR VII, Peptide exosite inhibitor A-183, SULFATE ION, ...
Authors:Eigenbrot, C., Kirchhofer, D., Dennis, M.S., Santell, L., Lazarus, R.A., Stamos, J., Ultsch, M.H.
Deposit date:2001-06-06
Release date:2001-07-11
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2 Å)
Cite:The factor VII zymogen structure reveals reregistration of beta strands during activation.
Structure, 9, 2001
1SI5
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PROTEASE-LIKE DOMAIN FROM 2-CHAIN HEPATOCYTE GROWTH FACTOR
Descriptor:hepatocyte growth factor
Authors:Kirchhofer, D., Yao, X., Peek, M., Eigenbrot, C., Lipari, M.T., Billeci, K.L., Maun, H.R., Moran, P., Santell, L., Lazarus, R.A.
Deposit date:2004-02-27
Release date:2004-12-28
Last modified:2019-08-14
Method:X-RAY DIFFRACTION (2.53 Å)
Cite:Structural and functional basis of the serine protease-like hepatocyte growth factor beta-chain in Met binding and signaling
J.Biol.Chem., 279, 2004
1YBW
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PROTEASE DOMAIN OF HGFA WITH NO INHIBITOR
Descriptor:Hepatocyte growth factor activator precursor, N-ACETYL-D-GLUCOSAMINE
Authors:Shia, S., Stamos, J., Kirchhofer, D., Fan, B., Wu, J., Corpuz, R.T., Santell, L., Lazarus, R.A., Eigenbrot, C.
Deposit date:2004-12-21
Release date:2005-02-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Conformational lability in serine protease active sites: structures of hepatocyte growth factor activator (HGFA) alone and with the inhibitory domain from HGFA inhibitor-1B.
J.Mol.Biol., 346, 2005
1YC0
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SHORT FORM HGFA WITH FIRST KUNITZ DOMAIN FROM HAI-1
Descriptor:Hepatocyte growth factor activator, Kunitz-type protease inhibitor 1, PHOSPHATE ION
Authors:Shia, S., Stamos, J., Kirchhofer, D., Fan, B., Wu, J., Corpuz, R.T., Santell, L., Lazarus, R.A., Eigenbrot, C.
Deposit date:2004-12-21
Release date:2005-02-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Conformational lability in serine protease active sites: structures of hepatocyte growth factor activator (HGFA) alone and with the inhibitory domain from HGFA inhibitor-1B.
J.Mol.Biol., 346, 2005
4AWN
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STRUCTURE OF RECOMBINANT HUMAN DNASE I (RHDNASEI) IN COMPLEX WITH MAGNESIUM AND PHOSPHATE.
Descriptor:DEOXYRIBONUCLEASE-1, CALCIUM ION, MAGNESIUM ION, ...
Authors:Parsiegla, G., Noguere, C., Santell, L., Lazarus, R.A., Bourne, Y.
Deposit date:2012-06-04
Release date:2013-01-09
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:The Structure of Human DNase I Bound to Magnesium and Phosphate Ions Points to a Catalytic Mechanism Common to Members of the DNase I-Like Superfamily.
Biochemistry, 51, 2012
1DVA
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CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN THE PEPTIDE EXOSITE INHIBITOR E-76 AND COAGULATION FACTOR VIIA
Descriptor:DES-GLA FACTOR VIIA (HEAVY CHAIN), DES-GLA FACTOR VIIA (LIGHT CHAIN), PEPTIDE E-76, ...
Authors:Eigenbrot, C., Ultsch, M.H.
Deposit date:2000-01-20
Release date:2000-05-12
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (3 Å)
Cite:Peptide exosite inhibitors of factor VIIa as anticoagulants.
Nature, 404, 2000
4K3J
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CRYSTAL STRUCTURE OF ONARTUZUMAB FAB IN COMPLEX WITH MET AND HGF-BETA
Descriptor:Hepatocyte growth factor, Hepatocyte growth factor beta chain, Onartuzumab Fab heavy chain, ...
Authors:Ma, X., Starovasnik, M.A.
Deposit date:2013-04-10
Release date:2013-08-28
Last modified:2014-08-20
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Monovalent antibody design and mechanism of action of onartuzumab, a MET antagonist with anti-tumor activity as a therapeutic agent.
Proc.Natl.Acad.Sci.USA, 110, 2013
4O3T
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ZYMOGEN HGF-BETA/MET WITH ZYMOGEN ACTIVATOR PEPTIDE ZAP.14
Descriptor:Hepatocyte growth factor, Hepatocyte growth factor receptor, ZAP.14, ...
Authors:Eigenbrot, C., Landgraf, K.E., Steffek, M.
Deposit date:2013-12-18
Release date:2014-06-04
Last modified:2014-07-02
Method:X-RAY DIFFRACTION (2.99 Å)
Cite:An allosteric switch for pro-HGF/Met signaling using zymogen activator peptides.
Nat.Chem.Biol., 10, 2014
4O3U
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ZYMOGEN HGF-BETA/MET WITH ZYMOGEN ACTIVATOR PEPTIDE ZAP2.3
Descriptor:Hepatocyte growth factor, Hepatocyte growth factor receptor, ZAP 2.3
Authors:Eigenbrot, C., Landgraf, K.E., Steffek, M.
Deposit date:2013-12-18
Release date:2014-06-04
Last modified:2014-07-02
Method:X-RAY DIFFRACTION (3.04 Å)
Cite:An allosteric switch for pro-HGF/Met signaling using zymogen activator peptides.
Nat.Chem.Biol., 10, 2014
1SHY
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THE CRYSTAL STRUCTURE OF HGF BETA-CHAIN IN COMPLEX WITH THE SEMA DOMAIN OF THE MET RECEPTOR.
Descriptor:Hepatocyte growth factor, Hepatocyte growth factor receptor
Authors:Stamos, J., Wiesmann, C.
Deposit date:2004-02-26
Release date:2004-06-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.22 Å)
Cite:Crystal structure of the HGF beta-chain in complex with the Sema domain of the Met receptor.
Embo J., 23, 2004