Author results

1BSI
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HUMAN PANCREATIC ALPHA-AMYLASE FROM PICHIA PASTORIS, GLYCOSYLATED PROTEIN
Descriptor:ALPHA-AMYLASE, N-ACETYL-D-GLUCOSAMINE, CALCIUM ION, ...
Authors:Rydberg, E.H., Sidhu, G., Vo, H.C., Hewitt, J., Cote, H.C.F., Wang, Y., Numao, S., Macgillivray, R.T.A., Overall, C.M., Brayer, G.D., Withers, S.G.
Deposit date:1998-08-28
Release date:1999-05-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Cloning, mutagenesis, and structural analysis of human pancreatic alpha-amylase expressed in Pichia pastoris.
Protein Sci., 8, 1999
1KBB
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MECHANISTIC ANALYSES OF CATALYSIS IN HUMAN PANCREATIC ALPHA-AMYLASE: DETAILED KINETIC AND STRUCTURAL STUDIES OF MUTANTS OF THREE CONSERVED CARBOXYLIC ACIDS
Descriptor:ALPHA-AMYLASE, PANCREATIC, CALCIUM ION, ...
Authors:Rydberg, E.H., Li, C., Maurus, R., Overall, C.M., Brayer, G.D., Withers, S.G.
Deposit date:2001-11-05
Release date:2002-04-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Mechanistic analyses of catalysis in human pancreatic alpha-amylase: detailed kinetic and structural studies of mutants of three conserved carboxylic acids.
Biochemistry, 41, 2002
1KBK
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MECHANISTIC ANALYSES OF CATALYSIS IN HUMAN PANCREATIC ALPHA-AMYLASE: DETAILED KINETIC AND STRUCTURAL STUDIES OF MUTANTS OF THREE CONSERVED CARBOXYLIC ACIDS
Descriptor:ALPHA-AMYLASE, PANCREATIC, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Rydberg, E.H., Li, C., Maurus, R., Overall, C.M., Brayer, G.D., Withers, S.G.
Deposit date:2001-11-06
Release date:2002-04-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Mechanistic analyses of catalysis in human pancreatic alpha-amylase: detailed kinetic and structural studies of mutants of three conserved carboxylic acids.
Biochemistry, 41, 2002
2CMF
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TORPEDO CALIFORNICA ACETYLCHOLINESTERASE COMPLEXED WITH ALKYLENE- LINKED BIS-TACRINE DIMER (5 CARBON LINKER)
Descriptor:ACETYLCHOLINESTERASE, N,N'-DI-1,2,3,4-TETRAHYDROACRIDIN-9-YLPENTANE-1,5-DIAMINE, N-ACETYL-D-GLUCOSAMINE
Authors:Rydberg, E.H., Brumshtein, B., Greenblatt, H.M., Wong, D.M., Pang, Y.P., Silman, I., Sussman, J.L.
Deposit date:2006-05-08
Release date:2006-09-04
Last modified:2019-02-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Complexes of alkylene-linked tacrine dimers with Torpedo californica acetylcholinesterase: Binding of Bis5-tacrine produces a dramatic rearrangement in the active-site gorge.
J. Med. Chem., 49, 2006
3GSZ
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STRUCTURE OF THE GENOTYPE 2B HCV POLYMERASE
Descriptor:RNA-directed RNA polymerase
Authors:Rydberg, E.H., Carfi, A.
Deposit date:2009-03-27
Release date:2009-07-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural basis for resistance of the genotype 2b hepatitis C virus NS5B polymerase to site A non-nucleoside inhibitors.
J.Mol.Biol., 390, 2009
2CKM
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TORPEDO CALIFORNICA ACETYLCHOLINESTERASE COMPLEXED WITH ALKYLENE- LINKED BIS-TACRINE DIMER (7 CARBON LINKER)
Descriptor:ACETYLCHOLINESTERASE, N,N'-DI-1,2,3,4-TETRAHYDROACRIDIN-9-YLHEPTANE-1,7-DIAMINE, N-ACETYL-D-GLUCOSAMINE
Authors:Brumshtein, B., Rydberg, E.H., Greenblatt, H.M., Wong, D.M., Shaya, D., Williams, L.D., Carlier, P.R., Pang, Y.P., Silman, I., Sussman, J.L.
Deposit date:2006-04-20
Release date:2006-09-04
Last modified:2019-02-13
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Complexes of alkylene-linked tacrine dimers with Torpedo californica acetylcholinesterase: Binding of Bis5-tacrine produces a dramatic rearrangement in the active-site gorge.
J. Med. Chem., 49, 2006
3HVO
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STRUCTURE OF THE GENOTYPE 2B HCV POLYMERASE BOUND TO A NNI
Descriptor:Genome polyprotein, 2-(3-bromophenyl)-6-[(2-hydroxyethyl)amino]-1h-benzo[de]isoquinoline-1,3(2h)-dione
Authors:Rydberg, E.H., Carfi, A.
Deposit date:2009-06-16
Release date:2009-08-04
Last modified:2019-01-23
Method:X-RAY DIFFRACTION (2 Å)
Cite:Identification and Biological Evaluation of a Series of 1H-Benzo[de]isoquinoline-1,3(2H)-diones as Hepatitis C Virus NS5B Polymerase Inhibitors
To be Published
1CPU
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SUBSITE MAPPING OF THE ACTIVE SITE OF HUMAN PANCREATIC ALPHA-AMYLASE USING SUBSTRATES, THE PHARMACOLOGICAL INHIBITOR ACARBOSE, AND AN ACTIVE SITE VARIANT
Descriptor:PROTEIN (ALPHA-AMYLASE), ALPHA-D-GLUCOSE, 4,6-DIDEOXY-4-AMINO-ALPHA-D-GLUCOSE, ...
Authors:Brayer, G.D., Sidhu, G., Maurus, R., Rydberg, E.H., Braun, C., Wang, Y., Nguyen, N.T., Overall, C.M., Withers, S.G.
Deposit date:1999-06-07
Release date:1999-06-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Subsite mapping of the human pancreatic alpha-amylase active site through structural, kinetic, and mutagenesis techniques.
Biochemistry, 39, 2000
2CPU
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SUBSITE MAPPING OF THE ACTIVE SITE OF HUMAN PANCREATIC ALPHA-AMYLASE USING SUBSTRATES, THE PHARMACOLOGICAL INHIBITOR ACARBOSE, AND AN ACTIVE SITE VARIANT
Descriptor:ALPHA-AMYLASE, CALCIUM ION, CHLORIDE ION
Authors:Brayer, G.D., Sidhu, G., Maurus, R., Rydberg, E.H., Braun, C., Wang, Y., Nguyen, N.T., Overall, C.M., Withers, S.G.
Deposit date:1999-06-08
Release date:2001-06-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Subsite mapping of the human pancreatic alpha-amylase active site through structural, kinetic, and mutagenesis techniques.
Biochemistry, 39, 2000
3CPU
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SUBSITE MAPPING OF THE ACTIVE SITE OF HUMAN PANCREATIC ALPHA-AMYLASE USING SUBSTRATES, THE PHARMACOLOGICAL INHIBITOR ACARBOSE, AND AN ACTIVE SITE VARIANT
Descriptor:ALPHA-AMYLASE, ALPHA-D-GLUCOSE, CALCIUM ION, ...
Authors:Brayer, G.D., Sidhu, G., Maurus, R., Rydberg, E.H., Braun, C., Wang, Y., Nguyen, N.T., Overall, C.M., Withers, S.G.
Deposit date:1999-06-08
Release date:2001-06-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Subsite mapping of the human pancreatic alpha-amylase active site through structural, kinetic, and mutagenesis techniques.
Biochemistry, 39, 2000
1ODC
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STRUCTURE OF ACETYLCHOLINESTERASE (E.C. 3.1.1.7) COMPLEXED WITH N-4'-QUINOLYL-N'-9"-(1",2",3",4"-TETRAHYDROACRIDINYL)-1,8- DIAMINOOCTANE AT 2.2A RESOLUTION
Descriptor:ACETYLCHOLINESTERASE, N-ACETYL-D-GLUCOSAMINE, N-QUINOLIN-4-YL-N'-(1,2,3,4-TETRAHYDROACRIDIN-9-YL)OCTANE-1,8-DIAMINE
Authors:Wong, D.M., Greenblatt, H.M., Carlier, P.R., Han, Y.-F., Pang, Y.-P., Silman, I., Sussman, J.L.
Deposit date:2003-02-15
Release date:2005-03-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Complexes of Alkylene-Linked Tacrine Dimers with Torpedo Californica Acetylcholinesterase: Binding of Bis(5)-Tacrine Produces a Dramatic Rearrangement in the Active-Site Gorge.
J.Med.Chem., 49, 2006
1UT6
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STRUCTURE OF ACETYLCHOLINESTERASE (E.C. 3.1.1.7) COMPLEXED WITH N-9-(1',2',3',4'-TETRAHYDROACRIDINYL)-1,8- DIAMINOOCTANE AT 2.4 ANGSTROMS RESOLUTION.
Descriptor:ACETYLCHOLINESTERASE, N-ACETYL-D-GLUCOSAMINE, N-9-(1',2',3',4'-TETRAHYDROACRIDINYL)-1,8-DIAMINOOCTANE
Authors:Brumshtein, B., Wong, D.M., Greenblatt, H.M., Carlier, P.R., Pang, Y.-P., Silman, I., Sussman, J.L.
Deposit date:2003-12-04
Release date:2005-04-21
Last modified:2016-09-28
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Complexes of Alkylene-Linked Tacrine Dimers with Torpedo Californica Acetylcholinesterase: Binding of Bis(5)-Tacrine Produces a Dramatic Rearrangement in the Active-Site Gorge.
J.Med.Chem., 49, 2006
2WHO
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CRYSTAL STRUCTURE OF HEPATITIS C VIRUS NS5B POLYMERASE FROM 1B GENOTYPE IN COMPLEX WITH A NON-NUCLEOSIDE INHIBITOR
Descriptor:RNA-DIRECTED RNA POLYMERASE, MANGANESE (II) ION, 2-(3-bromophenyl)-6-[(2-hydroxyethyl)amino]-1h-benzo[de]isoquinoline-1,3(2h)-dione
Authors:Di Marco, S.
Deposit date:2009-05-05
Release date:2009-08-11
Last modified:2019-01-23
Method:X-RAY DIFFRACTION (2 Å)
Cite:Identification and biological evaluation of a series of 1H-benzo[de]isoquinoline-1,3(2H)-diones as hepatitis C virus NS5B polymerase inhibitors.
J. Med. Chem., 52, 2009