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5FYD
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STRUCTURAL AND BIOCHEMICAL INSIGHTS INTO 7BETA-HYDROXYSTEROID DEHYDROGENASE STEREOSELECTIVITY
Descriptor:OXIDOREDUCTASE, SHORT CHAIN DEHYDROGENASE/REDUCTASE FAMILY PROTEIN, GLYCEROL
Authors:Savino, S., Ferrandi, E., Forneris, F., Rovida, S., Riva, S., Monti, D., Mattevi, A.
Deposit date:2016-03-07
Release date:2016-04-06
Last modified:2016-06-01
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structural and Biochemical Insights Into 7Beta-Hydroxysteroid Dehydrogenase Stereoselectivity.
Proteins, 84, 2016
1RZ0
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FLAVIN REDUCTASE PHEA2 IN NATIVE STATE
Descriptor:phenol 2-hydroxylase component B, FLAVIN-ADENINE DINUCLEOTIDE
Authors:van den Heuvel, R.H., Westphal, A.H., Heck, A.J., Walsh, M.A., Rovida, S., van Berkel, W.J., Mattevi, A.
Deposit date:2003-12-23
Release date:2004-04-06
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural Studies on Flavin Reductase PheA2 Reveal Binding of NAD in an Unusual Folded Conformation and Support Novel Mechanism of Action.
J.Biol.Chem., 279, 2004
1RZ1
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REDUCED FLAVIN REDUCTASE PHEA2 IN COMPLEX WITH NAD
Descriptor:phenol 2-hydroxylase component B, FLAVIN-ADENINE DINUCLEOTIDE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:Van Den Heuvel, R.H., Westphal, A.H., Heck, A.J., Walsh, M.A., Rovida, S., Van Berkel, W.J., Mattevi, A.
Deposit date:2003-12-23
Release date:2004-04-06
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural Studies on Flavin Reductase PheA2 Reveal Binding of NAD in an Unusual Folded Conformation and Support Novel Mechanism of Action.
J.Biol.Chem., 279, 2004
2YG3
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STRUCTURE-BASED REDESIGN OF COFACTOR BINDING IN PUTRESCINE OXIDASE: WILD TYPE ENZYME
Descriptor:PUTRESCINE OXIDASE, FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, ...
Authors:Kopacz, M.M., Rovida, S., van Duijn, E., Fraaije, M.W., Mattevi, A.
Deposit date:2011-04-11
Release date:2011-05-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure-Based Redesign of Cofactor Binding in Putrescine Oxidase.
Biochemistry, 50, 2011
2YG4
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STRUCTURE-BASED REDESIGN OF COFACTOR BINDING IN PUTRESCINE OXIDASE: WILD TYPE BOUND TO PUTRESCINE
Descriptor:PUTRESCINE OXIDASE, FLAVIN-ADENINE DINUCLEOTIDE, 4-HYDROXYBUTAN-1-AMINIUM, ...
Authors:Kopacz, M.M., Rovida, S., van Duijn, E., Fraaije, M.W., Mattevi, A.
Deposit date:2011-04-11
Release date:2011-05-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure-Based Redesign of Cofactor Binding in Putrescine Oxidase.
Biochemistry, 50, 2011
2YG5
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STRUCTURE-BASED REDESIGN OF COFACTOR BINDING IN PUTRESCINE OXIDASE: A394C MUTANT
Descriptor:PUTRESCINE OXIDASE, FLAVIN-ADENINE DINUCLEOTIDE, SULFATE ION, ...
Authors:Kopacz, M.M., Rovida, S., van Duijn, E., Fraaije, M.W., Mattevi, A.
Deposit date:2011-04-11
Release date:2011-05-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure-Based Redesign of Cofactor Binding in Putrescine Oxidase.
Biochemistry, 50, 2011
2YG6
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STRUCTURE-BASED REDESIGN OF COFACTOR BINDING IN PUTRESCINE OXIDASE: P15I-A394C DOUBLE MUTANT
Descriptor:PUTRESCINE OXIDASE, FLAVIN-ADENINE DINUCLEOTIDE, SULFATE ION, ...
Authors:Kopacz, M.M., Rovida, S., van Duijn, E., Fraaije, M.W., Mattevi, A.
Deposit date:2011-04-11
Release date:2011-05-18
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure-based redesign of cofactor binding in putrescine oxidase.
Biochemistry, 50, 2011
2YG7
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STRUCTURE-BASED REDESIGN OF COFACTOR BINDING IN PUTRESCINE OXIDASE: A394C-A396T-Q431G TRIPLE MUTANT
Descriptor:PUTRESCINE OXIDASE, FLAVIN-ADENINE DINUCLEOTIDE
Authors:Kopacz, M.M., Rovida, S., van Duijn, E., Fraaije, M.W., Mattevi, A.
Deposit date:2011-04-11
Release date:2011-05-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Structure-Based Redesign of Cofactor Binding in Putrescine Oxidase.
Biochemistry, 50, 2011
3ZYX
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CRYSTAL STRUCTURE OF HUMAN MONOAMINE OXIDASE B IN COMPLEX WITH METHYLENE BLUE AND BEARING THE DOUBLE MUTATION I199A-Y326A
Descriptor:AMINE OXIDASE [FLAVIN-CONTAINING] B, FLAVIN-ADENINE DINUCLEOTIDE, 3,7-BIS(DIMETHYLAMINO)PHENOTHIAZIN-5-IUM
Authors:Milczek, E.M., Binda, C., Rovida, S., Mattevi, A., Edmondson, D.E.
Deposit date:2011-08-29
Release date:2011-12-14
Last modified:2015-04-01
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The 'Gating' Residues Ile199 and Tyr326 in Human Monoamine Oxidase B Function in Substrate and Inhibitor Recognition.
FEBS J., 278, 2011
4UXN
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LSD1(KDM1A)-COREST IN COMPLEX WITH Z-PRO DERIVATIVE OF MC2580
Descriptor:LYSINE-SPECIFIC HISTONE DEMETHYLASE 1A, REST COREPRESSOR 1, FLAVIN-ADENINE DINUCLEOTIDE, ...
Authors:Rodriguez, V., Valente, S., Stazi, G., Lucidi, A., Mercurio, C., Vianello, P., Ciossani, G., Mattevi, A., Botrugno, O.A., Dessanti, P., Minucci, S., Varasi, M., Mai, A.
Deposit date:2014-08-27
Release date:2015-02-25
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Pyrrole- and Indole-Containing Tranylcypromine Derivatives as Novel Lysine-Specific Demethylase 1 Inhibitors Active on Cancer Cells
Chemmedchem, 6, 2015
5MQ6
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POLYCYCLIC KETONE MONOOXYGENASE FROM THE THERMOPHILIC FUNGUS THERMOTHELOMYCES THERMOPHILA
Descriptor:Pyridine nucleotide-disulfide oxidoreductase-like protein, FLAVIN-ADENINE DINUCLEOTIDE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
Authors:Savino, S., Furst, M.J.L.J., Fraaije, M.W., Mattevi, A.
Deposit date:2016-12-20
Release date:2017-01-11
Last modified:2017-01-25
Method:X-RAY DIFFRACTION (2 Å)
Cite:Polycyclic Ketone Monooxygenase from the Thermophilic Fungus Thermothelomyces thermophila: A Structurally Distinct Biocatalyst for Bulky Substrates.
J. Am. Chem. Soc., 139, 2017
1W1J
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STRUCTURE OF THE OCTAMERIC FLAVOENZYME VANILLYL-ALCOHOL OXIDASE: THE505SER MUTANT
Descriptor:VANILLYL-ALCOHOL OXIDASE, FLAVIN-ADENINE DINUCLEOTIDE, 2-methoxy-4-[(1E)-prop-1-en-1-yl]phenol
Authors:Van Den Heuvel, R.H.
Deposit date:2004-06-22
Release date:2004-07-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Laboratory-Evolved Vanillyl-Alcohol Oxidase Produces Natural Vanillin
J.Biol.Chem., 279, 2004
1W1K
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STRUCTURE OF THE OCTAMERIC FLAVOENZYME VANILLYL-ALCOHOL OXIDASE: ILE238THR MUTANT
Descriptor:VANILLYL-ALCOHOL OXIDASE, FLAVIN-ADENINE DINUCLEOTIDE, 2-methoxy-4-[(1E)-prop-1-en-1-yl]phenol
Authors:Van Den Heuvel, R.H.
Deposit date:2004-06-22
Release date:2004-07-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Laboratory-Evolved Vanillyl-Alcohol Oxidase Produces Natural Vanillin
J.Biol.Chem., 279, 2004
1W1L
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STRUCTURE OF THE OCTAMERIC FLAVOENZYME VANILLYL-ALCOHOL OXIDASE: PHE454TYR MUTANT
Descriptor:VANILLYL-ALCOHOL OXIDASE, FLAVIN-ADENINE DINUCLEOTIDE, 2-methoxy-4-[(1E)-prop-1-en-1-yl]phenol
Authors:Van Den Heuvel, R.H.
Deposit date:2004-06-22
Release date:2004-07-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Laboratory-Evolved Vanillyl-Alcohol Oxidase Produces Natural Vanillin
J.Biol.Chem., 279, 2004
1W1M
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STRUCTURE OF THE OCTAMERIC FLAVOENZYME VANILLYL-ALCOHOL OXIDASE: GLU502GLY MUTANT
Descriptor:VANILLYL-ALCOHOL OXIDASE, FLAVIN-ADENINE DINUCLEOTIDE, 2-methoxy-4-[(1E)-prop-1-en-1-yl]phenol
Authors:Van Den Heuvel, R.H.
Deposit date:2004-06-22
Release date:2004-07-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Laboratory-Evolved Vanillyl-Alcohol Oxidase Produces Natural Vanillin
J.Biol.Chem., 279, 2004
2VFR
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ALDITOL OXIDASE FROM STREPTOMYCES COELICOLOR A3(2): NATIVE ENZYME
Descriptor:XYLITOL OXIDASE, FLAVIN-ADENINE DINUCLEOTIDE, CHLORIDE ION
Authors:Forneris, F., Mattevi, A.
Deposit date:2007-11-05
Release date:2008-01-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:Structural Analysis of the Catalytic Mechanism and Stereoselectivity in Streptomyces Coelicolor Alditol Oxidase.
Biochemistry, 47, 2008
2VFS
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ALDITOL OXIDASE FROM STREPTOMYCES COELICOLOR A3(2): COMPLEX WITH XYLITOL
Descriptor:XYLITOL OXIDASE, FLAVIN-ADENINE DINUCLEOTIDE, D-XYLITOL, ...
Authors:Forneris, F., Mattevi, A.
Deposit date:2007-11-05
Release date:2008-01-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structural Analysis of the Catalytic Mechanism and Stereoselectivity in Streptomyces Coelicolor Alditol Oxidase.
Biochemistry, 47, 2008
2VFT
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ALDITOL OXIDASE FROM STREPTOMYCES COELICOLOR A3(2): COMPLEX WITH SORBITOL
Descriptor:XYLITOL OXIDASE, FLAVIN-ADENINE DINUCLEOTIDE, D-SORBITOL, ...
Authors:Forneris, F., Mattevi, A.
Deposit date:2007-11-05
Release date:2008-01-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structural Analysis of the Catalytic Mechanism and Stereoselectivity in Streptomyces Coelicolor Alditol Oxidase.
Biochemistry, 47, 2008
2VFU
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ALDITOL OXIDASE FROM STREPTOMYCES COELICOLOR A3(2): COMPLEX WITH MANNITOL
Descriptor:XYLITOL OXIDASE, FLAVIN-ADENINE DINUCLEOTIDE, D-MANNITOL
Authors:Forneris, F., Mattevi, A.
Deposit date:2007-11-05
Release date:2008-01-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural Analysis of the Catalytic Mechanism and Stereoselectivity in Streptomyces Coelicolor Alditol Oxidase.
Biochemistry, 47, 2008
2VFV
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ALDITOL OXIDASE FROM STREPTOMYCES COELICOLOR A3(2): COMPLEX WITH SULPHITE
Descriptor:XYLITOL OXIDASE, (S)-10-((2S,3S,4R)-5-((S)-((S)-(((2R,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-3,4-DIHYDROXY-TETRAHYDROFURAN-2-YL)METHOXY)(HYDROXY)PHOSPHORYLOXY)(HYDROXY)PHOSPHORYLOXY)-2,3,4-TRIHYDROXYPENTYL)-7,8-DIMETHYL-2,4-DIOXO-2,3,4,4A-TETRAHYDROBENZO[G]PTERIDINE-5(10H)-SULFONIC ACID, CHLORIDE ION
Authors:Forneris, F., Mattevi, A.
Deposit date:2007-11-05
Release date:2008-01-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.72 Å)
Cite:Structural Analysis of the Catalytic Mechanism and Stereoselectivity in Streptomyces Coelicolor Alditol Oxidase.
Biochemistry, 47, 2008