Author results

1MAM
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CRYSTAL STRUCTURE TO 2.45 A RESOLUTION OF A MONOCLONAL FAB SPECIFIC FOR THE BRUCELLA A CELL WALL POLYSACCHARIDE ANTIGEN
Descriptor:IGG2B-KAPPA YST9.1 FAB (LIGHT CHAIN), IGG2B-KAPPA YST9.1 FAB (HEAVY CHAIN)
Authors:Rose, D.R.
Deposit date:1992-01-14
Release date:1993-10-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Crystal structure to 2.45 A resolution of a monoclonal Fab specific for the Brucella A cell wall polysaccharide antigen.
Protein Sci., 2, 1993
1LYD
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CRYSTAL STRUCTURE OF T4-LYSOZYME GENERATED FROM SYNTHETIC CODING DNA EXPRESSED IN ESCHERICHIA COLI
Descriptor:T4 LYSOZYME
Authors:Rose, D.R.
Deposit date:1989-01-11
Release date:1990-04-15
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of T4-lysozyme generated from synthetic coding DNA expressed in Escherichia coli.
Protein Eng., 2, 1988
1EXP
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BETA-1,4-GLYCANASE CEX-CD
Descriptor:BETA-1,4-D-GLYCANASE CEX-CD, BETA-D-GLUCOSE, 2-deoxy-2-fluoro-alpha-D-glucopyranose
Authors:White, A., Tull, D., Johns, K.L., Withers, S.G., Rose, D.R.
Deposit date:1996-01-11
Release date:1997-01-27
Last modified:2011-11-16
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystallographic observation of a covalent catalytic intermediate in a beta-glycosidase.
Nat.Struct.Biol., 3, 1996
1MVU
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SINGLE CHAIN FV OF C219 HEAVY CHAIN V101L MUTANT IN COMPLEX WITH SYNTHETIC EPITOPE PEPTIDE
Descriptor:Ig kappa-chain VJ-region (Light chain), Ig VDJ-region (HEAVY CHAIN), P-GLYCOPROTEIN, ...
Authors:Chan, D.C.M., Kuntz, D.A., Rose, D.R.
Deposit date:2002-09-26
Release date:2003-10-07
Last modified:2013-09-18
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:Single Chain C219 V(101H)L Mutant Antibody Complexed with a Helical Peptide
To be Published
1RRO
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REFINEMENT OF RECOMBINANT ONCOMODULIN AT 1.30 ANGSTROMS RESOLUTION
Descriptor:RAT ONCOMODULIN, CALCIUM ION
Authors:Ahmed, F.R., Rose, D.R., Evans, S.V., Pippy, M.E., To, R.
Deposit date:1992-08-27
Release date:1993-10-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Refinement of recombinant oncomodulin at 1.30 A resolution.
J.Mol.Biol., 230, 1993
2HIS
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CELLULOMONAS FIMI XYLANASE/CELLULASE DOUBLE MUTANT E127A/H205N WITH COVALENT CELLOBIOSE
Descriptor:CELLULOMONAS FIMI FAMILY 10 BETA-1,4-GLYCANASE, BETA-D-GLUCOSE, ALPHA-D-GLUCOSE
Authors:Notenboom, V., Birsan, C., Nitz, M., Rose, D.R., Warren, R.A.J., Wither, S.G.
Deposit date:1998-02-23
Release date:1998-10-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.84 Å)
Cite:Insights into transition state stabilization of the beta-1,4-glycosidase Cex by covalent intermediate accumulation in active site mutants.
Nat.Struct.Biol., 5, 1998
1PLG
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EVIDENCE FOR THE EXTENDED HELICAL NATURE OF POLYSACCHARIDE EPITOPES. THE 2.8 ANGSTROMS RESOLUTION STRUCTURE AND THERMODYNAMICS OF LIGAND BINDING OF AN ANTIGEN BINDING FRAGMENT SPECIFIC FOR ALPHA-(2->8)-POLYSIALIC ACID
Descriptor:IGG2A=KAPPA=
Authors:Evans, S.V., Sigurskjold, B.W., Jennings, H.J., Brisson, J.-R., Tse, W.C., To, R., Altman, E., Frosch, M., Weisgerber, C., Kratzin, H., Klebert, S., Vaesen, M., Bitter-Suermann, D., Rose, D.R., Young, N.M., Bundle, D.R.
Deposit date:1995-04-24
Release date:1996-04-03
Last modified:2012-02-22
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Evidence for the extended helical nature of polysaccharide epitopes. The 2.8 A resolution structure and thermodynamics of ligand binding of an antigen binding fragment specific for alpha-(2-->8)-polysialic acid.
Biochemistry, 34, 1995
1BLN
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ANTI-P-GLYCOPROTEIN FAB MRK-16
Descriptor:PROTEIN (MONOCLONAL ANTIBODY MRK-16 (LIGHT CHAIN)), PROTEIN (MONOCLONAL ANTIBODY MRK-16 (HEAVY CHAIN))
Authors:Vasudevan, S., Tsuruo, T., Rose, D.R.
Deposit date:1998-07-16
Release date:1998-10-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Mode of binding of anti-P-glycoprotein antibody MRK-16 to its antigen. A crystallographic and molecular modeling study.
J.Biol.Chem., 273, 1998
1OMD
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STRUCTURE OF ONCOMODULIN REFINED AT 1.85 ANGSTROMS RESOLUTION. AN EXAMPLE OF EXTENSIVE MOLECULAR AGGREGATION VIA CA2+
Descriptor:ONCOMODULIN, CALCIUM ION
Authors:Ahmed, F.R., Przybylska, M., Rose, D.R., Birnbaum, G.I., Pippy, M.E., Macmanus, J.P.
Deposit date:1990-04-19
Release date:1991-07-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structure of oncomodulin refined at 1.85 A resolution. An example of extensive molecular aggregation via Ca2+.
J.Mol.Biol., 216, 1990
2AP2
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SINGLE CHAIN FV OF C219 IN COMPLEX WITH SYNTHETIC EPITOPE PEPTIDE
Descriptor:SINGLE CHAIN FV, P-GLYCOPROTEIN
Authors:Van Den Elsen, J.M.H., Rose, D.R.
Deposit date:1999-03-22
Release date:1999-11-24
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Antibody C219 recognizes an alpha-helical epitope on P-glycoprotein.
Proc.Natl.Acad.Sci.USA, 96, 1999
6FAB
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THREE-DIMENSIONAL STRUCTURE OF MURINE ANTI-P-AZOPHENYLARSONATE FAB 36-71. 1. X-RAY CRYSTALLOGRAPHY, SITE-DIRECTED MUTAGENESIS, AND MODELING OF THE COMPLEX WITH HAPTEN
Descriptor:IGG1-KAPPA 36-71 FAB (LIGHT CHAIN), IGG1-KAPPA 36-71 FAB (HEAVY CHAIN)
Authors:Strong, R.K., Rose, D.R., Petsko, G.A., Sharon, J., Margolies, M.N.
Deposit date:1991-01-17
Release date:1993-01-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Three-dimensional structure of murine anti-p-azophenylarsonate Fab 36-71. 1. X-ray crystallography, site-directed mutagenesis, and modeling of the complex with hapten.
Biochemistry, 30, 1991
1AP2
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SINGLE CHAIN FV OF C219
Descriptor:MONOCLONAL ANTIBODY C219
Authors:Hoedemaeker, P.J., Rose, D.R.
Deposit date:1997-07-23
Release date:1997-12-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.36 Å)
Cite:A single chain Fv fragment of P-glycoprotein-specific monoclonal antibody C219. Design, expression, and crystal structure at 2.4 A resolution.
J.Biol.Chem., 272, 1997
1FH7
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CRYSTAL STRUCTURE OF THE XYLANASE CEX WITH XYLOBIOSE-DERIVED INHIBITOR DEOXYNOJIRIMYCIN
Descriptor:BETA-1,4-XYLANASE, BETA-D-XYLOPYRANOSE, PIPERIDINE-3,4,5-TRIOL
Authors:Notenboom, V., Williams, S.J., Hoos, R., Withers, S.G., Rose, D.R.
Deposit date:2000-07-31
Release date:2000-08-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.82 Å)
Cite:Detailed structural analysis of glycosidase/inhibitor interactions: complexes of Cex from Cellulomonas fimi with xylobiose-derived aza-sugars.
Biochemistry, 39, 2000
1FH8
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CRYSTAL STRUCTURE OF THE XYLANASE CEX WITH XYLOBIOSE-DERIVED ISOFAGOMINE INHIBITOR
Descriptor:BETA-1,4-XYLANASE, BETA-D-XYLOPYRANOSE, PIPERIDINE-3,4-DIOL
Authors:Notenboom, V., Williams, S.J., Hoos, R., Withers, S.G., Rose, D.R.
Deposit date:2000-07-31
Release date:2000-08-23
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Detailed structural analysis of glycosidase/inhibitor interactions: complexes of Cex from Cellulomonas fimi with xylobiose-derived aza-sugars.
Biochemistry, 39, 2000
1FH9
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CRYSTAL STRUCTURE OF THE XYLANASE CEX WITH XYLOBIOSE-DERIVED LACTAM OXIME INHIBITOR
Descriptor:BETA-1,4-XYLANASE, BETA-D-XYLOPYRANOSE, 3,4,5-TRIHYDOXY-PIPERIDINE-2-ONE-OXIME
Authors:Notenboom, V., Williams, S.J., Hoos, R., Withers, S.G., Rose, D.R.
Deposit date:2000-07-31
Release date:2000-08-23
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (1.72 Å)
Cite:Detailed structural analysis of glycosidase/inhibitor interactions: complexes of Cex from Cellulomonas fimi with xylobiose-derived aza-sugars.
Biochemistry, 39, 2000
1FHD
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CRYSTAL STRUCTURE OF THE XYLANASE CEX WITH XYLOBIOSE-DERIVED IMIDAZOLE INHIBITOR
Descriptor:BETA-1,4-XYLANASE, BETA-D-XYLOPYRANOSE, 5,6,7,8-TETRAHYDRO-IMIDAZO[1,2-A]PYRIDINE-6,7,8-TRIOL
Authors:Notenboom, V., Williams, S.J., Hoos, R., Withers, S.G., Rose, D.R.
Deposit date:2000-07-31
Release date:2000-08-23
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Detailed structural analysis of glycosidase/inhibitor interactions: complexes of Cex from Cellulomonas fimi with xylobiose-derived aza-sugars.
Biochemistry, 39, 2000
1HTY
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GOLGI ALPHA-MANNOSIDASE II
Descriptor:ALPHA-MANNOSIDASE II, N-ACETYL-D-GLUCOSAMINE, ZINC ION, ...
Authors:van den Elsen, J.M.H., Kuntz, D.A., Rose, D.R.
Deposit date:2001-01-02
Release date:2002-01-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Structure of Golgi alpha-mannosidase II: a target for inhibition of growth and metastasis of cancer cells.
EMBO J., 20, 2001
1HWW
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GOLGI ALPHA-MANNOSIDASE II IN COMPLEX WITH SWAINSONINE
Descriptor:ALPHA-MANNOSIDASE II, N-ACETYL-D-GLUCOSAMINE, ZINC ION, ...
Authors:van den Elsen, J.M.H., Kuntz, D.A., Rose, D.R.
Deposit date:2001-01-10
Release date:2002-01-10
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (1.87 Å)
Cite:Structure of Golgi alpha-mannosidase II: a target for inhibition of growth and metastasis of cancer cells.
EMBO J., 20, 2001
1HXK
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GOLGI ALPHA-MANNOSIDASE II IN COMPLEX WITH DEOXYMANNOJIRIMICIN
Descriptor:ALPHA-MANNOSIDASE II, N-ACETYL-D-GLUCOSAMINE, ZINC ION, ...
Authors:van den Elsen, J.M.H., Kuntz, D.A., Rose, D.R.
Deposit date:2001-01-16
Release date:2002-01-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structure of Golgi alpha-mannosidase II: a target for inhibition of growth and metastasis of cancer cells.
EMBO J., 20, 2001
1HZF
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C4ADG FRAGMENT OF HUMAN COMPLEMENT FACTOR C4A
Descriptor:COMPLEMENT FACTOR C4A
Authors:van den Elsen, J.M.H., Martin, A., Wong, V., Clemenza, L., Rose, D.R., Isenman, D.E.
Deposit date:2001-01-24
Release date:2002-10-09
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:X-ray crystal structure of the C4d fragment of human complement component C4.
J.Mol.Biol., 322, 2002
1I82
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FAMILY 9 CARBOHYDRATE-BINDING MODULE FROM THERMOTOGA MARITIMA XYLANASE 10A WITH CELLOBIOSE
Descriptor:ENDO-1,4-BETA-XYLANASE A, BETA-D-GLUCOSE, CALCIUM ION
Authors:Notenboom, V., Boraston, A.B., Warren, R.A.J., Kilburn, D.G., Rose, D.R.
Deposit date:2001-03-12
Release date:2001-06-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structures of the family 9 carbohydrate-binding module from Thermotoga maritima xylanase 10A in native and ligand-bound forms.
Biochemistry, 40, 2001
1I8A
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FAMILY 9 CARBOHYDRATE-BINDING MODULE FROM THERMOTOGA MARITIMA XYLANASE 10A WITH GLUCOSE
Descriptor:ENDO-1,4-BETA-XYLANASE A, BETA-D-GLUCOSE, CALCIUM ION
Authors:Notenboom, V., Boraston, A.B., Warren, R.A.J., Kilburn, D.G., Rose, D.R.
Deposit date:2001-03-12
Release date:2001-06-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structures of the family 9 carbohydrate-binding module from Thermotoga maritima xylanase 10A in native and ligand-bound forms.
Biochemistry, 40, 2001
1I8U
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FAMILY 9 CARBOHYDRATE-BINDING MODULE FROM THERMOTOGA MARITIMA XYLANASE 10A
Descriptor:ENDO-1,4-BETA-XYLANASE A, CALCIUM ION
Authors:Notenboom, V., Boraston, A.B., Warren, R.A.J., Kilburn, D.G., Rose, D.R.
Deposit date:2001-03-16
Release date:2001-06-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structures of the family 9 carbohydrate-binding module from Thermotoga maritima xylanase 10A in native and ligand-bound forms.
Biochemistry, 40, 2001
1J01
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CRYSTAL STRUCTURE OF THE XYLANASE CEX WITH XYLOBIOSE-DERIVED INHIBITOR ISOFAGOMINE LACTAM
Descriptor:beta-1,4-xylanase, 3-HYDROXY-4-(3,4,5-TRIHYDROXY-TETRAHYDRO-PYRAN-2-YLOXY)-PIPERIDIN-2-ONE
Authors:Williams, S.J., Notenboom, V., Wicki, J., Rose, D.R., Withers, S.G.
Deposit date:2002-10-25
Release date:2002-11-06
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2 Å)
Cite:A New, Simple, High-Affinity Glycosidase Inhibitor: Analysis of Binding through X-ray Crystallography, Mutagenesis, and Kinetic Analysis
J.Am.Chem.Soc., 122, 2000
1J83
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STRUCTURE OF FAM17 CARBOHYDRATE BINDING MODULE FROM CLOSTRIDIUM CELLULOVORANS
Descriptor:ENDO-1,4-BETA GLUCANASE ENGF, CALCIUM ION
Authors:Notenboom, V., Boraston, A.B., Chiu, P., Freelove, A.C.J., Kilburn, D.G., Rose, D.R.
Deposit date:2001-05-20
Release date:2001-12-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Recognition of cello-oligosaccharides by a family 17 carbohydrate-binding module: an X-ray crystallographic, thermodynamic and mutagenic study.
J.Mol.Biol., 314, 2001