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1OSH
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A CHEMICAL, GENETIC, AND STRUCTURAL ANALYSIS OF THE NUCLEAR BILE ACID RECEPTOR FXR
Descriptor:Bile acid receptor, METHYL 3-{3-[(CYCLOHEXYLCARBONYL){[4'-(DIMETHYLAMINO)BIPHENYL-4-YL]METHYL}AMINO]PHENYL}ACRYLATE
Authors:Downes, M., Verdecia, M.A., Roecker, A.J., Hughes, R., Hogenesch, J.B., Kast-Woelbern, H.R., Bowman, M.E., Ferrer, J.-L., Anisfeld, A.M., Edwards, P.A., Rosenfeld, J.M., Alvarez, J.G.A., Noel, J.P., Nicolaou, K.C., Evans, R.M.
Deposit date:2003-03-19
Release date:2003-09-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:A chemical, genetic, and structural analysis of the nuclear bile acid receptor FXR
Mol.Cell, 11, 2003
2Q2Y
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CRYSTAL STRUCTURE OF KSP IN COMPLEX WITH INHIBITOR 1
Descriptor:Kinesin-like protein KIF11, MAGNESIUM ION, ADENOSINE-5'-DIPHOSPHATE, ...
Authors:Yan, Y.
Deposit date:2007-05-29
Release date:2007-09-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Kinesin spindle protein (KSP) inhibitors. Part 8: Design and synthesis of 1,4-diaryl-4,5-dihydropyrazoles as potent inhibitors of the mitotic kinesin KSP.
Bioorg.Med.Chem.Lett., 17, 2007
2Q2Z
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CRYSTAL STRUCTURE OF KSP IN COMPLEX WITH INHIBITOR 22
Descriptor:Kinesin-like protein KIF11, MAGNESIUM ION, ADENOSINE-5'-DIPHOSPHATE, ...
Authors:Yan, Y.
Deposit date:2007-05-29
Release date:2007-09-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Kinesin spindle protein (KSP) inhibitors. Part 8: Design and synthesis of 1,4-diaryl-4,5-dihydropyrazoles as potent inhibitors of the mitotic kinesin KSP.
Bioorg.Med.Chem.Lett., 17, 2007
4ZJ8
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STRUCTURES OF THE HUMAN OX1 OREXIN RECEPTOR BOUND TO SELECTIVE AND DUAL ANTAGONISTS
Descriptor:human OX1R fusion protein to P.abysii glycogen synthase, [(7R)-4-(5-chloro-1,3-benzoxazol-2-yl)-7-methyl-1,4-diazepan-1-yl][5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl]methanone, OLEIC ACID
Authors:Yin, J., Brautigam, C.A., Shao, Z., Clark, L., Harrell, C.M., Gotter, A.L., Coleman, P., Renger, J.J., Rosenbaum, D.M.
Deposit date:2015-04-29
Release date:2016-03-09
Last modified:2016-04-13
Method:X-RAY DIFFRACTION (2.751 Å)
Cite:Structure and ligand-binding mechanism of the human OX1 and OX2 orexin receptors.
Nat.Struct.Mol.Biol., 23, 2016
4ZJC
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STRUCTURES OF THE HUMAN OX1 OREXIN RECEPTOR BOUND TO SELECTIVE AND DUAL ANTAGONISTS
Descriptor:human OX1R fusion protein to P.abysii glycogen synthase, [5-(2-fluorophenyl)-2-methyl-1,3-thiazol-4-yl]{(2S)-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)methyl]pyrrolidin-1-yl}methanone, OLEIC ACID
Authors:Yin, J., Brautigam, C.A., Shao, Z., Clark, L., Harrell, C.M., Gotter, A.L., Coleman, P.J., Renger, J.J., Rosenbaum, D.M.
Deposit date:2015-04-29
Release date:2016-03-09
Last modified:2016-04-13
Method:X-RAY DIFFRACTION (2.832 Å)
Cite:Structure and ligand-binding mechanism of the human OX1 and OX2 orexin receptors.
Nat.Struct.Mol.Biol., 23, 2016