Author results

3DZW
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STRUCTURE OF NARCISSUS PSEUDONARCISSUS LECTIN COMPLEX WITH MANNOBIOSE AT 1.7 A RESOLUTION, FORM II
Descriptor:Agglutinin, ALPHA-D-MANNOSE, PHOSPHATE ION
Authors:Rizkallah, P.J., Ozbey, S., Sauerborn, M.K.
Deposit date:2008-07-30
Release date:2009-08-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structure of Narcissus pseudonarcissus lectin complex with Mannobiose at 1.7 A resolution, form II
To be Published
4Z77
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WEAK TCR BINDING TO AN UNSTABLE INSULIN EPITOPE DRIVES TYPE 1 DIABETES
Descriptor:H-2 class I histocompatibility antigen, K-D alpha chain, Beta-2-microglobulin, ...
Authors:Rizkallah, P.J., Cole, D.K.
Deposit date:2015-04-06
Release date:2015-06-24
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Weak TCR binding to an unstable insulin epitope drives type 1 diabetes
To Be Published
6EQB
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HLA CLASS I HISTOCOMPATIBILITY ANTIGEN
Descriptor:HLA class I histocompatibility antigen, A-2 alpha chain, Beta-2-microglobulin, ...
Authors:Rizkallah, P.J., Cole, D.K.
Deposit date:2017-10-12
Release date:2018-10-10
Method:X-RAY DIFFRACTION (2.81 Å)
Cite:HLA class I histocompatibility antigen
To Be Published
6FJO
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ADENOVIRUS SPECIES 26 KNOB PROTEIN, VERY HIGH RESOLUTION
Descriptor:Fiber, GLUTAMIC ACID, SULFATE ION, ...
Authors:Rizkallah, P.J., Parker, A.L., Baker, A.T.
Deposit date:2018-01-22
Release date:2019-02-06
Last modified:2019-09-25
Method:X-RAY DIFFRACTION (1.17 Å)
Cite:Human adenovirus type 26 uses sialic acid-bearing glycans as a primary cell entry receptor.
Sci Adv, 5, 2019
6FR3
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003 TCR STUDY OF CDR LOOP FLEXIBILITY
Descriptor:003 TCR Alpha Chain, 003 TCR Beta Chain, 1,2-ETHANEDIOL, ...
Authors:Rizkallah, P.J., Cole, D.K.
Deposit date:2018-02-15
Release date:2018-04-18
Last modified:2018-05-09
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:In Silicoand Structural Analyses Demonstrate That Intrinsic Protein Motions Guide T Cell Receptor Complementarity Determining Region Loop Flexibility.
Front Immunol, 9, 2018
6FR4
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003 TCR STUDY OF CDR LOOP FLEXIBILITY
Descriptor:TCR 003 alpha chain, TCR 003 Beta Chain, GLYCEROL, ...
Authors:Rizkallah, P.J., Cole, D.K.
Deposit date:2018-02-15
Release date:2018-04-18
Last modified:2018-05-09
Method:X-RAY DIFFRACTION (1.28 Å)
Cite:In Silicoand Structural Analyses Demonstrate That Intrinsic Protein Motions Guide T Cell Receptor Complementarity Determining Region Loop Flexibility.
Front Immunol, 9, 2018
6FR5
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HA1.7 TCR STUDY OF CDR LOOP FLEXIBILITY
Descriptor:TCR HA1.7 specific for FLU epitope PKYVKQNTLKLAT, alpha chain, beta chain, ...
Authors:Rizkallah, P.J., Cole, D.K.
Deposit date:2018-02-15
Release date:2018-04-18
Last modified:2018-05-09
Method:X-RAY DIFFRACTION (1.37 Å)
Cite:In Silicoand Structural Analyses Demonstrate That Intrinsic Protein Motions Guide T Cell Receptor Complementarity Determining Region Loop Flexibility.
Front Immunol, 9, 2018
2BCK
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CRYSTAL STRUCTURE OF HLA-A*2402 COMPLEXED WITH A TELOMERASE PEPTIDE
Descriptor:HLA class I histocompatibility antigen, A-24 alpha chain, Beta-2-microglobulin, ...
Authors:Rizkallah, P.J., Jakobsen, B.K., Cole, D.K., Gao, G.F.
Deposit date:2005-10-19
Release date:2006-01-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structure of HLA-A*2402 complexed with a telomerase peptide.
Eur.J.Immunol., 36, 2006
2F53
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DIRECTED EVOLUTION OF HUMAN T-CELL RECEPTOR CDR2 RESIDUES BY PHAGE DISPLAY DRAMATICALLY ENHANCES AFFINITY FOR COGNATE PEPTIDE-MHC WITHOUT APPARENT CROSS-REACTIVITY
Descriptor:HLA class I histocompatibility antigen, Beta-2-microglobulin, Cancer/testis antigen 1B, ...
Authors:Rizkallah, P.J., Jakobsen, B.K., Dunn, S.M., Sami, M.
Deposit date:2005-11-25
Release date:2006-04-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Directed evolution of human T cell receptor CDR2 residues by phage display dramatically enhances affinity for cognate peptide-MHC without increasing apparent cross-reactivity.
Protein Sci., 15, 2006
2F54
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DIRECTED EVOLUTION OF HUMAN T CELL RECEPTOR CDR2 RESIDUES BY PHAGE DISPLAY DRAMATICALLY ENHANCES AFFINITY FOR COGNATE PEPTIDE-MHC WITHOUT INCREASING APPARENT CROSS-REACTIVITY
Descriptor:HLA class I histocompatibility antigen, Beta-2-microglobulin, Cancer/testis antigen 1B, ...
Authors:Rizkallah, P.J., Jakobsen, B.K., Dunn, S.M., Sami, M.
Deposit date:2005-11-25
Release date:2006-04-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Directed evolution of human T cell receptor CDR2 residues by phage display dramatically enhances affinity for cognate peptide-MHC without increasing apparent cross-reactivity.
Protein Sci., 15, 2006
2HP4
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COMPUTATIONAL DESIGN AND CRYSTAL STRUCTURE OF AN ENHANCED AFFINITY MUTANT HUMAN CD8-ALPHA-ALPHA CO-RECEPTOR
Descriptor:T-cell surface glycoprotein CD8 alpha chain, SULFATE ION, GLYCEROL
Authors:Rizkallah, P.J., Cole, D.K., Jakobsen, B.K., Boulter, J.M., Glick, M., Gao, G.F.
Deposit date:2006-07-17
Release date:2007-02-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Computational design and crystal structure of an enhanced affinity mutant human CD8 alphaalpha coreceptor
Proteins, 67, 2007
3UTP
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1E6 TCR SPECIFIC FOR HLA-A*0201-ALWGPDPAAA
Descriptor:1E6 TCR alpha chain, 1E6 TCR beta chain, GLYCEROL, ...
Authors:Rizkallah, P.J., Cole, D.K., Sewell, A.K., Bulek, A.M.
Deposit date:2011-11-26
Release date:2012-01-25
Last modified:2012-03-07
Method:X-RAY DIFFRACTION (2.574 Å)
Cite:Structural basis for the killing of human beta cells by CD8(+) T cells in type 1 diabetes.
Nat.Immunol., 13, 2012
3UTQ
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HUMAN HLA-A*0201-ALWGPDPAAA
Descriptor:HLA class I histocompatibility antigen, A-2 alpha chain, Beta-2-microglobulin, ...
Authors:Rizkallah, P.J., Cole, D.K., Sewell, A.K., Bulek, A.M.
Deposit date:2011-11-26
Release date:2012-01-25
Last modified:2012-03-07
Method:X-RAY DIFFRACTION (1.67 Å)
Cite:Structural basis for the killing of human beta cells by CD8(+) T cells in type 1 diabetes.
Nat.Immunol., 13, 2012
3UTS
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1E6-A*0201-ALWGPDPAAA COMPLEX, MONOCLINIC
Descriptor:HLA class I histocompatibility antigen, A-2 alpha chain, Beta-2-microglobulin, ...
Authors:Rizkallah, P.J., Cole, D.K., Sewell, A.K., Bulek, A.M.
Deposit date:2011-11-26
Release date:2012-01-25
Last modified:2012-03-07
Method:X-RAY DIFFRACTION (2.712 Å)
Cite:Structural basis for the killing of human beta cells by CD8(+) T cells in type 1 diabetes.
Nat.Immunol., 13, 2012
3UTT
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1E6-A*0201-ALWGPDPAAA COMPLEX, TRICLINIC
Descriptor:HLA class I histocompatibility antigen, A-2 alpha chain, Beta-2-microglobulin, ...
Authors:Rizkallah, P.J., Cole, D.K., Sewell, A.K., Bulek, A.M., Rossjohn, J., Gras, S.
Deposit date:2011-11-26
Release date:2012-01-25
Last modified:2019-07-17
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural basis for the killing of human beta cells by CD8(+) T cells in type 1 diabetes.
Nat.Immunol., 13, 2012
4I4W
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PEPTIDE LENGTH DETERMINES THE OUTCOME OF T CELL RECEPTOR/PEPTIDE-MHCI ENGAGEMENT
Descriptor:HLA class I histocompatibility antigen, A-2 alpha chain, Beta-2-microglobulin, ...
Authors:Rizkallah, P.J., Wooldridge, L., Cole, D.K.
Deposit date:2012-11-28
Release date:2013-01-02
Last modified:2015-11-25
Method:X-RAY DIFFRACTION (1.77 Å)
Cite:Peptide length determines the outcome of TCR/peptide-MHCI engagement.
Blood, 121, 2013
4JFD
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PRESERVATION OF PEPTIDE SPECIFICITY DURING TCR-MHC CONTACT DOMINATED AFFINITY ENHANCEMENT OF A MELANOMA-SPECIFIC TCR
Descriptor:HLA class I histocompatibility antigen, A-2 alpha chain, Beta-2-microglobulin, ...
Authors:Rizkallah, P.J., Cole, D.K., Madura, F., Sewell, A.K.
Deposit date:2013-02-28
Release date:2013-05-29
Last modified:2013-07-17
Method:X-RAY DIFFRACTION (2.46 Å)
Cite:T-cell receptor specificity maintained by altered thermodynamics.
J.Biol.Chem., 288, 2013
4JFE
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PRESERVATION OF PEPTIDE SPECIFICITY DURING TCR-MHC CONTACT DOMINATED AFFINITY ENHANCEMENT OF A MELANOMA-SPECIFIC TCR
Descriptor:HLA class I histocompatibility antigen, A-2 alpha chain, Beta-2-microglobulin, ...
Authors:Rizkallah, P.J., Cole, D.K., Madura, F., Sewell, A.K.
Deposit date:2013-02-28
Release date:2013-05-29
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:T-cell receptor specificity maintained by altered thermodynamics.
J.Biol.Chem., 288, 2013
4JFF
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PRESERVATION OF PEPTIDE SPECIFICITY DURING TCR-MHC CONTACT DOMINATED AFFINITY ENHANCEMENT OF A MELANOMA-SPECIFIC TCR
Descriptor:HLA class I histocompatibility antigen, A-2 alpha chain, Beta-2-microglobulin, ...
Authors:Rizkallah, P.J., Cole, D.K., Madura, F., Sewell, A.K.
Deposit date:2013-02-28
Release date:2013-05-29
Last modified:2014-04-02
Method:X-RAY DIFFRACTION (2.43 Å)
Cite:T-cell receptor specificity maintained by altered thermodynamics.
J.Biol.Chem., 288, 2013
4JFH
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HIGH AFFINITY ALPHA24-BETA17 T CELL RECEPTOR FOR A2 HLA-MELANOMA PEPTIDE COMPLEX
Descriptor:alpha24 TCR allele, beta17 TCR allele, 1,2-ETHANEDIOL, ...
Authors:Rizkallah, P.J., Cole, D.K., Madura, F., Sewell, A.K.
Deposit date:2013-02-28
Release date:2013-05-29
Last modified:2013-07-17
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:T-cell receptor specificity maintained by altered thermodynamics.
J.Biol.Chem., 288, 2013
4JFO
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A2 HLA COMPLEX WITH E1A HETEROCLITIC VARIANT OF MELANOMA PEPTIDE
Descriptor:HLA class I histocompatibility antigen, A-2 alpha chain, Beta-2-microglobulin, ...
Authors:Rizkallah, P.J., Cole, D.K., Madura, F., Sewell, A.K., Baker, B.M.
Deposit date:2013-02-28
Release date:2013-05-29
Last modified:2013-07-17
Method:X-RAY DIFFRACTION (2.11 Å)
Cite:T-cell receptor specificity maintained by altered thermodynamics.
J.Biol.Chem., 288, 2013
4JFP
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A2 HLA COMPLEX WITH G4A HETEROCLITIC VARIANT OF MELANOMA PEPTIDE
Descriptor:HLA class I histocompatibility antigen, A-2 alpha chain, Beta-2-microglobulin, ...
Authors:Rizkallah, P.J., Cole, D.K., Madura, F., Sewell, A.K.
Deposit date:2013-02-28
Release date:2013-05-29
Last modified:2013-07-17
Method:X-RAY DIFFRACTION (1.91 Å)
Cite:T-cell receptor specificity maintained by altered thermodynamics.
J.Biol.Chem., 288, 2013
4JFQ
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A2 HLA COMPLEX WITH L8A HETEROCLITIC VARIANT OF MELANOMA PEPTIDE
Descriptor:HLA class I histocompatibility antigen, A-2 alpha chain, Beta-2-microglobulin, ...
Authors:Rizkallah, P.J., Cole, D.K., Madura, F., Sewell, A.K., Baker, B.M.
Deposit date:2013-02-28
Release date:2013-05-29
Last modified:2013-07-17
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:T-cell receptor specificity maintained by altered thermodynamics.
J.Biol.Chem., 288, 2013
4MJI
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T CELL RESPONSE TO A HIV REVERSE TRANSCRIPTASE EPITOPE PRESENTED BY THE PROTECTIVE ALLELE HLA-B*51:01
Descriptor:HLA class I histocompatibility antigen, B-51 alpha chain, Beta-2-microglobulin, ...
Authors:Rizkallah, P.J., Cole, D.K., Sewell, A.K., Motozono, C., Takiguchi, M.
Deposit date:2013-09-03
Release date:2014-05-28
Method:X-RAY DIFFRACTION (2.99 Å)
Cite:Molecular basis of a dominant T cell response to an HIV reverse transcriptase 8-mer epitope presented by the protective allele HLA-B*51:01
J.Immunol., 192, 2014
4MNQ
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TCR-PEPTIDE SPECIFICITY OVERRIDES AFFINITY ENHANCING TCR-MHC INTERACTIONS
Descriptor:HLA class I histocompatibility antigen, A-2 alpha chain, Beta-2-microglobulin, ...
Authors:Rizkallah, P.J., Cole, D.K., Sewell, A.K., Jakobsen, B.K.
Deposit date:2013-09-11
Release date:2013-11-13
Last modified:2017-08-02
Method:X-RAY DIFFRACTION (2.742 Å)
Cite:T-cell receptor (TCR)-peptide specificity overrides affinity-enhancing TCR-major histocompatibility complex interactions.
J.Biol.Chem., 289, 2014