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2BM2
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HUMAN BETA-II TRYPTASE IN COMPLEX WITH 4-(3-AMINOMETHYL-PHENYL)- PIPERIDIN-1-YL-(5-PHENETHYL- PYRIDIN-3-YL)-METHANONE
Descriptor:HUMAN BETA2 TRYPTASE, 1-[3-(1-{[5-(2-PHENYLETHYL)PYRIDIN-3-YL]CARBONYL}PIPERIDIN-4-YL)PHENYL]METHANAMINE
Authors:Maignan, S., Guilloteau, J.-P., Dupuy, A., Levell, J., Astles, P., Eastwood, P., Cairns, J., Houille, O., Aldous, S., Merriman, G., Whiteley, B., Pribish, J., Czekaj, M., Liang, G., Davidson, J., Harrison, T., Morley, A., Watson, S., Fenton, G., Mccarthy, C., Romano, J., Mathew, R., Engers, D., Gardyan, M., Sides, K., Kwong, J., Tsay, J., Rebello, S., Shen, L., Wang, J., Luo, Y., Giardino, O., Lim, H.-K., Smith, K., Pauls, H.
Deposit date:2005-03-09
Release date:2005-03-22
Last modified:2019-05-22
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure Based Design of 4-(3-Aminomethylphenyl) Piperidinyl-1-Amides: Novel, Potent, Selective, and Orally Bioavailable Inhibitors of Bii Tryptase
Bioorg.Med.Chem., 13, 2005
4A6L
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BETA-TRYPTASE INHIBITOR
Descriptor:TRYPTASE ALPHA/BETA-1, 1-{3-[1-({5-[(2-fluorophenyl)ethynyl]furan-2-yl}carbonyl)piperidin-4-yl]phenyl}methanamine
Authors:Mathieu, M., Maignan, S.
Deposit date:2011-11-04
Release date:2012-01-25
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Structure-Based Library Design and the Discovery of a Potent and Selective Mast Cell Beta-Tryptase Inhibitor as an Oral Therapeutic Agent.
Bioorg.Med.Chem.Lett., 22, 2012