Author results

5KBE
  • Download 5kbe
  • View 5kbe
Molmil generated image of 5kbe
CRYSTAL STRUCTURE OF THE AROMATIC SENSOR DOMAIN OF MOPR IN COMPLEX WITH PHENOL
分子名称:MopR, ZINC ION, PHENOL
著者Ray, S., Anand, R., Panjikar, S.
登録日2016-06-03
公開日2016-07-13
最終更新日2016-08-31
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structural Basis of Selective Aromatic Pollutant Sensing by the Effector Binding Domain of MopR, an NtrC Family Transcriptional Regulator.
Acs Chem.Biol., 11, 2016
5KBG
  • Download 5kbg
  • View 5kbg
Molmil generated image of 5kbg
CRYSTAL STRUCTURE OF THE AROMATIC SENSOR DOMAIN OF MOPR IN COMPLEX WITH OCRESOL
分子名称:MopR, ZINC ION, o-cresol
著者Ray, S., Anand, R., Panjikar, S.
登録日2016-06-03
公開日2016-07-13
最終更新日2016-08-31
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Structural Basis of Selective Aromatic Pollutant Sensing by the Effector Binding Domain of MopR, an NtrC Family Transcriptional Regulator.
Acs Chem.Biol., 11, 2016
5KBH
  • Download 5kbh
  • View 5kbh
Molmil generated image of 5kbh
CRYSTAL STRUCTURE OF THE AROMATIC SENSOR DOMAIN OF MOPR IN COMPLEX WITH 3-CHLORO-PHENOL
分子名称:MopR, ZINC ION, 3-CHLOROPHENOL
著者Ray, S., Anand, R., Panjikar, S.
登録日2016-06-03
公開日2016-07-13
最終更新日2016-08-31
実験手法X-RAY DIFFRACTION (2.55 Å)
主引用文献Structural Basis of Selective Aromatic Pollutant Sensing by the Effector Binding Domain of MopR, an NtrC Family Transcriptional Regulator.
Acs Chem.Biol., 11, 2016
5KBI
  • Download 5kbi
  • View 5kbi
Molmil generated image of 5kbi
CRYSTAL STRUCTURE OF THE AROMATIC SENSOR DOMAIN OF MOPR IN COMPLEX WITH CATACHOL
分子名称:MopR, ZINC ION, CATECHOL
著者Ray, S., Anand, R., Panjikar, S.
登録日2016-06-03
公開日2016-07-13
最終更新日2016-08-31
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Structural Basis of Selective Aromatic Pollutant Sensing by the Effector Binding Domain of MopR, an NtrC Family Transcriptional Regulator.
Acs Chem.Biol., 11, 2016
5XAY
  • Download 5xay
  • View 5xay
Molmil generated image of 5xay
CRYSTAL STRUCTURE OF FULL LENGTH TYLP, A TETR REGULATOR FROM STREPTOMYCES FRADIAE
分子名称:Gamma-butyrolactone receptor protein
著者Ray, S., Panjikar, S., Anand, R.
登録日2017-03-15
公開日2017-08-02
最終更新日2017-09-27
実験手法X-RAY DIFFRACTION (2.58 Å)
主引用文献Functional insights into the mode of DNA and ligand binding of the TetR family regulator TylP from Streptomyces fradiae
J. Biol. Chem., 292, 2017
5XAZ
  • Download 5xaz
  • View 5xaz
Molmil generated image of 5xaz
CRYSTAL STRUCTURE OF FULL LENGTH NATIVE TYLP, A TETR REGULATOR FROM STREPTOMYCES FRADIAE
分子名称:Gamma-butyrolactone receptor protein
著者Ray, S., Panjikar, S., Anand, R.
登録日2017-03-15
公開日2017-08-02
最終更新日2017-09-27
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Functional insights into the mode of DNA and ligand binding of the TetR family regulator TylP from Streptomyces fradiae
J. Biol. Chem., 292, 2017
6C4A
  • Download 6c4a
  • View 6c4a
Molmil generated image of 6c4a
CRYSTAL STRUCTURE OF 3-NITROPROPIONATE MODIFIED ISOCITRATE LYASE FROM MYCOBACTERIUM TUBERCULOSIS WITH PYRUVATE
分子名称:Isocitrate lyase 1, PYRUVIC ACID, MAGNESIUM ION, ...
著者Kreitler, D.F., Ray, S., Murkin, A.S., Gulick, A.M.
登録日2018-01-11
公開日2018-06-06
最終更新日2018-06-27
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献The Nitro Group as a Masked Electrophile in Covalent Enzyme Inhibition.
ACS Chem. Biol., 13, 2018
6C4C
  • Download 6c4c
  • View 6c4c
Molmil generated image of 6c4c
CRYSTAL STRUCTURE OF 3-NITROPROPIONATE MODIFIED ISOCITRATE LYASE FROM MYCOBACTERIUM TUBERCULOSIS WITH GLYOXYLATE AND PYRUVATE
分子名称:Isocitrate lyase 1, GLYOXYLIC ACID, MAGNESIUM ION, ...
著者Kreitler, D.F., Ray, S., Murkin, A.S., Gulick, A.M.
登録日2018-01-11
公開日2018-06-06
最終更新日2018-06-27
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献The Nitro Group as a Masked Electrophile in Covalent Enzyme Inhibition.
ACS Chem. Biol., 13, 2018
4FCP
  • Download 4fcp
  • View 4fcp
Molmil generated image of 4fcp
TARGETTING CONSERVED WATER MOLECULES: DESIGN OF 4-ARYL-5-CYANOPYRROLO [2,3-D] PYRIMIDINE HSP90 INHIBITORS USING FRAGMENT-BASED SCREENING AND STRUCTURE-BASED OPTIMIZATION
分子名称:Heat shock protein HSP 90-alpha, N,N-dimethyl-7H-purin-6-amine
著者Davies, N.G.M., Browne, H., Davies, B., Foloppe, N., Geoffrey, S., Gibbons, B., Hart, T., Drysdale, M., Mansell, H., Massey, A., Matassova, N., Moore, J.D., Murray, J., Pratt, R., Ray, S., Roughley, S.D., Jensen, M.R., Schoepfer, J., Scriven, K., Simmonite, H., Stokes, S., Surgenor, A., Webb, P., Wright, L., Brough, P.
登録日2012-05-25
公開日2012-10-24
最終更新日2012-11-07
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Targeting conserved water molecules: Design of 4-aryl-5-cyanopyrrolo[2,3-d]pyrimidine Hsp90 inhibitors using fragment-based screening and structure-based optimization.
Bioorg.Med.Chem., 20, 2012
4FCQ
  • Download 4fcq
  • View 4fcq
Molmil generated image of 4fcq
TARGETING CONSERVED WATER MOLECULES: DESIGN OF 4-ARYL-5-CYANOPYRROLO[2,3-D]PYRIMIDINE HSP90 INHIBITORS USING FRAGMENT-BASED SCREENING AND STRUCTURE-BASED OPTIMIZATION
分子名称:Heat shock protein HSP 90-alpha, 4-(2,4-dimethylphenyl)-2-(methylsulfanyl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile
著者Davies, N.G., Browne, H., Davis, B., Foloppe, N., Geoffrey, S., Gibbons, B., Hart, T., Drysdale, M.J., Mansell, H., Massey, A., Matassova, N., Moore, J.D., Murray, J., Pratt, R., Ray, S., Roughley, S.D., Jensen, M.R., Schoepfer, J., Scriven, K., Simmonite, H., Stokes, S., Surgenor, A., Webb, P., Wright, L., Brough, P.
登録日2012-05-25
公開日2012-10-24
最終更新日2012-11-07
実験手法X-RAY DIFFRACTION (2.151 Å)
主引用文献Targeting conserved water molecules: Design of 4-aryl-5-cyanopyrrolo[2,3-d]pyrimidine Hsp90 inhibitors using fragment-based screening and structure-based optimization.
Bioorg.Med.Chem., 20, 2012
4FCR
  • Download 4fcr
  • View 4fcr
Molmil generated image of 4fcr
TARGETING CONSERVED WATER MOLECULES: DESIGN OF 4-ARYL-5-CYANOPYRROLO[2,3-D]PYRIMIDINE HSP90 INHIBITORS USING FRAGMENT-BASED SCREENING AND STRUCTURE-BASED OPTIMIZATION
分子名称:Heat shock protein HSP 90-alpha, 2-{[4-(2-chloro-4,5-dimethoxyphenyl)-5-cyano-7H-pyrrolo[2,3-d]pyrimidin-2-yl]sulfanyl}-N,N-dimethylacetamide
著者Davies, N.G., Browne, H., Davis, B., Foloppe, N., Geoffrey, S., Gibbons, B., Hart, T., Drysdale, M.J., Mansell, H., Massey, A., Matassova, N., Moore, J.D., Murray, J., Pratt, R., Ray, S., Roughley, S.D., Jensen, M.R., Schoepfer, J., Scriven, K., Simmonite, H., Stokes, S., Surgenor, A., Webb, P., Wright, L., Brough, P.
登録日2012-05-25
公開日2012-10-24
最終更新日2012-11-07
実験手法X-RAY DIFFRACTION (1.698 Å)
主引用文献Targeting conserved water molecules: Design of 4-aryl-5-cyanopyrrolo[2,3-d]pyrimidine Hsp90 inhibitors using fragment-based screening and structure-based optimization.
Bioorg.Med.Chem., 20, 2012
6QFI
  • Download 6qfi
  • View 6qfi
Molmil generated image of 6qfi
STRUCTURE OF HUMAN MCL-1 IN COMPLEX WITH BIM BH3 PEPTIDE
分子名称:Induced myeloid leukemia cell differentiation protein Mcl-1, Bcl-2-like protein 11, ZINC ION
著者Dokurno, P., Murray, J., Davidson, J., Chen, I., Davis, B., Graham, C.J., Harris, R., Jordan, A.M., Matassova, N., Pedder, C., Ray, S., Roughley, S., Smith, J., Walmsley, C., Wang, Y., Whitehead, N., Williamson, D.S., Casara, P., Le Diguarher, T., Hickman, J., Stark, J., Kotschy, A., Geneste, O., Hubbard, R.E.
登録日2019-01-10
公開日2019-06-12
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Establishing Drug Discovery and Identification of Hit Series for the Anti-apoptotic Proteins, Bcl-2 and Mcl-1
Acs Omega, 2019
6QFM
  • Download 6qfm
  • View 6qfm
Molmil generated image of 6qfm
STRUCTURE OF HUMAN MCL-1 IN COMPLEX WITH PUMA BH3 PEPTIDE
分子名称:Induced myeloid leukemia cell differentiation protein Mcl-1, Bcl-2-binding component 3, ZINC ION, ...
著者Dokurno, P., Murray, J., Davidson, J., Chen, I., Davis, B., Graham, C.J., Harris, R., Jordan, A.M., Matassova, N., Pedder, C., Ray, S., Roughley, S., Smith, J., Walmsley, C., Wang, Y., Whitehead, N., Williamson, D.S., Casara, P., Le Diguarher, T., Hickman, J., Stark, J., Kotschy, A., Geneste, O., Hubbard, R.E.
登録日2019-01-10
公開日2019-06-12
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Establishing Drug Discovery and Identification of Hit Series for the Anti-apoptotic Proteins, Bcl-2 and Mcl-1
Acs Omega, 2019
6QFQ
  • Download 6qfq
  • View 6qfq
Molmil generated image of 6qfq
STRUCTURE OF HUMAN MCL-1 IN COMPLEX WITH INDOLE ACID INHIBITOR
分子名称:Induced myeloid leukemia cell differentiation protein Mcl-1, 7-(3,5-dimethyl-1~{H}-pyrazol-4-yl)-3-(3-naphthalen-1-yloxypropyl)-1~{H}-indole-2-carboxylic acid
著者Dokurno, P., Murray, J., Davidson, J., Chen, I., Davis, B., Graham, C.J., Harris, R., Jordan, A.M., Matassova, N., Pedder, C., Ray, S., Roughley, S., Smith, J., Walmsley, C., Wang, Y., Whitehead, N., Williamson, D.S., Casara, P., Le Diguarher, T., Hickman, J., Stark, J., Kotschy, A., Geneste, O., Hubbard, R.E.
登録日2019-01-10
公開日2019-06-12
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Establishing Drug Discovery and Identification of Hit Series for the Anti-apoptotic Proteins, Bcl-2 and Mcl-1
Acs Omega, 2019
6QG8
  • Download 6qg8
  • View 6qg8
Molmil generated image of 6qg8
STRUCTURE OF HUMAN BCL-2 IN COMPLEX WITH PUMA BH3 PEPTIDE
分子名称:Apoptosis regulator Bcl-2,Bcl-2-like protein 1,Apoptosis regulator Bcl-2,Bcl-2-like protein 1, Bcl-2-binding component 3
著者Dokurno, P., Murray, J., Davidson, J., Chen, I., Davis, B., Graham, C.J., Harris, R., Jordan, A.M., Matassova, N., Pedder, C., Ray, S., Roughley, S., Smith, J., Walmsley, C., Wang, Y., Whitehead, N., Williamson, D.S., Casara, P., Le Diguarher, T., Hickman, J., Stark, J., Kotschy, A., Geneste, O., Hubbard, R.E.
登録日2019-01-10
公開日2019-06-12
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Establishing Drug Discovery and Identification of Hit Series for the Anti-apoptotic Proteins, Bcl-2 and Mcl-1
Acs Omega, 2019
6QGD
  • Download 6qgd
  • View 6qgd
Molmil generated image of 6qgd
STRUCTURE OF HUMAN MCL-1 IN COMPLEX WITH THIENOPYRIMIDINE INHIBITOR
分子名称:Maltose-binding periplasmic protein,Induced myeloid leukemia cell differentiation protein Mcl-1, 2-[(6-ethyl-5-phenyl-thieno[2,3-d]pyrimidin-4-yl)amino]-3-oxidanyl-propanoic acid, MALTOSE, ...
著者Dokurno, P., Murray, J., Davidson, J., Chen, I., Davis, B., Graham, C.J., Harris, R., Jordan, A.M., Matassova, N., Pedder, C., Ray, S., Roughley, S., Smith, J., Walmsley, C., Wang, Y., Whitehead, N., Williamson, D.S., Casara, P., Le Diguarher, T., Hickman, J., Stark, J., Kotschy, A., Geneste, O., Hubbard, R.E.
登録日2019-01-11
公開日2019-06-12
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Establishing Drug Discovery and Identification of Hit Series for the Anti-apoptotic Proteins, Bcl-2 and Mcl-1
Acs Omega, 2019
6QGG
  • Download 6qgg
  • View 6qgg
Molmil generated image of 6qgg
STRUCTURE OF HUMAN BCL-2 IN COMPLEX WITH ANALOGUE OF ABT-737
分子名称:Apoptosis regulator Bcl-2,Bcl-2-like protein 1,Apoptosis regulator Bcl-2,Bcl-2-like protein 1, [(3~{R})-3-[[4-[[4-[4-[[2-(4-chlorophenyl)phenyl]methyl]piperazin-1-yl]phenyl]carbonylsulfamoyl]-2-nitro-phenyl]amino]-4-phenylsulfanyl-butyl]-(2-hydroxy-2-oxoethyl)-dimethyl-azanium
著者Dokurno, P., Murray, J., Davidson, J., Chen, I., Davis, B., Graham, C.J., Harris, R., Jordan, A.M., Matassova, N., Pedder, C., Ray, S., Roughley, S., Smith, J., Walmsley, C., Wang, Y., Whitehead, N., Williamson, D.S., Casara, P., Le Diguarher, T., Hickman, J., Stark, J., Kotschy, A., Geneste, O., Hubbard, R.E.
登録日2019-01-11
公開日2019-06-12
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Establishing Drug Discovery and Identification of Hit Series for the Anti-apoptotic Proteins, Bcl-2 and Mcl-1
Acs Omega, 2019
6QGH
  • Download 6qgh
  • View 6qgh
Molmil generated image of 6qgh
STRUCTURE OF HUMAN BCL-2 IN COMPLEX WITH ABT-263
分子名称:Apoptosis regulator Bcl-2,Bcl-2-like protein 1,Apoptosis regulator Bcl-2,Bcl-2-like protein 1, 4-(4-{[2-(4-chlorophenyl)-5,5-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-[(4-{[(2R)-4-(morpholin-4-yl)-1-(phenylsulfanyl)butan-2-yl]amino}-3-[(trifluoromethyl)sulfonyl]phenyl)sulfonyl]benzamide
著者Dokurno, P., Murray, J., Davidson, J., Chen, I., Davis, B., Graham, C.J., Harris, R., Jordan, A.M., Matassova, N., Pedder, C., Ray, S., Roughley, S., Smith, J., Walmsley, C., Wang, Y., Whitehead, N., Williamson, D.S., Casara, P., Le Diguarher, T., Hickman, J., Stark, J., Kotschy, A., Geneste, O., Hubbard, R.E.
登録日2019-01-11
公開日2019-06-12
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Establishing Drug Discovery and Identification of Hit Series for the Anti-apoptotic Proteins, Bcl-2 and Mcl-1
Acs Omega, 2019
6QGJ
  • Download 6qgj
  • View 6qgj
Molmil generated image of 6qgj
STRUCTURE OF HUMAN BCL-2 IN COMPLEX WITH FRAGMENT/ABT-263 HYBRID
分子名称:Apoptosis regulator Bcl-2,Bcl-2-like protein 1,Apoptosis regulator Bcl-2,Bcl-2-like protein 1, 4-[4-[(1~{R})-1-(6-methoxy-1,3-benzodioxol-5-yl)-2-pyrrolidin-1-yl-ethyl]phenyl]-~{N}-[4-[[(2~{R})-4-morpholin-4-yl-1-phenylsulfanyl-butan-2-yl]amino]-3-(trifluoromethylsulfonyl)phenyl]sulfonyl-benzamide
著者Dokurno, P., Murray, J., Davidson, J., Chen, I., Davis, B., Graham, C.J., Harris, R., Jordan, A.M., Matassova, N., Pedder, C., Ray, S., Roughley, S., Smith, J., Walmsley, C., Wang, Y., Whitehead, N., Williamson, D.S., Casara, P., Le Diguarher, T., Hickman, J., Stark, J., Kotschy, A., Geneste, O., Hubbard, R.E.
登録日2019-01-11
公開日2019-06-12
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Establishing Drug Discovery and Identification of Hit Series for the Anti-apoptotic Proteins, Bcl-2 and Mcl-1
Acs Omega, 2019
6QGK
  • Download 6qgk
  • View 6qgk
Molmil generated image of 6qgk
STRUCTURE OF HUMAN BCL-2 IN COMPLEX WITH THIQ-PHENYL PYRAZOLE COMPOUND
分子名称:Apoptosis regulator Bcl-2,Bcl-2-like protein 1,Apoptosis regulator Bcl-2,Bcl-2-like protein 1, 1-[2-[[(3~{S})-3-(aminomethyl)-3,4-dihydro-1~{H}-isoquinolin-2-yl]carbonyl]phenyl]-~{N},~{N}-dibutyl-5-methyl-pyrazole-3-carboxamide, ACETATE ION
著者Dokurno, P., Murray, J., Davidson, J., Chen, I., Davis, B., Graham, C.J., Harris, R., Jordan, A.M., Matassova, N., Pedder, C., Ray, S., Roughley, S., Smith, J., Walmsley, C., Wang, Y., Whitehead, N., Williamson, D.S., Casara, P., Le Diguarher, T., Hickman, J., Stark, J., Kotschy, A., Geneste, O., Hubbard, R.E.
登録日2019-01-11
公開日2019-06-12
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Establishing Drug Discovery and Identification of Hit Series for the Anti-apoptotic Proteins, Bcl-2 and Mcl-1
Acs Omega, 2019
1CX8
  • Download 1cx8
  • View 1cx8
Molmil generated image of 1cx8
CRYSTAL STRUCTURE OF THE ECTODOMAIN OF HUMAN TRANSFERRIN RECEPTOR
分子名称:TRANSFERRIN RECEPTOR PROTEIN, N-ACETYL-D-GLUCOSAMINE, SAMARIUM (III) ION
著者Lawrence, C.M., Ray, S., Babyonyshev, M., Galluser, R., Borhani, D., Harrison, S.C.
登録日1999-08-28
公開日1999-09-09
最終更新日2018-01-31
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Crystal structure of the ectodomain of human transferrin receptor.
Science, 286, 1999
1HMV
  • Download 1hmv
  • View 1hmv
Molmil generated image of 1hmv
THE STRUCTURE OF UNLIGANDED REVERSE TRANSCRIPTASE FROM THE HUMAN IMMUNODEFICIENCY VIRUS TYPE 1
分子名称:HIV-1 REVERSE TRANSCRIPTASE (SUBUNIT P66), HIV-1 REVERSE TRANSCRIPTASE (SUBUNIT P51), MAGNESIUM ION
著者Rodgers, D.W., Gamblin, S.J., Harris, B.A., Ray, S., Culp, J.S., Hellmig, B., Woolf, D.J., Debouck, C., Harrison, S.C.
登録日1994-12-15
公開日1995-03-31
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献The structure of unliganded reverse transcriptase from the human immunodeficiency virus type 1.
Proc.Natl.Acad.Sci.USA, 92, 1995
1JG8
  • Download 1jg8
  • View 1jg8
Molmil generated image of 1jg8
CRYSTAL STRUCTURE OF THREONINE ALDOLASE (LOW-SPECIFICITY)
分子名称:L-allo-threonine aldolase, CALCIUM ION, SODIUM ION
著者Kielkopf, C.L., Bonanno, J., Ray, S., Burley, S.K., New York SGX Research Center for Structural Genomics (NYSGXRC)
登録日2001-06-23
公開日2001-07-04
最終更新日2017-10-04
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Crystal Structure of Low-specificity Threonine Aldolase, a Key Enzyme in Glycine Biosynthesis
To be published
2VCI
  • Download 2vci
  • View 2vci
Molmil generated image of 2vci
4,5 DIARYL ISOXAZOLE HSP90 CHAPERONE INHIBITORS: POTENTIAL THERAPEUTIC AGENTS FOR THE TREATMENT OF CANCER
分子名称:HEAT SHOCK PROTEIN HSP 90-ALPHA, 5-[2,4-DIHYDROXY-5-(1-METHYLETHYL)PHENYL]-N-ETHYL-4-[4-(MORPHOLIN-4-YLMETHYL)PHENYL]ISOXAZOLE-3-CARBOXAMIDE
著者Brough, P.A., Aherne, W., Barril, X., Borgognoni, J., Boxal, K., Cansfield, J.E., Cheung, K.M., Collins, I., Davies, N.G.M., Drysdale, M.J., Dymock, B., Eccles, S.A., Finch, H., Fink, A., Hayes, A., Howes, R., Hubbard, R.E., James, K., Jordan, A.M., Lockie, A., Martins, V., Massey, A., Matthews, T.P., McDonald, E., Northfield, C.J., Pearl, L.H., Prodromou, C., Ray, S., Raynaud, F.I., Roughley, S.D., Sharp, S.Y., Surgenor, A., Walmsley, D.L., Webb, P., Wood, M., Workman, P., Wright, L.
登録日2007-09-24
公開日2007-12-11
最終更新日2018-02-28
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献4,5-diarylisoxazole Hsp90 chaperone inhibitors: potential therapeutic agents for the treatment of cancer.
J. Med. Chem., 51, 2008
2VCJ
  • Download 2vcj
  • View 2vcj
Molmil generated image of 2vcj
4,5 DIARYL ISOXAZOLE HSP90 CHAPERONE INHIBITORS: POTENTIAL THERAPEUTIC AGENTS FOR THE TREATMENT OF CANCER
分子名称:HEAT SHOCK PROTEIN HSP 90-ALPHA, 5-(5-chloro-2,4-dihydroxyphenyl)-N-ethyl-4-[4-(morpholin-4-ylmethyl)phenyl]isoxazole-3-carboxamide
著者Brough, P.A., Aherne, W., Barril, X., Borgognoni, J., Boxal, K., Cansfield, J.E., Cheung, K.M., Collins, I., Davies, N.G.M., Drysdale, M.J., Dymock, B., Eccles, S.A., Finch, H., Fink, A., Hayes, A., Howes, R., Hubbard, R.E., James, K., Jordan, A.M., Lockie, A., Martins, V., Massey, A., Matthews, T.P., McDonald, E., Northfield, C.J., Pearl, L.H., Prodromou, C., Ray, S., Raynaud, F.I., Roughley, S.D., Sharp, S.Y., Surgenor, A., Walmsley, D.L., Webb, P., Wood, M., Workman, P., Wright, L.
登録日2007-09-24
公開日2007-12-11
最終更新日2018-02-28
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献4,5-diarylisoxazole Hsp90 chaperone inhibitors: potential therapeutic agents for the treatment of cancer.
J. Med. Chem., 51, 2008
<12>