Author results

1MLX
  • Download 1mlx
  • View 1mlx
Molmil generated image of 1mlx
CRYSTAL STRUCTURE ANALYSIS OF A 2'-O-[2-(METHYLTHIO)-ETHYL]-MODIFIED OLIGODEOXYNUCLEOTIDE DUPLEX
Descriptor:5'-D(*GP*CP*GP*TP*AP*SMTP*AP*CP*GP*C)-3'
Authors:Prakash, T.P., Manoharan, M., Kawasaki, A.M., Fraser, A.S., Lesnik, E.A., Sioufi, N., Leeds, J.M., Teplova, M., Egli, M.
Deposit date:2002-08-31
Release date:2002-12-04
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:2'-O-[2-(Methylthio)ethyl]-Modified Oligonucleotide: An Analogue of 2'-O-[2-(Methoxy)-ethyl]-Modified Oligonucleotide with Improved Protein Binding Properties and High Binding Affinity to Target RNA
Biochemistry, 41, 2002
1R3G
  • Download 1r3g
  • View 1r3g
Molmil generated image of 1r3g
1.16A X-RAY STRUCTURE OF THE SYNTHETIC DNA FRAGMENT WITH THE INCORPORATED 2'-O-[(2-GUANIDINIUM)ETHYL]-5-METHYLURIDINE RESIDUES
Descriptor:5'-D(*GP*CP*GP*TP*AP*(GMU)P*AP*CP*GP*C)-3'), MAGNESIUM ION
Authors:Prakash, T.P., Puschl, A., Lesnik, E., Tereshko, V., Egli, M., Manoharan, M.
Deposit date:2003-10-01
Release date:2003-10-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.16 Å)
Cite:2'-O-[2-(Guanidinium)ethyl]-Modified Oligonucleotides: Stabilizing Effect on Duplex and Triplex Structures.
Org.Lett., 6, 2004
1I0F
  • Download 1i0f
  • View 1i0f
Molmil generated image of 1i0f
1.6 A STRUCTURE OF THE A-DECAMER GCGTATACGC WITH A SINGLE 2'-O-AMINOOXYETHYL THYMINE IN PLACE OF T6, BA-FORM
Descriptor:5'-D(*GP*CP*GP*TP*AP*(127)P*AP*CP*GP*C)-3', BARIUM ION
Authors:Tereshko, V., Wilds, C.J., Minasov, G., Prakash, T.P., Maier, M.A., Howard, A., Wawrzak, Z., Manoharan, M., Egli, M.
Deposit date:2001-01-29
Release date:2001-04-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Detection of alkali metal ions in DNA crystals using state-of-the-art X-ray diffraction experiments.
Nucleic Acids Res., 29, 2001
1I0G
  • Download 1i0g
  • View 1i0g
Molmil generated image of 1i0g
1.45 A STRUCTURE OF THE A-DECAMER GCGTATACGC WITH A SINGLE 2'-O-FLUOROETHYL THYMINE IN PLACE OF T6, MEDIUM NA-SALT
Descriptor:5'-D(*GP*CP*GP*TP*AP*(125)P*AP*CP*GP*C)-3', SODIUM ION
Authors:Tereshko, V., Wilds, C.J., Minasov, G., Prakash, T.P., Maier, M.A., Howard, A., Wawrzak, Z., Manoharan, M., Egli, M.
Deposit date:2001-01-29
Release date:2001-04-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Detection of alkali metal ions in DNA crystals using state-of-the-art X-ray diffraction experiments.
Nucleic Acids Res., 29, 2001
1I0J
  • Download 1i0j
  • View 1i0j
Molmil generated image of 1i0j
1.06 A STRUCTURE OF THE A-DECAMER GCGTATACGC WITH A SINGLE 2'-O-METHYL-3'-METHYLENEPHOSPHONATE (T23) THYMINE IN PLACE OF T6, HIGH CS-SALT
Descriptor:5'-D(*GP*CP*GP*TP*AP*(T23)P*AP*CP*GP*C)-3', CESIUM ION
Authors:Tereshko, V., Wilds, C.J., Minasov, G., Prakash, T.P., Maier, M.A., Howard, A., Wawrzak, Z., Manoharan, M., Egli, M.
Deposit date:2001-01-29
Release date:2001-04-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.06 Å)
Cite:Detection of alkali metal ions in DNA crystals using state-of-the-art X-ray diffraction experiments.
Nucleic Acids Res., 29, 2001
1I0K
  • Download 1i0k
  • View 1i0k
Molmil generated image of 1i0k
1.05 A STRUCTURE OF THE A-DECAMER GCGTATACGC WITH A SINGLE 2'-O-METHYL-[TRI(OXYETHYL)] THYMINE IN PLACE OF T6, MEDIUM CS-SALT
Descriptor:5'-D(*GP*CP*GP*TP*AP*(126)P*AP*CP*GP*C)-3', CESIUM ION
Authors:Tereshko, V., Wilds, C.J., Minasov, G., Prakash, T.P., Maier, M.A., Howard, A., Wawrzak, Z., Manoharan, M., Egli, M.
Deposit date:2001-01-29
Release date:2001-04-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.05 Å)
Cite:Detection of alkali metal ions in DNA crystals using state-of-the-art X-ray diffraction experiments.
Nucleic Acids Res., 29, 2001
1I0M
  • Download 1i0m
  • View 1i0m
Molmil generated image of 1i0m
1.05 A STRUCTURE OF THE A-DECAMER GCGTATACGC WITH A SINGLE 2'-O-FLUOROETHYL THYMINE IN PLACE OF T6, HIGH RB-SALT
Descriptor:5'-D(*GP*CP*GP*TP*AP*(125)P*AP*CP*GP*C)-3', RUBIDIUM ION
Authors:Tereshko, V., Wilds, C.J., Minasov, G., Prakash, T.P., Maier, M.A., Howard, A., Wawrzak, Z., Manoharan, M., Egli, M.
Deposit date:2001-01-29
Release date:2001-04-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.05 Å)
Cite:Detection of alkali metal ions in DNA crystals using state-of-the-art X-ray diffraction experiments.
Nucleic Acids Res., 29, 2001
1I0N
  • Download 1i0n
  • View 1i0n
Molmil generated image of 1i0n
1.3 A STRUCTURE OF THE A-DECAMER GCGTATACGC WITH A SINGLE 2'-O-METHYL-[TRI(OXYETHYL)] THYMINE IN PLACE OF T6, MEDIUM RB-SALT
Descriptor:5'-D(*GP*CP*GP*TP*AP*(126)P*AP*CP*GP*C)-3', RUBIDIUM ION
Authors:Tereshko, V., Wilds, C.J., Minasov, G., Prakash, T.P., Maier, M.A., Howard, A., Wawrzak, Z., Manoharan, M., Egli, M.
Deposit date:2001-01-29
Release date:2001-04-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Detection of alkali metal ions in DNA crystals using state-of-the-art X-ray diffraction experiments.
Nucleic Acids Res., 29, 2001
1I0O
  • Download 1i0o
  • View 1i0o
Molmil generated image of 1i0o
1.6 A STRUCTURE OF THE A-DECAMER GCGTATACGC WITH A SINGLE 2'-O-METHYL-3'-METHYLENEPHOSPHONATE THYMINE IN PLACE OF T6, HIGH K-SALT
Descriptor:5'-D(*GP*CP*GP*TP*AP*(T23)P*AP*CP*GP*C)-3', POTASSIUM ION
Authors:Tereshko, V., Wilds, C.J., Minasov, G., Prakash, T.P., Maier, M.A., Howard, A., Wawrzak, Z., Manoharan, M., Egli, M.
Deposit date:2001-01-29
Release date:2001-04-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Detection of alkali metal ions in DNA crystals using state-of-the-art X-ray diffraction experiments
Nucleic Acids Res., 29, 2001
1I0P
  • Download 1i0p
  • View 1i0p
Molmil generated image of 1i0p
1.3 A STRUCTURE OF THE A-DECAMER GCGTATACGC WITH A SINGLE 2'-O-METHYL-[TRI(OXYETHYL)], MEDIUM K-SALT
Descriptor:5'-D(*GP*CP*GP*TP*AP*(126)P*AP*CP*GP*C)-3', POTASSIUM ION
Authors:Tereshko, V., Wilds, C.J., Minasov, G., Prakash, T.P., Maier, M.A., Howard, A., Wawrzak, Z., Manoharan, M., Egli, M.
Deposit date:2001-01-29
Release date:2001-04-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Detection of alkali metal ions in DNA crystals using state-of-the-art X-ray diffraction experiments.
Nucleic Acids Res., 29, 2001
1I0Q
  • Download 1i0q
  • View 1i0q
Molmil generated image of 1i0q
1.3 A STRUCTURE OF THE A-DECAMER GCGTATACGC WITH A SINGLE 2'-O-METHYL-[TRI(OXYETHYL)] THYMINE IN PLACE OF T6, MEDIUM NA-SALT
Descriptor:5'-D(*GP*CP*GP*TP*AP*(126)P*AP*CP*GP*C)-3', SODIUM ION
Authors:Tereshko, V., Wilds, C.J., Minasov, G., Prakash, T.P., Maier, M.A., Howard, A., Wawrzak, Z., Manoharan, M., Egli, M.
Deposit date:2001-01-29
Release date:2001-04-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Detection of alkali metal ions in DNA crystals using state-of-the-art X-ray diffraction experiments.
Nucleic Acids Res., 29, 2001
1I0T
  • Download 1i0t
  • View 1i0t
Molmil generated image of 1i0t
0.6 A STRUCTURE OF Z-DNA CGCGCG
Descriptor:5'-D(*CP*GP*CP*GP*CP*G)-3', SPERMINE
Authors:Tereshko, V., Wilds, C.J., Minasov, G., Prakash, T.P., Maier, M.A., Howard, A., Wawrzak, Z., Manoharan, M., Egli, M.
Deposit date:2001-01-29
Release date:2001-04-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (0.6 Å)
Cite:Detection of alkali metal ions in DNA crystals using state-of-the-art X-ray diffraction experiments.
Nucleic Acids Res., 29, 2001
1NZG
  • Download 1nzg
  • View 1nzg
Molmil generated image of 1nzg
CRYSTAL STRUCTURE OF A-DNA DECAMER GCGTA(3ME)ACGC, WITH A MODIFIED 5-METHYLURIDINE
Descriptor:5'-D(*GP*CP*GP*TP*AP*(3ME)P*AP*CP*GP*C)-3'
Authors:Prhavc, M., Prakash, T.P., Minasov, G., Egli, M., Manoharan, M.
Deposit date:2003-02-17
Release date:2003-08-26
Last modified:2011-11-02
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:2'-O-[2-[2-(N,N-dimethylamino)ethoxy]ethyl] modified oligonucleotides: symbiosis of charge interaction factors and stereoelectronic effects
Org.Lett., 5, 2003
1WV5
  • Download 1wv5
  • View 1wv5
Molmil generated image of 1wv5
X-RAY STRUCTURE OF THE A-DECAMER GCGTATACGC WITH A SINGLE 2'-O-BUTYL THYMINE IN PLACE OF T6, MG-FORM
Descriptor:5'-D(*GP*CP*GP*TP*AP*(2BT)P*AP*CP*GP*C)-3', MAGNESIUM ION
Authors:Egli, M., Minasov, G., Tereshko, V., Pallan, P.S., Teplova, M., Inamati, G.B., Lesnik, E.A., Owens, S.R., Ross, B.S., Prakash, T.P., Manoharam, M.
Deposit date:2004-12-11
Release date:2005-06-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Probing the influence of stereoelectronic effects on the biophysical properties of oligonucleotides: comprehensive analysis of the RNA affinity, nuclease resistance, and crystal structure of ten 2'-O-ribonucleic acid modifications.
Biochemistry, 44, 2005
1WV6
  • Download 1wv6
  • View 1wv6
Molmil generated image of 1wv6
X-RAY STRUCTURE OF THE A-DECAMER GCGTATACGC WITH A SINGLE 2'-O-BUTYL THYMINE IN PLACE OF T6, SR-FORM
Descriptor:5'-D(*GP*CP*GP*TP*AP*(2BT)P*AP*CP*GP*C)-3', STRONTIUM ION
Authors:Egli, M., Minasov, G., Tereshko, V., Pallan, P.S., Teplova, M., Inamati, G.B., Lesnik, E.A., Owens, S.R., Ross, B.S., Prakash, T.P., Manoharam, M.
Deposit date:2004-12-11
Release date:2005-06-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Probing the influence of stereoelectronic effects on the biophysical properties of oligonucleotides: comprehensive analysis of the RNA affinity, nuclease resistance, and crystal structure of ten 2'-O-ribonucleic acid modifications.
Biochemistry, 44, 2005
1XUW
  • Download 1xuw
  • View 1xuw
Molmil generated image of 1xuw
STRUCTURAL RATIONALIZATION OF A LARGE DIFFERENCE IN RNA AFFINITY DESPITE A SMALL DIFFERENCE IN CHEMISTRY BETWEEN TWO 2'-O-MODIFIED NUCLEIC ACID ANALOGS
Descriptor:DNA (5'-D(*GP*CP*GP*TP*AP*(NMT)P*AP*CP*GP*C)-3')
Authors:Pattanayek, R., Sethaphong, L., Pan, C., Prhavc, M., Prakash, T.P., Manoharan, M., Egli, M.
Deposit date:2004-10-26
Release date:2004-12-14
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:Structural rationalization of a large difference in RNA affinity despite a small difference in chemistry between two 2'-O-modified nucleic acid analogues.
J.Am.Chem.Soc., 126, 2004
1XUX
  • Download 1xux
  • View 1xux
Molmil generated image of 1xux
STRUCTURAL RATIONALIZATION OF A LARGE DIFFERENCE IN RNA AFFINITY DESPITE A SMALL DIFFERENCE IN CHEMISTRY BETWEEN TWO 2'-O-MODIFIED NUCLEIC ACID ANALOGS
Descriptor:DNA (5'-D(*GP*CP*GP*TP*AP*(NMS)P*AP*CP*GP*C)-3')
Authors:Pattanayek, R., Sethaphong, L., Pan, C., Prhavc, M., Prakash, T.P., Manoharan, M., Egli, M.
Deposit date:2004-10-26
Release date:2004-12-14
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Structural rationalization of a large difference in RNA affinity despite a small difference in chemistry between two 2'-O-modified nucleic acid analogues.
J.Am.Chem.Soc., 126, 2004
1Y7F
  • Download 1y7f
  • View 1y7f
Molmil generated image of 1y7f
CRYSTAL STRUCTURE OF THE A-DNA GCGTAT*CGC WITH A 2'-O-[2-[HYDROXY(METHYLENEAMINO)OXY]ETHYL] THYMIDINE (T*)
Descriptor:5'-D(*GP*CP*GP*TP*AP*(2NT)P*AP*CP*GP*C)-3'), BARIUM ION
Authors:Egli, M., Minasov, G., Tereshko, V., Pallan, P.S., Teplova, M., Inamati, G.B., Lesnik, E.A., Owens, S.R., Ross, B.S., Prakash, T.P., Manoharan, M.
Deposit date:2004-12-08
Release date:2005-06-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Probing the Influence of Stereoelectronic Effects on the Biophysical Properties of Oligonucleotides: Comprehensive Analysis of the RNA Affinity, Nuclease Resistance, and Crystal Structure of Ten 2'-O-Ribonucleic Acid Modifications.
Biochemistry, 44, 2005
1Y84
  • Download 1y84
  • View 1y84
Molmil generated image of 1y84
CRYSTAL STRUCTURE OF THE A-DNA GCGTAT*CGC WITH A 2'-O-[2-(IMIDAZOLYL)ETHYL] THYMIDINE (T*)
Descriptor:5'-D(*GP*CP*GP*TP*AP*(EIT)P*AP*CP*GP*C)-3', MAGNESIUM ION, SPERMINE
Authors:Egli, M., Minasov, G., Tereshko, V., Pallan, P.S., Teplova, M., Inamati, G.B., Lesnik, E.A., Owens, S.R., Ross, B.S., Prakash, T.P., Manoharan, M.
Deposit date:2004-12-10
Release date:2005-06-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Probing the Influence of Stereoelectronic Effects on the Biophysical Properties of Oligonucleotides: Comprehensive Analysis of the RNA Affinity, Nuclease Resistance, and Crystal Structure of Ten 2'-O-Ribonucleic Acid Modifications.
Biochemistry, 44, 2005
1Y86
  • Download 1y86
  • View 1y86
Molmil generated image of 1y86
CRYSTAL STRUCTURE OF THE A-DNA GCGTAT*CGC WITH A 2'-O-[2-(FLUORO)ETHYL] THYMIDINE (T*)
Descriptor:5'-D(*GP*CP*GP*TP*AP*(125)P*AP*CP*GP*C)-3'
Authors:Egli, M., Minasov, G., Tereshko, V., Pallan, P.S., Teplova, M., Inamati, G.B., Lesnik, E.A., Owens, S.R., Ross, B.S., Prakash, T.P., Manoharan, M.
Deposit date:2004-12-10
Release date:2005-06-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Probing the Influence of Stereoelectronic Effects on the Biophysical Properties of Oligonucleotides: Comprehensive Analysis of the RNA Affinity, Nuclease Resistance, and Crystal Structure of Ten 2'-O-Ribonucleic Acid Modifications.
Biochemistry, 44, 2005
1Y8L
  • Download 1y8l
  • View 1y8l
Molmil generated image of 1y8l
CRYSTAL STRUCTURE OF THE A-DNA GCGTAT*CGC WITH A 2'-O-[2-(TRIFLUORO)ETHYL] THYMIDINE (T*)
Descriptor:5'-D(*GP*CP*GP*TP*AP*(TFE)P*AP*CP*GP*C)-3'), MAGNESIUM ION, SPERMINE
Authors:Egli, M., Minasov, G., Tereshko, V., Pallan, P.S., Teplova, M., Inamati, G.B., Lesnik, E.A., Owens, S.R., Ross, B.S., Prakash, T.P., Manoharan, M.
Deposit date:2004-12-13
Release date:2005-06-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Probing the Influence of Stereoelectronic Effects on the Biophysical Properties of Oligonucleotides: Comprehensive Analysis of the RNA Affinity, Nuclease Resistance, and Crystal Structure of Ten 2'-O-Ribonucleic Acid Modifications.
Biochemistry, 44, 2005
1Y8V
  • Download 1y8v
  • View 1y8v
Molmil generated image of 1y8v
CRYSTAL STRUCTURE OF THE A-DNA GCGTAT*CGC WITH A 2'-O-PROPYL THYMIDINE (T*)
Descriptor:5'-D(*GP*CP*GP*TP*AP*(P2T)P*AP*CP*GP*C)-3'
Authors:Egli, M., Minasov, G., Tereshko, V., Pallan, P.S., Teplova, M., Inamati, G.B., Lesnik, E.A., Owens, S.R., Ross, B.S., Prakash, T.P., Manoharan, M.
Deposit date:2004-12-13
Release date:2005-06-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Probing the Influence of Stereoelectronic Effects on the Biophysical Properties of Oligonucleotides: Comprehensive Analysis of the RNA Affinity, Nuclease Resistance, and Crystal Structure of Ten 2'-O-Ribonucleic Acid Modifications.
Biochemistry, 44, 2005
1Y9F
  • Download 1y9f
  • View 1y9f
Molmil generated image of 1y9f
CRYSTAL STRUCTURE OF THE A-DNA GCGTAT*CGC WITH A 2'-O-ALLYL THYMIDINE (T*)
Descriptor:5'-D(*GP*CP*GP*TP*AP*(2AT)P*AP*CP*GP*C)-3')
Authors:Egli, M., Minasov, G., Tereshko, V., Pallan, P.S., Teplova, M., Inamati, G.B., Lesnik, E.A., Owens, S.R., Ross, B.S., Prakash, T.P., Manoharan, M.
Deposit date:2004-12-15
Release date:2005-06-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Probing the Influence of Stereoelectronic Effects on the Biophysical Properties of Oligonucleotides: Comprehensive Analysis of the RNA Affinity, Nuclease Resistance, and Crystal Structure of Ten 2'-O-Ribonucleic Acid Modifications.
Biochemistry, 44, 2005
1Y9S
  • Download 1y9s
  • View 1y9s
Molmil generated image of 1y9s
CRYSTAL STRUCTURE OF THE A-DNA GCGTAT*CGC WITH A 2'-O-PROPARGYL THYMIDINE (T*)
Descriptor:5'-D(*GP*CP*GP*TP*AP*(2GT)P*AP*CP*GP*C)-3')
Authors:Egli, M., Minasov, G., Tereshko, V., Pallan, P.S., Teplova, M., Inamati, G.B., Lesnik, E.A., Owens, S.R., Ross, B.S., Prakash, T.P., Manoharan, M.
Deposit date:2004-12-16
Release date:2005-06-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Probing the Influence of Stereoelectronic Effects on the Biophysical Properties of Oligonucleotides: Comprehensive Analysis of the RNA Affinity, Nuclease Resistance, and Crystal Structure of Ten 2'-O-Ribonucleic Acid Modifications.
Biochemistry, 44, 2005
1YB9
  • Download 1yb9
  • View 1yb9
Molmil generated image of 1yb9
CRYSTAL STRUCTURE OF THE A-DNA GCGTAT*CGC WITH A 2'-O-[2-(N,N-DIMETHYLAMINOOXY)ETHYL] THYMIDINE (T*)
Descriptor:5'-D(*GP*CP*GP*TP*AP*(2OT)P*AP*CP*GP*C)-3'), SPERMINE
Authors:Egli, M., Minasov, G., Tereshko, V., Pallan, P.S., Teplova, M., Inamati, G.B., Lesnik, E.A., Owens, S.R., Ross, B.S., Prakash, T.P., Manoharan, M.
Deposit date:2004-12-20
Release date:2005-06-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Probing the Influence of Stereoelectronic Effects on the Biophysical Properties of Oligonucleotides: Comprehensive Analysis of the RNA Affinity, Nuclease Resistance, and Crystal Structure of Ten 2'-O-Ribonucleic Acid Modifications.
Biochemistry, 44, 2005
<12>