4R4P
| Crystal Structure of the VS ribozyme-A756G mutant | Descriptor: | MAGNESIUM ION, VS ribozyme RNA | Authors: | Piccirilli, J.A, Suslov, N.B, Dasgupta, S, Huang, H, Lilley, D.M.J, Rice, P.A. | Deposit date: | 2014-08-19 | Release date: | 2015-09-30 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (3.07 Å) | Cite: | Crystal structure of the Varkud satellite ribozyme. Nat.Chem.Biol., 11, 2015
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4R4V
| Crystal structure of the VS ribozyme - G638A mutant | Descriptor: | MAGNESIUM ION, POTASSIUM ION, VS ribozyme RNA | Authors: | Piccirilli, J.A, Suslov, N.B, Dasgupta, S, Huang, H, Lilley, D.M.J, Rice, P.A. | Deposit date: | 2014-08-19 | Release date: | 2015-09-30 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (3.07 Å) | Cite: | Crystal structure of the Varkud satellite ribozyme. Nat.Chem.Biol., 11, 2015
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2KZZ
| KLENOW FRAGMENT WITH NORMAL SUBSTRATE AND ZINC ONLY | Descriptor: | DNA (5'-D(*GP*CP*TP*T*AP*CP*G)-3'), PROTEIN (DNA POLYMERASE I), ZINC ION | Authors: | Brautigam, C.A, Sun, S, Piccirilli, J.A, Steitz, T.A. | Deposit date: | 1998-07-07 | Release date: | 1999-12-14 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Structures of normal single-stranded DNA and deoxyribo-3'-S-phosphorothiolates bound to the 3'-5' exonucleolytic active site of DNA polymerase I from Escherichia coli. Biochemistry, 38, 1999
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8SH5
| Crystal structure of 3'cap-independent translation enhancers (CITE) from Pea enation mosaic virus RNA 2 (PEMV2) with Fab BL3-6K170A | Descriptor: | Fab BL3-6K170A heavy chain, Fab BL3-6K170A light chain, RNA (88-MER) | Authors: | Lewicka, A, Roman, C, Rice, P.A, Piccirilli, J.A. | Deposit date: | 2023-04-13 | Release date: | 2023-08-16 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.75 Å) | Cite: | Crystal structure of a cap-independent translation enhancer RNA. Nucleic Acids Res., 51, 2023
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3IVK
| Crystal Structure of the Catalytic Core of an RNA Polymerase Ribozyme Complexed with an Antigen Binding Antibody Fragment | Descriptor: | CADMIUM ION, CHLORIDE ION, Fab heavy chain, ... | Authors: | Koldobskaya, Y, Duguid, E.M, Shechner, D.M, Koide, S, Kossiakoff, A.A, Bartel, D.P, Piccirilli, J.A. | Deposit date: | 2009-09-01 | Release date: | 2010-03-02 | Last modified: | 2017-11-01 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Crystal structure of the catalytic core of an RNA-polymerase ribozyme. Science, 326, 2009
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6MWN
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6B14
| Crystal structure of Spinach RNA aptamer in complex with Fab BL3-6S97N | Descriptor: | Heavy chain of Fab BL3-6S97N, Light chain of Fab BL3-6S97N, MAGNESIUM ION, ... | Authors: | DasGupta, S, Shelke, S.A, Piccirilli, J.A. | Deposit date: | 2017-09-16 | Release date: | 2017-12-27 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.64 Å) | Cite: | Affinity maturation of a portable Fab-RNA module for chaperone-assisted RNA crystallography. Nucleic Acids Res., 46, 2018
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6B3K
| Crystal structure of mutant Spinach RNA aptamer in complex with Fab BL3-6 | Descriptor: | Heavy chain of Fab BL3-6, Light chain of Fab BL3-6, MAGNESIUM ION, ... | Authors: | DasGupta, S, Koirala, D, Shelke, S.A, Piccirilli, J.A. | Deposit date: | 2017-09-22 | Release date: | 2017-12-27 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.09 Å) | Cite: | Affinity maturation of a portable Fab-RNA module for chaperone-assisted RNA crystallography. Nucleic Acids Res., 46, 2018
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2KZM
| KLENOW FRAGMENT WITH NORMAL SUBSTRATE AND ZINC AND MANGANESE | Descriptor: | DNA (5'-D(*GP*CP*TP*TP*A*CP*GP*C)-3'), MANGANESE (II) ION, PROTEIN (DNA POLYMERASE I), ... | Authors: | Brautigam, C.A, Sun, S, Piccirilli, J.A, Steitz, T.A. | Deposit date: | 1998-07-03 | Release date: | 1999-02-16 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structures of normal single-stranded DNA and deoxyribo-3'-S-phosphorothiolates bound to the 3'-5' exonucleolytic active site of DNA polymerase I from Escherichia coli. Biochemistry, 38, 1999
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8UTA
| yjdF riboswitch from R. gauvreauii in complex with proflavine bound to Fab BL3-6 S97N | Descriptor: | Fab BL3-6 S97N heavy chain, Fab BL3-6 S97N light chain, MAGNESIUM ION, ... | Authors: | Krochmal, D, Lewicka, A, Piccirilli, J.A. | Deposit date: | 2023-10-30 | Release date: | 2024-04-10 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (3.05 Å) | Cite: | Structural basis for promiscuity in ligand recognition by yjdF riboswitch. Cell Discov, 10, 2024
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8UIW
| yjdF riboswitch from R. gauvreauii in complex with chelerythrine bound to Fab BL3-6 S97N | Descriptor: | 1,2-dimethoxy-12-methyl[1,3]benzodioxolo[5,6-c]phenanthridin-12-ium, Fab BL3-6 S97N heavy chain, Fab BL3-6 S97N light chain, ... | Authors: | Krochmal, D, Lewicka, A, Piccirilli, J.A. | Deposit date: | 2023-10-10 | Release date: | 2024-04-10 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2.77 Å) | Cite: | Structural basis for promiscuity in ligand recognition by yjdF riboswitch. Cell Discov, 10, 2024
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7SZU
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7U0Y
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7JRS
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7JRR
| Crystal structures of artificially designed homomeric RNA nanoarchitectures | Descriptor: | MAGNESIUM ION, MANGANESE (II) ION, RNA (50-MER) | Authors: | Liu, D, Shao, Y, Piccirilli, J.A, Weizmann, Y. | Deposit date: | 2020-08-12 | Release date: | 2021-09-08 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.16 Å) | Cite: | Structures of artificially designed discrete RNA nanoarchitectures at near-atomic resolution. Sci Adv, 7, 2021
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7JRT
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2R8S
| High resolution structure of a specific synthetic FAB bound to P4-P6 RNA ribozyme domain | Descriptor: | Fab heavy chain, Fab light chain, MAGNESIUM ION, ... | Authors: | Ye, J.D, Tereshko, V, Sidhu, S.S, Koide, S, Kossiakoff, A.A, Piccirilli, J.A. | Deposit date: | 2007-09-11 | Release date: | 2007-12-04 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Synthetic antibodies for specific recognition and crystallization of structured RNA Proc.Natl.Acad.Sci.Usa, 105, 2008
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9AUR
| Crystal structure of loop-closed A21 2'-OMe dumbbell RNA bridged by glycine | Descriptor: | Fab BL3-6 heavy chain, Fab BL3-6 light chain, GLYCINE, ... | Authors: | Radakovic, A, Lewicka, A, Todisco, M, Aitken, H.R.M, Weiss, Z, Kim, S, Bannan, A, Piccirilli, J.A, Szostak, J.W. | Deposit date: | 2024-02-29 | Release date: | 2024-09-04 | Last modified: | 2024-09-11 | Method: | X-RAY DIFFRACTION (1.57 Å) | Cite: | A potential role for RNA aminoacylation prior to its role in peptide synthesis. Proc.Natl.Acad.Sci.USA, 121, 2024
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9AUS
| Crystal structure of loop-closed dumbbell RNA bridged by glycine | Descriptor: | Fab BL3-6 heavy chain, Fab BL3-6 light chain, GLYCINE, ... | Authors: | Radakovic, A, Lewicka, A, Todisco, M, Aitken, H.R.M, Weiss, Z, Kim, S, Bannan, A, Piccirilli, J.A, Szostak, J.W. | Deposit date: | 2024-02-29 | Release date: | 2024-09-04 | Method: | X-RAY DIFFRACTION (2.07 Å) | Cite: | A potential role for RNA aminoacylation prior to its role in peptide synthesis. Proc.Natl.Acad.Sci.USA, 121, 2024
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5V3I
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6XJQ
| Crystal structure of a self-alkylating ribozyme - alkylated form with biotinylated epoxide substrate | Descriptor: | 2-{[(4R)-4-hydroxyhexyl]oxy}ethyl 5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoate, Fab HAVx Heavy Chain, Fab HAVx Light Chain, ... | Authors: | Koirala, D, Piccirilli, J.A. | Deposit date: | 2020-06-24 | Release date: | 2022-01-19 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.708 Å) | Cite: | Structural basis for substrate binding and catalysis by a self-alkylating ribozyme. Nat.Chem.Biol., 18, 2022
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6XJW
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6DB8
| Structural basis for promiscuous binding and activation of fluorogenic dyes by DIR2s RNA aptamer | Descriptor: | 2-[(Z)-(3-methyl-1,3-benzoxazol-2(3H)-ylidene)methyl]-3-(3-sulfopropyl)-1,3-benzothiazol-3-ium, Fab-Heavy chain, Fab-Light chain, ... | Authors: | Shao, Y, Shelke, S.A, Laski, A, Piccirilli, J.A. | Deposit date: | 2018-05-02 | Release date: | 2018-11-14 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.86541343 Å) | Cite: | Structural basis for activation of fluorogenic dyes by an RNA aptamer lacking a G-quadruplex motif. Nat Commun, 9, 2018
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6DB9
| Structural basis for promiscuous binding and activation of fluorogenic dyes by DIR2s RNA aptamer | Descriptor: | Fab-Heavy-Chain, Fab-Light-Chain, MAGNESIUM ION, ... | Authors: | Shao, Y, Shelke, S.A, Laski, A, Piccirilli, J.A. | Deposit date: | 2018-05-02 | Release date: | 2018-11-14 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.025 Å) | Cite: | Structural basis for activation of fluorogenic dyes by an RNA aptamer lacking a G-quadruplex motif. Nat Commun, 9, 2018
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2KFZ
| KLENOW FRAGMENT WITH BRIDGING-SULFUR SUBSTRATE AND ZINC ONLY | Descriptor: | 5'-D(*GP*CP*TP*TP*AP*(US1)P*G)-3', KLENOW FRAGMENT OF DNA POLYMERASE I, MAGNESIUM ION, ... | Authors: | Brautigam, C.A, Sun, S, Piccirilli, J.A, Steitz, T.A. | Deposit date: | 1998-07-02 | Release date: | 1998-11-11 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.03 Å) | Cite: | Structures of normal single-stranded DNA and deoxyribo-3'-S-phosphorothiolates bound to the 3'-5' exonucleolytic active site of DNA polymerase I from Escherichia coli. Biochemistry, 38, 1999
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