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2UWD
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INHIBITION OF THE HSP90 MOLECULAR CHAPERONE IN VITRO AND IN VIVO BY NOVEL, SYNTHETIC, POTENT RESORCINYLIC PYRAZOLE, ISOXAZOLE AMIDE ANALOGS
Descriptor:HEAT SHOCK PROTEIN HSP 90-ALPHA, MAGNESIUM ION, SULFATE ION, ...
Authors:Sharp, S.Y., Prodromou, C., Boxall, K., Powers, M.V., Holmes, J.L., Box, G., Matthews, T.P., Cheung, K.M., Kalusa, A., James, K., Hayes, A., Hardcastle, A., Dymock, B., Brough, P.A., Barril, X., Cansfield, J.E., Wright, L.M., Surgenor, A., Foloppe, N., Aherne, W., Pearl, L., Jones, K., McDonald, E., Raynaud, F., Eccles, S., Drysdale, M., Workman, P.
Deposit date:2007-03-20
Release date:2007-04-24
Last modified:2018-02-28
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Inhibition of the heat shock protein 90 molecular chaperone in vitro and in vivo by novel, synthetic, potent resorcinylic pyrazole/isoxazole amide analogues.
Mol. Cancer Ther., 6, 2007
1PEA
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AMIDE RECEPTOR/NEGATIVE REGULATOR OF THE AMIDASE OPERON OF PSEUDOMONAS AERUGINOSA (AMIC) COMPLEXED WITH ACETAMIDE
Descriptor:AMIDASE OPERON, ACETAMIDE
Authors:Pearl, L.H., O'Hara, B.P.
Deposit date:1995-11-16
Release date:1996-04-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure of AmiC: the controller of transcription antitermination in the amidase operon of Pseudomonas aeruginosa.
EMBO J., 13, 1994
4APE
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THE ACTIVE SITE OF ASPARTIC PROTEINASES
Descriptor:ENDOTHIAPEPSIN
Authors:Pearl, L.H., Sewell, B.T., Jenkins, J.A., Cooper, J.B., Blundell, T.L.
Deposit date:1986-06-09
Release date:1986-07-14
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The Active Site of Aspartic Proteinases
FEBS Lett., 174, 1984
1ER8
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THE ACTIVE SITE OF ASPARTIC PROTEINASES
Descriptor:Endothiapepsin, H-77
Authors:Hemmings, A.M., Veerapandian, B., Szelke, M., Cooper, J.B., Blundell, T.L.
Deposit date:1989-10-16
Release date:1991-10-15
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2 Å)
Cite:The Active Site of Aspartic Proteinases
FEBS Lett., 174, 1984
3ER3
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THE ACTIVE SITE OF ASPARTIC PROTEINASES
Descriptor:ENDOTHIAPEPSIN, 6-ammonio-N-[(2R,4R,5R)-5-{[N-(tert-butoxycarbonyl)-L-phenylalanyl-3-(1H-imidazol-3-ium-4-yl)-L-alanyl]amino}-6-cyclohexyl-4-hydroxy-2-(2-methylpropyl)hexanoyl]-L-norleucylphenylalanine
Authors:Al-Karadaghi, S., Cooper, J.B., Veerapandian, B., Hoover, D., Blundell, T.L.
Deposit date:1991-01-02
Release date:1991-04-15
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2 Å)
Cite:The Active Site of Aspartic Proteinases
FEBS Lett., 174, 1984
4ER1
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THE ACTIVE SITE OF ASPARTIC PROTEINASES
Descriptor:ENDOTHIAPEPSIN, N-[(1R,2R,4R)-1-(cyclohexylmethyl)-2-hydroxy-6-methyl-4-{[(2R)-2-methylbutyl]carbamoyl}heptyl]-3-(1H-imidazol-3-ium-4-yl)-N~2~-[3-naphthalen-1-yl-2-(naphthalen-1-ylmethyl)propanoyl]-L-alaninamide
Authors:Quail, J.W., Cooper, J.B., Szelke, M., Blundell, T.L.
Deposit date:1990-10-14
Release date:1991-01-15
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2 Å)
Cite:The active site of aspartic proteinases
FEBS Lett., 174, 1984
4ER2
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THE ACTIVE SITE OF ASPARTIC PROTEINASES
Descriptor:ENDOTHIAPEPSIN, PEPSTATIN, SULFATE ION
Authors:Bailey, D., Veerapandian, B., Cooper, J.B., Blundell, T.L.
Deposit date:1990-10-20
Release date:1991-01-15
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2 Å)
Cite:The active site of aspartic proteinases
FEBS Lett., 174, 1984
1LAU
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URACIL-DNA GLYCOSYLASE
Descriptor:DNA (5'-D(*TP*TP*T)-3'), PROTEIN (URACIL-DNA GLYCOSYLASE (E.C.3.2.2.-))
Authors:Pearl, L.H., Savva, R.
Deposit date:1996-01-03
Release date:1996-06-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The structural basis of specific base-excision repair by uracil-DNA glycosylase.
Nature, 373, 1995
1UDG
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THE STRUCTURAL BASIS OF SPECIFIC BASE EXCISION REPAIR BY URACIL-DNA GLYCOSYLASE
Descriptor:URACIL-DNA GLYCOSYLASE, SULFATE ION
Authors:Pearl, L.H., Savva, R.
Deposit date:1995-06-23
Release date:1996-01-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:The structural basis of specific base-excision repair by uracil-DNA glycosylase.
Nature, 373, 1995
1UDH
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THE STRUCTURAL BASIS OF SPECIFIC BASE EXCISION REPAIR BY URACIL-DNA GLYCOSYLASE
Descriptor:URACIL-DNA GLYCOSYLASE, SULFATE ION, URACIL
Authors:Pearl, L.H., Savva, R.
Deposit date:1995-10-30
Release date:1996-03-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:The structural basis of specific base-excision repair by uracil-DNA glycosylase.
Nature, 373, 1995
4ER4
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HIGH-RESOLUTION X-RAY ANALYSES OF RENIN INHIBITOR-ASPARTIC PROTEINASE COMPLEXES
Descriptor:ENDOTHIAPEPSIN, H-142
Authors:Foundling, S.I., Watson, F.E., Szelke, M., Blundell, T.L.
Deposit date:1991-01-05
Release date:1991-04-15
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:High resolution X-ray analyses of renin inhibitor-aspartic proteinase complexes.
Nature, 327, 1987
2ER0
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X-RAY STUDIES OF ASPARTIC PROTEINASE-STATINE INHIBITOR COMPLEXES
Descriptor:ENDOTHIAPEPSIN, L364,099
Authors:Cooper, J.B., Foundling, S.I., Boger, J., Blundell, T.L.
Deposit date:1990-10-20
Release date:1991-01-15
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (3 Å)
Cite:X-ray studies of aspartic proteinase-statine inhibitor complexes.
Biochemistry, 28, 1989
2ER6
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THE STRUCTURE OF A SYNTHETIC PEPSIN INHIBITOR COMPLEXED WITH ENDOTHIAPEPSIN.
Descriptor:ENDOTHIAPEPSIN, H-256 peptide
Authors:Cooper, J.B., Foundling, S.I., Szelke, M., Blundell, T.L.
Deposit date:1990-10-13
Release date:1991-01-15
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2 Å)
Cite:The structure of a synthetic pepsin inhibitor complexed with endothiapepsin
Eur.J.Biochem., 169, 1987
2ER7
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X-RAY ANALYSES OF ASPARTIC PROTEINASES.III. THREE-DIMENSIONAL STRUCTURE OF ENDOTHIAPEPSIN COMPLEXED WITH A TRANSITION-STATE ISOSTERE INHIBITOR OF RENIN AT 1.6 ANGSTROMS RESOLUTION
Descriptor:ENDOTHIAPEPSIN, TRANSITION-STATE ISOSTERE INHIBITOR OF RENIN, SULFATE ION
Authors:Veerapandian, B., Cooper, J.B., Szelke, M., Blundell, T.L.
Deposit date:1990-11-12
Release date:1991-01-15
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:X-ray analyses of aspartic proteinases. III Three-dimensional structure of endothiapepsin complexed with a transition-state isostere inhibitor of renin at 1.6 A resolution.
J.Mol.Biol., 216, 1990
2ER9
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X-RAY STUDIES OF ASPARTIC PROTEINASE-STATINE INHIBITOR COMPLEXES.
Descriptor:ENDOTHIAPEPSIN, L363,564
Authors:Cooper, J.B., Foundling, S.I., Boger, J., Blundell, T.L.
Deposit date:1990-10-20
Release date:1991-01-15
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:X-ray studies of aspartic proteinase-statine inhibitor complexes.
Biochemistry, 28, 1989
5ER1
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A RATIONAL APPROACH TO THE DESIGN OF ANTIHYPERTENSIVES. X-RAY STUDIES OF COMPLEXES BETWEEN ASPARTIC PROTEINASES AND AMINOALCOHOL RENIN INHIBITORS
Descriptor:ENDOTHIAPEPSIN, methyl N-[(2S,3S)-3-amino-2-hydroxy-5-methylhexyl]-L-valyl-L-isoleucyl-L-phenylalaninate
Authors:Cooper, J.B., Foundling, S.I., Blundell, T.L.
Deposit date:1990-11-07
Release date:1991-01-15
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2 Å)
Cite:A Rational Approach to the Design of Antihypertensives. X-Ray Studies of Complexes between Aspartic Proteinases and Aminoalcohol Renin Inhibitors
Topics in Medicinal Chemistry, 1988
5ER2
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HIGH-RESOLUTION X-RAY DIFFRACTION STUDY OF THE COMPLEX BETWEEN ENDOTHIAPEPSIN AND AN OLIGOPEPTIDE INHIBITOR. THE ANALYSIS OF THE INHIBITOR BINDING AND DESCRIPTION OF THE RIGID BODY SHIFT IN THE ENZYME
Descriptor:ENDOTHIAPEPSIN, 6-ammonio-N-{[(2R,3R)-3-{[N-(tert-butoxycarbonyl)-L-phenylalanyl-3-(1H-imidazol-3-ium-4-yl)-L-alanyl]amino}-4-cyclohexyl-2-hydroxybutyl](2-methylpropyl)carbamoyl}-L-norleucyl-L-phenylalanine
Authors:Sali, A., Veerapandian, B., Cooper, J.B., Foundling, S.I., Hoover, D.J., Blundell, T.L.
Deposit date:1991-01-02
Release date:1991-04-15
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:High-resolution X-ray diffraction study of the complex between endothiapepsin and an oligopeptide inhibitor: the analysis of the inhibitor binding and description of the rigid body shift in the enzyme.
EMBO J., 8, 1989