8K6Q
| Crystal structure of HOIL-1L LTM domain | Descriptor: | RanBP-type and C3HC4-type zinc finger-containing protein 1 | Authors: | Yan, Z, Pan, L.F. | Deposit date: | 2023-07-25 | Release date: | 2024-07-03 | Method: | X-RAY DIFFRACTION (1.59 Å) | Cite: | Mechanistic insights into the homo-dimerization of HOIL-1L and SHARPIN. Biochem.Biophys.Res.Commun., 689, 2023
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8K6P
| Crystal structure of SHARPIN LTM motif | Descriptor: | Sharpin | Authors: | Yan, Z, Pan, L.F. | Deposit date: | 2023-07-25 | Release date: | 2024-07-03 | Method: | X-RAY DIFFRACTION (1.86 Å) | Cite: | Mechanistic insights into the homo-dimerization of HOIL-1L and SHARPIN. Biochem.Biophys.Res.Commun., 689, 2023
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7C7J
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7C7I
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7CWW
| Crystal structure of TsrL | Descriptor: | 3,6,9,12,15,18,21,24,27,30,33,36-dodecaoxaoctatriacontane-1,38-diol, TsrE | Authors: | Li, Y, Pan, L.F. | Deposit date: | 2020-08-31 | Release date: | 2021-09-15 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | crystal structure of TsrL To Be Published
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5Z7A
| Crystal structure of NDP52 SKICH region | Descriptor: | 2,3-DIHYDROXY-1,4-DITHIOBUTANE, Calcium-binding and coiled-coil domain-containing protein 2, GLYCEROL, ... | Authors: | Pan, L.F, Fu, T, Liu, J.P, Xie, X.Q. | Deposit date: | 2018-01-27 | Release date: | 2019-01-02 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.38 Å) | Cite: | Mechanistic insights into the interactions of NAP1 with the SKICH domains of NDP52 and TAX1BP1 Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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5Z7G
| Crystal structure of TAX1BP1 SKICH region in complex with NAP1 | Descriptor: | 5-azacytidine-induced protein 2, GLYCEROL, Tax1-binding protein 1 | Authors: | Pan, L.F, Fu, T, Liu, J.P, Xie, X.Q, Wang, Y.L, Hu, S.C. | Deposit date: | 2018-01-28 | Release date: | 2019-01-02 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.301 Å) | Cite: | Mechanistic insights into the interactions of NAP1 with the SKICH domains of NDP52 and TAX1BP1 Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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8X8K
| Crystal structure of STBD1 CBM20 domain in complex with maltotetraose | Descriptor: | GLYCEROL, Starch-binding domain-containing protein 1, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose | Authors: | Zhang, Y.C, Pan, L.F. | Deposit date: | 2023-11-27 | Release date: | 2024-09-18 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Decoding the molecular mechanism of selective autophagy of glycogen mediated by autophagy receptor STBD1. Proc.Natl.Acad.Sci.USA, 121, 2024
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8X8A
| Crystal structure of STBD1 LIR motif in complex with GABARAPL1 | Descriptor: | Gamma-aminobutyric acid receptor-associated protein-like 1, Starch-binding domain-containing protein 1 | Authors: | Zhang, Y.C, Pan, L.F. | Deposit date: | 2023-11-27 | Release date: | 2024-09-18 | Method: | X-RAY DIFFRACTION (1.53 Å) | Cite: | Decoding the molecular mechanism of selective autophagy of glycogen mediated by autophagy receptor STBD1. Proc.Natl.Acad.Sci.USA, 121, 2024
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3KYQ
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3PVL
| Structure of myosin VIIa MyTH4-FERM-SH3 in complex with the CEN1 of Sans | Descriptor: | GLYCEROL, Myosin VIIa isoform 1, PHOSPHATE ION, ... | Authors: | Wu, L, Pan, L.F, Wei, Z.Y, Zhang, M.J. | Deposit date: | 2010-12-07 | Release date: | 2011-03-02 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structure of MyTH4-FERM domains in myosin VIIa tail bound to cargo. Science, 331, 2011
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5Z7L
| Crystal structure of NDP52 SKICH region in complex with NAP1 | Descriptor: | 5-azacytidine-induced protein 2, Calcium-binding and coiled-coil domain-containing protein 2, GLYCEROL | Authors: | Fu, T, Pan, L.F. | Deposit date: | 2018-01-29 | Release date: | 2019-01-02 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2.02 Å) | Cite: | Mechanistic insights into the interactions of NAP1 with the SKICH domains of NDP52 and TAX1BP1 Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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7BV6
| Crystal structure of the autophagic STX17/SNAP29/VAMP8 SNARE complex | Descriptor: | Synaptosomal-associated protein 29, Syntaxin-17, Vesicle-associated membrane protein 8 | Authors: | Li, Y, Pan, L.F. | Deposit date: | 2020-04-09 | Release date: | 2020-09-02 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (3.05 Å) | Cite: | Decoding three distinct states of the Syntaxin17 SNARE motif in mediating autophagosome-lysosome fusion. Proc.Natl.Acad.Sci.USA, 117, 2020
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7D0E
| Crystal structure of FIP200 Claw/p-CCPG1 FIR2 | Descriptor: | 3-(2-hydroxyethyloxy)-2-[2-(2-hydroxyethyloxy)ethoxymethyl]-2-(2-hydroxyethyloxymethyl)propan-1-ol, Cell cycle progression protein 1 FIR2, DI(HYDROXYETHYL)ETHER, ... | Authors: | Zhou, Z.X, Pan, L.F. | Deposit date: | 2020-09-09 | Release date: | 2021-03-31 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Phosphorylation regulates the binding of autophagy receptors to FIP200 Claw domain for selective autophagy initiation. Nat Commun, 12, 2021
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7BV4
| Crystal structure of STX17 LIR region in complex with GABARAP | Descriptor: | DI(HYDROXYETHYL)ETHER, GLYCEROL, Gamma-aminobutyric acid receptor-associated protein, ... | Authors: | Li, Y, Pan, L.F. | Deposit date: | 2020-04-09 | Release date: | 2020-09-02 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Decoding three distinct states of the Syntaxin17 SNARE motif in mediating autophagosome-lysosome fusion. Proc.Natl.Acad.Sci.USA, 117, 2020
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7CZG
| Crystal structure of FIP200 Claw domain apo form | Descriptor: | DI(HYDROXYETHYL)ETHER, RB1-inducible coiled-coil protein 1 | Authors: | Zhou, Z.X, Pan, L.F. | Deposit date: | 2020-09-08 | Release date: | 2021-03-31 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Phosphorylation regulates the binding of autophagy receptors to FIP200 Claw domain for selective autophagy initiation. Nat Commun, 12, 2021
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7CZM
| Crystal structure of FIP200 Claw/p-OPtineurin LIR complex | Descriptor: | CHLORIDE ION, GLYCEROL, Optineurin LIR, ... | Authors: | Zhou, Z.X, Pan, L.F. | Deposit date: | 2020-09-09 | Release date: | 2021-03-31 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Phosphorylation regulates the binding of autophagy receptors to FIP200 Claw domain for selective autophagy initiation. Nat Commun, 12, 2021
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6KKG
| Crystal structure of MAGI2-Dendrin complex | Descriptor: | Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2, Peptide from Dendrin | Authors: | Zhu, J.W, Zhang, H.J, Lin, L, Zhang, R.G. | Deposit date: | 2019-07-25 | Release date: | 2020-07-29 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Phase separation of MAGI2-mediated complex underlies formation of slit diaphragm complex in glomerular filtration barrier To Be Published
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8H3T
| The crystal structure of AlpH | Descriptor: | AlpH, GLYCEROL | Authors: | Zhao, Y, Li, M, Jiang, M, Pan, L.F. | Deposit date: | 2022-10-09 | Release date: | 2023-09-13 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.866 Å) | Cite: | O-methyltransferase-like enzyme catalyzed diazo installation in polyketide biosynthesis. Nat Commun, 14, 2023
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8I2N
| The RIPK1 kinase domain in complex with QY7-2B compound | Descriptor: | Receptor-interacting serine/threonine-protein kinase 1, ~{N}-methyl-1-[4-[[[1-methyl-5-(phenylmethyl)pyrazol-3-yl]carbonylamino]methyl]phenyl]benzimidazole-5-carboxamide | Authors: | Gong, X.Y, Li, Y, Meng, H.Y, Pan, L.F. | Deposit date: | 2023-01-14 | Release date: | 2024-01-31 | Last modified: | 2024-08-21 | Method: | X-RAY DIFFRACTION (2.29 Å) | Cite: | Structure-based development of potent and selective type-II kinase inhibitors of RIPK1. Acta Pharm Sin B, 14, 2024
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8JC5
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8JCA
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8W6A
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8W6B
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7X81
| The crystal structure of PloI4-C16M/D46A/I137V in complex with exo-2+2 adduct | Descriptor: | (4S,4aS,6aR,8R,9R,11E,12aR,14aS,17E,18aR,18bR)-9-ethyl-4,8,19-trihydroxy-11,12a,13,18a-tetramethyl-2,3,4,4a,6a,7,8,9,10,12a,13,14,18a,18b-tetradecahydro-14a,17-(metheno)cyclobuta[b]naphtho[2,1-j][1]azacyclotetradecine-16,18(1H,15H)-dione, PloI4 | Authors: | Li, M, Pan, L.F. | Deposit date: | 2022-03-10 | Release date: | 2023-02-08 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.104 Å) | Cite: | A cyclase that catalyses competing 2 + 2 and 4 + 2 cycloadditions. Nat.Chem., 15, 2023
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