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2PVR
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BU of 2pvr by Molmil
Crystal structure of the catalytic subunit of protein kinase CK2 (C-terminal deletion mutant 1-335) in complex with two sulfate ions
Descriptor: Casein kinase II subunit alpha, catalytic subunit, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
Authors:Niefind, K, Yde, C.W, Ermakova, I, Issinger, O.-G.
Deposit date:2007-05-10
Release date:2007-06-26
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.605 Å)
Cite:Evolved to Be Active: Sulfate Ions Define Substrate Recognition Sites of CK2alpha and Emphasise its Exceptional Role within the CMGC Family of Eukaryotic Protein Kinases
J.Mol.Biol., 370, 2007
1DAY
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BU of 1day by Molmil
CRYSTAL STRUCTURE OF A BINARY COMPLEX OF PROTEIN KINASE CK2 (ALPHA-SUBUNIT) AND MG-GMPPNP
Descriptor: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, PROTEIN KINASE CK2
Authors:Niefind, K, Puetter, M, Guerra, B, Issinger, O.G, Schomburg, D.
Deposit date:1999-11-01
Release date:2000-05-03
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:GTP plus water mimic ATP in the active site of protein kinase CK2.
Nat.Struct.Biol., 6, 1999
1DAW
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BU of 1daw by Molmil
CRYSTAL STRUCTURE OF A BINARY COMPLEX OF PROTEIN KINASE CK2 (ALPHA-SUBUNIT) AND MG-AMPPNP
Descriptor: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, PROTEIN KINASE CK2
Authors:Niefind, K, Puetter, M, Guerra, B, Issinger, O.G, Schomburg, D.
Deposit date:1999-11-01
Release date:2000-05-03
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:GTP plus water mimic ATP in the active site of protein kinase CK2.
Nat.Struct.Biol., 6, 1999
1NXQ
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BU of 1nxq by Molmil
Crystal Structure of R-alcohol dehydrogenase (RADH) (apoenyzme) from Lactobacillus brevis
Descriptor: MAGNESIUM ION, R-alcohol dehydrogenase
Authors:Niefind, K, Muller, J, Riebel, B, Hummel, W, Schomburg, D.
Deposit date:2003-02-11
Release date:2003-04-15
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:The crystal structure of R-specific alcohol dehydrogenase from Lactobacillus brevis suggests the structural basis of its metal dependency
J.Mol.Biol., 327, 2003
1JWH
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BU of 1jwh by Molmil
Crystal Structure of Human Protein Kinase CK2 Holoenzyme
Descriptor: Casein kinase II beta chain, Casein kinase II, alpha chain, ...
Authors:Niefind, K, Guerra, B, Ermakowa, I, Issinger, O.G.
Deposit date:2001-09-04
Release date:2002-03-04
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Crystal structure of human protein kinase CK2: insights into basic properties of the CK2 holoenzyme.
EMBO J., 20, 2001
1HYH
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BU of 1hyh by Molmil
CRYSTAL STRUCTURE OF L-2-HYDROXYISOCAPROATE DEHYDROGENASE FROM LACTOBACILLUS CONFUSUS AT 2.2 ANGSTROMS RESOLUTION-AN EXAMPLE OF STRONG ASYMMETRY BETWEEN SUBUNITS
Descriptor: L-2-HYDROXYISOCAPROATE DEHYDROGENASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, SULFATE ION
Authors:Niefind, K, Hecht, H.-J, Schomburg, D.
Deposit date:1995-06-05
Release date:1995-10-15
Last modified:2023-07-26
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure of L-2-hydroxyisocaproate dehydrogenase from Lactobacillus confusus at 2.2 A resolution. An example of strong asymmetry between subunits.
J.Mol.Biol., 251, 1995
5M56
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BU of 5m56 by Molmil
Monoclinic complex structure of human protein kinase CK2 catalytic subunit (isoform CK2alpha') with the inhibitor 4'-carboxy-6,8-chloro-flavonol (FLC21)
Descriptor: 4-[6,8-bis(chloranyl)-3-oxidanyl-4-oxidanylidene-chromen-2-yl]benzoic acid, CHLORIDE ION, Casein kinase II subunit alpha', ...
Authors:Niefind, K, Bischoff, N, Yarmoluk, S.M, Bdzhola, V.G, Golub, A.G, Balanda, A.O, Prykhod'ko, A.O.
Deposit date:2016-10-20
Release date:2017-01-18
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.237 Å)
Cite:Structural Hypervariability of the Two Human Protein Kinase CK2 Catalytic Subunit Paralogs Revealed by Complex Structures with a Flavonol- and a Thieno[2,3-d]pyrimidine-Based Inhibitor.
Pharmaceuticals, 10, 2017
5M44
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BU of 5m44 by Molmil
Complex structure of human protein kinase CK2 catalytic subunit with a thieno[2,3-d]pyrimidin inhibitor crystallized under high-salt conditions
Descriptor: 3-[5-(4-methylphenyl)thieno[2,3-d]pyrimidin-4-yl]sulfanylpropanoic acid, CHLORIDE ION, Casein kinase II subunit alpha
Authors:Niefind, K, Bischoff, N, Yarmoluk, S.M, Bdzhola, V.G, Golub, A.G, Balanda, A.O, Prykhod'ko, A.O.
Deposit date:2016-10-18
Release date:2017-01-18
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.71 Å)
Cite:Structural Hypervariability of the Two Human Protein Kinase CK2 Catalytic Subunit Paralogs Revealed by Complex Structures with a Flavonol- and a Thieno[2,3-d]pyrimidine-Based Inhibitor.
Pharmaceuticals, 10, 2017
5M4U
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BU of 5m4u by Molmil
ORTHORHOMBIC COMPLEX STRUCTURE OF HUMAN PROTEIN KINASE CK2 CATALYTIC SUBUNIT (ISOFORM CK2ALPHA') WITH THE INHIBITOR 4'-CARBOXY-6,8-CHLORO- FLAVONOL (FLC21)
Descriptor: 4-[6,8-bis(chloranyl)-3-oxidanyl-4-oxidanylidene-chromen-2-yl]benzoic acid, ACETATE ION, CHLORIDE ION, ...
Authors:Niefind, K, Bischoff, N, Yarmoluk, S.M, Bdzhola, V.G, Golub, A.G, Balanda, A.O, Prykhod'ko, A.O.
Deposit date:2016-10-19
Release date:2017-01-18
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.195 Å)
Cite:Structural Hypervariability of the Two Human Protein Kinase CK2 Catalytic Subunit Paralogs Revealed by Complex Structures with a Flavonol- and a Thieno[2,3-d]pyrimidine-Based Inhibitor.
Pharmaceuticals, 10, 2017
5M4F
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BU of 5m4f by Molmil
Complex structure of human protein kinase CK2 catalytic subunit with the inhibitor 4'-carboxy-6,8-chloro-flavonol (FLC21) crystallized under low-salt conditions
Descriptor: 4-[6,8-bis(chloranyl)-3-oxidanyl-4-oxidanylidene-chromen-2-yl]benzoic acid, CHLORIDE ION, Casein kinase II subunit alpha, ...
Authors:Niefind, K, Bischoff, N, Yarmoluk, S.M, Bdzhola, V.G, Golub, A.G, Balanda, A.O, Prykhod'ko, A.O.
Deposit date:2016-10-18
Release date:2017-01-18
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.519 Å)
Cite:Structural Hypervariability of the Two Human Protein Kinase CK2 Catalytic Subunit Paralogs Revealed by Complex Structures with a Flavonol- and a Thieno[2,3-d]pyrimidine-Based Inhibitor.
Pharmaceuticals, 10, 2017
5M4I
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BU of 5m4i by Molmil
Complex structure of human protein kinase CK2 catalytic subunit with the inhibitor 4'-carboxy-6,8-chloro-flavonol (FLC21) crystallized under high-salt conditions
Descriptor: 4-[6,8-bis(chloranyl)-3-oxidanyl-4-oxidanylidene-chromen-2-yl]benzoic acid, CHLORIDE ION, Casein kinase II subunit alpha
Authors:Niefind, K, Bischoff, N, Yarmoluk, S.M, Bdzhola, V.G, Golub, A.G, Balanda, A.O, Prykhod'ko, A.O.
Deposit date:2016-10-18
Release date:2017-01-18
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.218 Å)
Cite:Structural Hypervariability of the Two Human Protein Kinase CK2 Catalytic Subunit Paralogs Revealed by Complex Structures with a Flavonol- and a Thieno[2,3-d]pyrimidine-Based Inhibitor.
Pharmaceuticals, 10, 2017
5M4C
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BU of 5m4c by Molmil
Complex structure of human protein kinase CK2 catalytic subunit with a thieno[2,3-d]pyrimidin inhibitor crystallized under low-salt conditions
Descriptor: 3-[5-(4-methylphenyl)thieno[2,3-d]pyrimidin-4-yl]sulfanylpropanoic acid, CHLORIDE ION, Casein kinase II subunit alpha, ...
Authors:Niefind, K, Bischoff, N, Yarmoluk, S.M, Bdzhola, V.G, Golub, A.G, Balanda, A.O, Prykhod'ko, A.O.
Deposit date:2016-10-18
Release date:2017-01-18
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.935 Å)
Cite:Structural Hypervariability of the Two Human Protein Kinase CK2 Catalytic Subunit Paralogs Revealed by Complex Structures with a Flavonol- and a Thieno[2,3-d]pyrimidine-Based Inhibitor.
Pharmaceuticals, 10, 2017
3U87
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BU of 3u87 by Molmil
Structure of a chimeric construct of human CK2alpha and human CK2alpha' in complex with a non-hydrolysable ATP-analogue
Descriptor: CHLORIDE ION, Casein kinase II subunit alpha, GLYCEROL, ...
Authors:Niefind, K, Raaf, J, Issinger, O.-G, Olsen, B.
Deposit date:2011-10-16
Release date:2012-05-30
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Low-density crystal packing of human protein kinase CK2 catalytic subunit in complex with resorufin or other ligands: a tool to study the unique hinge-region plasticity of the enzyme without packing bias.
Acta Crystallogr.,Sect.D, 68, 2012
3FWQ
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BU of 3fwq by Molmil
Inactive conformation of human protein kinase CK2 catalytic subunit
Descriptor: CHLORIDE ION, Casein kinase II subunit alpha, GLYCEROL, ...
Authors:Niefind, K, Raaf, J, Issinger, O.G.
Deposit date:2009-01-19
Release date:2009-02-17
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:First inactive conformation of CK2 alpha, the catalytic subunit of protein kinase CK2
J.Mol.Biol., 386, 2009
5OWH
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BU of 5owh by Molmil
High salt structure of human protein kinase CK2alpha in complex with 3-aminopropyl-4,5,6,7-tetrabromobenzimidazol
Descriptor: 3-[4,5,6,7-tetrakis(bromanyl)benzimidazol-1-yl]propan-1-amine, CHLORIDE ION, Casein kinase II subunit alpha
Authors:Niefind, K, Bretner, M, Chojnacki, C.
Deposit date:2017-09-01
Release date:2018-07-25
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Biological properties and structural study of new aminoalkyl derivatives of benzimidazole and benzotriazole, dual inhibitors of CK2 and PIM1 kinases.
Bioorg. Chem., 80, 2018
4UB7
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BU of 4ub7 by Molmil
High-salt structure of protein kinase CK2 catalytic subunit with 4'-carboxy-6,8-bromo-flavonol (FLC26) showing an extreme distortion of the ATP-binding loop combined with a pi-halogen bond
Descriptor: 4-(6,8-dibromo-3-hydroxy-4-oxo-4H-chromen-2-yl)benzoic acid, CHLORIDE ION, Casein kinase II subunit alpha
Authors:Niefind, K, Bischoff, N, Guerra, B, Golub, A, Issinger, O.-G.
Deposit date:2014-08-12
Release date:2015-07-01
Last modified:2019-07-17
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:A Note of Caution on the Role of Halogen Bonds for Protein Kinase/Inhibitor Recognition Suggested by High- And Low-Salt CK2 alpha Complex Structures.
Acs Chem.Biol., 10, 2015
4UBA
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BU of 4uba by Molmil
Low-salt structure of protein kinase CK2 catalytic subunit with 4'-carboxy-6,8-bromo-flavonol (FLC26)
Descriptor: 4-(6,8-dibromo-3-hydroxy-4-oxo-4H-chromen-2-yl)benzoic acid, Casein kinase II subunit alpha
Authors:Niefind, K, Bischoff, N, Guerra, B, Golub, A, Issinger, O.-G.
Deposit date:2014-08-12
Release date:2015-07-01
Method:X-RAY DIFFRACTION (2.995 Å)
Cite:A Note of Caution on the Role of Halogen Bonds for Protein Kinase/Inhibitor Recognition Suggested by High- And Low-Salt CK2 alpha Complex Structures.
Acs Chem.Biol., 10, 2015
3JUH
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BU of 3juh by Molmil
Crystal structure of a mutant of human protein kinase CK2alpha with altered cosubstrate specificity
Descriptor: CHLORIDE ION, Casein kinase II subunit alpha, GLYCEROL, ...
Authors:Niefind, K, Issinger, O.-G.
Deposit date:2009-09-15
Release date:2009-10-20
Last modified:2011-10-26
Method:X-RAY DIFFRACTION (1.66 Å)
Cite:Inclining the purine base binding plane in protein kinase CK2 by exchanging the flanking side-chains generates a preference for ATP as a cosubstrate
J.Mol.Biol., 347, 2005
1LP4
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BU of 1lp4 by Molmil
Crystal structure of a binary complex of the catalytic subunit of protein kinase CK2 with Mg-AMPPNP
Descriptor: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Protein kinase CK2
Authors:Niefind, K, Puetter, M, Guerra, B, Issinger, O.-G, Schomburg, D.
Deposit date:2002-05-07
Release date:2002-05-29
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Inclining the purine base binding plane in protein kinase CK2 by exchanging the flanking side-chains generates a preference for ATP as a cosubstrate.
J.Mol.Biol., 347, 2005
1LPU
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BU of 1lpu by Molmil
Low Temperature Crystal Structure of the Apo-form of the catalytic subunit of protein kinase CK2 from Zea mays
Descriptor: BENZAMIDINE, Protein kinase CK2
Authors:Niefind, K, Puetter, M, Guerra, B, Issinger, O.-G, Schomburg, D.
Deposit date:2002-05-08
Release date:2002-05-29
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Inclining the purine base binding plane in protein kinase CK2 by exchanging the flanking side-chains generates a preference for ATP as a cosubstrate.
J.Mol.Biol., 347, 2005
1LR4
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BU of 1lr4 by Molmil
Room Temperature Crystal Structure of the Apo-form of the catalytic subunit of protein kinase CK2 from Zea mays
Descriptor: BENZAMIDINE, Protein kinase CK2
Authors:Niefind, K, Puetter, M, Guerra, B, Issinger, O.-G, Schomburg, D.
Deposit date:2002-05-14
Release date:2002-05-29
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2 Å)
Cite:Inclining the purine base binding plane in protein kinase CK2 by exchanging the flanking side-chains generates a preference for ATP as a cosubstrate.
J.Mol.Biol., 347, 2005
7A22
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BU of 7a22 by Molmil
Crystal structure of human protein kinase CK2alpha' (CSNK2A2 gene product) in complex with the ATP-competitive inhibitor 5,6,7-tribromo-1H-triazolo[4,5-b]pyridine
Descriptor: 1,2-ETHANEDIOL, 5,6,7-tris(bromanyl)-1~{H}-[1,2,3]triazolo[4,5-b]pyridine, Casein kinase II subunit alpha'
Authors:Niefind, K, Lindenblatt, D, Toelzer, C, Bretner, M, Chojnacki, K, Wielechowska, M, Winska, P.
Deposit date:2020-08-15
Release date:2020-12-09
Last modified:2021-01-13
Method:X-RAY DIFFRACTION (1.01 Å)
Cite:Synthesis, biological properties and structural study of new halogenated azolo[4,5-b]pyridines as inhibitors of CK2 kinase.
Bioorg.Chem., 106, 2021
7A4B
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BU of 7a4b by Molmil
Crystal structure of human protein kinase CK2alpha (CSNK2A1 gene product) in complex with the ATP-competitive inhibitor 5,6-dibromo-1H-triazolo[4,5-b]pyridine
Descriptor: 5,6-dibromo-1H-triazolo[4,5-b]pyridine, Casein kinase II subunit alpha, GLYCEROL, ...
Authors:Niefind, K, Lindenblatt, D, Toelzer, C, Bretner, M, Chojnacki, K, Wielechowska, M, Winska, P.
Deposit date:2020-08-19
Release date:2020-12-09
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.06 Å)
Cite:Synthesis, biological properties and structural study of new halogenated azolo[4,5-b]pyridines as inhibitors of CK2 kinase.
Bioorg.Chem., 106, 2021
7A2H
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BU of 7a2h by Molmil
Crystal structure of human protein kinase CK2alpha' (CSNK2A2 gene product) in complex with the ATP-competitive inhibitor 5,6,7-tribromo-1H-imidazo[4,5-b]pyridine
Descriptor: 1,2-ETHANEDIOL, 5,6,7-tris(bromanyl)-1~{H}-imidazo[4,5-b]pyridine, Casein kinase II subunit alpha'
Authors:Niefind, K, Lindenblatt, D, Toelzer, C, Bretner, M, Chojnacki, K, Wielechowska, M, Winska, P.
Deposit date:2020-08-18
Release date:2020-12-09
Last modified:2021-01-13
Method:X-RAY DIFFRACTION (1.01 Å)
Cite:Synthesis, biological properties and structural study of new halogenated azolo[4,5-b]pyridines as inhibitors of CK2 kinase.
Bioorg.Chem., 106, 2021
7A4C
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BU of 7a4c by Molmil
Crystal structure of human protein kinase CK2alpha (CSNK2A1 gene product) in complex with the ATP-competitive inhibitor 5,6,7-tribromo-1H-triazolo[4,5-b]pyridine
Descriptor: 5,6,7-tris(bromanyl)-1~{H}-[1,2,3]triazolo[4,5-b]pyridine, Casein kinase II subunit alpha, GLYCEROL, ...
Authors:Niefind, K, Lindenblatt, D, Toelzer, C, Bretner, M, Chojnacki, K, Wielechowska, M, Winska, P.
Deposit date:2020-08-19
Release date:2020-12-09
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.502 Å)
Cite:Synthesis, biological properties and structural study of new halogenated azolo[4,5-b]pyridines as inhibitors of CK2 kinase.
Bioorg.Chem., 106, 2021

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