Author results

5TBW
  • Download 5tbw
  • View 5tbw
Molmil generated image of 5tbw
CRYSTAL STRUCTURE OF CHLOROLISSOCLIMIDE BOUND TO THE YEAST 80S RIBOSOME
Descriptor:25S ribosomal RNA, 5S ribosomal RNA, 5.8S ribosomal RNA, ...
Authors:Konst, Z.A., Szklarski, A.R., Pellegrino, S., Michalak, S.E., Meyer, M., Zanette, C., Cencic, R., Nam, S., Horne, D.A., Pelletier, J., Mobley, D.L., Yusupova, G., Yusupov, M., Vanderwal, C.D.
Deposit date:2016-09-13
Release date:2017-07-26
Last modified:2018-08-08
Method:X-RAY DIFFRACTION (3 Å)
Cite:Synthesis facilitates an understanding of the structural basis for translation inhibition by the lissoclimides.
Nat Chem, 9, 2017
4NP5
  • Download 4np5
  • View 4np5
Molmil generated image of 4np5
CRYSTAL STRUCTURE OF STAPHYLOCOCCAL NUCLEASE VARIANT DELTA+PHS V66A/I92N AT CRYOGENIC TEMPERATURE
Descriptor:Thermonuclease, CALCIUM ION, THYMIDINE-3',5'-DIPHOSPHATE
Authors:Caro, J.A., Nam, S., Schlessman, J.L., Heroux, A., Garcia-Moreno E., B.
Deposit date:2013-11-20
Release date:2013-12-04
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Pressure effects in proteins
To be Published
4XG2
  • Download 4xg2
  • View 4xg2
Molmil generated image of 4xg2
CRYSTAL STRUCTURE OF LIGAND-FREE SYK
Descriptor:Tyrosine-protein kinase SYK
Authors:Lee, S.J., Choi, J., Han, B.G., Song, H., Koh, J.S., Lee, B.I.
Deposit date:2014-12-30
Release date:2015-12-30
Last modified:2016-10-19
Method:X-RAY DIFFRACTION (2.21 Å)
Cite:Crystal structures of spleen tyrosine kinase in complex with novel inhibitors: structural insights for design of anticancer drugs
Febs J., 283, 2016
4XG3
  • Download 4xg3
  • View 4xg3
Molmil generated image of 4xg3
CRYSTAL STRUCTURE OF AN INHIBITOR-BOUND SYK
Descriptor:Tyrosine-protein kinase SYK, 4-{[5-fluoro-4-(3-{[(3R)-3-hydroxypyrrolidin-1-yl]methyl}-4-methyl-1H-pyrrol-1-yl)pyrimidin-2-yl]amino}-2,6-dimethylphenyl methanesulfonate
Authors:Lee, S.J., Choi, J., Han, B.G., Song, H., Koh, J.S., Lee, B.I.
Deposit date:2014-12-30
Release date:2015-12-30
Last modified:2016-10-19
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structures of spleen tyrosine kinase in complex with novel inhibitors: structural insights for design of anticancer drugs
Febs J., 283, 2016
4XG4
  • Download 4xg4
  • View 4xg4
Molmil generated image of 4xg4
CRYSTAL STRUCTURE OF AN INHIBITOR-BOUND SYK
Descriptor:Tyrosine-protein kinase SYK, (3R)-1-{[1-(5-fluoro-2-{[4-(2-hydroxyethoxy)-3,5-dimethylphenyl]amino}pyrimidin-4-yl)-4-methyl-1H-pyrrol-3-yl]methyl}pyrrolidin-3-ol
Authors:Lee, S.J., Choi, J., Han, B.G., Song, H., Koh, J.S., Lee, B.I.
Deposit date:2014-12-30
Release date:2015-12-30
Last modified:2016-10-19
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structures of spleen tyrosine kinase in complex with novel inhibitors: structural insights for design of anticancer drugs
Febs J., 283, 2016
4XG6
  • Download 4xg6
  • View 4xg6
Molmil generated image of 4xg6
CRYSTAL STRUCTURE OF AN INHIBITOR-BOUND SYK
Descriptor:Tyrosine-protein kinase SYK, 1-[(1-{2-[(3,5-dimethylphenyl)amino]pyrimidin-4-yl}-3-methyl-1H-pyrazol-4-yl)methyl]azetidin-3-ol
Authors:Lee, S.J., Choi, J., Han, B.G., Song, H., Koh, J.S., Lee, B.I.
Deposit date:2014-12-30
Release date:2015-12-30
Last modified:2016-10-19
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structures of spleen tyrosine kinase in complex with novel inhibitors: structural insights for design of anticancer drugs
Febs J., 283, 2016
4XG7
  • Download 4xg7
  • View 4xg7
Molmil generated image of 4xg7
CRYSTAL STRUCTURE OF AN INHIBITOR-BOUND SYK
Descriptor:Tyrosine-protein kinase SYK, 1-[(3-methyl-1-{2-[(1-methyl-1H-indazol-5-yl)amino]pyrimidin-4-yl}-1H-pyrazol-4-yl)methyl]azetidin-3-ol
Authors:Lee, S.J., Choi, J., Han, B.G., Song, H., Koh, J.S., Lee, B.I.
Deposit date:2014-12-30
Release date:2015-12-30
Last modified:2016-10-19
Method:X-RAY DIFFRACTION (1.76 Å)
Cite:Crystal structures of spleen tyrosine kinase in complex with novel inhibitors: structural insights for design of anticancer drugs
Febs J., 283, 2016
4XG8
  • Download 4xg8
  • View 4xg8
Molmil generated image of 4xg8
CRYSTAL STRUCTURE OF AN INHIBITOR-BOUND SYK
Descriptor:Tyrosine-protein kinase SYK, 1-[(1-{2-[(3-chloro-1-methyl-1H-indazol-5-yl)amino]pyrimidin-4-yl}-3-methyl-1H-pyrazol-4-yl)methyl]azetidin-3-ol
Authors:Lee, S.J., Choi, J., Han, B.G., Song, H., Koh, J.S., Lee, B.I.
Deposit date:2014-12-30
Release date:2015-12-30
Last modified:2016-10-19
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structures of spleen tyrosine kinase in complex with novel inhibitors: structural insights for design of anticancer drugs
Febs J., 283, 2016
4XG9
  • Download 4xg9
  • View 4xg9
Molmil generated image of 4xg9
CRYSTAL STRUCTURE OF AN INHIBITOR-BOUND SYK
Descriptor:Tyrosine-protein kinase SYK, 1-[(1-{2-[(3-chloro-1,2-dimethyl-1H-indol-5-yl)amino]pyrimidin-4-yl}-3-methyl-1H-pyrazol-4-yl)methyl]azetidin-3-ol
Authors:Lee, S.J., Choi, J., Han, B.G., Song, H., Koh, J.S., Lee, B.I.
Deposit date:2014-12-30
Release date:2015-12-30
Last modified:2016-10-19
Method:X-RAY DIFFRACTION (2.91 Å)
Cite:Crystal structures of spleen tyrosine kinase in complex with novel inhibitors: structural insights for design of anticancer drugs
Febs J., 283, 2016
5GHV
  • Download 5ghv
  • View 5ghv
Molmil generated image of 5ghv
CRYSTAL STRUCTURE OF AN INHIBITOR-BOUND SYK
Descriptor:Tyrosine-protein kinase SYK, 1-({1-[2-({3,5-dimethyl-4-[2-(pyrrolidin-1-yl)ethoxy]phenyl}amino)pyrimidin-4-yl]-4-methyl-1H-pyrrol-3-yl}methyl)azetidin-3-ol
Authors:Lee, S.J., Choi, J., Han, B.G., Song, H., Koh, J.S., Lee, B.I.
Deposit date:2016-06-20
Release date:2016-07-06
Last modified:2016-10-19
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structures of spleen tyrosine kinase in complex with novel inhibitors: structural insights for design of anticancer drugs
Febs J., 283, 2016