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5HRV
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CRYSTAL STRUCTURE OF THE FIFTH BROMODOMAIN OF HUMAN PB1 IN COMPLEX WITH 1-ETHYLISOCHROMENO[3,4-C]PYRAZOL-5(2H)-ONE) COMPOUND
Descriptor:Protein polybromo-1, 1-ethylisochromeno[3,4-c]pyrazol-5(3H)-one, 1,2-ETHANEDIOL
Authors:Tallant, C., Myrianthopoulos, V., Gaboriaud-Kolar, N., Newman, J.A., Picaud, S., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Mikros, E., Knapp, S.
Deposit date:2016-01-24
Release date:2016-10-12
Last modified:2016-10-26
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Discovery and Optimization of a Selective Ligand for the Switch/Sucrose Nonfermenting-Related Bromodomains of Polybromo Protein-1 by the Use of Virtual Screening and Hydration Analysis.
J.Med.Chem., 59, 2016
5HRW
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CRYSTAL STRUCTURE OF THE FIFTH BROMODOMAIN OF HUMAN PB1 IN COMPLEX WITH 1-PROPYLISOCHROMENO[3,4-C]PYRAZOL-5(2H)-ONE) COMPOUND
Descriptor:Protein polybromo-1, 1-propylisochromeno[3,4-c]pyrazol-5(3H)-one, 1,2-ETHANEDIOL, ...
Authors:Tallant, C., Myrianthopoulos, V., Gaboriaud-Kolar, N., Newman, J.A., Picaud, S., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Mikros, E., Knapp, S.
Deposit date:2016-01-24
Release date:2016-10-12
Last modified:2016-10-26
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Discovery and Optimization of a Selective Ligand for the Switch/Sucrose Nonfermenting-Related Bromodomains of Polybromo Protein-1 by the Use of Virtual Screening and Hydration Analysis.
J.Med.Chem., 59, 2016
5HRX
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CRYSTAL STRUCTURE OF THE FIFTH BROMODOMAIN OF HUMAN PB1 IN COMPLEX WITH 1-BUTYLISOCHROMENO[3,4-C]PYRAZOL-5(2H)-ONE) COMPOUND
Descriptor:Protein polybromo-1, 1,2-ETHANEDIOL, 1-butylisochromeno[3,4-c]pyrazol-5(3H)-one
Authors:Tallant, C., Myrianthopoulos, V., Gaboriaud-Kolar, N., Newman, J.A., Picaud, S., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Mikros, E., Knapp, S.
Deposit date:2016-01-24
Release date:2016-10-12
Last modified:2016-10-26
Method:X-RAY DIFFRACTION (1.73 Å)
Cite:Discovery and Optimization of a Selective Ligand for the Switch/Sucrose Nonfermenting-Related Bromodomains of Polybromo Protein-1 by the Use of Virtual Screening and Hydration Analysis.
J.Med.Chem., 59, 2016
5II1
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CRYSTAL STRUCTURE OF THE FIFTH BROMODOMAIN OF HUMAN POLYBROMO (PB1) IN COMPLEX WITH 1-METHYLISOCHROMENO[3,4-C]PYRAZOL-5(3H)-ONE
Descriptor:Protein polybromo-1, 1-methyl[2]benzopyrano[3,4-c]pyrazol-5(3H)-one
Authors:Filippakopoulos, P., Picaud, S., Felletar, I., Myrianthopoulos, V., Mikros, E., von Delft, F., Edwards, A.M., Arrowsmith, C.H., Bountra, C., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2016-03-01
Release date:2016-06-29
Last modified:2016-10-26
Method:X-RAY DIFFRACTION (2.02 Å)
Cite:Discovery and Optimization of a Selective Ligand for the Switch/Sucrose Nonfermenting-Related Bromodomains of Polybromo Protein-1 by the Use of Virtual Screening and Hydration Analysis.
J.Med.Chem., 59, 2016
3KVW
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CRYSTAL STRUCTURE OF DUAL-SPECIFICITY TYROSINE PHOSPHORYLATION REGULATED KINASE 2 (DYRK2) IN COMPLEX WITH AN INDIRUBIN LIGAND
Descriptor:Dual specificity tyrosine-phosphorylation-regulated kinase 2, (2Z,3E)-7'-bromo-3-(hydroxyimino)-2'-oxo-1,1',2',3-tetrahydro-2,3'-biindole-5-carboxylic acid, CHLORIDE ION
Authors:Filippakopoulos, P., Myrianthopoulos, V., Kritsanida, M., Magiatis, P., Skaltsounis, A.L., Soundararajan, M., Krojer, T., Gileadi, O., Hapka, E., Fedorov, O., Berridge, G., Wang, J., Shrestha, L., Vollmar, M., von Delft, F., Arrowsmith, C.H., Edwards, A., Weigelt, J., Bountra, C., Mikros, E., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2009-11-30
Release date:2010-01-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.28 Å)
Cite:Crystal Structure of dual-specificity tyrosine phosphorylation regulated kinase 2 (DYRK2) in complex with an indirubin ligand
To be Published
5II2
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CRYSTAL STRUCTURE OF THE FIFTH BROMODOMAIN OF HUMAN POLYBROMO (PB1) IN COMPLEX WITH 2-(3,4-DIHYDROXYPHENYL)-5,7-DIHYDROXY-4H-CHROMEN-4-ONE
Descriptor:Protein polybromo-1, POTASSIUM ION, CITRIC ACID, ...
Authors:Filippakopoulos, P., Picaud, S., Felletar, I., von Delft, F., Edwards, A.M., Arrowsmith, C.H., Bountra, C., Knapp, S.
Deposit date:2016-03-01
Release date:2016-06-29
Last modified:2016-10-26
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Discovery and Optimization of a Selective Ligand for the Switch/Sucrose Nonfermenting-Related Bromodomains of Polybromo Protein-1 by the Use of Virtual Screening and Hydration Analysis.
J.Med.Chem., 59, 2016
5IID
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CRYSTAL STRUCTURE OF THE FIFTH BROMODOMAIN OF HUMAN POLYBROMO (PB1) IN COMPLEX WITH 2-(3,4-DIHYDROXYPHENYL)-5-HYDROXY-4H-CHROMEN-4-ONE
Descriptor:Protein polybromo-1, 2-(3,4-dihydroxyphenyl)-5-hydroxy-4H-1-benzopyran-4-one
Authors:Filippakopoulos, P., Picaud, S., Felletar, I., von Delft, F., Edwards, A.M., Arrowsmith, C.H., Bountra, C., Knapp, S.
Deposit date:2016-03-01
Release date:2016-06-29
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Discovery and Optimization of a Selective Ligand for the Switch/Sucrose Nonfermenting-Related Bromodomains of Polybromo Protein-1 by the Use of Virtual Screening and Hydration Analysis.
J.Med.Chem., 59, 2016
3K2L
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CRYSTAL STRUCTURE OF DUAL-SPECIFICITY TYROSINE PHOSPHORYLATION REGULATED KINASE 2 (DYRK2)
Descriptor:Dual specificity tyrosine-phosphorylation-regulated kinase 2, SULFATE ION, SODIUM ION, ...
Authors:Filippakopoulos, P., Myrianthopoulos, V., Soundararajan, M., Krojer, T., Hapka, E., Fedorov, O., Berridge, G., Wang, J., Shrestha, L., Pike, A.C.W., Ugochukwu, E., von Delft, F., Arrowsmith, C.H., Edwards, A., Weigelt, J., Bountra, C., Mikros, E., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2009-09-30
Release date:2009-10-13
Last modified:2013-06-26
Method:X-RAY DIFFRACTION (2.36 Å)
Cite:Structures of Down Syndrome Kinases, DYRKs, Reveal Mechanisms of Kinase Activation and Substrate Recognition.
Structure, 21, 2013