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3TK5
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FACTOR XA IN COMPLEX WITH D102-4380
Descriptor:Factor X heavy chain, Factor X light chain, CALCIUM ION, ...
Authors:Suzuki, M., Mochizuki, A., Nagata, T., Takano, H., Kanno, H., Kishida, M., Ohta, T.
Deposit date:2011-08-25
Release date:2012-08-29
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Zwitter ionic potent durable orally active Factor Xa inhibitor.
To be Published
3TK6
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FACTOR XA IN COMPLEX WITH D46-5241
Descriptor:Factor X heavy chain, Factor X light chain, CALCIUM ION, ...
Authors:Suzuki, M., Mochizuki, A., Nagata, T., Takano, H., Kanno, H., Kishida, M., Ohta, T.
Deposit date:2011-08-25
Release date:2012-08-29
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Zwitter ionic potent durable orally active Factor Xa inhibitor.
To be Published
2D1J
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FACTOR XA IN COMPLEX WITH THE INHIBITOR 2-[[4-[(5-CHLOROINDOL-2-YL)SULFONYL]PIPERAZIN-1-YL] CARBONYL]THIENO[3,2-B]PYRIDINE N-OXIDE
Descriptor:Coagulation factor X, heavy chain, light chain, ...
Authors:Suzuki, M.
Deposit date:2005-08-24
Release date:2006-08-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Design, synthesis, and biological activity of non-basic compounds as factor Xa inhibitors: SAR study of S1 and aryl binding sites.
Bioorg.Med.Chem., 13, 2005
1WU1
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FACTOR XA IN COMPLEX WITH THE INHIBITOR 4-[(5-CHLOROINDOL-2-YL)SULFONYL]-2-(2-METHYLPROPYL)-1-[[5-(PYRIDIN-4-YL) PYRIMIDIN-2-YL]CARBONYL]PIPERAZINE
Descriptor:Coagulation factor X, heavy chain, light chain, ...
Authors:Suzuki, M.
Deposit date:2004-11-29
Release date:2005-11-29
Last modified:2012-06-20
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Design, synthesis, and biological activity of non-basic compounds as factor Xa inhibitors: SAR study of S1 and aryl binding sites
Bioorg.Med.Chem., 13, 2005
3IIT
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FACTOR XA IN COMPLEX WITH A CIS-1,2-DIAMINOCYCLOHEXANE DERIVATIVE
Descriptor:Activated factor Xa heavy chain, Factor X light chain, CALCIUM ION, ...
Authors:Suzuki, M.
Deposit date:2009-08-03
Release date:2010-08-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Design, synthesis, and SAR of cis-1,2-diaminocyclohexane derivatives as potent factor Xa inhibitors. Part II: exploration of 6-6 fused rings as alternative S1 moieties.
Bioorg.Med.Chem., 17, 2009
3Q3K
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FACTOR XA IN COMPLEX WITH A PHENYLENEDIAMINE DERIVATIVE
Descriptor:Activated factor Xa heavy chain, Factor X light chain, CALCIUM ION, ...
Authors:Suzuki, M., Imai, E.
Deposit date:2010-12-22
Release date:2011-12-28
Last modified:2012-06-20
Method:X-RAY DIFFRACTION (2 Å)
Cite:Design, synthesis and SAR of novel ethylenediamine and phenylenediamine derivatives as factor Xa inhibitors.
Bioorg.Med.Chem.Lett., 21, 2011
3VYD
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HUMAN RENIN IN COMPLEX WITH INHIBITOR 6
Descriptor:Renin, N-ACETYL-D-GLUCOSAMINE, (3S,5R)-5-{[4-(2-chlorophenyl)-2,2-dimethyl-5-oxopiperazin-1-yl]methyl}-N-(3-methylbutyl)piperidine-3-carboxamide
Authors:Takahashi, M., Hanzawa, H.
Deposit date:2012-09-24
Release date:2012-12-19
Method:X-RAY DIFFRACTION (2.81 Å)
Cite:Design and discovery of new (3S,5R)-5-[4-(2-chlorophenyl)-2,2-dimethyl-5-oxopiperazin-1-yl]piperidine-3-carboxamides as potent renin inhibitors
Bioorg.Med.Chem.Lett., 22, 2012
3VYE
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HUMAN RENIN IN COMPLEX WITH INHIBITOR 7
Descriptor:Renin, N-ACETYL-D-GLUCOSAMINE, (3S,5R)-5-[4-(2-chlorophenyl)-2,2-dimethyl-5-oxopiperazin-1-yl]-N-(3-methylbutyl)piperidine-3-carboxamide
Authors:Takahashi, M., Matsui, Y., Hanzawa, H.
Deposit date:2012-09-24
Release date:2012-12-19
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Design and discovery of new (3S,5R)-5-[4-(2-chlorophenyl)-2,2-dimethyl-5-oxopiperazin-1-yl]piperidine-3-carboxamides as potent renin inhibitors
Bioorg.Med.Chem.Lett., 22, 2012
3VYF
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HUMAN RENIN IN COMPLEX WITH INHIBITOR 9
Descriptor:Renin, N-ACETYL-D-GLUCOSAMINE, (3S,5R)-5-[4-(2-chlorophenyl)-2,2-dimethyl-5-oxopiperazin-1-yl]-N-(2,6-dimethylheptan-4-yl)piperidine-3-carboxamide
Authors:Takahashi, M., Hanzawa, H.
Deposit date:2012-09-24
Release date:2012-12-19
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Design and discovery of new (3S,5R)-5-[4-(2-chlorophenyl)-2,2-dimethyl-5-oxopiperazin-1-yl]piperidine-3-carboxamides as potent renin inhibitors
Bioorg.Med.Chem.Lett., 22, 2012