Author results

1IL3
  • Download 1il3
  • View 1il3
Molmil generated image of 1il3
STRUCTURE OF RICIN A CHAIN BOUND WITH INHIBITOR 7-DEAZAGUANINE
Descriptor:RICIN A CHAIN, 7-DEAZAGUANINE
Authors:Miller, D.J., Ravikumar, K., Shen, H., Suh, J.-K., Kerwin, S.M., Robertus, J.D.
Deposit date:2001-05-07
Release date:2002-01-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure-based design and characterization of novel platforms for ricin and shiga toxin inhibition.
J.Med.Chem., 45, 2002
1IL4
  • Download 1il4
  • View 1il4
Molmil generated image of 1il4
STRUCTURE OF RICIN A CHAIN BOUND WITH INHIBITOR 9-DEAZAGUANINE
Descriptor:RICIN A CHAIN, 9-DEAZAGUANINE
Authors:Miller, D.J., Ravikumar, K., Shen, H., Suh, J.-K., Kerwin, S.M., Robertus, J.D.
Deposit date:2001-05-07
Release date:2002-01-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure-based design and characterization of novel platforms for ricin and shiga toxin inhibition.
J.Med.Chem., 45, 2002
1IL5
  • Download 1il5
  • View 1il5
Molmil generated image of 1il5
STRUCTURE OF RICIN A CHAIN BOUND WITH INHIBITOR 2,5-DIAMINO-4,6-DIHYDROXYPYRIMIDINE (DDP)
Descriptor:RICIN A CHAIN, 2,4-DIAMINO-4,6-DIHYDROXYPYRIMIDINE
Authors:Miller, D.J., Ravikumar, K., Shen, H., Suh, J.-K., Kerwin, S.M., Robertus, J.D.
Deposit date:2001-05-07
Release date:2002-01-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure-based design and characterization of novel platforms for ricin and shiga toxin inhibition.
J.Med.Chem., 45, 2002
1IL9
  • Download 1il9
  • View 1il9
Molmil generated image of 1il9
STRUCTURE OF RICIN A CHAIN BOUND WITH INHIBITOR 8-METHYL-9-OXOGUANINE
Descriptor:RICIN A CHAIN, 5-AMINO-2-METHYL-6H-OXAZOLO[5,4-D]PYRIMIDIN-7-ONE
Authors:Miller, D.J., Ravikumar, K., Shen, H., Suh, J.-K., Kerwin, S.M., Robertus, J.D.
Deposit date:2001-05-07
Release date:2002-01-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structure-based design and characterization of novel platforms for ricin and shiga toxin inhibition.
J.Med.Chem., 45, 2002
1M6Y
  • Download 1m6y
  • View 1m6y
Molmil generated image of 1m6y
CRYSTAL STRUCTURE ANALYSIS OF TM0872, A PUTATIVE SAM-DEPENDENT METHYLTRANSFERASE, COMPLEXED WITH SAH
Descriptor:S-adenosyl-methyltransferase mraW, SULFATE ION, S-ADENOSYL-L-HOMOCYSTEINE
Authors:Miller, D.J., Anderson, W.F., Midwest Center for Structural Genomics (MCSG)
Deposit date:2002-07-17
Release date:2003-01-28
Last modified:2016-03-30
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal complexes of a predicted S-adenosylmethionine-dependent methyltransferase reveal a typical AdoMet binding domain and a substrate recognition domain
Protein Sci., 12, 2003
1N2X
  • Download 1n2x
  • View 1n2x
Molmil generated image of 1n2x
CRYSTAL STRUCTURE ANALYSIS OF TM0872, A PUTATIVE SAM-DEPENDENT METHYLTRANSFERASE, COMPLEXED WITH SAM
Descriptor:S-adenosyl-methyltransferase mraW, SULFATE ION, S-ADENOSYLMETHIONINE
Authors:Miller, D.J., Anderson, W.F., Midwest Center for Structural Genomics (MCSG)
Deposit date:2002-10-24
Release date:2003-01-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal complexes of a predicted S-adenosylmethionine-dependent methyltransferase reveal a typical AdoMet binding domain and a substrate recognition domain
Protein Sci., 12, 2003
1Q7R
  • Download 1q7r
  • View 1q7r
Molmil generated image of 1q7r
X-RAY CRYSTALLOGRAPHIC ANALYSIS OF A PREDICTED AMIDOTRANSFERASE FROM B. STEAROTHERMOPHILUS AT 1.9 A RESOLUTION
Descriptor:predicted amidotransferase, SULFATE ION, CHLORIDE ION, ...
Authors:Miller, D.J., Anderson, W.F., Midwest Center for Structural Genomics (MCSG)
Deposit date:2003-08-19
Release date:2003-11-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:X-ray structure analysis of a predicted amidotransferase from B. stearothermophilus at 1.9 A resolution
To be Published
1SU1
  • Download 1su1
  • View 1su1
Molmil generated image of 1su1
STRUCTURAL AND BIOCHEMICAL CHARACTERIZATION OF YFCE, A PHOSPHOESTERASE FROM E. COLI
Descriptor:Hypothetical protein yfcE, ZINC ION, SULFATE ION
Authors:Miller, D.J., Shuvalova, L., Evdokimova, E., Savchenko, A., Yakunin, A., Anderson, W.F., Midwest Center for Structural Genomics (MCSG)
Deposit date:2004-03-25
Release date:2004-08-17
Last modified:2018-10-03
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Structural and biochemical characterization of a novel Mn2+-dependent phosphodiesterase encoded by the yfcE gene.
Protein Sci., 16, 2007
1TT4
  • Download 1tt4
  • View 1tt4
Molmil generated image of 1tt4
STRUCTURE OF NP459575, A PREDICTED GLUTATHIONE SYNTHASE FROM SALMONELLA TYPHIMURIUM
Descriptor:putative cytoplasmic protein, MAGNESIUM ION, SULFATE ION
Authors:Miller, D.J., Shuvalova, L., Anderson, W.F., Midwest Center for Structural Genomics (MCSG)
Deposit date:2004-06-21
Release date:2004-08-17
Last modified:2012-09-26
Method:X-RAY DIFFRACTION (2.801 Å)
Cite:Structure of NP459575, a predicted glutathione synthase from Salmonella typhimurium
To be Published
2B4Q
  • Download 2b4q
  • View 2b4q
Molmil generated image of 2b4q
PSEUDOMONAS AERUGINOSA RHLG/NADP ACTIVE-SITE COMPLEX
Descriptor:Rhamnolipids biosynthesis 3-oxoacyl-[acyl-carrier-protein] reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Miller, D.J., White, S.W.
Deposit date:2005-09-26
Release date:2006-05-02
Last modified:2019-07-24
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure of RhlG, an Essential beta-Ketoacyl Reductase in the Rhamnolipid Biosynthetic Pathway of Pseudomonas aeruginosa.
J.Biol.Chem., 281, 2006
2GQD
  • Download 2gqd
  • View 2gqd
Molmil generated image of 2gqd
THE CRYSTAL STRUCTURE OF B-KETOACYL-ACP SYNTHASE II (FABF) FROM STAPHYLOCOCCUS AUREUS
Descriptor:3-oxoacyl-[acyl-carrier-protein] synthase 2
Authors:Miller, D.J., White, S.W., Zhang, Y.M., Rock, C.O.
Deposit date:2006-04-20
Release date:2006-05-02
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The crystal structure of B-ketoacyl-ACP synthase II (FabF) from Staphylococcus aureus
To be Published
2QV7
  • Download 2qv7
  • View 2qv7
Molmil generated image of 2qv7
CRYSTAL STRUCTURE OF DIACYLGLYCEROL KINASE DGKB IN COMPLEX WITH ADP AND MG
Descriptor:Diacylglycerol Kinase DgkB, MAGNESIUM ION, ADENOSINE-5'-DIPHOSPHATE
Authors:Miller, D.J., Jerga, A., Rock, C.O., White, S.W.
Deposit date:2007-08-07
Release date:2008-06-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Analysis of the Staphylococcus aureus DgkB Structure Reveals a Common Catalytic Mechanism for the Soluble Diacylglycerol Kinases.
Structure, 16, 2008
2QVL
  • Download 2qvl
  • View 2qvl
Molmil generated image of 2qvl
CRYSTAL STRUCTURE OF DIACYLGLYCEROL KINASE
Descriptor:Diacylglycerol Kinase DgkB
Authors:Miller, D.J., Jerga, A., Rock, C.O., White, S.W.
Deposit date:2007-08-08
Release date:2008-06-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Analysis of the Staphylococcus aureus DgkB Structure Reveals a Common Catalytic Mechanism for the Soluble Diacylglycerol Kinases.
Structure, 16, 2008
3LSJ
  • Download 3lsj
  • View 3lsj
Molmil generated image of 3lsj
CRYSTAL STRUCTURE OF DEST IN COMPLEX WITH PALMITOYL-COA
Descriptor:DesT, PALMITIC ACID, COENZYME A
Authors:Miller, D.J., White, S.W.
Deposit date:2010-02-12
Release date:2010-08-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural basis for the transcriptional regulation of membrane lipid homeostasis.
Nat.Struct.Mol.Biol., 17, 2010
3LSP
  • Download 3lsp
  • View 3lsp
Molmil generated image of 3lsp
CRYSTAL STRUCTURE OF DEST BOUND TO DESCB PROMOTER AND OLEOYL-COA
Descriptor:DesT, DNA (5'-D(*TP*TP*AP*CP*AP*TP*CP*AP*GP*TP*GP*AP*AP*CP*GP*CP*TP*TP*GP*TP*TP*GP*AP*CP*TP*CP*GP*AP*TP*TP*G)-3'), DNA (5'-D(*TP*CP*AP*AP*TP*CP*GP*AP*GP*TP*CP*AP*AP*CP*AP*AP*GP*CP*GP*TP*TP*CP*AP*CP*TP*GP*AP*TP*GP*TP*A)-3'), ...
Authors:Miller, D.J., White, S.W.
Deposit date:2010-02-12
Release date:2010-08-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.66 Å)
Cite:Structural basis for the transcriptional regulation of membrane lipid homeostasis.
Nat.Struct.Mol.Biol., 17, 2010
3LSR
  • Download 3lsr
  • View 3lsr
Molmil generated image of 3lsr
CRYSTAL STRUCTURE OF DEST IN COMPLEX WITH DUPLEX DNA
Descriptor:DesT, DNA (27-MER), SULFATE ION
Authors:Miller, D.J., White, S.W.
Deposit date:2010-02-12
Release date:2010-08-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Structural basis for the transcriptional regulation of membrane lipid homeostasis.
Nat.Struct.Mol.Biol., 17, 2010
4XEF
  • Download 4xef
  • View 4xef
Molmil generated image of 4xef
PYK2-FAT COMPLEXED WITH LEUPAXIN LD MOTIF LD1
Descriptor:Protein-tyrosine kinase 2-beta, 20-mer peptide containing LD1 motif of leupaxin
Authors:Miller, D.J.
Deposit date:2014-12-23
Release date:2015-12-23
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural Basis for the Interaction between Pyk2-FAT Domain and Leupaxin LD Repeats.
Biochemistry, 55, 2016
4XEK
  • Download 4xek
  • View 4xek
Molmil generated image of 4xek
PYK2-FAT DOMAIN IN COMPLEX WITH LEUPAXIN LD4 MOTIF
Descriptor:Protein-tyrosine kinase 2-beta, 19-mer peptide containing Leupaxin LD4 motif
Authors:Miller, D.J.
Deposit date:2014-12-24
Release date:2015-12-30
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (1.793 Å)
Cite:Structural Basis for the Interaction between Pyk2-FAT Domain and Leupaxin LD Repeats.
Biochemistry, 55, 2016
4XEV
  • Download 4xev
  • View 4xev
Molmil generated image of 4xev
FUSION OF PYK2-FAT DOMAIN WITH LEUPAXIN LD1 MOTIF, COMPLEXED WITH LEUPAXIN LD4 PEPTIDE
Descriptor:Fusion protein of Protein-tyrosine kinase 2-beta FAT domain and Leupaxin LD1 motif, 19-mer peptide containing Leupaxin LD4 motif
Authors:Miller, D.J.
Deposit date:2014-12-24
Release date:2015-12-30
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.0073 Å)
Cite:Structural Basis for the Interaction between Pyk2-FAT Domain and Leupaxin LD Repeats.
Biochemistry, 55, 2016
5UDH
  • Download 5udh
  • View 5udh
Molmil generated image of 5udh
HHARI/ARIH1-UBCH7~UBIQUITIN
Descriptor:E3 ubiquitin-protein ligase ARIH1, Ubiquitin-conjugating enzyme E2 L3, Ubiquitin C variant, ...
Authors:Miller, D.J., Schulman, B.A.
Deposit date:2016-12-27
Release date:2017-06-14
Last modified:2017-06-21
Method:X-RAY DIFFRACTION (3.24 Å)
Cite:Structural Studies of HHARI/UbcH7Ub Reveal Unique E2Ub Conformational Restriction by RBR RING1.
Structure, 25, 2017
5W93
  • Download 5w93
  • View 5w93
Molmil generated image of 5w93
P130CAS COMPLEX WITH PAXILLIN LD1
Descriptor:Breast cancer anti-estrogen resistance protein 1, Paxillin
Authors:Miller, D.J., Zheng, J.J.
Deposit date:2017-06-22
Release date:2017-09-06
Last modified:2017-12-06
Method:X-RAY DIFFRACTION (2.001 Å)
Cite:Structural and functional insights into the interaction between the Cas family scaffolding protein p130Cas and the focal adhesion-associated protein paxillin.
J. Biol. Chem., 292, 2017
6ASR
  • Download 6asr
  • View 6asr
Molmil generated image of 6asr
REV1 UBM2 DOMAIN COMPLEX WITH UBIQUITIN
Descriptor:Ubiquitin, DNA repair protein REV1, NICKEL (II) ION
Authors:Miller, D.J.
Deposit date:2017-08-25
Release date:2018-06-20
Last modified:2018-08-08
Method:X-RAY DIFFRACTION (2.356 Å)
Cite:Structures of REV1 UBM2 Domain Complex with Ubiquitin and with a Small-Molecule that Inhibits the REV1 UBM2-Ubiquitin Interaction.
J. Mol. Biol., 430, 2018
6NJ7
  • Download 6nj7
  • View 6nj7
Molmil generated image of 6nj7
11-BETA DEHYDROGENASE ISOZYME 1 IN COMPLEX WITH COLLETOIC ACID
Descriptor:Corticosteroid 11-beta-dehydrogenase isozyme 1, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, (1S,4S,5S,9S)-9-hydroxy-8-methyl-4-(propan-2-yl)spiro[4.5]dec-7-ene-1-carboxylic acid
Authors:Miller, D.J., Rivas, F.
Deposit date:2019-01-02
Release date:2019-07-24
Last modified:2019-08-21
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Mechanistic Insight on the Mode of Action of Colletoic Acid.
J.Med.Chem., 62, 2019
2AQ7
  • Download 2aq7
  • View 2aq7
Molmil generated image of 2aq7
STRUCTURE-ACTIVITY RELATIONSHIPS AT THE 5-POSIITON OF THIOLACTOMYCIN: AN INTACT 5(R)-ISOPRENE UNIT IS REQUIRED FOR ACTIVITY AGAINST THE CONDENSING ENZYMES FROM MYCOBACTERIUM TUBERCULOSIS AND ESCHERICHIA COLI
Descriptor:3-oxoacyl-[acyl-carrier-protein] synthase I, (5R)-4-HYDROXY-3,5-DIMETHYL-5-[(1E,3E)-2-METHYLPENTA-1,3-DIENYL]THIOPHEN-2(5H)-ONE
Authors:Kim, P., Zhang, Y.M., Shenoy, G., Nguyen, Q.A., Boshoff, H.I., Manjunatha, U.H., Goodwin, M.B., Lonsdale, J., Price, A.C., Miller, D.J.
Deposit date:2005-08-17
Release date:2006-01-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure-Activity Relationships at the 5-Position of Thiolactomycin: An Intact (5R)-Isoprene Unit Is Required for Activity against the Condensing Enzymes from Mycobacterium tuberculosis and Escherichia coli
J.Med.Chem., 49, 2006
2AQB
  • Download 2aqb
  • View 2aqb
Molmil generated image of 2aqb
STRUCTURE-ACTIVITY RELATIONSHIPS AT THE 5-POSITION OF THIOLACTOMYCIN: AN INTACT 5(R)-ISOPRENE UNIT IS REQUIRED FOR ACTIVITY AGAINST THE CONDENSING ENZYMES FROM MYCOBACTERIUM TUBERCULOSIS AND ESCHERCHIA COLI
Descriptor:3-oxoacyl-[acyl-carrier-protein] synthase I, (5R)-5-[(1E)-BUTA-1,3-DIENYL]-4-HYDROXY-3,5-DIMETHYLTHIOPHEN-2(5H)-ONE
Authors:Kim, P., Zhang, Y.M., Shenoy, G., Nguyen, Q.A., Boshoff, H.I., Manjunatha, U.H., Goodwin, M.B., Lonsdale, J., Price, A.C., Miller, D.J.
Deposit date:2005-08-17
Release date:2006-01-17
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.19 Å)
Cite:Structure-Activity Relationships at the 5-Position of Thiolactomycin: An Intact (5R)-Isoprene Unit Is Required for Activity against the Condensing Enzymes from Mycobacterium tuberculosis and Escherichia coli
J.Med.Chem., 49, 2006