Author results

5OQZ
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CRYSTAL STRUCTURE OF THE LASSO PEPTIDE RUBRIVINODIN
Descriptor:Rubrivinodin
Authors:Fage, C.D., Hegemann, J.D., Marahiel, M.A.
Deposit date:2017-08-14
Release date:2018-02-07
Last modified:2019-10-16
Method:X-RAY DIFFRACTION (0.806 Å)
Cite:General rules of fragmentation evidencing lasso structures in CID and ETD.
Analyst, 143, 2018
5M6P
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CRYSTAL STRUCTURE OF THE EPIMERIZATION DOMAIN FROM MODULE 3 OF TYROCIDINE SYNTHETASE B, TYCB3(E)
Descriptor:Tyrocidine synthase 2
Authors:Fage, C.D., Marahiel, M.A.
Deposit date:2016-10-25
Release date:2017-12-20
Last modified:2018-05-23
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Communication Breakdown: Dissecting the COM Interfaces between the Subunits of Nonribosomal Peptide Synthetases
To Be Published
5T3E
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CRYSTAL STRUCTURE OF A NONRIBOSOMAL PEPTIDE SYNTHETASE HETEROCYCLIZATION DOMAIN.
Descriptor:Bacillamide synthetase heterocyclization domain, SULFATE ION
Authors:Bloudoff, K., Schmeing, T.M.
Deposit date:2016-08-25
Release date:2016-11-02
Last modified:2017-01-11
Method:X-RAY DIFFRACTION (2.297 Å)
Cite:Structural and mutational analysis of the nonribosomal peptide synthetase heterocyclization domain provides insight into catalysis.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5JRK
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CRYSTAL STRUCTURE OF THE SPHINGOPYXIN I LASSO PEPTIDE ISOPEPTIDASE SPI-ISOP (SEMET-DERIVED)
Descriptor:Dipeptidyl aminopeptidases/acylaminoacyl-peptidases-like protein, BETA-D-GLUCOSE
Authors:Fage, C.D., Hegemann, J.D., Bange, G., Marahiel, M.A.
Deposit date:2016-05-06
Release date:2016-09-28
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structure and Mechanism of the Sphingopyxin I Lasso Peptide Isopeptidase.
Angew.Chem.Int.Ed.Engl., 55, 2016
5JRL
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CRYSTAL STRUCTURE OF THE SPHINGOPYXIN I LASSO PEPTIDE ISOPEPTIDASE SPI-ISOP (NATIVE)
Descriptor:Dipeptidyl aminopeptidases/acylaminoacyl-peptidases-like protein
Authors:Fage, C.D., Hegemann, J.D., Bange, G., Marahiel, M.A.
Deposit date:2016-05-06
Release date:2016-09-14
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structure and Mechanism of the Sphingopyxin I Lasso Peptide Isopeptidase.
Angew.Chem.Int.Ed.Engl., 55, 2016
5JQF
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CRYSTAL STRUCTURE OF THE LASSO PEPTIDE SPHINGOPYXIN I (SPI)
Descriptor:Sphingopyxin I
Authors:Fage, C.D., Hegemann, J.D., Harms, K., Bange, G., Marahiel, M.A.
Deposit date:2016-05-04
Release date:2016-09-14
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (0.85 Å)
Cite:Structure and Mechanism of the Sphingopyxin I Lasso Peptide Isopeptidase.
Angew. Chem. Int. Ed. Engl., 55, 2016
5J8Q
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CRYSTAL STRUCTURE OF THE CYSTEINE DESULFURASE SUFS OF BACILLUS SUBTILIS
Descriptor:Cysteine desulfurase SufS, PYRIDOXAL-5'-PHOSPHATE, ALANINE
Authors:Altegoer, F., Bange, G.
Deposit date:2016-04-08
Release date:2016-07-27
Method:X-RAY DIFFRACTION (1.702 Å)
Cite:Crystal Structure of Bacillus subtilis Cysteine Desulfurase SufS and Its Dynamic Interaction with Frataxin and Scaffold Protein SufU.
Plos One, 11, 2016
5F2V
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CRYSTAL STRUCTURE OF THE SMALL ALARMONE SYNTHETHASE 1 FROM BACILLUS SUBTILIS BOUND TO AMPCPP
Descriptor:GTP pyrophosphokinase YjbM, DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, MAGNESIUM ION
Authors:Steinchen, W., Schuhmacher, J.S., Altegoer, F., Bange, G.
Deposit date:2015-12-02
Release date:2015-12-16
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Catalytic mechanism and allosteric regulation of an oligomeric (p)ppGpp synthetase by an alarmone.
Proc.Natl.Acad.Sci.USA, 112, 2015
5DKI
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YEAST 20S PROTEASOME IN COMPLEX WITH ALKYNE-PI
Descriptor:Proteasome subunit alpha type-2, Proteasome subunit alpha type-3, Proteasome subunit alpha type-4, ...
Authors:Beck, P., Cui, H., Groll, M.
Deposit date:2015-09-03
Release date:2015-10-28
Last modified:2016-01-27
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Targeted Delivery of Proteasome Inhibitors to Somatostatin-Receptor-Expressing Cancer Cells by Octreotide Conjugation.
Chemmedchem, 10, 2015
5DKJ
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YEAST 20S PROTEASOME IN COMPLEX WITH OCTREOTIDE-PI
Descriptor:Proteasome subunit alpha type-2, Proteasome subunit alpha type-3, Proteasome subunit alpha type-4, ...
Authors:Beck, P., Cui, H., Groll, M.
Deposit date:2015-09-03
Release date:2015-10-28
Last modified:2016-01-27
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Targeted Delivery of Proteasome Inhibitors to Somatostatin-Receptor-Expressing Cancer Cells by Octreotide Conjugation.
Chemmedchem, 10, 2015
5DEC
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CRYSTAL STRUCTURE OF THE SMALL ALARMONE SYNTHETASE 1 FROM BACILLUS SUBTILIS
Descriptor:GTP pyrophosphokinase YjbM
Authors:Steinchen, W., Altegoer, A., Schuhmacher, J.S., Bange, G.
Deposit date:2015-08-25
Release date:2015-10-28
Last modified:2018-06-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Catalytic mechanism and allosteric regulation of an oligomeric (p)ppGpp synthetase by an alarmone.
Proc.Natl.Acad.Sci.USA, 112, 2015
5DED
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CRYSTAL STRUCTURE OF THE SMALL ALARMONE SYNTHETHASE 1 FROM BACILLUS SUBTILIS BOUND TO ITS PRODUCT PPPGPP
Descriptor:GTP pyrophosphokinase YjbM, guanosine 5'-(tetrahydrogen triphosphate) 3'-(trihydrogen diphosphate), MAGNESIUM ION
Authors:Steinchen, W., Schuhmacher, J.S., Altegoer, F., Bange, G.
Deposit date:2015-08-25
Release date:2015-10-28
Method:X-RAY DIFFRACTION (2.942 Å)
Cite:Catalytic mechanism and allosteric regulation of an oligomeric (p)ppGpp synthetase by an alarmone.
Proc.Natl.Acad.Sci.USA, 112, 2015
5D9E
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CRYSTAL STRUCTURE OF THE PROLINE-RICH LASSO PEPTIDE CAULOSEGNIN II
Descriptor:Caulosegnin II, CHLORIDE ION
Authors:Fage, C.D., Hegemann, J.D., Harms, K., Marahiel, M.A.
Deposit date:2015-08-18
Release date:2016-02-17
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (0.859 Å)
Cite:The ring residue proline 8 is crucial for the thermal stability of the lasso peptide caulosegnin II.
Mol Biosyst, 12, 2016
4R1J
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CRYSTAL STRUCTURE OF ARC1P-C
Descriptor:GU4 nucleic-binding protein 1, GLYCEROL
Authors:Altegoer, F., Bange, G.
Deposit date:2014-08-06
Release date:2015-02-18
Last modified:2015-03-11
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:A Synthetic Adenylation-Domain-Based tRNA-Aminoacylation Catalyst.
Angew.Chem.Int.Ed.Engl., 54, 2015
2MMW
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LASSO PEPTIDE BASED INTEGRIN INHIBITOR: MICROCIN J25 VARIANT WITH RGD SUBSTITUTION OF GLY12-ILE13-GLY14
Descriptor:Microcin J25
Authors:Knappe, T.A., Linne, U., Xie, X., Marahiel, M.A.
Deposit date:2014-03-20
Release date:2014-05-14
Method:SOLUTION NMR
Cite:Introducing lasso peptides as molecular scaffolds for drug design: engineering of an integrin antagonist.
Angew.Chem.Int.Ed.Engl., 50, 2011
2MMT
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LASSO PEPTIDE-BASED INTEGRIN INHIBITOR: MICROCIN J25 VARIANT WITH RGDF SUBSTITUTION OF GLY12-ILE13-GLY14-THR15
Descriptor:Microcin J25 RGDF mutant
Authors:Hegemann, J.D., Zimmermann, M., Knappe, T.A., Xie, X., Marahiel, M.A.
Deposit date:2014-03-18
Release date:2014-07-02
Last modified:2014-07-23
Method:SOLUTION NMR
Cite:Rational improvement of the affinity and selectivity of integrin binding of grafted lasso peptides.
J.Med.Chem., 57, 2014
2MLJ
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STRUCTURE OF LASSO PEPTIDE CAULONODIN V
Descriptor:Caulonodin V
Authors:Zimmermann, M., Hegemann, J.D., Xie, X., Marahiel, M.A.
Deposit date:2014-02-28
Release date:2015-01-14
Method:SOLUTION NMR
Cite:Characterization of caulonodin lasso peptides revealed unprecedented N-terminal residues and a precursor motif essential for peptide maturation
CHEM SCI, 5, 2014
2MFV
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STRUCTURE OF LASSO PEPTIDE XANTHOMONIN II
Descriptor:Xanthomonin II
Authors:Hegemann, J.D., Zimmermann, M., Harms, K., Xie, X., Marahiel, M.A.
Deposit date:2013-10-23
Release date:2014-10-29
Method:SOLUTION NMR
Cite:Xanthomonin I-III are Lasso Peptides Featuring Macrolactam Rings Consisting of Only Seven Amino Acids
To be Published
4NAG
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XANTHOMONINS I III ARE A NEW CLASS OF LASSO PEPTIDES FEATURINGA SEVEN-MEMBERED MACROLACTAM RING
Descriptor:Xanthomonin I, HEXANE-1,6-DIOL
Authors:Hegemann, J.D., Zimmermann, M., Zhu, S., Steuber, H., Harms, K., Xie, X., Marahiel, M.A.
Deposit date:2013-10-22
Release date:2014-04-30
Last modified:2014-05-21
Method:X-RAY DIFFRACTION (0.81 Å)
Cite:Xanthomonins I-III: A New Class of Lasso Peptides with a Seven-Residue Macrolactam Ring.
Angew.Chem.Int.Ed.Engl., 53, 2014
4MRT
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STRUCTURE OF THE PHOSPHOPANTETHEINE TRANSFERASE SFP IN COMPLEX WITH COENZYME A AND A PEPTIDYL CARRIER PROTEIN
Descriptor:Tyrocidine synthase 3, 4'-phosphopantetheinyl transferase sfp, MAGNESIUM ION, ...
Authors:Tufar, P., Rahighi, S., Kraas, F.I., Kirchner, D.K., Loehr, F., Henrich, E., Koepke, J., Dikic, I., Guentert, P., Marahiel, M.A., Doetsch, V.
Deposit date:2013-09-17
Release date:2014-04-23
Last modified:2014-05-14
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal Structure of a PCP/Sfp Complex Reveals the Structural Basis for Carrier Protein Posttranslational Modification.
Chem.Biol., 21, 2014
2MD9
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SOLUTION STRUCTURE OF AN ACTIVE SITE MUTANT PEPITDYL CARRIER PROTEIN
Descriptor:Tyrocidine synthase 3
Authors:Tufar, P., Rahighi, S., Kraas, F.I., Kirchner, D.K., Loehr, F., Henrich, E., Koepke, J., Dikic, I., Guentert, P., Marahiel, M.A., Doetsch, V.
Deposit date:2013-09-06
Release date:2014-04-23
Last modified:2017-11-29
Method:SOLUTION NMR
Cite:Crystal Structure of a PCP/Sfp Complex Reveals the Structural Basis for Carrier Protein Posttranslational Modification.
Chem.Biol., 21, 2014
2M37
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STRUCTURE OF LASSO PEPTIDE ASTEXIN-1
Descriptor:ASTEXIN-1
Authors:Zimmermann, M., Hegemann, J.D., Xie, X., Marahiel, M.A.
Deposit date:2013-01-14
Release date:2013-05-01
Method:SOLUTION NMR
Cite:The astexin-1 lasso peptides: biosynthesis, stability, and structural studies.
Chem.Biol., 20, 2013
2LX6
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STRUCTURE OF LASSO PEPTIDE CAULOSEGNIN I
Descriptor:Putative uncharacterized protein
Authors:Hegemann, J.D., Zimmermann, M., Xie, X., Marahiel, M.A.
Deposit date:2012-08-15
Release date:2012-12-26
Last modified:2013-01-23
Method:SOLUTION NMR
Cite:Caulosegnins I-III: A Highly Diverse Group of Lasso Peptides Derived from a Single Biosynthetic Gene Cluster.
J.Am.Chem.Soc., 135, 2013
2XUZ
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CRYSTAL STRUCTURE OF THE TRISCATECHOLATE SIDEROPHORE BINDING PROTEIN FEUA FROM BACILLUS SUBTILIS COMPLEXED WITH FERRI-ENTEROBACTIN
Descriptor:IRON-UPTAKE SYSTEM-BINDING PROTEIN, N,N',N''-[(3S,7S,11S)-2,6,10-trioxo-1,5,9-trioxacyclododecane-3,7,11-triyl]tris(2,3-dihydroxybenzamide), FE (III) ION, ...
Authors:Peuckert, F., Miethke, M., Schwoerer, C.J., Albrecht, A.G., Oberthuer, M., Marahiel, M.A.
Deposit date:2010-10-22
Release date:2011-08-10
Last modified:2012-03-28
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The Siderophore Binding Protein Feua Shows Limited Promiscuity Toward Exogenous Triscatecholates
Chem.Biol., 18, 2011
2XV1
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CRYSTAL STRUCTURE OF THE TRISCATECHOLATE SIDEROPHORE BINDING PROTEIN FEUA FROM BACILLUS SUBTILIS COMPLEXED WITH FERRIC MECAM
Descriptor:IRON-UPTAKE SYSTEM-BINDING PROTEIN, N,N',N''-[BENZENE-1,3,5-TRIYLTRIS(METHYLENE)]TRIS(2,3-DIHYDROXYBENZAMIDE), FE (III) ION, ...
Authors:Peuckert, F., Miethke, M., Schwoerer, C.J., Albrecht, A.G., Oberthuer, M., Marahiel, M.A.
Deposit date:2010-10-22
Release date:2011-08-10
Last modified:2012-03-28
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:The Siderophore Binding Protein Feua Shows Limited Promiscuity Toward Exogenous Triscatecholates
Chem.Biol., 18, 2011
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