Author results

1AMU
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PHENYLALANINE ACTIVATING DOMAIN OF GRAMICIDIN SYNTHETASE 1 IN A COMPLEX WITH AMP AND PHENYLALANINE
Descriptor:GRAMICIDIN SYNTHETASE 1, MAGNESIUM ION, SULFATE ION, ...
Authors:Conti, E., Stachelhaus, T., Marahiel, M.A., Brick, P.
Deposit date:1997-06-18
Release date:1998-07-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural basis for the activation of phenylalanine in the non-ribosomal biosynthesis of gramicidin S.
EMBO J., 16, 1997
1DNY
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SOLUTION STRUCTURE OF PCP, A PROTOTYPE FOR THE PEPTIDYL CARRIER DOMAINS OF MODULAR PEPTIDE SYNTHETASES
Descriptor:NON-RIBOSOMAL PEPTIDE SYNTHETASE PEPTIDYL CARRIER PROTEIN
Authors:Weber, T., Baumgartner, R., Renner, C., Marahiel, M.A., Holak, T.A.
Deposit date:1999-12-17
Release date:2000-05-17
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure of PCP, a prototype for the peptidyl carrier domains of modular peptide synthetases.
Structure Fold.Des., 8, 2000
1JMK
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STRUCTURAL BASIS FOR THE CYCLIZATION OF THE LIPOPEPTIDE ANTIBIOTIC SURFACTIN BY THE THIOESTERASE DOMAIN SRFTE
Descriptor:Surfactin Synthetase, SULFATE ION
Authors:Bruner, S.D., Weber, T., Kohli, R.M., Schwarzer, D., Marahiel, M.A., Walsh, C.T., Stubbs, M.T.
Deposit date:2001-07-18
Release date:2002-03-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.71 Å)
Cite:Structural basis for the cyclization of the lipopeptide antibiotic surfactin by the thioesterase domain SrfTE.
Structure, 10, 2002
1MD9
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CRYSTAL STRUCTURE OF DHBE IN COMPLEX WITH DHB AND AMP
Descriptor:2,3-dihydroxybenzoate-AMP ligase, ADENOSINE MONOPHOSPHATE, 2,3-DIHYDROXY-BENZOIC ACID
Authors:May, J.J., Kessler, N., Marahiel, M.A., Stubbs, M.T.
Deposit date:2002-08-07
Release date:2002-09-11
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structure of DhbE, an archetype for aryl acid activating domains of modular nonribosomal peptide synthetases.
Proc.Natl.Acad.Sci.USA, 99, 2002
1MDB
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CRYSTAL STRUCTURE OF DHBE IN COMPLEX WITH DHB-ADENYLATE
Descriptor:2,3-dihydroxybenzoate-AMP ligase, SULFATE ION, ADENOSINE MONOPHOSPHATE, ...
Authors:May, J.J., Kessler, N., Marahiel, M.A., Stubbs, M.T.
Deposit date:2002-08-07
Release date:2002-09-11
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Crystal structure of DhbE, an archetype for aryl acid activating domains of modular nonribosomal peptide synthetases.
Proc.Natl.Acad.Sci.USA, 99, 2002
1MDF
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CRYSTAL STRUCTURE OF DHBE IN ABSENCE OF SUBSTRATE
Descriptor:2,3-dihydroxybenzoate-AMP ligase, SULFATE ION
Authors:May, J.J., Kessler, N., Marahiel, M.A., Stubbs, M.T.
Deposit date:2002-08-07
Release date:2002-09-11
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of DhbE, an archetype for aryl acid activating domains of modular nonribosomal peptide synthetases.
Proc.Natl.Acad.Sci.USA, 99, 2002
2CB9
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CRYSTAL STRUCTURE OF THE THIOESTERASE DOMAIN OF THE FENGYCIN BIOSYNTHESIS CLUSTER
Descriptor:FENGYCIN SYNTHETASE, ACETIC ACID
Authors:Samel, S., Marahiel, M.A., Essen, L.-O.
Deposit date:2006-01-03
Release date:2007-03-06
Last modified:2017-07-05
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The Thioesterase Domain of the Fengycin Biosynthesis Cluster: A Structural Base for the Macrocyclization of a Non-Ribosomal Lipopeptide
J.Mol.Biol., 359, 2006
2CBG
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CRYSTAL STRUCTURE OF THE PMSF-INHIBITED THIOESTERASE DOMAIN OF THE FENGYCIN BIOSYNTHESIS CLUSTER
Descriptor:FENGYCIN SYNTHETASE, phenylmethanesulfonic acid
Authors:Samel, S., Marahiel, M.A., Essen, L.-O.
Deposit date:2006-01-03
Release date:2007-03-06
Last modified:2017-07-05
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:The Thioesterase Domain of the Fengycin Biosynthesis Cluster: A Structural Base for the Macrocyclization of a Non-Ribosomal Lipopeptide
J.Mol.Biol., 359, 2006
2GDW
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SOLUTION STRUCTURE OF THE B. BREVIS TYCC3-PCP IN A/H-STATE
Descriptor:Tyrocidine synthetase III
Authors:Koglin, A., Loehr, F., Rogov, V.V., Marahiel, M.A., Bernhard, F., Doetsch, V.
Deposit date:2006-03-17
Release date:2006-08-01
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Conformational switches modulate protein interactions in peptide antibiotic synthetases
Science, 312, 2006
2GDX
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SOLUTION STRUCTURE OF THE B. BREVIS TYCC3-PCP IN H-STATE
Descriptor:Tyrocidine synthetase III
Authors:Koglin, A., Loehr, F., Rogov, V.V., Marahiel, M.A., Bernhard, F., Doetsch, V.
Deposit date:2006-03-17
Release date:2006-08-01
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Conformational switches modulate protein interactions in peptide antibiotic synthetases
Science, 312, 2006
2GDY
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SOLUTION STRUCTURE OF THE B. BREVIS TYCC3-PCP IN A-STATE
Descriptor:Tyrocidine synthetase III
Authors:Koglin, A., Loehr, F., Rogov, V.V., Marahiel, M.A., Bernhard, F., Doetsch, V.
Deposit date:2006-03-17
Release date:2006-08-01
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Conformational switches modulate protein interactions in peptide antibiotic synthetases
Science, 312, 2006
2JGP
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STRUCTURE OF THE TYCC5-6 PCP-C BIDOMAIN OF THE TYROCIDINE SYNTHETASE TYCC
Descriptor:TYROCIDINE SYNTHETASE 3, SULFATE ION, 1,4-DIETHYLENE DIOXIDE, ...
Authors:Samel, S.A., Schoenafinger, G., Knappe, T.A., Marahiel, M.A., Essen, L.-O.
Deposit date:2007-02-13
Release date:2007-10-30
Last modified:2012-06-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structural and Functional Insights Into a Peptide Bond-Forming Bidomain from a Nonribosomal Peptide Synthetase.
Structure, 15, 2007
2K2Q
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COMPLEX STRUCTURE OF THE EXTERNAL THIOESTERASE OF THE SURFACTIN-SYNTHETASE WITH A CARRIER DOMAIN
Descriptor:Tyrocidine synthetase 3 (Tyrocidine synthetase III), Surfactin synthetase thioesterase subunit
Authors:Koglin, A., Lohr, F., Bernhard, F., Rogov, V.V., Frueh, D.P., Strieter, E.R., Mofid, M.R., Guntert, P., Wagner, G., Walsh, C.T., Marahiel, M.A., Dotsch, V.
Deposit date:2008-04-10
Release date:2008-12-09
Last modified:2018-01-24
Method:SOLUTION NMR
Cite:Structural basis for the selectivity of the external thioesterase of the surfactin synthetase.
Nature, 454, 2008
2LX6
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STRUCTURE OF LASSO PEPTIDE CAULOSEGNIN I
Descriptor:Putative uncharacterized protein
Authors:Hegemann, J.D., Zimmermann, M., Xie, X., Marahiel, M.A.
Deposit date:2012-08-15
Release date:2012-12-26
Last modified:2013-01-23
Method:SOLUTION NMR
Cite:Caulosegnins I-III: A Highly Diverse Group of Lasso Peptides Derived from a Single Biosynthetic Gene Cluster.
J.Am.Chem.Soc., 135, 2013
2M37
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STRUCTURE OF LASSO PEPTIDE ASTEXIN-1
Descriptor:ASTEXIN-1
Authors:Zimmermann, M., Hegemann, J.D., Xie, X., Marahiel, M.A.
Deposit date:2013-01-14
Release date:2013-05-01
Method:SOLUTION NMR
Cite:The astexin-1 lasso peptides: biosynthesis, stability, and structural studies.
Chem.Biol., 20, 2013
2MD9
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SOLUTION STRUCTURE OF AN ACTIVE SITE MUTANT PEPITDYL CARRIER PROTEIN
Descriptor:Tyrocidine synthase 3
Authors:Tufar, P., Rahighi, S., Kraas, F.I., Kirchner, D.K., Loehr, F., Henrich, E., Koepke, J., Dikic, I., Guentert, P., Marahiel, M.A., Doetsch, V.
Deposit date:2013-09-06
Release date:2014-04-23
Last modified:2017-11-29
Method:SOLUTION NMR
Cite:Crystal Structure of a PCP/Sfp Complex Reveals the Structural Basis for Carrier Protein Posttranslational Modification.
Chem.Biol., 21, 2014
2MFV
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STRUCTURE OF LASSO PEPTIDE XANTHOMONIN II
Descriptor:Xanthomonin II
Authors:Hegemann, J.D., Zimmermann, M., Harms, K., Xie, X., Marahiel, M.A.
Deposit date:2013-10-23
Release date:2014-10-29
Method:SOLUTION NMR
Cite:Xanthomonin I-III are Lasso Peptides Featuring Macrolactam Rings Consisting of Only Seven Amino Acids
To be Published
2MLJ
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STRUCTURE OF LASSO PEPTIDE CAULONODIN V
Descriptor:Caulonodin V
Authors:Zimmermann, M., Hegemann, J.D., Xie, X., Marahiel, M.A.
Deposit date:2014-02-28
Release date:2015-01-14
Method:SOLUTION NMR
Cite:Characterization of caulonodin lasso peptides revealed unprecedented N-terminal residues and a precursor motif essential for peptide maturation
CHEM SCI, 5, 2014
2MMT
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LASSO PEPTIDE-BASED INTEGRIN INHIBITOR: MICROCIN J25 VARIANT WITH RGDF SUBSTITUTION OF GLY12-ILE13-GLY14-THR15
Descriptor:Microcin J25 RGDF mutant
Authors:Hegemann, J.D., Zimmermann, M., Knappe, T.A., Xie, X., Marahiel, M.A.
Deposit date:2014-03-18
Release date:2014-07-02
Last modified:2014-07-23
Method:SOLUTION NMR
Cite:Rational improvement of the affinity and selectivity of integrin binding of grafted lasso peptides.
J.Med.Chem., 57, 2014
2MMW
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LASSO PEPTIDE BASED INTEGRIN INHIBITOR: MICROCIN J25 VARIANT WITH RGD SUBSTITUTION OF GLY12-ILE13-GLY14
Descriptor:Microcin J25
Authors:Knappe, T.A., Linne, U., Xie, X., Marahiel, M.A.
Deposit date:2014-03-20
Release date:2014-05-14
Method:SOLUTION NMR
Cite:Introducing lasso peptides as molecular scaffolds for drug design: engineering of an integrin antagonist.
Angew.Chem.Int.Ed.Engl., 50, 2011
2RON
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THE EXTERNAL THIOESTERASE OF THE SURFACTIN-SYNTHETASE
Descriptor:Surfactin synthetase thioesterase subunit
Authors:Koglin, A., Lohr, F., Bernhard, F., Rogov, V.V., Frueh, D.P., Strieter, E.R., Mofid, M.R., Guentert, P., Wagner, G., Walsh, C.T., Marahiel, M.A., Doetsch, V.
Deposit date:2008-04-04
Release date:2008-08-12
Last modified:2016-10-26
Method:SOLUTION NMR
Cite:Structural basis for the selectivity of the external thioesterase of the surfactin synthetase
Nature, 454, 2008
2VSQ
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STRUCTURE OF SURFACTIN A SYNTHETASE C (SRFA-C), A NONRIBOSOMAL PEPTIDE SYNTHETASE TERMINATION MODULE
Descriptor:SURFACTIN SYNTHETASE SUBUNIT 3, LEUCINE, SULFATE ION
Authors:Tanovic, A., Samel, S.A., Essen, L.-O., Marahiel, M.A.
Deposit date:2008-04-29
Release date:2008-07-08
Last modified:2019-01-30
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal structure of the termination module of a nonribosomal peptide synthetase.
Science, 321, 2008
2WBO
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CRYSTAL STRUCTURE OF VIOC IN COMPLEX WITH L-ARGININE
Descriptor:L-ARGININE BETA-HYDROXYLASE, ARGININE, FE (II) ION, ...
Authors:Helmetag, V., Samel, S.A., Thomas, M.G., Marahiel, M.A., Essen, L.-O.
Deposit date:2009-03-02
Release date:2009-06-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Structural Basis for the Erythro-Stereospecificity of the L-Arginine Oxygenase Vioc in Viomycin Biosynthesis.
FEBS J., 276, 2009
2WBP
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CRYSTAL STRUCTURE OF VIOC IN COMPLEX WITH FE(II), (2S,3S)- HYDROXYARGININE, AND SUCCINATE
Descriptor:L-ARGININE BETA-HYDROXYLASE, ARGININE, FE (II) ION, ...
Authors:Helmetag, V., Samel, S.A., Thomas, M.G., Marahiel, M.A., Essen, L.-O.
Deposit date:2009-03-02
Release date:2009-06-23
Last modified:2013-05-08
Method:X-RAY DIFFRACTION (1.16 Å)
Cite:Structural Basis for the Erythro-Stereospecificity of the L-Arginine Oxygenase Vioc in Viomycin Biosynthesis.
FEBS J., 276, 2009
2WBQ
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CRYSTAL STRUCTURE OF VIOC IN COMPLEX WITH (2S,3S)-HYDROXYARGININE
Descriptor:L-ARGININE BETA-HYDROXYLASE, ACETATE ION, (2S,3S)-3-HYDROXYARGININE
Authors:Helmetag, V., Samel, S.A., Thomas, M.G., Marahiel, M.A., Essen, L.-O.
Deposit date:2009-03-02
Release date:2009-06-23
Last modified:2013-05-08
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:Structural Basis for the Erythro-Stereospecificity of the L-Arginine Oxygenase Vioc in Viomycin Biosynthesis.
FEBS J., 276, 2009
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