5V7I
| Crystal structure of homo sapiens serine hydroxymethyltransferase 2 (mitochondrial) (SHMT2), in complex with glycine, PLP and folate-competitive pyrazolopyran inhibitor: 6-amino-4-isopropyl-3-methyl-4-(3-(pyrrolidin-1-yl)-5-(trifluoromethyl)phenyl)-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile | Descriptor: | (4R)-6-amino-3-methyl-4-(propan-2-yl)-4-[3-(pyrrolidin-1-yl)-5-(trifluoromethyl)phenyl]-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... | Authors: | Ducker, G.S, Ghergurovich, J.M, Mainolfi, N, Suri, V, Jeong, S, Friedman, A, Manfredi, M, Kim, H, Rabinowitz, J.D. | Deposit date: | 2017-03-20 | Release date: | 2017-10-11 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.47 Å) | Cite: | Human SHMT inhibitors reveal defective glycine import as a targetable metabolic vulnerability of diffuse large B-cell lymphoma. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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5TR4
| Structure of Ubiquitin activating enzyme (Uba1) in complex with ubiquitin and TAK-243 | Descriptor: | Ubiquitin, Ubiquitin-activating enzyme E1 1, [(1~{R},2~{R},3~{S},4~{R})-2,3-bis(oxidanyl)-4-[[2-[3-(trifluoromethylsulfanyl)phenyl]pyrazolo[1,5-a]pyrimidin-7-yl]amino]cyclopentyl]methyl sulfamate | Authors: | Sintchak, M.D. | Deposit date: | 2016-10-25 | Release date: | 2017-11-01 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Identification and Characterization of a Small Molecule Inhibitor of the Ubiquitin Activating Enzyme (TAK-243) To be published
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7S3V
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1DKE
| NI BETA HEME HUMAN HEMOGLOBIN | Descriptor: | HEMOGLOBIN: ALPHA CHAIN, HEMOGLOBIN: BETA CHAIN, PROTOPORPHYRIN IX CONTAINING FE, ... | Authors: | Bruno, S, Bettatti, S, Mozzarelli, A, Bolognesi, M, Deriu, D, Rosano, C, Tsuneshige, A, Yonetani, T, Henry, E.R. | Deposit date: | 1999-12-07 | Release date: | 2000-05-23 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Oxygen binding by alpha(Fe2+)2beta(Ni2+)2 hemoglobin crystals. Protein Sci., 9, 2000
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1FN3
| CRYSTAL STRUCTURE OF NICKEL RECONSTITUTED HEMOGLOBIN-A CASE FOR PERMANENT, T-STATE HEMOGLOBIN | Descriptor: | HEMOGLOBIN ALPHA CHAIN, HEMOGLOBIN BETA CHAIN, PROTOPORPHYRIN IX CONTAINING NI(II) | Authors: | Venkateshrao, S, Deepthi, S, Pattabhi, V, Manoharan, P.T. | Deposit date: | 2000-08-20 | Release date: | 2003-10-07 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (2.48 Å) | Cite: | Crystal Structure of Nickel Reconstituted Hemoglobin - A Case for Permanent, T-State Hemoglobin CURR.SCI., 84, 2003
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