Author results

1UN6
  • Download 1un6
  • View 1un6
Molmil generated image of 1un6
THE CRYSTAL STRUCTURE OF A ZINC FINGER - RNA COMPLEX REVEALS TWO MODES OF MOLECULAR RECOGNITION
Descriptor:TRANSCRIPTION FACTOR IIIA, 5S RIBOSOMAL RNA, ZINC ION, ...
Authors:Lu, D., Searles, M.A., Klug, A.
Deposit date:2003-09-04
Release date:2003-11-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Crystal Structure of a Zinc-Finger-RNA Complex Reveals Two Modes of Molecular Recognition
Nature, 426, 2003
2J7J
  • Download 2j7j
  • View 2j7j
Molmil generated image of 2j7j
INVARIANCE OF THE ZINC FINGER MODULE: A COMPARISON OF THE FREE STRUCTURE WITH THOSE IN NUCLEIC-ACID COMPLEXES
Descriptor:TRANSCRIPTION FACTOR IIIA, ZINC ION, SULFATE ION
Authors:Lu, D., Klug, A.
Deposit date:2006-10-10
Release date:2007-10-09
Last modified:2012-10-10
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Invariance of the Zinc Finger Module: A Comparison of the Free Structure with Those in Nucleic-Acid Complexes.
Proteins, 67, 2007
2W5Q
  • Download 2w5q
  • View 2w5q
Molmil generated image of 2w5q
STRUCTURE-BASED MECHANISM OF LIPOTEICHOIC ACID SYNTHESIS BY STAPHYLOCOCCUS AUREUS LTAS.
Descriptor:PROCESSED GLYCEROL PHOSPHATE LIPOTEICHOIC ACID SYNTHASE, MANGANESE (II) ION, 1,2-ETHANEDIOL
Authors:Lu, D., Wormann, M.E., Zhang, X., Scheewind, O., Grundling, A., Freemont, P.S.
Deposit date:2008-12-11
Release date:2009-02-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Structure-Based Mechanism of Lipoteichoic Acid Synthesis by Staphylococcus Aureus Ltas.
Proc.Natl.Acad.Sci.USA, 106, 2009
2W5R
  • Download 2w5r
  • View 2w5r
Molmil generated image of 2w5r
STRUCTURE-BASED MECHANISM OF LIPOTEICHOIC ACID SYNTHESIS BY STAPHYLOCOCCUS AUREUS LTAS.
Descriptor:PROCESSED GLYCEROL PHOSPHATE LIPOTEICHOIC ACID SYNTHASE, ACETATE ION, MANGANESE (II) ION, ...
Authors:Lu, D., Wormann, M.E., Zhang, X., Schneewind, O., Grundling, A., Freemont, P.S.
Deposit date:2008-12-11
Release date:2009-02-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structure-Based Mechanism of Lipoteichoic Acid Synthesis by Staphylococcus Aureus Ltas.
Proc.Natl.Acad.Sci.USA, 106, 2009
2W5S
  • Download 2w5s
  • View 2w5s
Molmil generated image of 2w5s
STRUCTURE-BASED MECHANISM OF LIPOTEICHOIC ACID SYNTHESIS BY STAPHYLOCOCCUS AUREUS LTAS.
Descriptor:PROCESSED GLYCEROL PHOSPHATE LIPOTEICHOIC ACID SYNTHASE, MANGANESE (II) ION, ACETATE ION, ...
Authors:Lu, D., Wormann, M.E., Zhang, X., Schneewind, O., Grundling, A., Freemont, P.S.
Deposit date:2008-12-11
Release date:2009-02-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure-Based Mechanism of Lipoteichoic Acid Synthesis by Staphylococcus Aureus Ltas.
Proc.Natl.Acad.Sci.USA, 106, 2009
2W5T
  • Download 2w5t
  • View 2w5t
Molmil generated image of 2w5t
STRUCTURE-BASED MECHANISM OF LIPOTEICHOIC ACID SYNTHESIS BY STAPHYLOCOCCUS AUREUS LTAS.
Descriptor:PROCESSED GLYCEROL PHOSPHATE LIPOTEICHOIC ACID SYNTHASE, MANGANESE (II) ION, ACETATE ION, ...
Authors:Lu, D., Wormann, M.E., Zhang, X., Schneewind, O., Grundling, A., Freemont, P.S.
Deposit date:2008-12-11
Release date:2009-02-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structure-Based Mechanism of Lipoteichoic Acid Synthesis by Staphylococcus Aureus Ltas.
Proc.Natl.Acad.Sci.USA, 106, 2009
2XRN
  • Download 2xrn
  • View 2xrn
Molmil generated image of 2xrn
CRYSTAL STRUCTURE OF TTGV
Descriptor:HTH-TYPE TRANSCRIPTIONAL REGULATOR TTGV
Authors:Lu, D., Fillet, S., Meng, C., Alguel, Y., Kloppsteck, P., Bergeron, J., Krell, T., Gallegos, M.-T., Ramos, J., Zhang, X.
Deposit date:2010-09-17
Release date:2010-12-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Crystal Structure of Ttgv in Complex with its DNA Operator Reveals a General Model for Cooperative DNA Binding of Tetrameric Gene Regulators.
Genes Dev., 24, 2010
2XRO
  • Download 2xro
  • View 2xro
Molmil generated image of 2xro
CRYSTAL STRUCTURE OF TTGV IN COMPLEX WITH ITS DNA OPERATOR
Descriptor:HTH-TYPE TRANSCRIPTIONAL REGULATOR TTGV, TTGV OPERATOR DNA, OSMIUM ION
Authors:Lu, D., Fillet, S., Meng, C., Alguel, Y., Kloppsteck, P., Bergeron, J., Krell, T., Gallegos, M.-T., Ramos, J., Zhang, X.
Deposit date:2010-09-17
Release date:2010-12-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Crystal Structure of Ttgv in Complex with its DNA Operator Reveals a General Model for Cooperative DNA Binding of Tetrameric Gene Regulators.
Genes Dev., 24, 2010
3C94
  • Download 3c94
  • View 3c94
Molmil generated image of 3c94
EXOI/SSB-CT COMPLEX
Descriptor:Exodeoxyribonuclease I, Single-stranded DNA-binding C-terminal tail peptide, MAGNESIUM ION
Authors:Lu, D., Keck, J.L.
Deposit date:2008-02-15
Release date:2008-07-08
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural basis of Escherichia coli single-stranded DNA-binding protein stimulation of exonuclease I.
Proc.Natl.Acad.Sci.USA, 105, 2008
4B5F
  • Download 4b5f
  • View 4b5f
Molmil generated image of 4b5f
SUBSTRATE BOUND NEISSERIA AP ENDONUCLEASE IN ABSENCE OF METAL IONS (CRYSTAL FORM 1)
Descriptor:PUTATIVE EXODEOXYRIBONUCLEASE, 5'-D(*GP*CP*TP*AP*CP*3DRP*GP*AP*TP*CP*GP)-3', 5'-D(*CP*GP*AP*TP*CP*GP*GP*TP*AP*GP*CP)-3'
Authors:Lu, D., Silhan, J., MacDonald, J.T., Carpenter, E.P., Jensen, K., Tang, C.M., Baldwin, G.S., Freemont, P.S.
Deposit date:2012-08-03
Release date:2012-10-17
Last modified:2018-02-28
Method:X-RAY DIFFRACTION (2.005 Å)
Cite:Structural basis for the recognition and cleavage of abasic DNA in Neisseria meningitidis.
Proc. Natl. Acad. Sci. U.S.A., 109, 2012
4B5G
  • Download 4b5g
  • View 4b5g
Molmil generated image of 4b5g
SUBSTRATE BOUND NEISSERIA AP ENDONUCLEASE IN ABSENCE OF METAL IONS (CRYSTAL FORM 2)
Descriptor:EXODEOXYRIBONUCLEASE, 5'-D(*GP*CP*TP*AP*CP*(3DR)P*CP*AP*TP*CP*GP)-3', 5'-D(*CP*GP*AP*TP*GP*GP*GP*TP*AP*GP*CP)-3'
Authors:Lu, D., Silhan, J., MacDonald, J.T., Carpenter, E.P., Jensen, K., Tang, C.M., Baldwin, G.S., Freemont, P.S.
Deposit date:2012-08-03
Release date:2012-10-17
Last modified:2018-02-28
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Structural basis for the recognition and cleavage of abasic DNA in Neisseria meningitidis.
Proc. Natl. Acad. Sci. U.S.A., 109, 2012
4B5H
  • Download 4b5h
  • View 4b5h
Molmil generated image of 4b5h
SUBSTATE BOUND INACTIVE MUTANT OF NEISSERIA AP ENDONUCLEASE IN PRESENCE OF METAL IONS
Descriptor:PUTATIVE EXODEOXYRIBONUCLEASE, 5'-D(*GP*CP*TP*AP*CP*3DRP*CP*AP*TP*CP*GP)-3', 5'-D(*CP*GP*AP*TP*GP*GP*GP*TP*AP*GP*CP)-3', ...
Authors:Lu, D., Silhan, J., MacDonald, J.T., Carpenter, E.P., Jensen, K., Tang, C.M., Baldwin, G.S., Freemont, P.S.
Deposit date:2012-08-03
Release date:2012-10-17
Last modified:2018-02-28
Method:X-RAY DIFFRACTION (3.05 Å)
Cite:Structural basis for the recognition and cleavage of abasic DNA in Neisseria meningitidis.
Proc. Natl. Acad. Sci. U.S.A., 109, 2012
4B5I
  • Download 4b5i
  • View 4b5i
Molmil generated image of 4b5i
PRODUCT COMPLEX OF NEISSERIA AP ENDONUCLEASE IN PRESENCE OF METAL IONS
Descriptor:PUTATIVE EXODEOXYRIBONUCLEASE, 5'-D(*GP*CP*TP*AP*CP)-3', 5'-D(*CP*GP*AP*TP*GP*GP*GP*TP*AP*GP*CP)-3', ...
Authors:Lu, D., Silhan, J., MacDonald, J.T., Carpenter, E.P., Jensen, K., Tang, C.M., Baldwin, G.S., Freemont, P.S.
Deposit date:2012-08-03
Release date:2012-10-17
Last modified:2018-02-28
Method:X-RAY DIFFRACTION (2.555 Å)
Cite:Structural basis for the recognition and cleavage of abasic DNA in Neisseria meningitidis.
Proc. Natl. Acad. Sci. U.S.A., 109, 2012
4B5J
  • Download 4b5j
  • View 4b5j
Molmil generated image of 4b5j
NEISSERIA AP ENDONUCLEASE BOUND TO THE SUBSTRATE WITH AN ORPHAN ADENINE BASE
Descriptor:PUTATIVE EXODEOXYRIBONUCLEASE, 5'-D(*GP*CP*TP*AP*CP*(3DR)P*CP*AP*TP*CP*GP)-3', 5'-D(*CP*GP*AP*TP*GP*AP*GP*TP*AP*GP*CP)-3'
Authors:Lu, D., Silhan, J., MacDonald, J.T., Carpenter, E.P., Jensen, K., Tang, C.M., Baldwin, G.S., Freemont, P.S.
Deposit date:2012-08-03
Release date:2012-10-17
Last modified:2018-02-28
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural basis for the recognition and cleavage of abasic DNA in Neisseria meningitidis.
Proc. Natl. Acad. Sci. U.S.A., 109, 2012
4B5M
  • Download 4b5m
  • View 4b5m
Molmil generated image of 4b5m
NEISSERIA AP ENDONUCLEASE BOUND TO THE SUBSTRATE WITH A CYTOSINE ORPHAN BASE
Descriptor:PUTATIVE EXODEOXYRIBONUCLEASE, 5'-D(*3DRP*CP*AP*TP*CP*GP)-3', 5'-D(*GP*CP*TP*AP*CP)-3', ...
Authors:Lu, D., Silhan, J., MacDonald, J.T., Carpenter, E.P., Jensen, K., Tang, C.M., Baldwin, G.S., Freemont, P.S.
Deposit date:2012-08-06
Release date:2012-10-17
Last modified:2018-02-28
Method:X-RAY DIFFRACTION (2.758 Å)
Cite:Structural basis for the recognition and cleavage of abasic DNA in Neisseria meningitidis.
Proc. Natl. Acad. Sci. U.S.A., 109, 2012
4R1D
  • Download 4r1d
  • View 4r1d
Molmil generated image of 4r1d
THE CRYSTAL STRUCTURE OF TLE4-TLI4 COMPLEX
Descriptor:Uncharacterized protein, CALCIUM ION
Authors:Lu, D.
Deposit date:2014-08-05
Release date:2014-12-17
Method:X-RAY DIFFRACTION (1.749 Å)
Cite:The structural basis of the Tle4-Tli4 complex reveals the self-protection mechanism of H2-T6SS in Pseudomonas aeruginosa.
Acta Crystallogr.,Sect.D, 70, 2014
1EKB
  • Download 1ekb
  • View 1ekb
Molmil generated image of 1ekb
THE SERINE PROTEASE DOMAIN OF ENTEROPEPTIDASE BOUND TO INHIBITOR VAL-ASP-ASP-ASP-ASP-LYS-CHLOROMETHANE
Descriptor:ENTEROPEPTIDASE, VAL-ASP-ASP-ASP-ASP-LYK PEPTIDE, ZINC ION
Authors:Fuetterer, K., Lu, D., Sadler, J.E., Waksman, G.
Deposit date:1999-05-02
Release date:1999-10-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of enteropeptidase light chain complexed with an analog of the trypsinogen activation peptide.
J.Mol.Biol., 292, 1999
3C95
  • Download 3c95
  • View 3c95
Molmil generated image of 3c95
EXONUCLEASE I (APO)
Descriptor:Exodeoxyribonuclease I, MAGNESIUM ION
Authors:Keck, J.L., Lu, D.
Deposit date:2008-02-15
Release date:2008-07-08
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural basis of Escherichia coli single-stranded DNA-binding protein stimulation of exonuclease I.
Proc.Natl.Acad.Sci.USA, 105, 2008
6HMG
  • Download 6hmg
  • View 6hmg
Molmil generated image of 6hmg
STRUCTURE OF THE GH99 ENDO-ALPHA-MANNANASE FROM BACTEROIDES XYLANISOLVENS IN COMPLEX WITH ALPHA-GLC-1,3-(1,2-ANHYDRO-CARBA-GLUCOSAMINE)
Descriptor:Glycosyl hydrolase family 71, ACETATE ION, (1~{S},2~{R},3~{R},4~{R},6~{S})-4-(hydroxymethyl)-7-azabicyclo[4.1.0]heptane-2,3-diol, ...
Authors:Sobala, L.F., Lu, D., Zhu, S., Bernardo-Seisdedos, G., Millet, O., Zhang, Y., Sollogoub, M., Jimenez-Barbero, J., Davies, G.J.
Deposit date:2018-09-12
Release date:2018-09-26
Last modified:2019-04-24
Method:X-RAY DIFFRACTION (1.27 Å)
Cite:From 1,4-Disaccharide to 1,3-Glycosyl Carbasugar: Synthesis of a Bespoke Inhibitor of Family GH99 Endo-alpha-mannosidase.
Org.Lett., 20, 2018
6HMH
  • Download 6hmh
  • View 6hmh
Molmil generated image of 6hmh
STRUCTURE OF THE GH99 ENDO-ALPHA-MANNANASE FROM BACTEROIDES XYLANISOLVENS IN COMPLEX WITH ALPHA-GLC-1,3-(1,2-ANHYDRO-CARBA-GLUCOSAMINE) AND ALPHA-1,2-MANNOBIOSE
Descriptor:Glycosyl hydrolase family 71, ACETATE ION, (1~{S},2~{R},3~{R},4~{R},6~{S})-4-(hydroxymethyl)-7-azabicyclo[4.1.0]heptane-2,3-diol, ...
Authors:Sobala, L.F., Lu, D., Zhu, S., Bernardo-Seisdedos, G., Millet, O., Zhang, Y., Sollogoub, M., Jimenez-Barbero, J., Davies, G.J.
Deposit date:2018-09-12
Release date:2018-09-26
Last modified:2019-04-24
Method:X-RAY DIFFRACTION (1.03 Å)
Cite:From 1,4-Disaccharide to 1,3-Glycosyl Carbasugar: Synthesis of a Bespoke Inhibitor of Family GH99 Endo-alpha-mannosidase.
Org.Lett., 20, 2018
1LVC
  • Download 1lvc
  • View 1lvc
Molmil generated image of 1lvc
CRYSTAL STRUCTURE OF THE ADENYLYL CYCLASE DOMAIN OF ANTHRAX EDEMA FACTOR (EF) IN COMPLEX WITH CALMODULIN AND 2' DEOXY, 3' ANTHRANILOYL ATP
Descriptor:calmodulin-sensitive adenylate cyclase, calmodulin, YTTERBIUM (III) ION, ...
Authors:Shen, Y., Lee, Y.-S., Soelaiman, S., Bergson, P., Lu, D., Chen, A., Beckingham, K., Grabarek, Z., Mrksich, M., Tang, W.-J.
Deposit date:2002-05-28
Release date:2002-12-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:Physiological calcium concentrations regulate calmodulin binding and catalysis of adenylyl cyclase exotoxins
Embo J., 21, 2002
3SFV
  • Download 3sfv
  • View 3sfv
Molmil generated image of 3sfv
CRYSTAL STRUCTURE OF THE GDP-BOUND RAB1A S25N MUTANT IN COMPLEX WITH THE COILED-COIL DOMAIN OF LIDA FROM LEGIONELLA PNEUMOPHILA
Descriptor:Ras-related protein Rab-1A, LidA protein, substrate of the Dot/Icm system, ...
Authors:Yin, K., Lu, D., Zhu, D., Zhang, H., Li, B., Xu, S., Gu, L.
Deposit date:2011-06-14
Release date:2012-04-18
Method:X-RAY DIFFRACTION (1.73 Å)
Cite:Structural Insights into a Unique Legionella pneumophila Effector LidA Recognizing Both GDP and GTP Bound Rab1 in Their Active State
Plos Pathog., 8, 2012
3TKL
  • Download 3tkl
  • View 3tkl
Molmil generated image of 3tkl
CRYSTAL STRUCTURE OF THE GTP-BOUND RAB1A IN COMPLEX WITH THE COILED-COIL DOMAIN OF LIDA FROM LEGIONELLA PNEUMOPHILA
Descriptor:Ras-related protein Rab-1A, LidA protein, substrate of the Dot/Icm system, ...
Authors:Cheng, W., Yin, K., Lu, D., Li, B., Zhu, D., Chen, Y., Zhang, H., Xu, S., Chai, J., Gu, L.
Deposit date:2011-08-27
Release date:2012-06-27
Method:X-RAY DIFFRACTION (2.183 Å)
Cite:Structural insights into a unique Legionella pneumophila effector LidA recognizing both GDP and GTP bound Rab1 in their active state
Plos Pathog., 8, 2012
4F5W
  • Download 4f5w
  • View 4f5w
Molmil generated image of 4f5w
CRYSTAL STRUCTURE OF LIGAND FREE HUMAN STING CTD
Descriptor:Transmembrane protein 173, CALCIUM ION
Authors:Gu, L., Shang, G., Zhu, D., Li, N., Zhang, J., Zhu, C., Lu, D., Liu, C., Yu, Q., Zhao, Y., Xu, S.
Deposit date:2012-05-13
Release date:2012-06-27
Last modified:2013-09-04
Method:X-RAY DIFFRACTION (2.201 Å)
Cite:Crystal structures of STING protein reveal basis for recognition of cyclic di-GMP
Nat.Struct.Mol.Biol., 19, 2012
4F5Y
  • Download 4f5y
  • View 4f5y
Molmil generated image of 4f5y
CRYSTAL STRUCTURE OF HUMAN STING CTD COMPLEX WITH C-DI-GMP
Descriptor:Transmembrane protein 173, CALCIUM ION, 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one)
Authors:Gu, L., Shang, G., Zhu, D., Li, N., Zhang, J., Zhu, C., Lu, D., Liu, C., Yu, Q., Zhao, Y., Xu, S.
Deposit date:2012-05-13
Release date:2012-06-27
Last modified:2013-09-04
Method:X-RAY DIFFRACTION (2.396 Å)
Cite:Crystal structures of STING protein reveal basis for recognition of cyclic di-GMP
Nat.Struct.Mol.Biol., 19, 2012
<123>