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4G6V
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BU of 4g6v by Molmil
CdiA-CT/CdiI toxin and immunity complex from Burkholderia pseudomallei
Descriptor: Adhesin/hemolysin, BROMIDE ION, CdiI
Authors:Morse, R.P, Nikolakakis, K, Willet, J, Gerrick, E, Low, D.A, Hayes, C.S, Goulding, C.W.
Deposit date:2012-07-19
Release date:2012-12-12
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.64 Å)
Cite:Structural basis of toxicity and immunity in contact-dependent growth inhibition (CDI) systems.
Proc.Natl.Acad.Sci.USA, 109, 2012
4G6U
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BU of 4g6u by Molmil
CdiA-CT/CdiI toxin and immunity complex from Escherichia coli
Descriptor: ACETATE ION, CHLORIDE ION, EC869 CdiA-CT, ...
Authors:Morse, R.P, Nikolakakis, K, Willet, J, Gerrick, E, Low, D.A, Hayes, C.S, Goulding, C.W.
Deposit date:2012-07-19
Release date:2012-12-12
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.353 Å)
Cite:Structural basis of toxicity and immunity in contact-dependent growth inhibition (CDI) systems.
Proc.Natl.Acad.Sci.USA, 109, 2012
5J5V
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BU of 5j5v by Molmil
CdiA-CT from uropathogenic Escherichia coli in complex with cognate immunity protein and CysK
Descriptor: Cysteine synthase A, Immunity protein CdiI, tRNA nuclease CdiA
Authors:Goulding, C.W, Johnson, P.M, Morse, R.P.
Deposit date:2016-04-04
Release date:2016-07-27
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Unraveling the essential role of CysK in CDI toxin activation.
Proc. Natl. Acad. Sci. U.S.A., 113, 2016
5I4R
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BU of 5i4r by Molmil
Contact-dependent inhibition system from Escherichia coli NC101 - ternary CdiA/CdiI/EF-Tu complex (trypsin-modified)
Descriptor: Contact-dependent inhibitor A, Contact-dependent inhibitor I, Elongation factor Tu, ...
Authors:Michalska, K, Stols, L, Eschenfeldt, W, Hayes, C.S, Goulding, C.W, Joachimiak, A, Midwest Center for Structural Genomics (MCSG), Structure-Function Analysis of Polymorphic CDI Toxin-Immunity Protein Complexes (UC4CDI)
Deposit date:2016-02-12
Release date:2017-06-28
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Structure of a novel antibacterial toxin that exploits elongation factor Tu to cleave specific transfer RNAs.
Nucleic Acids Res., 45, 2017
5HKQ
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BU of 5hkq by Molmil
Crystal structure of CDI complex from Escherichia coli STEC_O31
Descriptor: CdiI immunity protein, Contact-dependent inhibitor A
Authors:Michalska, K, Stols, L, Eschenfeldt, W, Goulding, C.W, Joachimiak, A, Midwest Center for Structural Genomics (MCSG), Structure-Function Analysis of Polymorphic CDI Toxin-Immunity Protein Complexes (UC4CDI)
Deposit date:2016-01-14
Release date:2017-01-18
Last modified:2020-03-04
Method:X-RAY DIFFRACTION (2 Å)
Cite:Functional plasticity of antibacterial EndoU toxins.
Mol.Microbiol., 109, 2018
5I4Q
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BU of 5i4q by Molmil
Contact-dependent inhibition system from Escherichia coli NC101 - ternary CdiA/CdiI/EF-Tu complex (domains 2 and 3)
Descriptor: CHLORIDE ION, Contact-dependent inhibitor A, Contact-dependent inhibitor I, ...
Authors:Michalska, K, Stols, L, Eschenfeldt, W, Hayes, C.S, Goulding, C.W, Joachimiak, A, Midwest Center for Structural Genomics (MCSG), Structure-Function Analysis of Polymorphic CDI Toxin-Immunity Protein Complexes (UC4CDI)
Deposit date:2016-02-12
Release date:2017-06-28
Last modified:2019-12-25
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Structure of a novel antibacterial toxin that exploits elongation factor Tu to cleave specific transfer RNAs.
Nucleic Acids Res., 45, 2017
4NTQ
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BU of 4ntq by Molmil
CdiA-CT/CdiI toxin and immunity complex from Enterobacter cloacae
Descriptor: Contact-dependent inhibitor A, ECL CdiI
Authors:Morse, R.P, Goulding, C.W.
Deposit date:2013-12-02
Release date:2014-03-26
Last modified:2014-05-14
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:CdiA from Enterobacter cloacae Delivers a Toxic Ribosomal RNase into Target Bacteria.
Structure, 22, 2014
6VQL
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BU of 6vql by Molmil
CRYSTAL STRUCTURE OF INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 4 (IRAK4-WT) COMPLEX WITH A NICOTINAMIDE INHIBITOR
Descriptor: 6-[(1,3-benzothiazol-6-yl)amino]-4-(cyclopropylamino)-N-[(2R)-2-fluoro-3-hydroxy-3-methylbutyl]pyridine-3-carboxamide, Interleukin-1 receptor-associated kinase 4, SULFATE ION
Authors:Sack, J.S.
Deposit date:2020-02-05
Release date:2020-06-24
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.069 Å)
Cite:Optimization of Nicotinamides as Potent and Selective IRAK4 Inhibitors with Efficacy in a Murine Model of Psoriasis.
Acs Med.Chem.Lett., 11, 2020
5J43
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BU of 5j43 by Molmil
CdiA-CT from uropathogenic Escherichia coli in complex with CysK
Descriptor: Cysteine synthase A, tRNA nuclease CdiA
Authors:Morse, R.P, Goulding, C.W, Johnson, P.M.
Deposit date:2016-03-31
Release date:2016-07-27
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Unraveling the essential role of CysK in CDI toxin activation.
Proc. Natl. Acad. Sci. U.S.A., 113, 2016
4Q7O
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BU of 4q7o by Molmil
The crystal structure of an immunity protein NMB0503 from Neisseria meningitidis MC58
Descriptor: BROMIDE ION, FORMIC ACID, Immunity protein
Authors:Tan, K, Stols, L, Eschenfeldt, W, Babnigg, G, Low, D.A, Hayes, C.S, Goulding, C.W, Joachimiak, A, Midwest Center for Structural Genomics (MCSG), Structure-Function Analysis of Polymorphic CDI Toxin-Immunity Protein Complexes (UC4CDI)
Deposit date:2014-04-25
Release date:2014-05-14
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:The structure of a contact-dependent growth-inhibition (CDI) immunity protein from Neisseria meningitidis MC58.
Acta Crystallogr F Struct Biol Commun, 71, 2015
6LXY
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BU of 6lxy by Molmil
IRAK4 in complex with inhibitor
Descriptor: Interleukin-1 receptor-associated kinase 4, N-[(2R)-2-fluoranyl-3-methyl-3-oxidanyl-butyl]-6-[(6-fluoranylpyrazolo[1,5-a]pyrimidin-5-yl)amino]-4-(propan-2-ylamino)pyridine-3-carboxamide, SULFATE ION
Authors:Ghosh, K, Bose, S.
Deposit date:2020-02-12
Release date:2020-11-25
Method:X-RAY DIFFRACTION (2.19 Å)
Cite:Optimization of Nicotinamides as Potent and Selective IRAK4 Inhibitors with Efficacy in a Murine Model of Psoriasis.
Acs Med.Chem.Lett., 11, 2020

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PDB entries from 2024-09-18

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