Author results

6XQB
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SARS-COV-2 RDRP/RNA COMPLEX
Descriptor:RNA-directed RNA polymerase, Non-structural protein 8, Non-structural protein 7, ...
Authors:Liu, B., Shi, W., Yang, Y.
Deposit date:2020-07-09
Release date:2020-07-29
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Structure of SARS-CoV-2 RdRp/RNA complex at 3.4 Angstroms resolution
To Be Published
6KHN
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CRYSTAL STRUCTURE OF ORYZA SATIVA TDC WITH PLP AND SEROTONIN
Descriptor:Tryptophan decarboxylase 1, PYRIDOXAL-5'-PHOSPHATE, SEROTONIN, ...
Authors:Zhou, Y.Z., Liao, L.J., Liu, X.K., Guo, Y., Zhao, Y.C., Zeng, Z.X.
Deposit date:2019-07-16
Release date:2020-07-15
Method:X-RAY DIFFRACTION (2.293 Å)
Cite:Crystal structure ofOryza sativaTDC reveals the substrate specificity for TDC-mediated melatonin biosynthesis.
J Adv Res, 24, 2020
6KHO
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CRYSTAL STRUCTURE OF ORYZA SATIVA TDC WITH PLP
Descriptor:Tryptophan decarboxylase 1, PYRIDOXAL-5'-PHOSPHATE, ACETATE ION, ...
Authors:Zhou, Y.Z., Liao, L.J., Liu, X.K., Guo, Y., Zhao, Y.C., Zeng, Z.X.
Deposit date:2019-07-16
Release date:2020-07-15
Method:X-RAY DIFFRACTION (1.972 Å)
Cite:Crystal structure ofOryza sativaTDC reveals the substrate specificity for TDC-mediated melatonin biosynthesis.
J Adv Res, 24, 2020
6KHP
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CRYSTAL STRUCTURE OF ORYZA SATIVA TDC WITH PLP AND TRYPTAMINE
Descriptor:Tryptophan decarboxylase 1, PYRIDOXAL-5'-PHOSPHATE, 2-(1H-INDOL-3-YL)ETHANAMINE, ...
Authors:Zhou, Y.Z., Liao, L.J., Liu, X.K., Guo, Y., Zhao, Y.C., Zeng, Z.X.
Deposit date:2019-07-16
Release date:2020-07-15
Method:X-RAY DIFFRACTION (2.299 Å)
Cite:Crystal structure ofOryza sativaTDC reveals the substrate specificity for TDC-mediated melatonin biosynthesis.
J Adv Res, 24, 2020
6K5M
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THE CRYSTAL STRUCTURE OF A SEROTONIN N-ACETYLTRANSFERASE FROM ORYZA SATIVA (RICE)
Descriptor:Serotonin N-acetyltransferase 1, chloroplastic
Authors:Zhou, Y.Z., Liao, L.J., Liu, X.K., Guo, Y., Zhao, Y.C., Zeng, Z.X.
Deposit date:2019-05-29
Release date:2020-06-03
Last modified:2020-07-15
Method:X-RAY DIFFRACTION (1.793 Å)
Cite:Crystal structure ofOryza sativaTDC reveals the substrate specificity for TDC-mediated melatonin biosynthesis.
J Adv Res, 24, 2020
6PMI
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SIGM28-TRANSCRIPTION INITIATION COMPLEX WITH SPECIFIC PROMOTER AT THE STATE 1
Descriptor:DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Liu, B., Shi, W.
Deposit date:2019-07-02
Release date:2020-05-13
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (3.86 Å)
Cite:Structural basis of bacterial sigma28-mediated transcription reveals roles of the RNA polymerase zinc-binding domain.
Embo J., 39, 2020
6PMJ
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SIGM28-TRANSCRIPTION INITIATION COMPLEX WITH SPECIFIC PROMOTER AT THE STATE 2
Descriptor:DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Liu, B., Shi, W.
Deposit date:2019-07-02
Release date:2020-05-13
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (3.91 Å)
Cite:Structural basis of bacterial sigma28-mediated transcription reveals roles of the RNA polymerase zinc-binding domain.
Embo J., 39, 2020
7BOV
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THE STRUCTURE OF BACILLUS SUBTILIS GLYCOSYLTRANSFERASE,BS-YJIC
Descriptor:Uncharacterized UDP-glucosyltransferase YjiC, SODIUM ION, GLYCEROL
Authors:Zhao, C., Liu, B., Zhao, N.L., Luo, Y.Z., Bao, R.
Deposit date:2020-03-20
Release date:2020-05-13
Method:X-RAY DIFFRACTION (2.293 Å)
Cite:Structural of the glycosyltransferase Bs-YjiC from Bacillus subtilis
To Be Published
6JTF
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COMPLEX OF MARH AND L-TRP
Descriptor:Cupin superfamily protein, ZINC ION, TRYPTOPHAN
Authors:Liu, B., Hu, K.F., Zhang, R.D.
Deposit date:2019-04-10
Release date:2020-04-15
Method:SOLUTION NMR
Cite:Structural of MarH in complex with L-Trp
To Be Published
6PB4
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THE E. COLI CLASS-II CAP-DEPENDENT TRANSCRIPTION ACTIVATION COMPLEX WITH DE NOVO RNA TRANSCRIPT AT THE STATE 2
Descriptor:DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Liu, B., Shi, W.
Deposit date:2019-06-13
Release date:2020-03-18
Last modified:2020-04-29
Method:ELECTRON MICROSCOPY (4.35 Å)
Cite:Visualization of two architectures in class-II CAP-dependent transcription activation
Plos Biol., 18, 2020
6PB5
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THE E. COLI CLASS-II CAP-DEPENDENT TRANSCRIPTION ACTIVATION COMPLEX AT THE STATE 1 ARCHITECTURE
Descriptor:DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Liu, B., Shi, W.
Deposit date:2019-06-13
Release date:2020-03-18
Last modified:2020-04-29
Method:ELECTRON MICROSCOPY (4.52 Å)
Cite:Visualization of two architectures in class-II CAP-dependent transcription activation
Plos Biol., 18, 2020
6PB6
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THE E. COLI CLASS-II CAP-DEPENDENT TRANSCRIPTION ACTIVATION COMPLEX AT THE STATE 2
Descriptor:DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Liu, B., Shi, W.
Deposit date:2019-06-13
Release date:2020-03-18
Last modified:2020-04-29
Method:ELECTRON MICROSCOPY (4.29 Å)
Cite:Visualization of two architectures in class-II CAP-dependent transcription activation
Plos Biol., 18, 2020
6JBH
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CRYO-EM STRUCTURE AND TRANSPORT MECHANISM OF A WALL TEICHOIC ACID ABC TRANSPORTER
Descriptor:TarH, TarG
Authors:Chen, L., Hou, W.T., Fan, T., Li, Y.H., Liu, B.H., Jiang, Y.L., Sun, L.F., Chen, Y., Zhou, C.Z.
Deposit date:2019-01-25
Release date:2020-03-04
Last modified:2020-04-08
Method:ELECTRON MICROSCOPY (3.94 Å)
Cite:Cryo-electron Microscopy Structure and Transport Mechanism of a Wall Teichoic Acid ABC Transporter.
Mbio, 11, 2020
6UIP
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DYRK1A KINASE DOMAIN IN COMPLEX WITH A 6-AZAINDOLE DERIVATIVE, GNF2133.
Descriptor:Dual specificity tyrosine-phosphorylation-regulated kinase 1A, 4-ethyl-N-{4-[1-(oxan-4-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]pyridin-2-yl}piperazine-1-carboxamide
Authors:DiDonato, M., Spraggon, G.
Deposit date:2019-10-01
Release date:2020-03-04
Last modified:2020-04-08
Method:X-RAY DIFFRACTION (3.7 Å)
Cite:Selective DYRK1A Inhibitor for the Treatment of Type 1 Diabetes: Discovery of 6-Azaindole Derivative GNF2133.
J.Med.Chem., 63, 2020
6JLR
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CRYSTAL STRUCTURE OF WILD TYPE MNK2 IN COMPLEX WITH INHIBITOR
Descriptor:MAP kinase-interacting serine/threonine-protein kinase 2, 4-[5-(1-methylpyrazol-4-yl)pyridin-3-yl]benzamide
Authors:Baburajendran, N., Hill, J.
Deposit date:2019-03-06
Release date:2020-02-12
Method:X-RAY DIFFRACTION (2.901 Å)
Cite:Stepwise Evolution of Fragment Hits against MAPK Interacting Kinases 1 and 2.
J.Med.Chem., 63, 2020
6SP6
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ULTRA-HIGH RESOLUTION CRYSTAL STRUCTURE OF THE CTX-M-15 EXTENDED-SPECTRUM BETA-LACTAMASE IN COMPLEX WITH TANIBORBACTAM (VNRX-5133)
Descriptor:Beta-lactamase, SULFATE ION, (3~{R})-3-[2-[4-(2-azanylethylamino)cyclohexyl]ethanoylamino]-2-oxidanyl-3,4-dihydro-1,2-benzoxaborinine-8-carboxylic acid, ...
Authors:Docquier, J.D., Pozzi, C., De Luca, F., Benvenuti, M., Mangani, S.
Deposit date:2019-08-31
Release date:2020-01-22
Last modified:2020-04-08
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:Discovery of Taniborbactam (VNRX-5133): A Broad-Spectrum Serine- and Metallo-beta-lactamase Inhibitor for Carbapenem-Resistant Bacterial Infections.
J.Med.Chem., 63, 2020
6SP7
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CRYSTAL STRUCTURE OF THE VIM-2 ACQUIRED METALLO-BETA-LACTAMASE IN COMPLEX WITH TANIBORBACTAM (VNRX-5133)
Descriptor:Metallo-beta-lactamase VIM-2, ZINC ION, ACETATE ION, ...
Authors:Docquier, J.D., Pozzi, C., De Luca, F., Benvenuti, M., Mangani, S.
Deposit date:2019-08-31
Release date:2020-01-22
Last modified:2020-04-08
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Discovery of Taniborbactam (VNRX-5133): A Broad-Spectrum Serine- and Metallo-beta-lactamase Inhibitor for Carbapenem-Resistant Bacterial Infections.
J.Med.Chem., 63, 2020
6J4B
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CRYSTAL STRUCTURE OF MARH, AN EPIMERASE FOR BIOSYNTHESIS OF MAREMYCINS IN STREPTOMYCES, UNDER 400 MM ZINC ACETATE
Descriptor:Cupin superfamily protein, ZINC ION, GLYCEROL, ...
Authors:Hou, Y., Liu, B., Hu, K., Zhang, R.
Deposit date:2019-01-08
Release date:2020-01-15
Method:X-RAY DIFFRACTION (1.58 Å)
Cite:Structural basis of the mechanism of beta-methyl epimerization by enzyme MarH.
Org.Biomol.Chem., 17, 2019
6J4C
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CRYSTAL STRUCTURE OF MARH, AN EPIMERASE FOR BIOSYNTHESIS OF MAREMYCINS IN STREPTOMYCES, UNDER 10 MM ZNSO4
Descriptor:Cupin superfamily protein, ZINC ION, GLYCEROL, ...
Authors:Hou, Y., Liu, B., Hu, K., Zhang, R.
Deposit date:2019-01-08
Release date:2020-01-15
Method:X-RAY DIFFRACTION (1.58 Å)
Cite:Structural basis of the mechanism of beta-methyl epimerization by enzyme MarH.
Org.Biomol.Chem., 17, 2019
6J4D
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CRYSTAL STRUCTURE OF MARH, AN EPIMERASE FOR BIOSYNTHESIS OF MAREMYCINS IN STREPTOMYCES, UNDER PH 4.7, WITHOUT ZN
Descriptor:Cupin superfamily protein, CITRATE ANION, GLYCEROL
Authors:Hou, Y., Liu, B., Hu, K., Zhang, R.
Deposit date:2019-01-08
Release date:2020-01-15
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Structural Basis for the Isomerization Mechanism of MarH
To Be Published
6KOB
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X-RAY STRUCTURE OF THE PROTON-PUMPING CYTOCHROME AA3-600 MENAQUINOL OXIDASE FROM BACILLUS SUBTILIS
Descriptor:AA3-600 quinol oxidase subunit I, Quinol oxidase subunit 2, AA3-600 quinol oxidase subunit IIII, ...
Authors:Xu, J., Ding, Z., Liu, B., Li, J., Gennis, R.B., Zhu, J.
Deposit date:2019-08-09
Release date:2020-01-15
Last modified:2020-01-29
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:Structure of the cytochromeaa3-600 heme-copper menaquinol oxidase bound to inhibitor HQNO shows TM0 is part of the quinol binding site.
Proc.Natl.Acad.Sci.USA, 117, 2020
6KOC
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X-RAY STRUCTURE OF THE PROTON-PUMPING CYTOCHROME AA3-600 MENAQUINOL OXIDASE FROM BACILLUS SUBTILIS COMPLEXED WITH 3-IODO-N-OXO-2-HEPTYL-4-HYDROXYQUINOLINE
Descriptor:AA3-600 quinol oxidase subunit I, Quinol oxidase subunit 2, AA3-600 quinol oxidase subunit IIII, ...
Authors:Xu, J., Ding, Z., Liu, B., Li, J., Gennis, R.B., Zhu, J.
Deposit date:2019-08-09
Release date:2020-01-15
Last modified:2020-01-29
Method:X-RAY DIFFRACTION (3.8 Å)
Cite:Structure of the cytochromeaa3-600 heme-copper menaquinol oxidase bound to inhibitor HQNO shows TM0 is part of the quinol binding site.
Proc.Natl.Acad.Sci.USA, 117, 2020
6KOE
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X-RAY STRUCTURE OF THE PROTON-PUMPING CYTOCHROME AA3-600 MENAQUINOL OXIDASE FROM BACILLUS SUBTILIS
Descriptor:AA3-600 quinol oxidase subunit I, Quinol oxidase subunit 2, AA3-600 quinol oxidase subunit IIII, ...
Authors:Xu, J., Ding, Z., Liu, B., Li, J., Gennis, R.B., Zhu, J.
Deposit date:2019-08-09
Release date:2020-01-15
Last modified:2020-01-29
Method:X-RAY DIFFRACTION (3.75 Å)
Cite:Structure of the cytochromeaa3-600 heme-copper menaquinol oxidase bound to inhibitor HQNO shows TM0 is part of the quinol binding site.
Proc.Natl.Acad.Sci.USA, 117, 2020
6IUP
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CRYSTAL STRUCTURE OF FGFR4 KINASE DOMAIN IN COMPLEX WITH COMPOUND 5
Descriptor:Fibroblast growth factor receptor 4, N-{4-[4-amino-3-(3,5-dimethyl-1-benzofuran-2-yl)-7-oxo-6,7-dihydro-2H-pyrazolo[3,4-d]pyridazin-2-yl]phenyl}prop-2-enamide, DIMETHYL SULFOXIDE
Authors:Xu, Y., Liu, Q.
Deposit date:2018-11-29
Release date:2019-11-06
Method:X-RAY DIFFRACTION (2 Å)
Cite:Discovery and Development of a Series of Pyrazolo[3,4-d]pyridazinone Compounds as the Novel Covalent Fibroblast Growth Factor Receptor Inhibitors by the Rational Drug Design.
J.Med.Chem., 62, 2019
6J0D
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CRYSTAL STRUCTURE OF OSSUF4
Descriptor:transcription factor, ZINC ION
Authors:Wang, B., Luo, Q.
Deposit date:2018-12-24
Release date:2019-11-06
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The transcription factor OsSUF4 interacts with SDG725 in promoting H3K36me3 establishment.
Nat Commun, 10, 2019
167327
數據於2020-08-05公開中