Author results

1APL
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CRYSTAL STRUCTURE OF A MAT-ALPHA2 HOMEODOMAIN-OPERATOR COMPLEX SUGGESTS A GENERAL MODEL FOR HOMEODOMAIN-DNA INTERACTIONS
Descriptor:DNA (5'-D(*AP*CP*AP*TP*GP*TP*AP*AP*TP*TP*CP*AP*TP*TP*TP*AP*C P*AP*CP*GP*C)-3'), DNA (5'-D(*TP*GP*CP*GP*TP*GP*TP*AP*AP*AP*TP*GP*AP*AP*TP*TP*A P*CP*AP*TP*G)-3'), PROTEIN (MAT-ALPHA2 HOMEODOMAIN)
Authors:Wolberger, C., Vershon, A.K., Liu, B., Johnson, A.D., Pabo, C.O.
Deposit date:1993-10-04
Release date:1993-10-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal structure of a MAT alpha 2 homeodomain-operator complex suggests a general model for homeodomain-DNA interactions.
Cell(Cambridge,Mass.), 67, 1991
1B9E
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HUMAN INSULIN MUTANT SERB9GLU
Descriptor:PROTEIN (INSULIN)
Authors:Wang, D.C., Zeng, Z.H., Yao, Z.P., Li, H.M.
Deposit date:1998-11-12
Release date:1999-11-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure of an insulin dimer in an orthorhombic crystal: the structure analysis of a human insulin mutant (B9 Ser-->Glu).
Acta Crystallogr.,Sect.D, 55, 1999
1CN4
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ERYTHROPOIETIN COMPLEXED WITH EXTRACELLULAR DOMAINS OF ERYTHROPOIETIN RECEPTOR
Descriptor:PROTEIN (ERYTHROPOIETIN RECEPTOR), PROTEIN (ERYTHROPOIETIN)
Authors:Stroud, R.M., Reid, S.W.
Deposit date:1999-05-25
Release date:1999-08-11
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Efficiency of signalling through cytokine receptors depends critically on receptor orientation.
Nature, 395, 1998
1DU0
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ENGRAILED HOMEODOMAIN Q50A VARIANT DNA COMPLEX
Descriptor:DNA (5'-D(*TP*TP*TP*TP*GP*CP*CP*AP*TP*GP*TP*AP*AP*TP*TP*AP*CP*CP*TP*AP*A)-3'), DNA (5'-D(*AP*TP*TP*AP*GP*GP*TP*AP*AP*TP*TP*AP*CP*AP*TP*GP*GP*CP*AP*AP*A)-3'), ENGRAILED HOMEODOMAIN
Authors:Grant, R.A., Rould, M.A., Klemm, J.D., Pabo, C.O.
Deposit date:2000-01-13
Release date:2000-07-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Exploring the role of glutamine 50 in the homeodomain-DNA interface: crystal structure of engrailed (Gln50 --> ala) complex at 2.0 A.
Biochemistry, 39, 2000
1EER
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CRYSTAL STRUCTURE OF HUMAN ERYTHROPOIETIN COMPLEXED TO ITS RECEPTOR AT 1.9 ANGSTROMS
Descriptor:ERYTHROPOIETIN, ERYTHROPOIETIN RECEPTOR
Authors:Syed, R.S., Li, C.
Deposit date:1998-07-24
Release date:1999-10-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Efficiency of signalling through cytokine receptors depends critically on receptor orientation.
Nature, 395, 1998
1ENH
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STRUCTURAL STUDIES OF THE ENGRAILED HOMEODOMAIN
Descriptor:ENGRAILED HOMEODOMAIN
Authors:Clarke, N.D., Kissinger, C.R., Desjarlais, J., Gilliland, G.L., Pabo, C.O.
Deposit date:1994-05-20
Release date:1994-08-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural studies of the engrailed homeodomain.
Protein Sci., 3, 1994
1FSH
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STRUCTURAL BASIS OF THE RECOGNITION OF THE DISHEVELLED DEP DOMAIN IN THE WNT SIGNALING PATHWAY
Descriptor:DISHEVELLED-1
Authors:Wong, H.C., Zheng, J.
Deposit date:2000-09-08
Release date:2001-03-08
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structural basis of the recognition of the dishevelled DEP domain in the Wnt signaling pathway.
Nat.Struct.Biol., 7, 2000
1HDD
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CRYSTAL STRUCTURE OF AN ENGRAILED HOMEODOMAIN-DNA COMPLEX AT 2.8 ANGSTROMS RESOLUTION: A FRAMEWORK FOR UNDERSTANDING HOMEODOMAIN-DNA INTERACTIONS
Descriptor:DNA (5'-D(*TP*TP*TP*TP*GP*CP*CP*AP*TP*GP*TP*AP*AP*TP*TP*AP*C P*CP*TP*AP*A)-3'), DNA (5'-D(*AP*TP*TP*AP*GP*GP*TP*AP*AP*TP*TP*AP*CP*AP*TP*GP*G P*CP*AP*AP*A)-3'), PROTEIN (ENGRAILED HOMEODOMAIN)
Authors:Kissinger, C.R., Liu, B., Martin-Blanco, E., Kornberg, T.B., Pabo, C.O.
Deposit date:1991-09-16
Release date:1992-01-15
Last modified:2017-02-15
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structure of an engrailed homeodomain-DNA complex at 2.8 A resolution: a framework for understanding homeodomain-DNA interactions.
Cell(Cambridge,Mass.), 63, 1990
1HPX
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HIV-1 PROTEASE COMPLEXED WITH THE INHIBITOR KNI-272
Descriptor:HIV-1 PROTEASE, (4R)-N-tert-butyl-3-[(2S,3S)-2-hydroxy-3-({N-[(isoquinolin-5-yloxy)acetyl]-S-methyl-L-cysteinyl}amino)-4-phenylbutanoyl]-1,3-thiazolidine-4-carboxamide
Authors:Bhat, T.N., Erickson, J.W.
Deposit date:1995-05-18
Release date:1996-03-08
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of HIV-1 protease with KNI-272, a tight-binding transition-state analog containing allophenylnorstatine.
Structure, 3, 1995
1HVC
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CRYSTAL STRUCTURE OF A TETHERED DIMER OF HIV-1 PROTEASE COMPLEXED WITH AN INHIBITOR
Descriptor:HIV-1 PROTEASE, N-{1-BENZYL-(2S,3S)-2,3-DIHYDROXY-4-[3-METHYL-2-(3-METHYL-3-PYRIDIN-2-YLMETHYL-UREIDO)-BUTYRYLAMINO]-5-PHENYL-PENTYL}-3-METHYL-2-(3-METHYL-3-PYRIDIN-2-YLMETHYL-UREIDO)-BUTYRAMIDE
Authors:Bhat, T.N., Baldwin, E.T., Erickson, J.W.
Deposit date:1994-06-22
Release date:1994-10-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of a tethered dimer of HIV-1 proteinase complexed with an inhibitor.
Nat.Struct.Biol., 1, 1994
1HVI
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INFLUENCE OF STEREOCHEMISTRY ON ACTIVITY AND BINDING MODES FOR C2 SYMMETRY-BASED DIOL INHIBITORS OF HIV-1 PROTEASE
Descriptor:HIV-1 PROTEASE, N-{1-BENZYL-(2R,3S)-2,3-DIHYDROXY-4-[3-METHYL-2-(3-METHYL-3-PYRIDIN-2-YLMETHYL-UREIDO)-BUTYRYLAMINO]-5-PHENYL-PENTYL}-3-METHYL-2-(3-METHYL-3-PYRIDIN-2-YLMETHYL-UREIDO)-BUTYRAMIDE
Authors:Bhat, T.N., Hosur, M.V., Baldwin, E.T., Erickson, J.W.
Deposit date:1994-01-26
Release date:1994-04-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Influence of Stereochemistry on Activity and Binding Modes for C2 Symmetry-Based Diol Inhibitors of HIV-1 Protease
J.Am.Chem.Soc., 116, 1994
1HVJ
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INFLUENCE OF STEREOCHEMISTRY ON ACTIVITY AND BINDING MODES FOR C2 SYMMETRY-BASED DIOL INHIBITORS OF HIV-1 PROTEASE
Descriptor:HIV-1 PROTEASE, N-{1-BENZYL-3-HYDROXY-4-[3-METHYL-2-(3-METHYL-3-PYRIDIN-2-YLMETHYL-UREIDO)-BUTYRYLAMINO]-5-PHENYL-PENTYL}-3-METHYL-2-(3-METHYL-3-PYRIDIN-2-YLMETHYL-UREIDO)-BUTYRAMIDE
Authors:Bhat, T.N., Hosur, M.V., Baldwin, E.T., Erickson, J.W.
Deposit date:1994-01-26
Release date:1994-04-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Influence of Stereochemistry on Activity and Binding Modes for C2 Symmetry-Based Diol Inhibitors of HIV-1 Protease
J.Am.Chem.Soc., 116, 1994
1HVK
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INFLUENCE OF STEREOCHEMISTRY ON ACTIVITY AND BINDING MODES FOR C2 SYMMETRY-BASED DIOL INHIBITORS OF HIV-1 PROTEASE
Descriptor:HIV-1 PROTEASE, N-{1-BENZYL-(2S,3S)-2,3-DIHYDROXY-4-[3-METHYL-2-(3-METHYL-3-PYRIDIN-2-YLMETHYL-UREIDO)-BUTYRYLAMINO]-5-PHENYL-PENTYL}-3-METHYL-2-(3-METHYL-3-PYRIDIN-2-YLMETHYL-UREIDO)-BUTYRAMIDE
Authors:Bhat, T.N., Hosur, M.V., Baldwin, E.T., Erickson, J.W.
Deposit date:1994-01-26
Release date:1994-04-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Influence of Stereochemistry on Activity and Binding Modes for C2 Symmetry-Based Diol Inhibitors of HIV-1 Protease
J.Am.Chem.Soc., 116, 1994
1HVL
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INFLUENCE OF STEREOCHEMISTRY ON ACTIVITY AND BINDING MODES FOR C2 SYMMETRY-BASED DIOL INHIBITORS OF HIV-1 PROTEASE
Descriptor:HIV-1 PROTEASE, N-{1-BENZYL-(2R,3R)-2,3-DIHYDROXY-4-[3-METHYL-2-(3-METHYL-3-PYRIDIN-2-YLMETHYL-UREIDO)-BUTYRYLAMINO]-5-PHENYL-PENTYL}-3-METHYL-2-(3-METHYL-3-PYRIDIN-2-YLMETHYL-UREIDO)-BUTYRAMIDE
Authors:Bhat, T.N., Hosur, M.V., Baldwin, E.T., Erickson, J.W.
Deposit date:1994-01-26
Release date:1994-04-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Influence of Stereochemistry on Activity and Binding Modes for C2 Symmetry-Based Diol Inhibitors of HIV-1 Protease
J.Am.Chem.Soc., 116, 1994
1HVS
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STRUCTURAL BASIS OF DRUG RESISTANCE FOR THE V82A MUTANT OF HIV-1 PROTEASE: BACKBONE FLEXIBILITY AND SUBSITE REPACKING
Descriptor:HIV-1 PROTEASE, N-{1-BENZYL-(2R,3S)-2,3-DIHYDROXY-4-[3-METHYL-2-(3-METHYL-3-PYRIDIN-2-YLMETHYL-UREIDO)-BUTYRYLAMINO]-5-PHENYL-PENTYL}-3-METHYL-2-(3-METHYL-3-PYRIDIN-2-YLMETHYL-UREIDO)-BUTYRAMIDE
Authors:Baldwin, E.T., Bhat, T.N., Liu, B., Pattabiraman, N., Erickson, J.W.
Deposit date:1994-11-17
Release date:1995-02-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Structural basis of drug resistance for the V82A mutant of HIV-1 proteinase.
Nat.Struct.Biol., 2, 1995
1MNM
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YEAST MATALPHA2/MCM1/DNA TERNARY TRANSCRIPTION COMPLEX CRYSTAL STRUCTURE
Descriptor:DNA (STE6 OPERATOR DNA), PROTEIN (MCM1 TRANSCRIPTIONAL REGULATOR), PROTEIN (MAT ALPHA-2 TRANSCRIPTIONAL REPRESSOR)
Authors:Tan, S., Richmond, T.J.
Deposit date:1997-11-03
Release date:1998-03-18
Last modified:2017-02-15
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Crystal structure of the yeast MATalpha2/MCM1/DNA ternary complex.
Nature, 391, 1998
1STR
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STREPTAVIDIN DIMERIZED BY DISULFIDE-BONDED PEPTIDE AC-CHPQNT-NH2 DIMER
Descriptor:STREPTAVIDIN, AC-CHPQNT-NH2
Authors:Katz, B.A., Cass, R.T., Liu, B., Arze, R., Collins, N.
Deposit date:1995-09-12
Release date:1996-03-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Topochemical catalysis achieved by structure-based ligand design.
J.Biol.Chem., 270, 1995
1STS
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STREPTAVIDIN DIMERIZED BY DISULFIDE-BONDED PEPTIDE FCHPQNT-NH2 DIMER
Descriptor:STREPTAVIDIN, FCHPQNT-NH2
Authors:Katz, B.A., Cass, R.T., Liu, B., Arze, R., Collins, N.
Deposit date:1995-09-12
Release date:1996-03-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Topochemical catalysis achieved by structure-based ligand design.
J.Biol.Chem., 270, 1995
1T0Z
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STRUCTURE OF AN EXCITATORY INSECT-SPECIFIC TOXIN WITH AN ANALGESIC EFFECT ON MAMMALIAN FROM SCORPION BUTHUS MARTENSII KARSCH
Descriptor:insect neurotoxin, SULFATE ION
Authors:Li, C., Guan, R.-J., Xiang, Y., Zhang, Y., Wang, D.-C.
Deposit date:2004-04-14
Release date:2004-12-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure of an excitatory insect-specific toxin with an analgesic effect on mammals from the scorpion Buthus martensii Karsch.
Acta Crystallogr.,Sect.D, 61, 2005
1UDE
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CRYSTAL STRUCTURE OF THE INORGANIC PYROPHOSPHATASE FROM THE HYPERTHERMOPHILIC ARCHAEON PYROCOCCUS HORIKOSHII OT3
Descriptor:Inorganic pyrophosphatase
Authors:Liu, B., Gao, R., Zhou, W., Bartlam, M., Rao, Z.
Deposit date:2003-04-29
Release date:2004-01-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.66 Å)
Cite:Crystal Structure of the Hyperthermophilic Inorganic Pyrophosphatase from the Archaeon Pyrococcus horikoshii.
Biophys.J., 86, 2004
1VWA
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STREPTAVIDIN-FSHPQNT
Descriptor:STREPTAVIDIN, PEPTIDE LIGAND CONTAINING HPQ
Authors:Katz, B.A., Cass, R.T.
Deposit date:1997-03-03
Release date:1998-03-18
Last modified:2011-11-16
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:In crystals of complexes of streptavidin with peptide ligands containing the HPQ sequence the pKa of the peptide histidine is less than 3.0.
J.Biol.Chem., 272, 1997
1VWB
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STREPTAVIDIN-CYCLO-AC-[CHPQFC]-NH2, PH 11.8
Descriptor:STREPTAVIDIN, PEPTIDE LIGAND CONTAINING HPQ
Authors:Katz, B.A., Cass, R.T.
Deposit date:1997-03-03
Release date:1998-03-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.82 Å)
Cite:In crystals of complexes of streptavidin with peptide ligands containing the HPQ sequence the pKa of the peptide histidine is less than 3.0.
J.Biol.Chem., 272, 1997
1VWC
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STREPTAVIDIN-CYCLO-AC-[CHPQFC]-NH2, PH 2.0
Descriptor:STREPTAVIDIN, PEPTIDE LIGAND CONTAINING HPQ
Authors:Katz, B.A., Cass, R.T.
Deposit date:1997-03-03
Release date:1998-03-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:In crystals of complexes of streptavidin with peptide ligands containing the HPQ sequence the pKa of the peptide histidine is less than 3.0.
J.Biol.Chem., 272, 1997
1VWD
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STREPTAVIDIN-CYCLO-AC-[CHPQFC]-NH2, PH 3.0
Descriptor:STREPTAVIDIN, PEPTIDE LIGAND CONTAINING HPQ
Authors:Katz, B.A., Cass, R.T.
Deposit date:1997-03-03
Release date:1998-03-18
Last modified:2011-11-16
Method:X-RAY DIFFRACTION (1.87 Å)
Cite:In crystals of complexes of streptavidin with peptide ligands containing the HPQ sequence the pKa of the peptide histidine is less than 3.0.
J.Biol.Chem., 272, 1997
1VWE
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STREPTAVIDIN-CYCLO-AC-[CHPQFC]-NH2, PH 3.6
Descriptor:STREPTAVIDIN, PEPTIDE LIGAND CONTAINING HPQ
Authors:Katz, B.A., Cass, R.T.
Deposit date:1997-03-03
Release date:1998-03-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:In crystals of complexes of streptavidin with peptide ligands containing the HPQ sequence the pKa of the peptide histidine is less than 3.0.
J.Biol.Chem., 272, 1997