Author results

1ZZQ
  • Download 1zzq
  • View 1zzq
Molmil generated image of 1zzq
RAT NNOS D597N MUTANT WITH L-N(OMEGA)-NITROARGININE-(4R)-AMINO-L-PROLINE AMIDE BOUND
Descriptor:Nitric-oxide synthase, brain, ACETATE ION, ...
Authors:Li, H., Flinspach, M.L., Igarashi, J., Jamal, J., Yang, W., Gomez-Vidal, J.A., Litzinger, E.A., Silverman, R.B., Poulos, T.L.
Deposit date:2005-06-14
Release date:2005-12-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Exploring the Binding Conformations of Bulkier Dipeptide Amide Inhibitors in Constitutive Nitric Oxide Synthases.
Biochemistry, 44, 2005
1ZZR
  • Download 1zzr
  • View 1zzr
Molmil generated image of 1zzr
RAT NNOS D597N/M336V DOUBLE MUTANT WITH L-N(OMEGA)-NITROARGININE-(4R)-AMINO-L-PROLINE AMIDE BOUND
Descriptor:Nitric-oxide synthase, brain, ZINC ION, ...
Authors:Li, H., Flinspach, M.L., Igarashi, J., Jamal, J., Yang, W., Gomez-Vidal, J.A., Litzinger, E.A., Silverman, R.B., Poulos, T.L.
Deposit date:2005-06-14
Release date:2005-12-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Exploring the Binding Conformations of Bulkier Dipeptide Amide Inhibitors in Constitutive Nitric Oxide Synthases.
Biochemistry, 44, 2005
1ZZS
  • Download 1zzs
  • View 1zzs
Molmil generated image of 1zzs
BOVINE ENOS N368D SINGLE MUTANT WITH L-N(OMEGA)-NITROARGININE-(4R)-AMINO-L-PROLINE AMIDE BOUND
Descriptor:Nitric-oxide synthase, endothelial, ACETATE ION, ...
Authors:Li, H., Flinspach, M.L., Igarashi, J., Jamal, J., Yang, W., Gomez-Vidal, J.A., Litzinger, E.A., Silverman, R.B., Poulos, T.L.
Deposit date:2005-06-14
Release date:2005-12-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Exploring the Binding Conformations of Bulkier Dipeptide Amide Inhibitors in Constitutive Nitric Oxide Synthases.
Biochemistry, 44, 2005
1ZZT
  • Download 1zzt
  • View 1zzt
Molmil generated image of 1zzt
BOVINE ENOS N368D/V106M DOUBLE MUTANT WITH L-N(OMEGA)-NITROARGININE-(4R)-AMINO-L-PROLINE AMIDE BOUND
Descriptor:Nitric-oxide synthase, endothelial, ACETATE ION, ...
Authors:Li, H., Flinspach, M.L., Igarashi, J., Jamal, J., Yang, W., Gomez-Vidal, J.A., Litzinger, E.A., Silverman, R.B., Poulos, T.L.
Deposit date:2005-06-14
Release date:2005-12-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.14 Å)
Cite:Exploring the Binding Conformations of Bulkier Dipeptide Amide Inhibitors in Constitutive Nitric Oxide Synthases.
Biochemistry, 44, 2005
1ZZU
  • Download 1zzu
  • View 1zzu
Molmil generated image of 1zzu
RAT NNOS D597N/M336V DOUBLE MUTANT WITH L-N(OMEGA)-NITROARGININE-2,4-L-DIAMINOBUTYRIC AMIDE BOUND
Descriptor:Nitric-oxide synthase, brain, ACETATE ION, ...
Authors:Li, H., Flinspach, M.L., Igarashi, J., Jamal, J., Yang, W., Gomez-Vidal, J.A., Litzinger, E.A., Silverman, R.B., Poulos, T.L.
Deposit date:2005-06-14
Release date:2005-12-06
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Exploring the Binding Conformations of Bulkier Dipeptide Amide Inhibitors in Constitutive Nitric Oxide Synthases.
Biochemistry, 44, 2005
1P6H
  • Download 1p6h
  • View 1p6h
Molmil generated image of 1p6h
RAT NEURONAL NOS HEME DOMAIN WITH L-N(OMEGA)-NITROARGININE-2,4-L-DIAMINOBUTYRIC AMIDE BOUND
Descriptor:Nitric-oxide synthase, brain, ACETATE ION, ...
Authors:Flinspach, M.L., Li, H., Jamal, J., Yang, W., Huang, H., Hah, J.-M., Gomez-Vidal, J.A., Litzinger, E.A., Silverman, R.B., Poulos, T.L.
Deposit date:2003-04-29
Release date:2004-01-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Structural basis for dipeptide amide isoform-selective inhibition of neuronal nitric oxide synthase.
Nat.Struct.Mol.Biol., 11, 2004
1P6I
  • Download 1p6i
  • View 1p6i
Molmil generated image of 1p6i
RAT NEURONAL NOS HEME DOMAIN WITH (4S)-N-(4-AMINO-5-[AMINOETHYL]AMINOPENTYL)-N'-NITROGUANIDINE BOUND
Descriptor:Nitric-oxide synthase, brain, ACETATE ION, ...
Authors:Flinspach, M.L., Li, H., Jamal, J., Yang, W., Huang, H., Hah, J.-M., Gomez-Vidal, J.A., Litzinger, E.A., Silverman, R.B., Poulos, T.L.
Deposit date:2003-04-29
Release date:2004-01-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural basis for dipeptide amide isoform-selective inhibition of neuronal nitric oxide synthase.
Nat.Struct.Mol.Biol., 11, 2004
1P6J
  • Download 1p6j
  • View 1p6j
Molmil generated image of 1p6j
RAT NEURONAL NOS HEME DOMAIN WITH L-N(OMEGA)-NITROARGININE-(4R)-AMINO-L-PROLINE AMIDE BOUND
Descriptor:Nitric-oxide synthase, brain, ACETATE ION, ...
Authors:Flinspach, M.L., Li, H., Jamal, J., Yang, W., Huang, H., Hah, J.-M., Gomez-Vidal, J.A., Litzinger, E.A., Silverman, R.B., Poulos, T.L.
Deposit date:2003-04-29
Release date:2004-01-13
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural basis for dipeptide amide isoform-selective inhibition of neuronal nitric oxide synthase.
Nat.Struct.Mol.Biol., 11, 2004
1P6K
  • Download 1p6k
  • View 1p6k
Molmil generated image of 1p6k
RAT NEURONAL NOS D597N MUTANT HEME DOMAIN WITH L-N(OMEGA)-NITROARGININE-2,4-L-DIAMINOBUTYRIC AMIDE BOUND
Descriptor:Nitric-oxide synthase, brain, D-MANNITOL, ...
Authors:Flinspach, M.L., Li, H., Jamal, J., Yang, W., Huang, H., Hah, J.-M., Gomez-Vidal, J.A., Litzinger, E.A., Silverman, R.B., Poulos, T.L.
Deposit date:2003-04-29
Release date:2004-01-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:Structural basis for dipeptide amide isoform-selective inhibition of neuronal nitric oxide synthase.
Nat.Struct.Mol.Biol., 11, 2004
1P6L
  • Download 1p6l
  • View 1p6l
Molmil generated image of 1p6l
BOVINE ENDOTHELIAL NOS HEME DOMAIN WITH L-N(OMEGA)-NITROARGININE-2,4-L-DIAMINOBUTYRIC AMIDE BOUND
Descriptor:Nitric-oxide synthase, endothelial, CACODYLATE ION, ...
Authors:Flinspach, M.L., Li, H., Jamal, J., Yang, W., Huang, H., Hah, J.-M., Gomez-Vidal, J.A., Litzinger, E.A., Silverman, R.B., Poulos, T.L.
Deposit date:2003-04-29
Release date:2004-01-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Structural basis for dipeptide amide isoform-selective inhibition of neuronal nitric oxide synthase.
Nat.Struct.Mol.Biol., 11, 2004
1P6M
  • Download 1p6m
  • View 1p6m
Molmil generated image of 1p6m
BOVINE ENDOTHELIAL NOS HEME DOMAIN WITH (4S)-N-(4-AMINO-5-[AMINOETHYL]AMINOPENTYL)-N'-NITROGUANIDINE BOUND
Descriptor:Nitric-oxide synthase, endothelial, CACODYLATE ION, ...
Authors:Flinspach, M.L., Li, H., Jamal, J., Yang, W., Huang, H., Hah, J.-M., Gomez-Vidal, J.A., Litzinger, E.A., Silverman, R.B., Poulos, T.L.
Deposit date:2003-04-29
Release date:2004-01-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.27 Å)
Cite:Structural basis for dipeptide amide isoform-selective inhibition of neuronal nitric oxide synthase.
Nat.Struct.Mol.Biol., 11, 2004
1P6N
  • Download 1p6n
  • View 1p6n
Molmil generated image of 1p6n
BOVINE ENDOTHELIAL NOS HEME DOMAIN WITH L-N(OMEGA)-NITROARGININE-(4R)-AMINO-L-PROLINE AMIDE BOUND
Descriptor:Nitric-oxide synthase, endothelial, CACODYLATE ION, ...
Authors:Flinspach, M.L., Li, H., Jamal, J., Yang, W., Huang, H., Hah, J.-M., Gomez-Vidal, J.A., Litzinger, E.A., Silverman, R.B., Poulos, T.L.
Deposit date:2003-04-29
Release date:2004-01-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural basis for dipeptide amide isoform-selective inhibition of neuronal nitric oxide synthase.
Nat.Struct.Mol.Biol., 11, 2004
1Q2O
  • Download 1q2o
  • View 1q2o
Molmil generated image of 1q2o
BOVINE ENDOTHELIAL NITRIC OXIDE SYNTHASE N368D MUTANT HEME DOMAIN DIMER WITH L-N(OMEGA)-NITROARGININE-2,4-L-DIAMINOBUTYRAMIDE BOUND
Descriptor:Nitric-oxide synthase, endothelial, CACODYLATE ION, ...
Authors:Flinspach, M.L., Li, H., Jamal, J., Yang, W., Huang, H., Hah, J.M., Gomez-Vidal, J.A., Litzinger, E.A., Silverman, R.B., Poulos, T.L.
Deposit date:2003-07-25
Release date:2004-01-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.74 Å)
Cite:Structural basis for dipeptide amide isoform-selective inhibition of neuronal nitric oxide synthase.
Nat.Struct.Mol.Biol., 11, 2004
2HX2
  • Download 2hx2
  • View 2hx2
Molmil generated image of 2hx2
BOVINE ENOS HEME DOMAIN COMPLEXED WITH (4S)-N-{4-AMINO-5-[(2-AMINOETHYL)-HYDROXYAMINO]-PENTYL}-N'-NITROGUANIDINE
Descriptor:Nitric-oxide synthase, CACODYLATE ION, ACETATE ION, ...
Authors:Igarashi, J., Li, H., Poulos, T.L.
Deposit date:2006-08-02
Release date:2007-04-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structure-Based Design and Synthesis of N(omega)-Nitro-l-Arginine-Containing Peptidomimetics as Selective Inhibitors of Neuronal Nitric Oxide Synthase. Displacement of the Heme Structural Water.
J.Med.Chem., 50, 2007
2HX3
  • Download 2hx3
  • View 2hx3
Molmil generated image of 2hx3
RAT NNOS HEME DOMAIN COMPLEXED WITH (4S)-N-{4-AMINO-5-[(2-AMINOETHYL)-HYDROXYAMINO]-PENTYL}-N'-NITROGUANIDINE
Descriptor:Nitric-oxide synthase, ACETATE ION, ZINC ION, ...
Authors:Igarashi, J., Li, H., Poulos, T.L.
Deposit date:2006-08-02
Release date:2007-04-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure-Based Design and Synthesis of N(omega)-Nitro-l-Arginine-Containing Peptidomimetics as Selective Inhibitors of Neuronal Nitric Oxide Synthase. Displacement of the Heme Structural Water.
J.Med.Chem., 50, 2007
2HX4
  • Download 2hx4
  • View 2hx4
Molmil generated image of 2hx4
RAT NNOS HEME DOMAIN COMPLEXED WITH 4-N-(NW-NITRO-L-ARGININYL)-TRANS-4-HYDROXYAMINO-L-PROLINE AMIDE
Descriptor:Nitric-oxide synthase, ACETATE ION, ZINC ION, ...
Authors:Igarashi, J., Li, H., Poulos, T.L.
Deposit date:2006-08-02
Release date:2007-04-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Structure-Based Design and Synthesis of N(omega)-Nitro-l-Arginine-Containing Peptidomimetics as Selective Inhibitors of Neuronal Nitric Oxide Synthase. Displacement of the Heme Structural Water.
J.Med.Chem., 50, 2007