Author results

1FLI
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DNA-BINDING DOMAIN OF FLI-1
Descriptor:FLI-1
Authors:Liang, H., Mao, X., Olejniczak, E.T., Nettesheim, D.G., Yu, L., Meadows, R.P., Thompson, C.B., Fesik, S.W.
Deposit date:1994-09-15
Release date:1995-09-15
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure of the ets domain of Fli-1 when bound to DNA.
Nat.Struct.Biol., 1, 1994
2KI0
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NMR STRUCTURE OF A DE NOVO DESIGNED BETA ALPHA BETA
Descriptor:DS119
Authors:Liang, H., Chen, H., Fan, K., Wei, P., Guo, X., Jin, C., Zeng, C., Tang, C., Lai, L.
Deposit date:2009-04-18
Release date:2009-10-20
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:De novo design of a beta alpha beta motif.
Angew.Chem.Int.Ed.Engl., 48, 2009
1DHM
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DNA-BINDING DOMAIN OF E2 FROM HUMAN PAPILLOMAVIRUS-31, NMR, MINIMIZED AVERAGE STRUCTURE
Descriptor:E2 PROTEIN
Authors:Liang, H., Petros, A.P., Meadows, R.P., Yoon, H.S., Egan, D.A., Walter, K., Holzman, T.F., Robins, T., Fesik, S.W.
Deposit date:1995-08-15
Release date:1996-12-07
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure of the DNA-binding domain of a human papillomavirus E2 protein: evidence for flexible DNA-binding regions.
Biochemistry, 35, 1996
1ONY
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OXALYL-ARYL-AMINO BENZOIC ACID INHIBITORS OF PTP1B, COMPOUND 17
Descriptor:Protein-tyrosine phosphatase, non-receptor type 1, 2-{[2-(2-CARBAMOYL-VINYL)-4-(2-METHANESULFONYLAMINO-2-PENTYLCARBAMOYL-ETHYL)-PHENYL]-OXALYL-AMINO}-BENZOIC ACID
Authors:Liu, G., Szczepankiewicz, B.G., Pei, Z., Janowich, D.A., Xin, Z., Hadjuk, P.J., Abad-Zapatero, C., Liang, H., Hutchins, C.W., Fesik, S.W., Ballaron, S.J., Stashko, M.A., Lubben, T., Mika, A.K., Zinker, B.A., Trevillyan, J.M., Jirousek, M.R.
Deposit date:2003-03-02
Release date:2003-05-20
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Discovery and Structure-Activity Relationship of Oxalylarylaminobenzoic Acids as Inhibitors of Protein Tyrosine Phosphatase 1B
J.Med.Chem., 46, 2003
1ONZ
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OXALYL-ARYL-AMINO BENZOIC ACID INHIBITORS OF PTP1B, COMPOUND 8B
Descriptor:Protein-tyrosine phosphatase, non-receptor type 1, 2-[(7-HYDROXY-NAPHTHALEN-1-YL)-OXALYL-AMINO]-BENZOIC ACID
Authors:Liu, G., Szczepankiewicz, B.G., Pei, Z., Janowich, D.A., Xin, Z., Hadjuk, P.J., Abad-Zapatero, C., Liang, H., Hutchins, C.W., Fesik, S.W., Ballaron, S.J., Stashko, M.A., Lubben, T., Mika, A.K., Zinker, B.A., Trevillyan, J.M., Jirousek, M.R.
Deposit date:2003-03-02
Release date:2003-05-20
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Discovery and Structure-Activity Relationship of Oxalylarylaminobenzoic Acids as Inhibitors of Protein Tyrosine Phosphatase 1B
J.Med.Chem., 46, 2003
1PYN
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DUAL-SITE POTENT, SELECTIVE PROTEIN TYROSINE PHOSPHATASE 1B INHIBITOR USING A LINKED FRAGMENT STRATEGY AND A MALONATE HEAD ON THE FIRST SITE
Descriptor:Protein-tyrosine phosphatase, non-receptor type 1, 2-(4-{2-TERT-BUTOXYCARBONYLAMINO-2-[4-(3-HYDROXY-2-METHOXYCARBONYL-PHENOXY)-BUTYLCARBAMOYL]-ETHYL}-PHENOXY)-MALONIC ACID
Authors:Szczepankiewicz, B.G., Liu, G., Hajduk, P.J., Abad-Zapatero, C., Zhonghua, P., Lubben, T., Trevillyan, J.M., Stashko, M., Ballaron, S.J., Liang, H.
Deposit date:2003-07-09
Release date:2003-09-16
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Discovery and SAR of novel, potent and selective protein tyrosine phosphatase 1B inhibitors.
Bioorg.Med.Chem.Lett., 13, 2003
4G1T
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CRYSTAL STRUCTURE OF INTERFERON-STIMULATED GENE 54
Descriptor:Interferon-induced protein with tetratricopeptide repeats 2
Authors:Yang, Z., Liang, H., Zhou, Q., Li, Y., Chen, H., Ye, W., Chen, D., Fleming, J., Shu, H., Liu, Y.
Deposit date:2012-07-11
Release date:2012-08-15
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structure of ISG54 reveals a novel RNA binding structure and potential functional mechanisms.
Cell Res., 2012
5J2Y
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MOLECULAR INSIGHT INTO THE REGULATORY MECHANISM OF THE QUORUM-SENSING REPRESSOR RSAL IN PSEUDOMONAS AERUGINOSA
Descriptor:Regulatory protein, DNA (26-MER)
Authors:Zhao, J., Gan, J., Zhang, J., Kang, H., Kong, W., Zhu, M., Li, F., Song, Y., Qin, J., Liang, H.
Deposit date:2016-03-30
Release date:2017-04-12
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Molecular insight into the regulatory mechanism of the quorum-sensing repressor RsaL in Pseudomonas aeruginosa
To Be Published
5XF7
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CRYSTAL STRUCTURE OF HUMAN PROTEIN DISULFIDE ISOMERASE-LIKE PROTEIN OF THE TESTIS
Descriptor:Protein disulfide-isomerase-like protein of the testis
Authors:Li, H., Li, J., Liu, Y., Liang, H.
Deposit date:2017-04-08
Release date:2017-12-13
Last modified:2018-02-07
Method:X-RAY DIFFRACTION (2.381 Å)
Cite:Crystal and solution structures of human protein-disulfide isomerase-like protein of the testis (PDILT) provide insight into its chaperone activity
J. Biol. Chem., 293, 2018
1BXL
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STRUCTURE OF BCL-XL/BAK PEPTIDE COMPLEX, NMR, MINIMIZED AVERAGE STRUCTURE
Descriptor:BCL-XL, BAK PEPTIDE
Authors:Sattler, M., Liang, H., Nettesheim, D., Meadows, R.P., Harlan, J.E., Eberstadt, M., Yoon, H., Shuker, S.B., Chang, B.S., Minn, A.J., Thompson, C.B., Fesik, S.W.
Deposit date:1996-10-16
Release date:1997-10-29
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structure of Bcl-xL-Bak peptide complex: recognition between regulators of apoptosis.
Science, 275, 1997
4HQM
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THE CRYSTAL STRUCTURE OF QSRR-MENADIONE COMPLEX
Descriptor:QsrR protein, 2-methylnaphthalene-1,4-diol
Authors:Ji, Q., Zhang, L., Jones, M.B., Sun, F., Deng, X., Liang, H., Brugarolas, P., Gao, N., Peterson, S.N., Lan, L., Bae, T., He, C.
Deposit date:2012-10-25
Release date:2013-03-06
Last modified:2013-05-22
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Molecular mechanism of quinone signaling mediated through S-quinonization of a YodB family repressor QsrR.
Proc.Natl.Acad.Sci.USA, 110, 2013
5I5N
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CRYSTAL STRUCTURE OF N-TERMINAL DOMAIN OF MATRIX PROTEIN OF THOGOTO VIRUS AT ACIDIC PH.
Descriptor:Matrix protein
Authors:Liu, Y., Liang, H., Yang, M.
Deposit date:2016-02-15
Release date:2016-08-17
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (1.418 Å)
Cite:pH-dependent conformational changes of a Thogoto virus matrix protein reveal mechanisms of viral assembly and uncoating
J.Gen.Virol., 97, 2016
5I5O
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CRYSTAL STRUCTURE OF N-TERMINAL DOMAIN OF MATRIX PROTEIN OF THOGOTO VIRUS AT NEUTRAL PH.
Descriptor:Matrix protein
Authors:Liu, Y., Liang, H., Yang, M.
Deposit date:2016-02-15
Release date:2016-08-17
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.682 Å)
Cite:pH-dependent conformational changes of a Thogoto virus matrix protein reveal mechanisms of viral assembly and uncoating
J.Gen.Virol., 97, 2016
1LXL
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NMR STRUCTURE OF BCL-XL, AN INHIBITOR OF PROGRAMMED CELL DEATH, MINIMIZED AVERAGE STRUCTURE
Descriptor:BCL-XL
Authors:Muchmore, S.W., Sattler, M., Liang, H., Meadows, R.P., Harlan, J.E., Yoon, H.S., Nettesheim, D., Chang, B.S., Thompson, C.B., Wong, S.L., Ng, S.C., Fesik, S.W.
Deposit date:1996-04-04
Release date:1997-04-21
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death.
Nature, 381, 1996
1MAZ
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X-RAY STRUCTURE OF BCL-XL, AN INHIBITOR OF PROGRAMMED CELL DEATH
Descriptor:Bcl-2-like protein 1
Authors:Muchmore, S.W., Sattler, M., Liang, H., Meadows, R.P., Harlan, J.E., Yoon, H.S., Nettesheim, D., Chang, B.S., Thompson, C.B., Wong, S.L., Ng, S.C., Fesik, S.W.
Deposit date:1996-04-09
Release date:1997-04-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death.
Nature, 381, 1996
1NL9
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POTENT, SELECTIVE PROTEIN TYROSINE PHOSPHATASE 1B INHIBITOR COMPOUND 12 USING A LINKED-FRAGMENT STRATEGY
Descriptor:Protein-tyrosine phosphatase, non-receptor type 1, 2-{[4-(2-ACETYLAMINO-2-PENTYLCARBAMOYL-ETHYL)-NAPHTHALEN-1-YL]-OXALYL-AMINO}-BENZOIC ACID
Authors:Szczepankiewicz, B.G., Liu, G., Hajduk, P.J., Abad-Zapatero, C., Pei, Z., Xin, Z., Lubben, T., Trevillyan, J.M., Stashko, M.A., Ballaron, S.J., Liang, H., Huang, F., Hutchins, C.W., Fesik, S.W., Jirousek, M.R.
Deposit date:2003-01-06
Release date:2003-04-08
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Discovery of a Potent, Selective Protein Tyrosine Phosphatase 1B Inhibitor Using a Linked-Fragment Strategy
J.Am.Chem.Soc., 125, 2003
1NNY
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POTENT, SELECTIVE PROTEIN TYROSINE PHOSPHATASE 1B INHIBITOR COMPOUND 23 USING A LINKED-FRAGMENT STRATEGY
Descriptor:Protein-tyrosine phosphatase, non-receptor type 1, 3-({5-[(N-ACETYL-3-{4-[(CARBOXYCARBONYL)(2-CARBOXYPHENYL)AMINO]-1-NAPHTHYL}-L-ALANYL)AMINO]PENTYL}OXY)-2-NAPHTHOIC ACID
Authors:Szczepankiewicz, B.G., Liu, G., Hajduk, P.J., Abad-Zapatero, C., Pei, Z., Xin, Z., Lubben, T., Trevillyan, J.M., Stashko, M.A., Ballaron, S.J., Liang, H., Huang, F., Hutchins, C.W., Fesik, S.W., Jirousek, M.R.
Deposit date:2003-01-14
Release date:2003-04-08
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Discovery of a Potent, Selective Protein Tyrosine Phosphatase 1B Inhibitor Using a Linked-Fragment Strategy
J.Am.Chem.Soc., 125, 2003
1NO6
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POTENT, SELECTIVE PROTEIN TYROSINE PHOSPHATASE 1B INHIBITOR COMPOUND 5 USING A LINKED-FRAGMENT STRATEGY
Descriptor:Protein-tyrosine phosphatase, non-receptor type 1, 2-[(CARBOXYCARBONYL)(1-NAPHTHYL)AMINO]BENZOIC ACID
Authors:Szczepankiewicz, B.G., Liu, G., Hajduk, P.J., Abad-Zapatero, C., Pei, Z., Xin, Z., Lubben, T., Trevillyan, J.M., Stashko, M.A., Ballaron, S.J., Liang, H., Huang, F., Hutchins, C.W., Fesik, S.W., Jirousek, M.R.
Deposit date:2003-01-15
Release date:2003-04-08
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Discovery of a Potent, Selective Protein Tyrosine Phosphatase 1B Inhibitor Using a Linked-Fragment Strategy
J.Am.Chem.Soc., 125, 2003
1PH0
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NON-CARBOXYLIC ACID-CONTAINING INHIBITOR OF PTP1B TARGETING THE SECOND PHOSPHOTYROSINE SITE
Descriptor:Protein-tyrosine phosphatase, non-receptor type 1, 2-{4-[2-(S)-ALLYLOXYCARBONYLAMINO-3-{4-[(2-CARBOXY-PHENYL)-OXALYL-AMINO]-PHENYL}-PROPIONYLAMINO]-BUTOXY}-6-HYDROXY-BENZOIC ACID METHYL ESTER
Authors:Liu, G., Xin, Z., Liang, H., Abad-Zapatero, C., Hajduk, P., Janowick, D., Szczepankiewicz, B., Pei, Z., Hutchins, C.W., Ballaron, S.J.
Deposit date:2003-05-29
Release date:2003-07-29
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Selective Protein Tyrosine Phosphatase 1B Inhibitors: Targeting the Second Phosphotyrosine Binding Site with Non-Carboxylic Acid-Containing Ligands.
J.Med.Chem., 46, 2003
4EFO
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CRYSTAL STRUCTURE OF THE UBIQUITIN-LIKE DOMAIN OF HUMAN TBK1
Descriptor:Serine/threonine-protein kinase TBK1
Authors:Li, J., Li, J., Miyahira, A., Sun, J., Liu, Y., Cheng, G., Liang, H.
Deposit date:2012-03-30
Release date:2012-06-27
Method:X-RAY DIFFRACTION (1.769 Å)
Cite:Crystal structure of the ubiquitin-like domain of human TBK1.
Protein Cell, 3, 2012
4GJH
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CRYSTAL STRUCTURE OF THE TRAF DOMAIN OF TRAF5
Descriptor:TNF receptor-associated factor 5
Authors:Zhang, P., Reichardt, A., Liang, H., Wang, Y., Cheng, D., Aliyari, R., Cheng, G., Liu, Y.
Deposit date:2012-08-09
Release date:2012-11-28
Method:X-RAY DIFFRACTION (2.805 Å)
Cite:Single Amino Acid Substitutions Confer the Antiviral Activity of the TRAF3 Adaptor Protein onto TRAF5
Sci.Signal., 5, 2012
4J0U
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CRYSTAL STRUCTURE OF IFIT5/ISG58
Descriptor:Interferon-induced protein with tetratricopeptide repeats 5
Authors:Liu, Y., Liang, H., Feng, F., Yuan, L., Wang, Y.E., Crowley, C., Lv, Z., Li, J., Zeng, S., Cheng, G.
Deposit date:2013-01-31
Release date:2013-02-13
Method:X-RAY DIFFRACTION (1.969 Å)
Cite:Crystal Structure of IFIT5
To be Published
4WJA
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CRYSTAL STRUCTURE OF PAXX
Descriptor:Uncharacterized protein C9orf142
Authors:Xing, M., Yang, M., Huo, W., Feng, F., Wei, L., Ning, S., Yan, Z., Li, W., Wang, Q., Hou, M., Dong, C., Guo, R., Gao, G., Ji, J., Lan, L., Liang, H., Xu, D.
Deposit date:2014-09-29
Release date:2015-03-11
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Interactome analysis identifies a new paralogue of XRCC4 in non-homologous end joining DNA repair pathway.
Nat Commun, 6, 2015
5EJO
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CRYSTAL STRUCTURE OF THE WINGED HELIX DOMAIN IN CHROMATIN ASSEMBLY FACTOR 1 SUBUNIT P90
Descriptor:Chromatin assembly factor 1 subunit p90
Authors:Zhang, K., Gao, Y., Li, J., Burgess, R., Han, J., Liang, H., Zhang, Z., Liu, Y.
Deposit date:2015-11-02
Release date:2016-03-16
Last modified:2016-07-06
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:A DNA binding winged helix domain in CAF-1 functions with PCNA to stabilize CAF-1 at replication forks
Nucleic Acids Res., 44, 2016
5Y6I
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CRYSTAL STRUCTURE OF PSEUDOMONAS AERUGINOSA HMGR
Descriptor:Transcriptional regulator KdgR
Authors:Gu, T., Ji, Q., Liang, H.
Deposit date:2017-08-11
Release date:2018-08-15
Method:X-RAY DIFFRACTION (2.517 Å)
Cite:Crystal structure of Pseudomonas aeruginosa HmgR
To Be Published
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