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4GV1
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PKB ALPHA IN COMPLEX WITH AZD5363
Descriptor:RAC-alpha serine/threonine-protein kinase, 4-amino-N-[(1S)-1-(4-chlorophenyl)-3-hydroxypropyl]-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide, GLYCEROL
Authors:Addie, M., Ballard, P., Bird, G., Buttar, D., Currie, G., Davies, B., Debreczeni, J., Dry, H., Dudley, P., Greenwood, R., Hatter, G., Jestel, A., Johnson, P.D., Kettle, J.G., Lane, C., Lamont, G., Leach, A., Luke, R.W.A., Ogilvie, D., Page, K., Pass, M., Steinbacher, S., Steuber, H., Pearson, S., Ruston, L.
Deposit date:2012-08-30
Release date:2013-02-27
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.49 Å)
Cite:Discovery of 4-Amino-N-[(1S)-1-(4-chlorophenyl)-3-hydroxypropyl]-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide (AZD5363), an Orally Bioavailable, Potent Inhibitor of Akt Kinases.
J.Med.Chem., 56, 2013
5AK2
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OXYPHENYLPROPENOIC ACIDS AS ORAL SELECTIVE ESTROGEN RECEPTOR DOWN- REGULATORS.
Descriptor:ESTROGEN RECEPTOR, (E)-3-[4-[[3-(4-fluoranyl-2-methyl-phenyl)-7-oxidanyl-2-oxidanylidene-chromen-4-yl]methyl]phenyl]prop-2-enoic acid
Authors:Degorce, S., Bailey, A., Callis, R., De Savi, C., Ducray, R., Lamot, P., MacFaul, P., Maudet, M., Norman, R.A., Scott, J.S., Phillips, C.
Deposit date:2015-02-27
Release date:2015-04-22
Last modified:2018-04-25
Method:X-RAY DIFFRACTION (2.19 Å)
Cite:Investigation of (E)-3-[4-(2-Oxo-3-Aryl-Chromen-4-Yl)Oxyphenyl]Acrylic Acids as Oral Selective Estrogen Receptor Down-Regulators.
J.Med.Chem., 58, 2015
5KBQ
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PAK1 IN COMPLEX WITH BIS-ANILINO PYRIMIDINE INHIBITOR
Descriptor:Serine/threonine-protein kinase PAK 1, [4-methyl-3-[methyl-[2-[(3-methylsulfonyl-5-morpholin-4-yl-phenyl)amino]pyrimidin-4-yl]amino]phenyl]methanol
Authors:Ferguson, A.
Deposit date:2016-06-03
Release date:2016-09-28
Last modified:2017-01-11
Method:X-RAY DIFFRACTION (2.58 Å)
Cite:Optimization of Highly Kinase Selective Bis-anilino Pyrimidine PAK1 Inhibitors.
ACS Med Chem Lett, 7, 2016
5KBR
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PAK1 IN COMPLEX WITH 7-AZAINDOLE INHIBITOR
Descriptor:Serine/threonine-protein kinase PAK 1, (4-chlorophenyl)-[5-(1-piperidin-4-ylpyrazol-4-yl)-1~{H}-pyrrolo[2,3-b]pyridin-3-yl]methanone
Authors:Ferguson, A.
Deposit date:2016-06-03
Release date:2016-09-28
Last modified:2017-01-11
Method:X-RAY DIFFRACTION (2.36 Å)
Cite:Optimization of Highly Kinase Selective Bis-anilino Pyrimidine PAK1 Inhibitors.
ACS Med Chem Lett, 7, 2016