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3H98
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CRYSTAL STRUCTURE OF HCV NS5B 1B WITH (1,1-DIOXO-2H-[1,2,4]BENZOTHIADIAZIN-3-YL) AZOLO[1,5-A]PYRIMIDINE DERIVATIVE
Descriptor:RNA-directed RNA polymerase, N-{3-[5-hydroxy-8-(3-methylbutyl)-7-oxo-7,8-dihydroimidazo[1,2-a]pyrimidin-6-yl]-1,1-dioxido-4H-1,2,4-benzothiadiazin-7-yl}methanesulfonamide, GLYCEROL
Authors:Wang, G., Lei, H., Wang, X., Das, D., Mackinnon, C., Montalbetti, C.A.G., Mears, R., Gai, X., Bailey, S., Ruhrmund, D., Hooi, L., Misialek, S., Rajagopalan, R., Cheng, R.K.Y., Barker, J.L., Felicetti, B., Stoycheva, A., Buckman, B., Kossen, K., Seiwert, S., Beigelmana, L.
Deposit date:2009-04-30
Release date:2009-10-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:HCV NS5B polymerase inhibitors 2: Synthesis and in vitro activity of (1,1-dioxo-2H-[1,2,4]benzothiadiazin-3-yl) azolo[1,5-a]pyridine and azolo[1,5-a]pyrimidine derivatives.
Bioorg.Med.Chem.Lett., 19, 2009
4WXP
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X-RAY CRYSTAL STRUCTURE OF NS3 HELICASE FROM HCV WITH A BOUND FRAGMENT INHIBITOR AT 2.08 A RESOLUTION
Descriptor:NS3-4 protease, SODIUM ION, CHLORIDE ION, ...
Authors:Davies, D.R.
Deposit date:2014-11-14
Release date:2015-12-23
Method:X-RAY DIFFRACTION (2.08 Å)
Cite:crystal structure of NS3 Helicase from HCV with a bound fragment inhibitor
TO BE PUBLISHED
4WXR
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X-RAY CRYSTAL STRUCTURE OF NS3 HELICASE FROM HCV WITH A BOUND INHIBITOR AT 2.42 A RESOLUTION
Descriptor:NS3, {6-(3,5-diaminophenyl)-1-[4-(propan-2-yl)benzyl]-1H-indol-3-yl}acetic acid
Authors:Davies, D.R., Kim, H., Lorimer, D.
Deposit date:2014-11-14
Release date:2015-12-23
Method:X-RAY DIFFRACTION (2.42 Å)
Cite:crystal structure of NS3 Helicase from HCV with a bound inhibitor
TO BE PUBLISHED