Author results

5IK0
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TOBACCO 5-EPI-ARISTOLOCHENE SYNTHASE WITH FPP
Descriptor:5-epi-aristolochene synthase, MAGNESIUM ION, FARNESYL DIPHOSPHATE
Authors:Koo, H.J., Xu, Y., Louie, G.V., Bowman, M., Noel, J.P.
Deposit date:2016-03-03
Release date:2016-10-05
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Biosynthetic potential of sesquiterpene synthases: product profiles of Egyptian Henbane premnaspirodiene synthase and related mutants.
J.Antibiot., 69, 2016
5IK6
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TOBACCO 5-EPI-ARISTOLOCHENE SYNTHASE WITH GERMACRENE A AND PPI
Descriptor:5-epi-aristolochene synthase, MAGNESIUM ION, GERMACRENE A, ...
Authors:Koo, H.J., Xu, Y., Louie, G.V., Bowman, M., Noel, J.P.
Deposit date:2016-03-03
Release date:2016-10-05
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Biosynthetic potential of sesquiterpene synthases: product profiles of Egyptian Henbane premnaspirodiene synthase and related mutants.
J.Antibiot., 69, 2016
5IK9
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TOBACCO 5-EPI-ARISTOLOCHENE WITH FARNESYL MONOPHOSPHATE
Descriptor:5-epi-aristolochene synthase, MAGNESIUM ION, (2E,6Z)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl dihydrogen phosphate
Authors:Koo, H.J., Xu, Y., Louie, G.V., Bowman, M., Noel, J.P.
Deposit date:2016-03-03
Release date:2016-10-05
Method:X-RAY DIFFRACTION (2.23 Å)
Cite:Biosynthetic potential of sesquiterpene synthases: product profiles of Egyptian Henbane premnaspirodiene synthase and related mutants.
J.Antibiot., 69, 2016
5IKA
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TOBACCO 5-EPI-ARISTOLOCHENE SYNTHASE WITH PPI
Descriptor:5-epi-aristolochene synthase, MAGNESIUM ION, DIPHOSPHATE
Authors:Koo, H.J., Xu, Y., Louie, G.V., Bowman, M., Noel, J.P.
Deposit date:2016-03-03
Release date:2016-10-05
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Biosynthetic potential of sesquiterpene synthases: product profiles of Egyptian Henbane premnaspirodiene synthase and related mutants.
J.Antibiot., 69, 2016
5IKH
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TOBACCO 5-EPI-ARISTOLOCHENE SYNTHASE M4 MUTANT WITH (-)-PREMNASPIRODIENE
Descriptor:5-epi-aristolochene synthase, (2R,5S,10R)-6,10-dimethyl-2-(prop-1-en-2-yl)spiro[4.5]dec-6-ene, MAGNESIUM ION
Authors:Koo, H.J., O'Maille, P.E., Louie, G.V., Bowman, M., Noel, J.P.
Deposit date:2016-03-03
Release date:2016-10-05
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Biosynthetic potential of sesquiterpene synthases: product profiles of Egyptian Henbane premnaspirodiene synthase and related mutants.
J.Antibiot., 69, 2016
5IL3
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TOBACCO 5-EPI-ARISTOLOCHENE SYNTHASE WITH MOPSO BUFFER MOLECULE AND MG2+ IONS
Descriptor:5-epi-aristolochene synthase, MAGNESIUM ION, (2S)-2-hydroxy-3-(morpholin-4-yl)propane-1-sulfonic acid, ...
Authors:Koo, H.J., Louie, G.V., Xu, Y., Bowman, M., Noel, J.P.
Deposit date:2016-03-04
Release date:2017-03-08
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Small-molecule buffer components can directly affect terpene-synthase activity by interacting with the substrate-binding site of the enzyme
To Be Published
5IL8
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TOBACCO 5-EPI-ARISTOLOCHENE SYNTHASE WITH MOPSO BUFFER MOLECULE AND CA2+ IONS
Descriptor:5-epi-aristolochene synthase, CALCIUM ION, (2S)-2-hydroxy-3-(morpholin-4-yl)propane-1-sulfonic acid, ...
Authors:Koo, H.J., Louie, G.V., Xu, Y., Bowman, M., Noel, J.P.
Deposit date:2016-03-04
Release date:2017-03-08
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Small-molecule buffer components can directly affect terpene-synthase activity by interacting with the substrate-binding site of the enzyme
To Be Published
5ILD
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TOBACCO 5-EPI-ARISTOLOCHENE SYNTHASE WITH MES BUFFER MOLECULE AND MG2+ IONS
Descriptor:5-epi-aristolochene synthase, MAGNESIUM ION, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID
Authors:Koo, H.J., Louie, G.V., Xu, Y., Bowman, M., Noel, J.P.
Deposit date:2016-03-04
Release date:2017-03-08
Method:X-RAY DIFFRACTION (2.12 Å)
Cite:Small-molecule buffer components can directly affect terpene-synthase activity by interacting with the substrate-binding site of the enzyme
To Be Published
5ILH
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TOBACCO 5-EPI-ARISTOLOCHENE SYNTHASE WITH CAPSO BUFFER MOLECULE AND CA2+ IONS
Descriptor:5-epi-aristolochene synthase, CALCIUM ION, (2R)-3-(cyclohexylamino)-2-hydroxypropane-1-sulfonic acid, ...
Authors:Koo, H.J., Louie, G.V., Xu, Y., Bowman, M., Noel, J.P.
Deposit date:2016-03-04
Release date:2017-03-08
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Small-molecule buffer components can directly affect terpene-synthase activity by interacting with the substrate-binding site of the enzyme
To Be Published
5ILI
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TOBACCO 5-EPI-ARISTOLOCHENE SYNTHASE WITH CAPSO BUFFER MOLECULE AND MG2+ IONS
Descriptor:5-epi-aristolochene synthase, MAGNESIUM ION, (2R)-3-(cyclohexylamino)-2-hydroxypropane-1-sulfonic acid, ...
Authors:Koo, H.J., Louie, G.V., Xu, Y., Bowman, M., Noel, J.P.
Deposit date:2016-03-04
Release date:2017-03-08
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Small-molecule buffer components can directly affect terpene-synthase activity by interacting with the substrate-binding site of the enzyme
To Be Published
5ILJ
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TOBACCO 5-EPI-ARISTOLOCHENE SYNTHASE WITH BIS-TRIS BUFFER MOLECULE
Descriptor:5-epi-aristolochene synthase, 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL
Authors:Koo, H.J., Louie, G.V., Xu, Y., Bowman, M., Noel, J.P.
Deposit date:2016-03-04
Release date:2017-03-08
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Small-molecule buffer components can directly affect terpene-synthase activity by interacting with the substrate-binding site of the enzyme
To Be Published
5ILK
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TOBACCO 5-EPI-ARISTOLOCHENE SYNTHASE WITH PARTIAL DENSITY FROM MOPSO OR BIS-TRIS BUFFER MOLECULE IN THE ACTIVE SITE
Descriptor:5-epi-aristolochene synthase
Authors:Koo, H.J., Louie, G.V., Xu, Y., Bowman, M., Noel, J.P.
Deposit date:2016-03-04
Release date:2017-03-08
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Small-molecule buffer components can directly affect terpene-synthase activity by interacting with the substrate-binding site of the enzyme
To Be Published
5ILY
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TOBACCO 5-EPI-ARISTOLOCHENE SYNTHASE WITH BIS-TRIS BUFFER MOLECULE AND DIPHOSPHATE (PPI)
Descriptor:5-epi-aristolochene synthase, MAGNESIUM ION, 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ...
Authors:Koo, H.J., Louie, G.V., Xu, Y., Bowman, M., Noel, J.P.
Deposit date:2016-03-05
Release date:2017-03-08
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Small-molecule buffer components can directly affect terpene-synthase activity by interacting with the substrate-binding site of the enzyme
To Be Published
5ILZ
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TOBACCO 5-EPI-ARISTOLOCHENE SYNTHASE WITH BIS-TRIS PROPANE (BTP) BUFFER MOLECULE
Descriptor:5-epi-aristolochene synthase, 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL
Authors:Koo, H.J., Louie, G.V., Xu, Y., Bowman, M., Noel, J.P.
Deposit date:2016-03-05
Release date:2017-03-08
Method:X-RAY DIFFRACTION (1.92 Å)
Cite:Small-molecule buffer components can directly affect terpene-synthase activity by interacting with the substrate-binding site of the enzyme
To Be Published
5IM1
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TOBACCO 5-EPI-ARISTOLOCHENE SYNTHASE WITHOUT BUFFER MOLECULE IN THE ACTIVE SITE
Descriptor:5-epi-aristolochene synthase
Authors:Koo, H.J., Louie, G.V., Xu, Y., Bowman, M., Noel, J.P.
Deposit date:2016-03-05
Release date:2017-03-08
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:Small-molecule buffer components can directly affect terpene-synthase activity by interacting with the substrate-binding site of the enzyme
To Be Published
5JO7
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HENBANE PREMNASPIRODIENE SYNTHASE (HPS), ALSO KNOWN AS HENBANE VETISPIRADIENE SYNTHASE (HVS) FROM HYOSCYAMUS MUTICUS
Descriptor:Vetispiradiene synthase 1
Authors:Koo, H.J., Xu, Y., Louie, G.V., Bowman, M., Noel, J.P.
Deposit date:2016-05-02
Release date:2017-05-03
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Functional study of terpene synthase from 512 mutant library of henbane premnaspirodiene synthase reveals protein residue interactions
To Be Published
4RNQ
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CRYSTAL STRUCTURE OF TOBACCO 5-EPI-ARISTOLOCHENE SYNTHASE (TEAS) WITH ANILINOGERANYL DIPHOSPHATE (AGPP) AND GERANILINE
Descriptor:5-epi-aristolochene synthase, MAGNESIUM ION, (2E,6E)-3,7-dimethyl-8-(phenylamino)octa-2,6-dien-1-yl trihydrogen diphosphate, ...
Authors:Koo, H.J., Crenshaw, C.M., Starks, C., Spielmann, H.P., Chappell, J., Noel, J.P.
Deposit date:2014-10-24
Release date:2015-05-06
Last modified:2015-07-29
Method:X-RAY DIFFRACTION (2.47 Å)
Cite:Formation of a Novel Macrocyclic Alkaloid from the Unnatural Farnesyl Diphosphate Analogue Anilinogeranyl Diphosphate by 5-Epi-Aristolochene Synthase.
Acs Chem.Biol., 10, 2015