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1J3F
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CRYSTAL STRUCTURE OF AN ARTIFICIAL METALLOPROTEIN:CR(III)(3,3'-ME2-SALOPHEN)/APO-A71G MYOGLOBIN
Descriptor:Myoglobin, CHROMIUM ION, PHOSPHATE ION, ...
Authors:Koshiyama, T., Kono, M., Ohashi, M., Ueno, T., Suzuki, A., Yamane, T., Watanabe, Y.
Deposit date:2003-01-24
Release date:2004-05-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Coordinated Design of Cofactor and Active Site Structures in Development of New Protein Catalysts
J.Am.Chem.Soc., 127, 2005
1UFJ
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CRYSTAL STRUCTURE OF AN ARTIFICIAL METALLOPROTEIN:FE(III)(3,3'-ME2-SALOPHEN)/APO-A71G MYOGLOBIN
Descriptor:MYOGLOBIN, FE (III) ION, PHOSPHATE ION, ...
Authors:Ueno, T., Ohashi, M., Kono, M., Kondo, K., Suzuki, A., Yamane, T., Watanabe, Y.
Deposit date:2003-05-30
Release date:2004-05-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Crystal Structures of Artificial Metalloproteins: Tight Binding of Fe(III)(Schiff-Base) by Mutation of Ala71 to Gly in Apo-Myoglobin
Inorg.Chem., 43, 2004
1UFP
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CRYSTAL STRUCTURE OF AN ARTIFICIAL METALLOPROTEIN:FE(III)(3,3'-ME2-SALOPHEN)/APO-WILD TYPE MYOGLOBIN
Descriptor:Myoglobin, PHOSPHATE ION
Authors:Ueno, T., Ohashi, M., Kono, M., Kondo, K., Suzuki, A., Yamane, T., Watanabe, Y.
Deposit date:2003-06-04
Release date:2004-05-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal Structures of Artificial Metalloproteins: Tight Binding of Fe(III)(Schiff-Base) by Mutation of Ala71 to Gly in Apo-Myoglobin
Inorg.Chem., 43, 2004
1V9Q
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CRYSTAL STRUCTURE OF AN ARTIFICIAL METALLOPROTEIN:MN(III)(3,3'-ME2-SALOPHEN)/APO-A71G MYOGLOBIN
Descriptor:Myoglobin, PHOSPHATE ION, 'N,N'-BIS-(2-HYDROXY-3-METHYL-BENZYLIDENE)-BENZENE-1,2-DIAMINE', ...
Authors:Ueno, T., Koshiyama, T., Kono, M., Kondo, K., Ohashi, M., Suzuki, A., Yamane, T., Watanabe, Y.
Deposit date:2004-01-29
Release date:2005-05-17
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Coordinated Design of Cofactor and Active Site Structures in Development of New Protein Catalysts
J.Am.Chem.Soc., 127, 2005
1WMX
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CRYSTAL STRUCTURE OF FAMILY 30 CARBOHYDRATE BINDING MODULE
Descriptor:COG3291: FOG: PKD repeat, SULFATE ION
Authors:Horiguchi, Y., Kono, M., Suzuki, A., Yamane, T., Arai, M., Sakka, K., Omiya, K.
Deposit date:2004-07-21
Release date:2004-08-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal Structure of Family 30 Carbohydrate Binding Module
To be Published
1WZX
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CRYSTAL STRUCTURE OF FAMILY 30 CARBOHYDRATE BINDING MODULE.
Descriptor:COG3291: FOG: PKD repeat
Authors:Horiguchi, Y., Kono, M., Suzuki, A., Yamane, T., Arai, M., Sakka, K., Omiya, K.
Deposit date:2005-03-10
Release date:2005-03-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.52 Å)
Cite:Crystal Structure of Family 30 Carbohydrate Binding Module
To be Published
4HBP
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CRYSTAL STRUCTURE OF FAAH IN COMPLEX WITH INHIBITOR
Descriptor:Fatty-acid amide hydrolase 1, 4-(3-phenyl-1,2,4-thiadiazol-5-yl)-N-(pyridin-3-yl)piperazine-1-carboxamide
Authors:Behnke, C., Skene, R.J.
Deposit date:2012-09-28
Release date:2013-02-06
Method:X-RAY DIFFRACTION (2.91 Å)
Cite:Synthesis, SAR study, and biological evaluation of a series of piperazine ureas as fatty acid amide hydrolase (FAAH) inhibitors.
Bioorg.Med.Chem., 21, 2013
6BR2
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STRUCTURE OF RORGT IN COMPLEX WITH A NOVEL ISOQUINOLINE INVERSE AGONIST.
Descriptor:Nuclear receptor ROR-gamma, (4S)-2-METHYL-2,4-PENTANEDIOL, (1R)-N-(4-tert-butyl-3-fluorophenyl)-6-methoxy-2-[(3-oxo-2,3-dihydro-1,2-oxazol-5-yl)acetyl]-1,2,3,4-tetrahydroisoquinoline-1-carboxamide
Authors:Skene, R.J., Hoffman, I.
Deposit date:2017-11-29
Release date:2018-03-21
Last modified:2018-04-25
Method:X-RAY DIFFRACTION (3.18 Å)
Cite:Discovery of [ cis-3-({(5 R)-5-[(7-Fluoro-1,1-dimethyl-2,3-dihydro-1 H-inden-5-yl)carbamoyl]-2-methoxy-7,8-dihydro-1,6-naphthyridin-6(5 H)-yl}carbonyl)cyclobutyl]acetic Acid (TAK-828F) as a Potent, Selective, and Orally Available Novel Retinoic Acid Receptor-Related Orphan Receptor gamma t Inverse Agonist.
J. Med. Chem., 61, 2018
6BR3
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STRUCTURE OF RORGT IN COMPLEX WITH A NOVEL INVERSE AGONIST TAK-828.
Descriptor:Nuclear receptor ROR-gamma, (4S)-2-METHYL-2,4-PENTANEDIOL, {cis-3-[(5R)-5-[(7-fluoro-1,1-dimethyl-1H-inden-5-yl)carbamoyl]-2-methoxy-7,8-dihydro-1,6-naphthyridine-6(5H)-carbonyl]cyclobutyl}acetic acid
Authors:Skene, R.J., Hoffman, I.
Deposit date:2017-11-29
Release date:2018-03-21
Last modified:2018-04-25
Method:X-RAY DIFFRACTION (3 Å)
Cite:Discovery of [ cis-3-({(5 R)-5-[(7-Fluoro-1,1-dimethyl-2,3-dihydro-1 H-inden-5-yl)carbamoyl]-2-methoxy-7,8-dihydro-1,6-naphthyridin-6(5 H)-yl}carbonyl)cyclobutyl]acetic Acid (TAK-828F) as a Potent, Selective, and Orally Available Novel Retinoic Acid Receptor-Related Orphan Receptor gamma t Inverse Agonist.
J. Med. Chem., 61, 2018
6B30
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STRUCTURE OF RORGT IN COMPLEX WITH A NOVEL INVERSE AGONIST 1
Descriptor:Nuclear receptor ROR-gamma, N-[(1R)-1-(4-methoxyphenyl)-2-oxo-2-{[4-(trimethylsilyl)phenyl]amino}ethyl]-N-methyl-3-oxo-2,3-dihydro-1,2-oxazole-5-carboxamide
Authors:Skene, R.J., Hoffman, I.
Deposit date:2017-09-20
Release date:2018-01-03
Last modified:2018-01-10
Method:X-RAY DIFFRACTION (2.69 Å)
Cite:Discovery of orally efficacious ROR gamma t inverse agonists, part 1: Identification of novel phenylglycinamides as lead scaffolds.
Bioorg. Med. Chem., 26, 2018
6B31
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STRUCTURE OF RORGT IN COMPLEX WITH A NOVEL INVERSE AGONIST 2
Descriptor:Nuclear receptor ROR-gamma, (3S)-N~1~-(3-chloro-4-cyanophenyl)-N~5~-(1,3-diethyl-2,4-dioxo-1,2,3,4-tetrahydroquinazolin-6-yl)-3-methylpentanediamide
Authors:Skene, R.J., Hoffman, I.
Deposit date:2017-09-20
Release date:2018-08-01
Method:X-RAY DIFFRACTION (3.18 Å)
Cite:Identification of novel quinazolinedione derivatives as ROR gamma t inverse agonist.
Bioorg. Med. Chem., 26, 2018
6B33
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STRUCTURE OF RORGT IN COMPLEX WITH A NOVEL INVERSE AGONIST 3
Descriptor:Nuclear receptor ROR-gamma, (2R)-N~2~-(3-chloro-4-cyanophenyl)-N~4~-[3-(cyclopropylmethyl)-2,4-dioxo-1-(propan-2-yl)-1,2,3,4-tetrahydroquinazolin-6-yl]morpholine-2,4-dicarboxamide
Authors:Skene, R.J., Hoffman, I., Snell, G.
Deposit date:2017-09-20
Release date:2018-11-21
Last modified:2019-11-06
Method:X-RAY DIFFRACTION (2.48 Å)
Cite:Design and Synthesis of Conformationally Constrained ROR gamma t Inverse Agonists.
Chemmedchem, 2019
1QM8
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STRUCTURE OF BACTERIORHODOPSIN AT 100 K
Descriptor:BACTERIORHODOPSIN, RETINAL, 3-PHOSPHORYL-[1,2-DI-PHYTANYL]GLYCEROL, ...
Authors:Takeda, K., Matsui, Y., Sato, H., Hino, T., Kanamori, E., Okumura, H., Yamane, T., Kamiya, N., Kouyama, T.
Deposit date:1999-09-22
Release date:2000-08-16
Last modified:2019-03-06
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:A Novel Three-Dimensional Crystal of Bacteriorhodopsin Obtained by Successive Fusion of the Vesicular Assemblies.
J.Mol.Biol., 283, 1998
1SUJ
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X-RAY CRYSTAL STRUCTURE OF AMBYSTOMA TIGRINUM CONE ARRESTIN
Descriptor:cone arrestin
Authors:Sutton, R.B., Navarro, J.
Deposit date:2004-03-26
Release date:2005-08-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.38 Å)
Cite:Crystal structure of cone arrestin at 2.3A: evolution of receptor specificity.
J.Mol.Biol., 354, 2005
6E3E
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STRUCTURE OF RORGT IN COMPLEX WITH A NOVEL INVERSE AGONIST.
Descriptor:Nuclear receptor ROR-gamma, SULFATE ION, (4S)-2-METHYL-2,4-PENTANEDIOL, ...
Authors:Skene, R.J., Hoffman, I.
Deposit date:2018-07-13
Release date:2019-07-17
Method:X-RAY DIFFRACTION (2.47 Å)
Cite:Design, Synthesis, and Biological Evaluation of Retinoic-acid-related orphan receptor (RORc) agonist
To Be Published
6E3G
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STRUCTURE OF RORGT IN COMPLEX WITH A NOVEL AGONIST.
Descriptor:Nuclear receptor ROR-gamma, co-activator peptide, 1,2-ETHANEDIOL, ...
Authors:Skene, R.J., Hoffman, I.
Deposit date:2018-07-13
Release date:2019-06-12
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Design, Synthesis, and Biological Evaluation of Retinoic Acid-Related Orphan Receptor gamma t (ROR gamma t) Agonist Structure-Based Functionality Switching Approach from In House ROR gamma t Inverse Agonist to ROR gamma t Agonist.
J.Med.Chem., 62, 2019
1BM1
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CRYSTAL STRUCTURE OF BACTERIORHODOPSIN IN THE LIGHT-ADAPTED STATE
Descriptor:BACTERIORHODOPSIN, RETINAL, PHOSPHORIC ACID 2,3-BIS-(3,7,11,15-TETRAMETHYL-HEXADECYLOXY)-PROPYL ESTER 2-HYDROXO-3-PHOSPHONOOXY-PROPYL ESTER
Authors:Sato, H., Takeda, K., Tani, K., Hino, T., Okada, T., Nakasako, M., Kamiya, N., Kouyama, T.
Deposit date:1998-07-28
Release date:1999-04-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Specific lipid-protein interactions in a novel honeycomb lattice structure of bacteriorhodopsin.
Acta Crystallogr.,Sect.D, 55, 1999