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3IIO
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EVOLUTIONARY OPTIMIZATION OF COMPUTATIONALLY DESIGNED ENZYMES: KEMP ELIMINASES OF THE KE07 SERIES
Descriptor:KE07
Authors:Khersonsky, O., Dym, O., Tawfik, D.S.
Deposit date:2009-08-03
Release date:2010-03-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Evolutionary Optimization of Computationally Designed Enzymes: Kemp Eliminases of the KE07 Series.
J.Mol.Biol., 396, 2010
3IIP
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EVOLUTIONARY OPTIMIZATION OF COMPUTATIONALLY DESIGNED ENZYMES: KEMP ELIMINASES OF THE KE07 SERIES
Descriptor:KE7 R6 3/7F, POLYETHYLENE GLYCOL (N=34)
Authors:Khersonsky, O., Dym, O., Tawfik, D.S.
Deposit date:2009-08-03
Release date:2010-03-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Evolutionary Optimization of Computationally Designed Enzymes: Kemp Eliminases of the KE07 Series.
J.Mol.Biol., 396, 2010
3IIV
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EVOLUTIONARY OPTIMIZATION OF COMPUTATIONALLY DESIGNED ENZYMES: KEMP ELIMINASES OF THE KE07 SERIES
Descriptor:KE7 KE7_R7_1/3H, MAGNESIUM ION
Authors:Khersonsky, O., Dym, O., Tawfik, D.S.
Deposit date:2009-08-03
Release date:2010-03-02
Last modified:2014-12-02
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Evolutionary Optimization of Computationally Designed Enzymes: Kemp Eliminases of the KE07 Series.
J.Mol.Biol., 396, 2010
3NPU
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OPTIMIZATION OF THE IN SILICO DESIGNED KEMP ELIMINASE KE70 BY COMPUTATIONAL DESIGN AND DIRECTED EVOLUTION
Descriptor:deoxyribose phosphate aldolase
Authors:Khersonsky, O., Rothlisberge, D., Wollacott, A.M., Dym, O., Baker, D., Tawfik, D.S., Israel Structural Proteomics Center (ISPC)
Deposit date:2010-06-29
Release date:2011-02-09
Last modified:2014-03-19
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Optimization of the in-silico-designed kemp eliminase KE70 by computational design and directed evolution
J.Mol.Biol., 407, 2011
3NPV
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OPTIMIZATION OF THE IN SILICO DESIGNED KEMP ELIMINASE KE70 BY COMPUTATIONAL DESIGN AND DIRECTED EVOLUTION
Descriptor:deoxyribose phosphate aldolase
Authors:Khersonsky, O., Rothlisberge, D., Wollacott, A.M., Dym, O., Baker, D., Tawfik, D.S., Israel Structural Proteomics Center (ISPC)
Deposit date:2010-06-29
Release date:2011-02-09
Last modified:2014-03-19
Method:X-RAY DIFFRACTION (1.48 Å)
Cite:Optimization of the in-silico-designed kemp eliminase KE70 by computational design and directed evolution
J.Mol.Biol., 407, 2011
3NPW
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IN SILICO DESIGNED OF AN IMPROVED KEMP ELIMINASE KE70 MUTANT BY COMPUTATIONAL DESIGN AND DIRECTED EVOLUTION
Descriptor:deoxyribose phosphate aldolase
Authors:Khersonsky, O., Rothlisberge, D., Wollacott, A.M., Dym, O., Baker, D., Tawfik, D.S., Israel Structural Proteomics Center (ISPC)
Deposit date:2010-06-29
Release date:2011-02-09
Last modified:2014-03-19
Method:X-RAY DIFFRACTION (2.14 Å)
Cite:Optimization of the in-silico-designed kemp eliminase KE70 by computational design and directed evolution
J.Mol.Biol., 407, 2011
3NPX
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OPTIMIZATION OF THE IN SILICO DESIGNED KEMP ELIMINASE KE70 BY COMPUTATIONAL DESIGN AND DIRECTED EVOLUTION
Descriptor:deoxyribose phosphate aldolase
Authors:Khersonsky, O., Rothlisberge, D., Wollacott, A.M., Dym, O., Baker, D., Tawfik, D.S., Israel Structural Proteomics Center (ISPC)
Deposit date:2010-06-29
Release date:2011-02-09
Last modified:2014-03-19
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:Optimization of the in-silico-designed kemp eliminase KE70 by computational design and directed evolution
J.Mol.Biol., 407, 2011
3NQ2
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OPTIMIZATION OF THE IN SILICO DESIGNED KEMP ELIMINASE KE70 BY COMPUTATIONAL DESIGN AND DIRECTED EVOLUTION R2 3/5G
Descriptor:deoxyribose phosphate aldolase, IMIDAZOLE
Authors:Khersonsky, O., Rothlisberge, D., Wollacott, A.M., Dym, O., Baker, D., Tawfik, D.S., Israel Structural Proteomics Center (ISPC)
Deposit date:2010-06-29
Release date:2011-02-09
Last modified:2014-03-19
Method:X-RAY DIFFRACTION (2.02 Å)
Cite:Optimization of the in-silico-designed kemp eliminase KE70 by computational design and directed evolution
J.Mol.Biol., 407, 2011
3NQ8
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OPTIMIZATION OF THE IN SILICO DESIGNED KEMP ELIMINASE KE70 BY COMPUTATIONAL DESIGN AND DIRECTED EVOLUTION R4 8/5A
Descriptor:deoxyribose phosphate aldolase, NITRATE ION, BENZAMIDINE
Authors:Khersonsky, O., Rothlisberge, D., Wollacott, A.M., Dym, O., Baker, D., Tawfik, D.S., Israel Structural Proteomics Center (ISPC)
Deposit date:2010-06-29
Release date:2011-02-09
Last modified:2014-03-19
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Optimization of the in-silico-designed kemp eliminase KE70 by computational design and directed evolution
J.Mol.Biol., 407, 2011
3NQV
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OPTIMIZATION OF THE IN SILICO DESIGNED KEMP ELIMINASE KE70 BY COMPUTATIONAL DESIGN AND DIRECTED EVOLUTION R5 7/4A
Descriptor:deoxyribose phosphate aldolase, BENZAMIDINE
Authors:Khersonsky, O., Rothlisberge, D., Wollacott, A.M., Dym, O., Baker, D., Tawfik, D.S., Israel Structural Proteomics Center (ISPC)
Deposit date:2010-06-29
Release date:2011-02-09
Last modified:2014-03-19
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Optimization of the in-silico-designed kemp eliminase KE70 by computational design and directed evolution
J.Mol.Biol., 407, 2011
3NR0
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OPTIMIZATION OF THE IN SILICO DESIGNED KEMP ELIMINASE KE70 BY COMPUTATIONAL DESIGN AND DIRECTED EVOLUTION R6 6/10A
Descriptor:deoxyribose phosphate aldolase
Authors:Khersonsky, O., Rothlisberge, D., Wollacott, A.M., Dym, O., Baker, D., Tawfik, D.S., Israel Structural Proteomics Center (ISPC)
Deposit date:2010-06-30
Release date:2011-02-09
Last modified:2014-03-19
Method:X-RAY DIFFRACTION (2.19 Å)
Cite:Optimization of the in-silico-designed kemp eliminase KE70 by computational design and directed evolution
J.Mol.Biol., 407, 2011
3Q2D
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OPTIMIZATION OF THE IN SILICO DESIGNED KEMP ELIMINASE KE70 BY COMPUTATIONAL DESIGN AND DIRECTED EVOLUTION
Descriptor:Deoxyribose phosphate aldolase, 5-nitro-1H-benzotriazole
Authors:Khersonsky, O., Rothlisberge, D., Wollacott, A.M., Murphy, P., Dym, O., Albeck, S., Kiss, G., Houk, K.N., Baker, D., Tawfik, D.S., Israel Structural Proteomics Center (ISPC)
Deposit date:2010-12-20
Release date:2011-02-09
Last modified:2014-03-19
Method:X-RAY DIFFRACTION (2.19 Å)
Cite:Optimization of the in-silico-designed kemp eliminase KE70 by computational design and directed evolution
J.Mol.Biol., 407, 2011
3UXA
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DESIGNED PROTEIN KE59 R1 7/10H
Descriptor:Kemp eliminase KE59 R1 7/10H, PHOSPHATE ION
Authors:Khersonsky, O., Kiss, G., Roethlisberger, D., Dym, O., Albeck, S., Houk, K.N., Baker, D., Tawfik, D.S., Israel Structural Proteomics Center (ISPC)
Deposit date:2011-12-05
Release date:2012-06-06
Last modified:2012-07-11
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Bridging the gaps in design methodologies by evolutionary optimization of the stability and proficiency of designed Kemp eliminase KE59.
Proc.Natl.Acad.Sci.USA, 109, 2012
3UXD
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DESIGNED PROTEIN KE59 R1 7/10H WITH DICHLOROBENZOTRIAZOLE (DBT)
Descriptor:Kemp eliminase KE59 R1 7/10H, 5,7-dichloro-1H-benzotriazole, PHOSPHATE ION
Authors:Khersonsky, O., Kiss, G., Roethlisberger, D., Dym, O., Albeck, S., Houk, K.N., Baker, D., Tawfik, D.S., Israel Structural Proteomics Center (ISPC)
Deposit date:2011-12-05
Release date:2012-06-06
Last modified:2012-07-11
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Bridging the gaps in design methodologies by evolutionary optimization of the stability and proficiency of designed Kemp eliminase KE59.
Proc.Natl.Acad.Sci.USA, 109, 2012
3UY7
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DESIGNED PROTEIN KE59 R1 7/10H WITH G130S MUTATION
Descriptor:Kemp eliminase KE59 R1 7/10H, SULFATE ION, SODIUM ION
Authors:Khersonsky, O., Kiss, G., Roethlisberger, D., Dym, O., Albeck, S., Houk, K.N., Baker, D., Tawfik, D.S., Israel Structural Proteomics Center (ISPC)
Deposit date:2011-12-06
Release date:2012-06-27
Last modified:2012-07-11
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Bridging the gaps in design methodologies by evolutionary optimization of the stability and proficiency of designed Kemp eliminase KE59.
Proc.Natl.Acad.Sci.USA, 109, 2012
3UY8
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DESIGNED PROTEIN KE59 R5_11/5F
Descriptor:Kemp eliminase KE59 R5_11/5F, SULFATE ION
Authors:Khersonsky, O., Kiss, G., Roethlisberger, D., Dym, O., Albeck, S., Houk, K.N., Baker, D., Tawfik, D.S., Israel Structural Proteomics Center (ISPC)
Deposit date:2011-12-06
Release date:2012-06-06
Last modified:2012-07-11
Method:X-RAY DIFFRACTION (2.41 Å)
Cite:Bridging the gaps in design methodologies by evolutionary optimization of the stability and proficiency of designed Kemp eliminase KE59.
Proc.Natl.Acad.Sci.USA, 109, 2012
3UYC
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DESIGNED PROTEIN KE59 R8_2/7A
Descriptor:Kemp eliminase KE59 R8_2/7A, PHOSPHATE ION
Authors:Khersonsky, O., Kiss, G., Roethlisberger, D., Dym, O., Albeck, S., Houk, K.N., Baker, D., Tawfik, D.S., Israel Structural Proteomics Center (ISPC)
Deposit date:2011-12-06
Release date:2012-06-06
Last modified:2012-07-11
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Bridging the gaps in design methodologies by evolutionary optimization of the stability and proficiency of designed Kemp eliminase KE59.
Proc.Natl.Acad.Sci.USA, 109, 2012
3UZ5
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DESIGNED PROTEIN KE59 R13 3/11H
Descriptor:Kemp eliminase KE59 R13 3/11H, 5,7-dichloro-1H-benzotriazole, PHOSPHATE ION, ...
Authors:Khersonsky, O., Kiss, G., Roethlisberger, D., Dym, O., Albeck, S., Houk, K.N., Baker, D., Tawfik, D.S., Israel Structural Proteomics Center (ISPC)
Deposit date:2011-12-07
Release date:2012-06-06
Last modified:2012-07-11
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Bridging the gaps in design methodologies by evolutionary optimization of the stability and proficiency of designed Kemp eliminase KE59.
Proc.Natl.Acad.Sci.USA, 109, 2012
3UZJ
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DESIGNED PROTEIN KE59 R13 3/11H WITH BENZOTRIAZOLE
Descriptor:Kemp eliminase KE59 R13 3/11H, 1H-benzotriazole, PHOSPHATE ION
Authors:Khersonsky, O., Kiss, G., Roethlisberger, D., Dym, O., Albeck, S., Houk, K.N., Baker, D., Tawfik, D.S., Israel Structural Proteomics Center (ISPC)
Deposit date:2011-12-07
Release date:2012-06-06
Last modified:2012-07-11
Method:X-RAY DIFFRACTION (1.69 Å)
Cite:Bridging the gaps in design methodologies by evolutionary optimization of the stability and proficiency of designed Kemp eliminase KE59.
Proc.Natl.Acad.Sci.USA, 109, 2012
6GBJ
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REPERTOIRES OF FUNCTIONALLY DIVERSE ENZYMES THROUGH COMPUTATIONAL DESIGN AT EPISTATIC ACTIVE-SITE POSITIONS
Descriptor:Parathion hydrolase, FORMIC ACID, ZINC ION, ...
Authors:Khersonsky, O., Lipsh, R., Avizemer, Z., Goldsmith, M., Ashani, Y., Leader, H., Dym, O., Rogotner, S., Trudeau, D., Tawfik, D.S., Fleishman, S.J.
Deposit date:2018-04-15
Release date:2018-10-24
Method:X-RAY DIFFRACTION (1.63 Å)
Cite:Automated Design of Efficient and Functionally Diverse Enzyme Repertoires.
Mol. Cell, 72, 2018
6GBK
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REPERTOIRES OF FUNCTIONALLY DIVERSE ENZYMES THROUGH COMPUTATIONAL DESIGN AT EPISTATIC ACTIVE-SITE POSITIONS
Descriptor:Parathion hydrolase, FORMIC ACID, ZINC ION, ...
Authors:Khersonsky, O., Lipsh, R., Avizemer, Z., Goldsmith, M., Ashani, Y., Leader, H., Dym, O., Rogotner, S., Trudeau, D., Tawfik, D.S., Fleishman, S.J.
Deposit date:2018-04-15
Release date:2018-10-24
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Automated Design of Efficient and Functionally Diverse Enzyme Repertoires.
Mol. Cell, 72, 2018
6GBL
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REPERTOIRES OF FUNCTIONALLY DIVERSE ENZYMES THROUGH COMPUTATIONAL DESIGN AT EPISTATIC ACTIVE-SITE POSITIONS
Descriptor:Parathion hydrolase, FORMIC ACID, ZINC ION, ...
Authors:Khersonsky, O., Lipsh, R., Avizemer, Z., Goldsmith, M., Ashani, Y., Leader, H., Dym, O., Rogotner, S., Trudeau, D., Tawfik, D.S., Fleishman, S.J.
Deposit date:2018-04-15
Release date:2018-10-24
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Automated Design of Efficient and Functionally Diverse Enzyme Repertoires.
Mol. Cell, 72, 2018
2RKX
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THE 3D STRUCTURE OF CHAIN D, CYCLASE SUBUNIT OF IMIDAZOLEGLYCEROL_EVOLVEDCEROLPHOSPHATE SYNTHASE
Descriptor:Cyclase subunit of imidazoleglycerol_evolvedcerolphosphate synthase
Authors:Tawfik, D., Khersonsky, O., Albeck, S., Dym, O., Israel Structural Proteomics Center (ISPC)
Deposit date:2007-10-18
Release date:2008-03-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Kemp elimination catalysts by computational enzyme design.
Nature, 453, 2008
6FHE
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HIGHLY ACTIVE ENZYMES BY AUTOMATED MODULAR BACKBONE ASSEMBLY AND SEQUENCE DESIGN
Descriptor:Synthetic construct
Authors:Lapidot, G., Khersonsky, O., Lipsh, R., Dym, O., Albeck, S., Rogotner, S., Fleishman, J.S.
Deposit date:2018-01-14
Release date:2018-07-25
Last modified:2018-08-01
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:Highly active enzymes by automated combinatorial backbone assembly and sequence design.
Nat Commun, 9, 2018
6FHF
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HIGHLY ACTIVE ENZYMES BY AUTOMATED MODULAR BACKBONE ASSEMBLY AND SEQUENCE DESIGN
Descriptor:Design, SODIUM ION
Authors:Lapidot, G., Khersonsky, O., Lipsh, R., Dym, O., Albeck, S., Rogotner, S., Fleishman, J.S.
Deposit date:2018-01-14
Release date:2018-07-25
Last modified:2018-08-01
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Highly active enzymes by automated combinatorial backbone assembly and sequence design.
Nat Commun, 9, 2018
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