Author results

3L6V
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CRYSTAL STRUCTURE OF THE XANTHOMONAS CAMPESTRIS GYRASE A C-TERMINAL DOMAIN
Descriptor:DNA gyrase subunit A
Authors:Hsieh, T.J., Yen, T.J., Lin, T.S., Chang, H.T., Huang, S.Y., Farh, L., Chan, N.L.
Deposit date:2009-12-26
Release date:2010-03-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.19 Å)
Cite:Twisting of the DNA binding surface by a beta-strand-bearing proline modulates DNA gyrase activity
To be Published
4XBL
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CRYSTAL STRUCTURE OF HUMAN GALECTIN-1 IN COMPLEX WITH TYPE 1 N-ACETYLLACTOSAMINE
Descriptor:Galectin-1, BETA-D-GALACTOSE, N-ACETYL-D-GLUCOSAMINE
Authors:Hsieh, T.J., Lin, H.Y., Lin, C.H.
Deposit date:2014-12-17
Release date:2015-05-20
Method:X-RAY DIFFRACTION (1.931 Å)
Cite:Structural Basis Underlying the Binding Preference of Human Galectins-1, -3 and -7 for Gal beta 1-3/4GlcNAc.
Plos One, 10, 2015
4XBN
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CRYSTAL STRUCTURE OF HUMAN GALECTIN-3 CRD IN COMPLEX WITH TYPE 1 N-ACETYLLACTOSAMINE
Descriptor:Galectin-3, BETA-D-GALACTOSE, N-ACETYL-D-GLUCOSAMINE
Authors:Hsieh, T.J., Lin, H.Y., Lin, C.H.
Deposit date:2014-12-17
Release date:2015-05-20
Method:X-RAY DIFFRACTION (2.208 Å)
Cite:Structural Basis Underlying the Binding Preference of Human Galectins-1, -3 and -7 for Gal beta 1-3/4GlcNAc.
Plos One, 10, 2015
4XBQ
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CRYSTAL STRUCTURE OF HUMAN GALECTIN-7 IN COMPLEX WITH TYPE 1 N-ACETYLLACTOSAMINE
Descriptor:Galectin-7, BETA-D-GALACTOSE, N-ACETYL-D-GLUCOSAMINE
Authors:Hsieh, T.J., Lin, H.Y., Lin, C.H.
Deposit date:2014-12-17
Release date:2015-05-20
Method:X-RAY DIFFRACTION (2.234 Å)
Cite:Structural Basis Underlying the Binding Preference of Human Galectins-1, -3 and -7 for Gal beta 1-3/4GlcNAc.
Plos One, 10, 2015
5H9P
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CRYSTAL STRUCTURE OF HUMAN GALECTIN-3 CRD IN COMPLEX WITH TD139
Descriptor:Galectin-3, 3-deoxy-3-[4-(3-fluorophenyl)-1H-1,2,3-triazol-1-yl]-beta-D-galactopyranosyl 3-deoxy-3-[4-(3-fluorophenyl)-1H-1,2,3-triazol-1-yl]-1-thio-beta-D-galactopyranoside
Authors:Hsieh, T.J., Lin, H.Y., Lin, C.H.
Deposit date:2015-12-29
Release date:2016-06-29
Last modified:2016-07-27
Method:X-RAY DIFFRACTION (2.04 Å)
Cite:Dual thio-digalactoside-binding modes of human galectins as the structural basis for the design of potent and selective inhibitors
Sci Rep, 6, 2016
5H9Q
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CRYSTAL STRUCTURE OF HUMAN GALECTIN-7 IN COMPLEX WITH TD139
Descriptor:Galectin-7, 3-deoxy-3-[4-(3-fluorophenyl)-1H-1,2,3-triazol-1-yl]-beta-D-galactopyranosyl 3-deoxy-3-[4-(3-fluorophenyl)-1H-1,2,3-triazol-1-yl]-1-thio-beta-D-galactopyranoside
Authors:Hsieh, T.J., Lin, H.Y., Lin, C.H.
Deposit date:2015-12-29
Release date:2016-06-29
Last modified:2016-07-27
Method:X-RAY DIFFRACTION (1.931 Å)
Cite:Dual thio-digalactoside-binding modes of human galectins as the structural basis for the design of potent and selective inhibitors
Sci Rep, 6, 2016
5H9R
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CRYSTAL STRUCTURE OF HUMAN GALECTIN-3 CRD IN COMPLEX WITH TAZTDG
Descriptor:Galectin-3, (2~{S},3~{R},4~{S},5~{R},6~{R})-2-[(2~{S},3~{R},4~{S},5~{R},6~{R})-4-[4-(3-fluorophenyl)-1,2,3-triazol-1-yl]-6-(hydroxymethyl)-3,5-bis(oxidanyl)oxan-2-yl]sulfanyl-6-(hydroxymethyl)oxane-3,4,5-triol
Authors:Hsieh, T.J., Lin, H.Y., Lin, C.H.
Deposit date:2015-12-29
Release date:2016-06-29
Last modified:2016-07-27
Method:X-RAY DIFFRACTION (1.58 Å)
Cite:Dual thio-digalactoside-binding modes of human galectins as the structural basis for the design of potent and selective inhibitors
Sci Rep, 6, 2016
5H9S
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CRYSTAL STRUCTURE OF HUMAN GALECTIN-7 IN COMPLEX WITH TAZTDG
Descriptor:Galectin-7, (2~{S},3~{R},4~{S},5~{R},6~{R})-2-[(2~{S},3~{R},4~{S},5~{R},6~{R})-4-[4-(3-fluorophenyl)-1,2,3-triazol-1-yl]-6-(hydroxymethyl)-3,5-bis(oxidanyl)oxan-2-yl]sulfanyl-6-(hydroxymethyl)oxane-3,4,5-triol
Authors:Hsieh, T.J., Lin, H.Y., Lin, C.H.
Deposit date:2015-12-29
Release date:2016-06-29
Last modified:2016-07-27
Method:X-RAY DIFFRACTION (1.821 Å)
Cite:Dual thio-digalactoside-binding modes of human galectins as the structural basis for the design of potent and selective inhibitors
Sci Rep, 6, 2016
4Y24
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COMPLEX OF HUMAN GALECTIN-1 AND TD-139
Descriptor:Galectin-1, 3-deoxy-3-[4-(3-fluorophenyl)-1H-1,2,3-triazol-1-yl]-beta-D-galactopyranosyl 3-deoxy-3-[4-(3-fluorophenyl)-1H-1,2,3-triazol-1-yl]-1-thio-beta-D-galactopyranoside
Authors:Lin, H.Y., Hsieh, T.J., Lin, C.H.
Deposit date:2015-02-09
Release date:2016-04-27
Last modified:2016-08-03
Method:X-RAY DIFFRACTION (2.32 Å)
Cite:Dual thio-digalactoside-binding modes of human galectins as the structural basis for the design of potent and selective inhibitors.
Sci Rep, 6, 2016
4Y1U
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COMPLEX OF HUMAN GALECTIN-1 AND GALBETA1-4GLCNAC
Descriptor:Galectin-1, BETA-D-GALACTOSE, BETA-METHYL-N-ACETYL-D-GLUCOSAMINE
Authors:Lin, H.Y., Hsieh, T.J., Lin, C.H.
Deposit date:2015-02-09
Release date:2016-04-06
Method:X-RAY DIFFRACTION (1.762 Å)
Cite:Structural basis of human galectin-1 inhibition with Ki values in the micro- to nanomolar range
To Be Published
4Y1V
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COMPLEX OF HUMAN GALECTIN-1 AND GALBETA1-3GLCNAC
Descriptor:Galectin-1, BETA-METHYL-N-ACETYL-D-GLUCOSAMINE, BETA-D-GALACTOSE
Authors:Lin, H.Y., Hsieh, T.J., Lin, C.H.
Deposit date:2015-02-09
Release date:2016-04-06
Method:X-RAY DIFFRACTION (2.32 Å)
Cite:Structural basis of human galectin-1 inhibition with Ki values in the micro- to nanomolar range
To Be Published
4Y1X
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COMPLEX OF HUMAN GALECTIN-1 AND GALBETA1-4(6OSO3)GLCNAC
Descriptor:Galectin-1, BETA-D-GALACTOSE, methyl 2-(acetylamino)-2-deoxy-6-O-sulfo-beta-D-glucopyranoside
Authors:Lin, H.Y., Hsieh, T.J., Lin, C.H.
Deposit date:2015-02-09
Release date:2016-04-06
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Structural basis of human galectin-1 inhibition with Ki values in the micro- to nanomolar range
To Be Published
4Y1Y
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COMPLEX OF HUMAN GALECTIN-1 AND (6OSO3)GALBETA1-3GLCNAC
Descriptor:Galectin-1, BETA-D-GALACTOSE, methyl 2-(acetylamino)-2-deoxy-6-O-sulfo-beta-D-glucopyranoside
Authors:Lin, H.Y., Hsieh, T.J., Lin, C.H.
Deposit date:2015-02-09
Release date:2016-04-06
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Structural basis of human galectin-1 inhibition with Ki values in the micro- to nanomolar range
To Be Published
4Y1Z
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COMPLEX OF HUMAN GALECTIN-1 AND GALBETA1-4(6CO2)GLCNAC
Descriptor:Galectin-1, BETA-D-GALACTOSE, methyl 2-(acetylamino)-2-deoxy-beta-D-glucopyranosiduronic acid
Authors:Lin, H.Y., Hsieh, T.J., Lin, C.H.
Deposit date:2015-02-09
Release date:2016-04-06
Method:X-RAY DIFFRACTION (2.23 Å)
Cite:Structural basis of human galectin-1 inhibition with Ki values in the micro- to nanomolar range
To Be Published
4Y20
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COMPLEX OF HUMAN GALECTIN-1 AND NEUACALPHA2-3GALBETA1-4GLC
Descriptor:Galectin-1, 5-(ACETYLAMINO)-3,5-DIDEOXYNON-2-ULOPYRANONOSYL-(2->3)-BETA-D-LYXO-HEXOPYRANOSYL-(1->4)HEXOPYRANOSE
Authors:Lin, H.Y., Hsieh, T.J., Lin, C.H.
Deposit date:2015-02-09
Release date:2016-04-06
Method:X-RAY DIFFRACTION (2.204 Å)
Cite:Structural basis of human galectin-1 inhibition with Ki values in the micro- to nanomolar range
To Be Published
4Y22
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COMPLEX OF HUMAN GALECTIN-1 AND (3OSO3)GALBETA1-3GLCNAC
Descriptor:Galectin-1, O3-SULFONYLGALACTOSE, BETA-METHYL-N-ACETYL-D-GLUCOSAMINE
Authors:Lin, H.Y., Hsieh, T.J., Lin, C.H.
Deposit date:2015-02-09
Release date:2016-04-06
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural basis of human galectin-1 inhibition with Ki values in the micro- to nanomolar range
To Be Published
4Y26
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COMPLEX OF HUMAN GALECTIN-7 AND GALBETA1-3(6OSO3)GLCNAC
Descriptor:Galectin-7, BETA-D-GALACTOSE, methyl 2-(acetylamino)-2-deoxy-6-O-sulfo-beta-D-glucopyranoside
Authors:Lin, H.Y., Hsieh, T.J., Lin, C.H.
Deposit date:2015-02-09
Release date:2016-04-06
Method:X-RAY DIFFRACTION (2.611 Å)
Cite:Structural basis of human galectin-1 inhibition with Ki values in the micro- to nanomolar range
To Be Published
5XGU
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ESCHERICHIA COLI. RNASE R
Descriptor:Ribonuclease R, MAGNESIUM ION
Authors:Chu, L.Y., Hsieh, T.J., Yuan, H.S.
Deposit date:2017-04-17
Release date:2017-10-18
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.846 Å)
Cite:Structural insights into RNA unwinding and degradation by RNase R.
Nucleic Acids Res., 45, 2017
5XVS
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CRYSTAL STRUCTURE OF UDP-GLCNAC 2-EPIMERASE NEUC COMPLEXED WITH UDP
Descriptor:GDP/UDP-N,N'-diacetylbacillosamine 2-epimerase (Hydrolyzing), LITHIUM ION, URIDINE-5'-DIPHOSPHATE, ...
Authors:Ko, T.P., Hsieh, T.J., Chen, S.C., Wu, S.C., Guan, H.H., Yang, C.H., Chen, C.J., Chen, Y.
Deposit date:2017-06-28
Release date:2018-04-11
Last modified:2018-07-11
Method:X-RAY DIFFRACTION (2.383 Å)
Cite:The tetrameric structure of sialic acid-synthesizing UDP-GlcNAc 2-epimerase fromAcinetobacter baumannii: A comparative study with human GNE.
J. Biol. Chem., 293, 2018
5YI6
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CRISPR ASSOCIATED PROTEIN CAS6
Descriptor:CRISPR-associated endoribonuclease Cas6 1, GLYCEROL, PHOSPHATE ION
Authors:Ko, T.P., Hsieh, T.J., Chen, Y.
Deposit date:2017-10-03
Release date:2018-09-12
Method:X-RAY DIFFRACTION (1.852 Å)
Cite:Expression, Purification, Crystallization, and X-ray Structural Analysis of CRISPR-Associated Protein Cas6 from Methanocaldococcus jannaschii
Crystals, 7, 2018
5ZLR
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STRUCTURE OF NEUC
Descriptor:GDP/UDP-N,N'-diacetylbacillosamine 2-epimerase (Hydrolyzing), SULFATE ION, LITHIUM ION
Authors:Ko, T.P., Hsieh, T.J., Yang, C.S., Chen, Y.
Deposit date:2018-03-29
Release date:2018-05-16
Last modified:2018-07-11
Method:X-RAY DIFFRACTION (2.001 Å)
Cite:The tetrameric structure of sialic acid-synthesizing UDP-GlcNAc 2-epimerase fromAcinetobacter baumannii: A comparative study with human GNE.
J. Biol. Chem., 293, 2018
5ZLT
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CRYSTAL STRUCTURE OF UDP-GLCNAC 2-EPIMERASE NEUC COMPLEXED WITH UDP
Descriptor:GDP/UDP-N,N'-diacetylbacillosamine 2-epimerase (Hydrolyzing), SULFATE ION, URIDINE-5'-DIPHOSPHATE
Authors:Ko, T.P., Hsieh, T.J., Yang, C.S., Chen, Y.
Deposit date:2018-03-29
Release date:2018-05-16
Last modified:2018-07-11
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:The tetrameric structure of sialic acid-synthesizing UDP-GlcNAc 2-epimerase fromAcinetobacter baumannii: A comparative study with human GNE.
J. Biol. Chem., 293, 2018
5Z18
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THE CRYSTAL STRUCTURE OF RUMINOCOCCUS GNAVUS BETA-GLUCURONIDASE
Descriptor:Beta-glucuronidase
Authors:Dashnyam, P., Lin, H.Y., Lin, C.H.
Deposit date:2017-12-25
Release date:2018-12-12
Method:X-RAY DIFFRACTION (2.495 Å)
Cite:Dissection of the substrate preference and structure of gut microbial beta-glucuronidases identifies the major bacteria causing xenobiotic toxicity
To Be Published
5Z19
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THE CRYSTAL STRUCTURE OF RUMINOCOCCUS GNAVUS BETA-GLUCURONIDASE IN COMPLEX WITH URONIC ISOFAGOMINE
Descriptor:Beta-glucuronidase, (3S,4R,5R)-4,5-dihydroxypiperidine-3-carboxylic acid
Authors:Dashnyam, P., Lin, H.Y., Lin, C.H.
Deposit date:2017-12-25
Release date:2018-12-12
Last modified:2019-04-03
Method:X-RAY DIFFRACTION (2.503 Å)
Cite:Dissection of the substrate preference and structure of gut microbial beta-glucuronidases identifies the major bacteria causing xenobiotic toxicity
To Be Published
5Z1A
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THE CRYSTAL STRUCTURE OF BACTEROIDES FRAGILIS BETA-GLUCURONIDASE IN COMPLEX WITH URONIC ISOFAGOMINE
Descriptor:Putative beta-galactosidase, (3S,4R,5R)-4,5-dihydroxypiperidine-3-carboxylic acid
Authors:Dashnyam, P., Lin, H.Y., Lin, C.H.
Deposit date:2017-12-25
Release date:2018-12-12
Method:X-RAY DIFFRACTION (1.859 Å)
Cite:Dissection of the substrate preference and structure of gut microbial-glucuronidases identifies the major bacteria causing xenobiotic toxicity
To Be Published
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