Author results

4BKG
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CRYSTAL STRUCTURE OF HUMAN DISUMO-2
Descriptor:SMALL UBIQUITIN-RELATED MODIFIER 2
Authors:Keusekotten, K., Bade, V.N., Meyer-Teschendorf, K., Sriramachandran, A., Fischer-Schrader, K., Krause, A., Horst, C., Hofmann, K., Dohmen, R.J., Praefcke, G.J.K.
Deposit date:2013-04-25
Release date:2013-11-06
Last modified:2018-06-06
Method:X-RAY DIFFRACTION (2.11 Å)
Cite:Multivalent Interactions of the Sumo-Interaction Motifs in the Ring-Finger Protein 4 (Rnf4) Determine the Specificity for Chains of the Small Ubiquitin-Related Modifier (Sumo).
Biochem.J., 457, 2014
1B89
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CLATHRIN HEAVY CHAIN PROXIMAL LEG SEGMENT (BOVINE)
Descriptor:PROTEIN (CLATHRIN HEAVY CHAIN)
Authors:Ybe, J.A., Brodsky, F.M., Hofmann, K., Lin, K., Liu, S.-H., Chen, L., Earnest, T.N., Fletterick, R.J., Hwang, P.K.
Deposit date:1999-05-27
Release date:1999-06-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Clathrin self-assembly is mediated by a tandemly repeated superhelix.
Nature, 399, 1999
3ZNV
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CRYSTAL STRUCTURE OF THE OTU DOMAIN OF OTULIN AT 1.3 ANGSTROMS.
Descriptor:PROTEIN FAM105B, GLYCEROL, CALCIUM ION, ...
Authors:Keusekotten, K., Elliott, P.R., Glockner, L., Kulathu, Y., Wauer, T., Krappmann, D., Hofmann, K., Komander, D.
Deposit date:2013-02-18
Release date:2013-06-26
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Otulin Antagonizes Lubac Signaling by Specifically Hydrolyzing met1-Linked Polyubiquitin.
Cell(Cambridge,Mass.), 153, 2013
3ZNX
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CRYSTAL STRUCTURE OF THE OTU DOMAIN OF OTULIN D336A MUTANT
Descriptor:PROTEIN FAM105B, CALCIUM ION, CHLORIDE ION, ...
Authors:Keusekotten, K., Elliott, P.R., Glockner, L., Kulathu, Y., Wauer, T., Krappmann, D., Hofmann, K., Komander, D.
Deposit date:2013-02-18
Release date:2013-06-26
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Otulin Antagonizes Lubac Signaling by Specifically Hydrolyzing met1-Linked Polyubiquitin.
Cell(Cambridge,Mass.), 153, 2013
3ZNZ
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CRYSTAL STRUCTURE OF OTULIN OTU DOMAIN (C129A) IN COMPLEX WITH MET1- DI UBIQUITIN
Descriptor:PROTEIN FAM105B, POLYUBIQUITIN-C, SULFATE ION
Authors:Keusekotten, K., Elliott, P.R., Glockner, L., Kulathu, Y., Wauer, T., Krappmann, D., Hofmann, K., Komander, D.
Deposit date:2013-02-18
Release date:2013-06-26
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Otulin Antagonizes Lubac Signaling by Specifically Hydrolyzing met1-Linked Polyubiquitin.
Cell(Cambridge,Mass.), 153, 2013
6EI1
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CRYSTAL STRUCTURE OF THE COVALENT COMPLEX BETWEEN DEUBIQUITINASE ZUFSP (ZUP1) AND UBIQUITIN-PA
Descriptor:Zinc finger with UFM1-specific peptidase domain protein, Polyubiquitin-B, prop-2-en-1-amine, ...
Authors:Pichlo, C., Baumann, U., Hofmann, K., Hermanns, T.
Deposit date:2017-09-16
Release date:2018-03-07
Last modified:2018-03-14
Method:X-RAY DIFFRACTION (1.732 Å)
Cite:A family of unconventional deubiquitinases with modular chain specificity determinants.
Nat Commun, 9, 2018
2VHF
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STRUCTURE OF THE CYLD USP DOMAIN
Descriptor:UBIQUITIN CARBOXYL-TERMINAL HYDROLASE CYLD, ZINC ION
Authors:Komander, D., Lord, C.J., Scheel, H., Swift, S., Hofmann, K., Ashworth, A., Barford, D.
Deposit date:2007-11-21
Release date:2008-03-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:The Structure of the Cyld Usp Domain Explains its Specificity for Lys63-Linked Polyubiquitin and Reveals a B-Box Module
Mol.Cell.Biol., 29, 2008
2WWZ
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TAB2 NZF DOMAIN IN COMPLEX WITH LYS63-LINKED DI-UBIQUITIN, P212121
Descriptor:UBIQUITIN, MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 7-INTERACTING PROTEIN 2, ZINC ION
Authors:Kulathu, Y., Akutsu, M., Bremm, A., Hofmann, K., Komander, D.
Deposit date:2009-10-30
Release date:2009-11-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Two-Sided Ubiquitin Binding Explains Specificity of the Tab2 Nzf Domain
Nat.Struct.Mol.Biol., 16, 2009
2WX0
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TAB2 NZF DOMAIN IN COMPLEX WITH LYS63-LINKED DI-UBIQUITIN, P21
Descriptor:UBIQUITIN, MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 7-INTERACTING PROTEIN 2, ZINC ION
Authors:Kulathu, Y., Akutsu, M., Bremm, A., Hofmann, K., Komander, D.
Deposit date:2009-10-30
Release date:2009-11-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Two-Sided Ubiquitin Binding Explains Specificity of the Tab2 Nzf Domain
Nat.Struct.Mol.Biol., 16, 2009
2WX1
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TAB2 NZF DOMAIN IN COMPLEX WITH LYS63-LINKED TRI-UBIQUITIN, P212121
Descriptor:UBIQUITIN, MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 7-INTERACTING PROTEIN 2, ZINC ION
Authors:Kulathu, Y., Akutsu, M., Bremm, A., Hofmann, K., Komander, D.
Deposit date:2009-10-30
Release date:2009-11-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Two-Sided Ubiquitin Binding Explains Specificity of the Tab2 Nzf Domain
Nat.Struct.Mol.Biol., 16, 2009
4AE4
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THE UBAP1 SUBUNIT OF ESCRT-I INTERACTS WITH UBIQUITIN VIA A NOVEL SOUBA DOMAIN
Descriptor:UBIQUITIN-ASSOCIATED PROTEIN 1, 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, POTASSIUM ION, ...
Authors:Agromayor, M., Soler, N., Caballe, A., Kueck, T., Freund, S.M., Allen, M.D., Bycroft, M., Perisic, O., Ye, Y., McDonald, B., Scheel, H., Hofmann, K., Neil, S.J.D., Martin-Serrano, J., Williams, R.L.
Deposit date:2012-01-06
Release date:2012-03-21
Last modified:2018-02-28
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:The UBAP1 subunit of ESCRT-I interacts with ubiquitin via a SOUBA domain.
Structure, 20, 2012
5N12
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CRYSTAL STRUCTURE OF TCE TREATED RPPEP-1
Descriptor:Pro-Pro endopeptidase, ZINC ION, 2,2,2-tris-chloroethanol, ...
Authors:Pichlo, C., Schacherl, M., Baumann, U.
Deposit date:2017-02-04
Release date:2018-05-30
Method:X-RAY DIFFRACTION (1.38 Å)
Cite:Improved protein-crystal identification by using 2,2,2-trichloroethanol as a fluorescence enhancer.
Acta Crystallogr F Struct Biol Commun, 74, 2018
6FSJ
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CRYSTAL STRUCTURE OF TCE-TREATED LYSOZYME
Descriptor:Lysozyme C, 1,2-ETHANEDIOL, CITRIC ACID
Authors:Pichlo, C., Baumann, U.
Deposit date:2018-02-19
Release date:2018-05-02
Last modified:2018-05-09
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Improved protein-crystal identification by using 2,2,2-trichloroethanol as a fluorescence enhancer.
Acta Crystallogr F Struct Biol Commun, 74, 2018
6FSM
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CRYSTAL STRUCTURE OF TCE-TREATED THERMOLYSIN
Descriptor:Thermolysin, ZINC ION, CALCIUM ION, ...
Authors:Pichlo, C., Baumann, U.
Deposit date:2018-02-19
Release date:2018-05-02
Last modified:2018-05-09
Method:X-RAY DIFFRACTION (1.39 Å)
Cite:Improved protein-crystal identification by using 2,2,2-trichloroethanol as a fluorescence enhancer.
Acta Crystallogr F Struct Biol Commun, 74, 2018
2N7D
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SOLUTION STRUCTURE OF THE UBL DOMAIN OF HUMAN DDI2
Descriptor:Protein DDI1 homolog 2
Authors:Siva, M., Grantz Saskova, K., Veverka, V.
Deposit date:2015-09-08
Release date:2016-07-20
Last modified:2016-08-10
Method:SOLUTION NMR
Cite:Human DNA-Damage-Inducible 2 Protein Is Structurally and Functionally Distinct from Its Yeast Ortholog.
Sci Rep, 6, 2016
2Z4D
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NMR STRUCTURES OF YEAST PROTEASOME COMPONENT RPN13
Descriptor:26S proteasome regulatory subunit RPN13
Authors:Zhang, N., Walters, K.J.
Deposit date:2007-06-15
Release date:2008-05-20
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Proteasome subunit Rpn13 is a novel ubiquitin receptor.
Nature, 453, 2008
5JKN
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CRYSTAL STRUCTURE OF DEUBIQUITINASE MINDY-1
Descriptor:Protein FAM63A, DI(HYDROXYETHYL)ETHER, PHOSPHATE ION, ...
Authors:Abdul Rehman, S.A., Kulathu, Y.
Deposit date:2016-04-26
Release date:2016-06-22
Last modified:2016-07-20
Method:X-RAY DIFFRACTION (3 Å)
Cite:MINDY-1 Is a Member of an Evolutionarily Conserved and Structurally Distinct New Family of Deubiquitinating Enzymes.
Mol.Cell, 63, 2016
5JQS
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CRYSTAL STRUCTURE OF DEUBIQUITINASE MINDY-1 IN COMPLEX WITH UBIQUITIN
Descriptor:Protein FAM63A, Ubiquitin-40S ribosomal protein S27a, prop-2-en-1-amine, ...
Authors:Abdul Rehman, S.A., Kulathu, Y.
Deposit date:2016-05-05
Release date:2016-06-22
Last modified:2016-07-20
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:MINDY-1 Is a Member of an Evolutionarily Conserved and Structurally Distinct New Family of Deubiquitinating Enzymes.
Mol.Cell, 63, 2016
5O6C
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CRYSTAL STRUCTURE OF A THREONINE-SELECTIVE RCR E3 LIGASE
Descriptor:E3 ubiquitin-protein ligase MYCBP2, ZINC ION
Authors:Pao, K.-C., Rafie, K.Z., van Aalten, D., Virdee, S.
Deposit date:2017-06-06
Release date:2018-04-18
Last modified:2018-05-02
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Activity-based E3 ligase profiling uncovers an E3 ligase with esterification activity.
Nature, 556, 2018
3M62
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CRYSTAL STRUCTURE OF UFD2 IN COMPLEX WITH THE UBIQUITIN-LIKE (UBL) DOMAIN OF RAD23
Descriptor:Ubiquitin conjugation factor E4, UV excision repair protein RAD23, PENTAETHYLENE GLYCOL, ...
Authors:Haenzelmann, P., Schindelin, H.
Deposit date:2010-03-15
Release date:2010-04-28
Last modified:2013-09-25
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:The yeast E4 ubiquitin ligase Ufd2 interacts with the ubiquitin-like domains of Rad23 and Dsk2 via a novel and distinct ubiquitin-like binding domain.
J.Biol.Chem., 285, 2010
3M63
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CRYSTAL STRUCTURE OF UFD2 IN COMPLEX WITH THE UBIQUITIN-LIKE (UBL) DOMAIN OF DSK2
Descriptor:Ubiquitin conjugation factor E4, Ubiquitin domain-containing protein DSK2, PENTAETHYLENE GLYCOL, ...
Authors:Haenzelmann, P., Schindelin, H.
Deposit date:2010-03-15
Release date:2010-04-28
Last modified:2013-09-25
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:The yeast E4 ubiquitin ligase Ufd2 interacts with the ubiquitin-like domains of Rad23 and Dsk2 via a novel and distinct ubiquitin-like binding domain.
J.Biol.Chem., 285, 2010
5K57
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HDD DOMAIN FROM HUMAN DDI2
Descriptor:Protein DDI1 homolog 2
Authors:Veverka, V.
Deposit date:2016-05-23
Release date:2016-08-10
Last modified:2019-05-08
Method:SOLUTION NMR
Cite:Human DNA-Damage-Inducible 2 Protein Is Structurally and Functionally Distinct from Its Yeast Ortholog.
Sci Rep, 6, 2016
1DP7
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COCRYSTAL STRUCTURE OF RFX-DBD IN COMPLEX WITH ITS COGNATE X-BOX BINDING SITE
Descriptor:DNA (5'-D(*CP*GP*(BRU)P*TP*AP*CP*CP*AP*(BRU)P*GP*GP*TP*AP*AP*CP*G)-3'), MHC CLASS II TRANSCRIPTION FACTOR HRFX1, 1,2-ETHANEDIOL, ...
Authors:Gajiwala, K.S., Chen, H., Cornille, F., Roques, B.P., Reith, W., Mach, B., Burley, S.K.
Deposit date:1999-12-23
Release date:2000-03-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structure of the winged-helix protein hRFX1 reveals a new mode of DNA binding.
Nature, 403, 2000
6NYC
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MUNC13-1 C2B-DOMAIN, CALCIUM FREE
Descriptor:Munc13-1, CHLORIDE ION, 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL
Authors:Tomchick, D.R., Rizo, J., Machius, M., Lu, J.
Deposit date:2019-02-11
Release date:2019-02-20
Method:X-RAY DIFFRACTION (1.893 Å)
Cite:Munc13 C2B domain is an activity-dependent Ca2+ regulator of synaptic exocytosis.
Nat. Struct. Mol. Biol., 17, 2010
6NYT
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MUNC13-1 C2B-DOMAIN, CALCIUM BOUND
Descriptor:Protein unc-13 homolog A, CALCIUM ION, CHLORIDE ION, ...
Authors:Tomchick, D.R., Rizo, J., Machius, M., Lu, J.
Deposit date:2019-02-12
Release date:2019-02-20
Method:X-RAY DIFFRACTION (1.369 Å)
Cite:Munc13 C2B domain is an activity-dependent Ca2+ regulator of synaptic exocytosis.
Nat. Struct. Mol. Biol., 17, 2010