Author results

4CCC
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STRUCTURE OF MOUSE GALACTOCEREBROSIDASE WITH 4NBDG: ENZYME-SUBSTRATE COMPLEX
Descriptor:GALACTOCEREBROSIDASE, 1-O-[P-NITROPHENYL]-BETA-D-GALACTOPYRANOSE, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Hill, C.H., Graham, S.C., Read, R.J., Deane, J.E.
Deposit date:2013-10-21
Release date:2013-12-11
Last modified:2014-01-08
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:Structural Snapshots Illustrate the Catalytic Cycle of Beta-Galactocerebrosidase, the Defective Enzyme in Krabbe Disease
Proc.Natl.Acad.Sci.USA, 110, 2013
4CCD
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STRUCTURE OF MOUSE GALACTOCEREBROSIDASE WITH D-GALACTAL: ENZYME- INTERMEDIATE COMPLEX
Descriptor:GALACTOCEREBROSIDASE, 2-DEOXY-BETA-D-GALACTOSE, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Hill, C.H., Graham, S.C., Read, R.J., Deane, J.E.
Deposit date:2013-10-21
Release date:2013-12-11
Last modified:2014-01-08
Method:X-RAY DIFFRACTION (1.97 Å)
Cite:Structural Snapshots Illustrate the Catalytic Cycle of Beta-Galactocerebrosidase, the Defective Enzyme in Krabbe Disease
Proc.Natl.Acad.Sci.USA, 110, 2013
4CCE
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STRUCTURE OF MOUSE GALACTOCEREBROSIDASE WITH GALACTOSE: ENZYME- PRODUCT COMPLEX
Descriptor:GALACTOCEREBROSIDASE, BETA-D-GALACTOSE, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Hill, C.H., Graham, S.C., Read, R.J., Deane, J.E.
Deposit date:2013-10-21
Release date:2013-12-11
Last modified:2014-01-08
Method:X-RAY DIFFRACTION (2.06 Å)
Cite:Structural Snapshots Illustrate the Catalytic Cycle of Beta-Galactocerebrosidase, the Defective Enzyme in Krabbe Disease
Proc.Natl.Acad.Sci.USA, 110, 2013
4UEX
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STRUCTURE OF HUMAN SAPOSIN A AT LYSOSOMAL PH
Descriptor:PROSAPOSIN
Authors:Hill, C.H., Read, R.J., Deane, J.E.
Deposit date:2014-12-20
Release date:2015-07-15
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure of Human Saposin a at Lysosomal Ph.
Acta Crystallogr.,Sect.D, 71, 2015
4UFH
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MOUSE GALACTOCEREBROSIDASE COMPLEXED WITH ISO-GALACTO-FAGOMINE IGF
Descriptor:GALACTOCEREBROSIDASE, D-galacto-isofagomine, NICKEL (II) ION, ...
Authors:Hill, C.H., Viuff, A.H., Spratley, S.J., Salamone, S., Christensen, S.H., Read, R.J., Moriarty, N.W., Jensen, H.H., Deane, J.E.
Deposit date:2015-03-17
Release date:2015-03-25
Last modified:2015-06-10
Method:X-RAY DIFFRACTION (2.16 Å)
Cite:Azasugar Inhibitors as Pharmacological Chaperones for Krabbe Disease.
Chem.Sci., 6, 2015
4UFI
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MOUSE GALACTOCEREBROSIDASE COMPLEXED WITH AZA-GALACTO-FAGOMINE AGF
Descriptor:GALACTOCEREBROSIDASE, (3R,4S,5R)-3-(hydroxymethyl)-1,2-diazinane-4,5-diol, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Hill, C.H., Viuff, A.H., Spratley, S.J., Salamone, S., Christensen, S.H., Read, R.J., Moriarty, N.W., Jensen, H.H., Deane, J.E.
Deposit date:2015-03-17
Release date:2015-03-25
Last modified:2015-06-10
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Azasugar Inhibitors as Pharmacological Chaperones for Krabbe Disease.
Chem.Sci., 6, 2015
4UFJ
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MOUSE GALACTOCEREBROSIDASE COMPLEXED WITH ISO-GALACTO-FAGOMINE LACTAM IGL
Descriptor:GALACTOCEREBROSIDASE, (3S,4S,5R)-5-(hydroxymethyl)-3,4-bis(oxidanyl)piperidin-2-one, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Hill, C.H., Viuff, A.H., Spratley, S.J., Salamone, S., Christensen, S.H., Read, R.J., Moriarty, N.W., Jensen, H.H., Deane, J.E.
Deposit date:2015-03-17
Release date:2015-03-25
Last modified:2015-06-10
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Azasugar Inhibitors as Pharmacological Chaperones for Krabbe Disease.
Chem.Sci., 6, 2015
4UFK
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MOUSE GALACTOCEREBROSIDASE COMPLEXED WITH DIDEOXY-IMINO-LYXITOL DIL
Descriptor:GALACTOCEREBROSIDASE, DIDEOXY-IMINO-LYXITOL, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Hill, C.H., Viuff, A.H., Spratley, S.J., Salamone, S., Christensen, S.H., Read, R.J., Moriarty, N.W., Jensen, H.H., Deane, J.E.
Deposit date:2015-03-17
Release date:2015-03-25
Last modified:2015-06-10
Method:X-RAY DIFFRACTION (2.402 Å)
Cite:Azasugar Inhibitors as Pharmacological Chaperones for Krabbe Disease.
Chem.Sci., 6, 2015
4UFL
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MOUSE GALACTOCEREBROSIDASE COMPLEXED WITH DEOXY-GALACTO-NOEUROSTEGINE DGN
Descriptor:GALACTOCEREBROSIDASE, DEOXY-GALACTO-NOEUROSTEGINE, CALCIUM ION, ...
Authors:Hill, C.H., Viuff, A.H., Spratley, S.J., Salamone, S., Christensen, S.H., Read, R.J., Moriarty, N.W., Jensen, H.H., Deane, J.E.
Deposit date:2015-03-17
Release date:2015-03-25
Last modified:2015-06-10
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Azasugar Inhibitors as Pharmacological Chaperones for Krabbe Disease.
Chem.Sci., 6, 2015
4UFM
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MOUSE GALACTOCEREBROSIDASE COMPLEXED WITH 1-DEOXY-GALACTO-NOJIRIMYCIN DGJ
Descriptor:GALACTOCEREBROSIDASE, (2R,3S,4R,5S)-2-(hydroxymethyl)piperidine-3,4,5-triol, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Hill, C.H., Viuff, A.H., Spratley, S.J., Salamone, S., Christensen, S.H., Read, R.J., Moriarty, N.W., Jensen, H.H., Deane, J.E.
Deposit date:2015-03-17
Release date:2015-04-01
Last modified:2015-06-10
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Azasugar Inhibitors as Pharmacological Chaperones for Krabbe Disease.
Chem.Sci., 6, 2015
6I1D
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STRUCTURE OF THE YSH1-MPE1 NUCLEASE COMPLEX FROM S.CEREVISIAE
Descriptor:Endoribonuclease YSH1, Protein MPE1, ZINC ION, ...
Authors:Hill, C.H., Boreikaite, V., Kumar, A., Casanal, A., Kubik, P., Degliesposti, G., Maslen, S., Mariani, A., von Loeffelholz, O., Girbig, M., Skehel, M., Passmore, L.A.
Deposit date:2018-10-28
Release date:2019-02-13
Method:X-RAY DIFFRACTION (2.28 Å)
Cite:Activation of the Endonuclease that Defines mRNA 3' Ends Requires Incorporation into an 8-Subunit Core Cleavage and Polyadenyl
Mol.Cell, 2019
5NXB
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MOUSE GALACTOCEREBROSIDASE IN COMPLEX WITH SAPOSIN A
Descriptor:Galactocerebrosidase, Prosaposin, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Graham, S.C., Hill, C.H., Deane, J.E.
Deposit date:2017-05-09
Release date:2017-05-24
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:The mechanism of glycosphingolipid degradation revealed by a GALC-SapA complex structure.
Nat Commun, 9, 2018
5FQL
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INSIGHTS INTO HUNTER SYNDROME FROM THE STRUCTURE OF IDURONATE-2- SULFATASE
Descriptor:IDURONATE-2-SULFATASE, CALCIUM ION, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Demydchuk, M., Hill, C.H., Zhou, A., Bunkoczi, G., Stein, P.E., Marchesan, D., Deane, J.E., Read, R.J.
Deposit date:2015-12-11
Release date:2017-01-18
Last modified:2017-06-21
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Insights into Hunter syndrome from the structure of iduronate-2-sulfatase.
Nat Commun, 8, 2017
6EOJ
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POLYA POLYMERASE MODULE OF THE CLEAVAGE AND POLYADENYLATION FACTOR (CPF) FROM SACCHAROMYCES CEREVISIAE
Descriptor:Protein CFT1, mRNA 3'-end-processing protein YTH1, Polyadenylation factor subunit 2,Polyadenylation factor subunit 2, ...
Authors:Casanal, A., Kumar, A., Hill, C.H., Emsley, P., Passmore, L.
Deposit date:2017-10-09
Release date:2017-11-15
Last modified:2018-01-31
Method:ELECTRON MICROSCOPY (3.55 Å)
Cite:Architecture of eukaryotic mRNA 3'-end processing machinery.
Science, 358, 2017
6FPP
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STRUCTURE OF S. POMBE MMI1
Descriptor:YTH domain-containing protein mmi1, GLYCEROL, MAGNESIUM ION
Authors:Stowell, J.A.W., Hill, C.H., Yu, M., Wagstaff, J.L., McLaughlin, S.H., Freund, S.M.V., Passmore, L.A.
Deposit date:2018-02-11
Release date:2018-05-09
Last modified:2018-06-27
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:A low-complexity region in the YTH domain protein Mmi1 enhances RNA binding.
J. Biol. Chem., 293, 2018
6FPQ
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STRUCTURE OF S. POMBE MMI1 IN COMPLEX WITH 7-MER RNA
Descriptor:YTH domain-containing protein mmi1, RNA (5'-R(*UP*UP*AP*AP*AP*CP*C)-3'), (4R)-2-METHYLPENTANE-2,4-DIOL
Authors:Stowell, J.A.W., Hill, C.H., Yu, M., Wagstaff, J.L., McLaughlin, S.H., Freund, S.M.V., Passmore, L.A.
Deposit date:2018-02-11
Release date:2018-05-09
Last modified:2018-06-27
Method:X-RAY DIFFRACTION (1.42 Å)
Cite:A low-complexity region in the YTH domain protein Mmi1 enhances RNA binding.
J. Biol. Chem., 293, 2018
6FPX
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STRUCTURE OF S. POMBE MMI1 IN COMPLEX WITH 11-MER RNA
Descriptor:YTH domain-containing protein mmi1, RNA (5'-R(P*UP*UP*UP*AP*AP*AP*CP*CP*UP*A)-3'), GLYCEROL
Authors:Stowell, J.A.W., Hill, C.H., Yu, M., Wagstaff, J.L., McLaughlin, S.H., Freund, S.M.V., Passmore, L.A.
Deposit date:2018-02-12
Release date:2018-05-09
Last modified:2018-06-27
Method:X-RAY DIFFRACTION (1.97 Å)
Cite:A low-complexity region in the YTH domain protein Mmi1 enhances RNA binding.
J. Biol. Chem., 293, 2018
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