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5LPG
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BU of 5lpg by Molmil
Structure of NUDT15 in complex with 6-thio-GMP
Descriptor: MAGNESIUM ION, Probable 8-oxo-dGTP diphosphatase NUDT15, [(2~{R},3~{S},4~{R},5~{R})-5-(2-azanyl-6-sulfanyl-purin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl dihydrogen phosphate
Authors:Masuyer, G, Carter, M, Rehling, D, Stenmark, P, Helleday, T, Jemth, A.-S, Valerie, N.C.K, Homan, E, Herr, P, Bevc, L, Page, B.D.G, Hagenkort, A.
Deposit date:2016-08-12
Release date:2016-08-24
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:NUDT15 Hydrolyzes 6-Thio-DeoxyGTP to Mediate the Anticancer Efficacy of 6-Thioguanine.
Cancer Res., 76, 2016
6RLW
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BU of 6rlw by Molmil
Structure of the human 8-oxoguanine DNA Glycosylase hOGG1 in complex with inhibitor TH5487
Descriptor: 4-(4-bromanyl-2-oxidanylidene-3~{H}-benzimidazol-1-yl)-~{N}-(4-iodophenyl)piperidine-1-carboxamide, N-glycosylase/DNA lyase
Authors:Masuyer, G, Stenmark, P.
Deposit date:2019-05-03
Release date:2020-07-22
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Targeting OGG1 arrests cancer cell proliferation by inducing replication stress.
Nucleic Acids Res., 48, 2020
5LOU
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BU of 5lou by Molmil
human NUDT22
Descriptor: Nucleoside diphosphate-linked moiety X motif 22, PHOSPHATE ION
Authors:Carter, M, Stenmark, P.
Deposit date:2016-08-10
Release date:2017-09-13
Last modified:2019-03-27
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Human NUDT22 Is a UDP-Glucose/Galactose Hydrolase Exhibiting a Unique Structural Fold.
Structure, 26, 2018
4XHU
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BU of 4xhu by Molmil
The complex structure of Timeless_PAB and PARP-1_catalytic domain
Descriptor: ACETATE ION, CALCIUM ION, GLYCEROL, ...
Authors:Xie, S, Qian, C.
Deposit date:2015-01-06
Release date:2015-09-30
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.089 Å)
Cite:Timeless Interacts with PARP-1 to Promote Homologous Recombination Repair.
Mol.Cell, 60, 2015
4XHT
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BU of 4xht by Molmil
Crystal structure of Timeless_PAB domain native form
Descriptor: Protein timeless homolog
Authors:Xie, S, Qian, C.
Deposit date:2015-01-06
Release date:2015-09-30
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.651 Å)
Cite:Timeless Interacts with PARP-1 to Promote Homologous Recombination Repair.
Mol.Cell, 60, 2015
4XHW
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BU of 4xhw by Molmil
Crystal structure of Timeless_PAB domain in SeMet-labelled form
Descriptor: Protein timeless homolog
Authors:Xie, S, Qian, C.
Deposit date:2015-01-06
Release date:2015-09-30
Last modified:2015-10-14
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Timeless Interacts with PARP-1 to Promote Homologous Recombination Repair.
Mol.Cell, 60, 2015
4FJV
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BU of 4fjv by Molmil
Crystal Structure of Human Otubain2 and Ubiquitin Complex
Descriptor: ETHANAMINE, GLYCEROL, Polyubiquitin-C, ...
Authors:Altun, M, Walter, T.S, Kramer, H.B, Iphofer, A, David, Y, Komsany, A, Ternette, N, Nicholson, B, Navon, A, Stuart, D.I, Ren, J, Kessler, B.M.
Deposit date:2012-06-12
Release date:2013-06-12
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.047 Å)
Cite:The human otubain2-ubiquitin structure provides insights into the cleavage specificity of poly-ubiquitin-linkages.
Plos One, 10, 2015

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