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5JDK
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CRYSTAL STRUCTURE OF THE DNA BINDING DOMAIN OF SAP1 IN FISSION YEAST S.POMBE
Descriptor:Switch-activating protein 1, GLYCEROL
Authors:He, P., Wang, T.
Deposit date:2016-04-17
Release date:2017-02-22
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (0.998 Å)
Cite:Sap1 is a replication-initiation factor essential for the assembly of pre-replicative complex in the fission yeast Schizosaccharomyces pombe.
J. Biol. Chem., 292, 2017
2R5V
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HYDROXYMANDELATE SYNTHASE CRYSTAL STRUCTURE
Descriptor:PCZA361.1, COBALT (II) ION, (2S)-hydroxy(4-hydroxyphenyl)ethanoic acid, ...
Authors:Brownlee, J.M., He, P., Moran, G.R., Harrison, D.H.T.
Deposit date:2007-09-04
Release date:2008-03-18
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Two roads diverged: the structure of hydroxymandelate synthase from Amycolatopsis orientalis in complex with 4-hydroxymandelate.
Biochemistry, 47, 2008
5JM5
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CRYSTAL STRUCTURE OF AKR1C3 COMPLEXED WITH A PRO-DRUG
Descriptor:Aldo-keto reductase family 1 member C3, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, (1R)-1-{3-[3-(dimethylcarbamoyl)phenoxy]-4-nitrophenyl}ethyl bis[(aziridin-1-yl)]phosphinate, ...
Authors:Wang, C., Wang, C., Li, Q., Wang, Z., Xie, W.
Deposit date:2016-04-28
Release date:2017-05-03
Method:X-RAY DIFFRACTION (1.994 Å)
Cite:An AKR1C3 based Pro-drug TH3424 has potent anti-tumor activity against liver cancer
To Be Published
5TOS
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BOTRYTIS-INDUCED KINASE 1 (BIK1) FROM ARABIDOPSIS THALIANA
Descriptor:Serine/threonine-protein kinase BIK1
Authors:Hurlburt, N.K., Lal, N.K., Fisher, A.J.
Deposit date:2016-10-18
Release date:2018-04-18
Last modified:2018-08-29
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:The Receptor-like Cytoplasmic Kinase BIK1 Localizes to the Nucleus and Regulates Defense Hormone Expression during Plant Innate Immunity.
Cell Host Microbe, 23, 2018
4TVG
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HIV PROTEASE (PR) DIMER IN CLOSED FORM WITH PEPSTATIN IN ACTIVE SITE AND FRAGMENT AK-2097 IN THE OUTSIDE/TOP OF FLAP
Descriptor:HIV Protease, Pepstatin, 3-(morpholin-4-ylmethyl)-1H-indole-6-carboxylic acid, ...
Authors:Tiefenbrunn, T., Kislukhin, A., Finn, M.G., Stout, C.D.
Deposit date:2014-06-26
Release date:2014-09-24
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.18 Å)
Cite:Distinguishing Binders from False Positives by Free Energy Calculations: Fragment Screening Against the Flap Site of HIV Protease.
J.Phys.Chem.B, 119, 2015
4TVH
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HIV PROTEASE (PR) DIMER IN CLOSED FORM WITH TL-3 IN ACTIVE SITE AND FRAGMENT AK-2097 IN THE OUTSIDE/TOP OF FLAP
Descriptor:Protease, benzyl [(1S,4S,7S,8R,9R,10S,13S,16S)-7,10-dibenzyl-8,9-dihydroxy-1,16-dimethyl-4,13-bis(1-methylethyl)-2,5,12,15,18-pentaoxo-20-phenyl-19-oxa-3,6,11,14,17-pentaazaicos-1-yl]carbamate, BETA-MERCAPTOETHANOL, ...
Authors:Tiefenbrunn, T., Kislukhin, A., Finn, M.G., Stout, C.D.
Deposit date:2014-06-26
Release date:2014-09-17
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.195 Å)
Cite:Distinguishing Binders from False Positives by Free Energy Calculations: Fragment Screening Against the Flap Site of HIV Protease.
J.Phys.Chem.B, 119, 2015
5B7J
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STRUCTURE MODEL OF SAP1-DNA COMPLEX
Descriptor:Switch-activating protein 1, DNA (5'-D(*CP*AP*AP*AP*AP*CP*AP*AP*TP*AP*TP*T)-3'), DNA (5'-D(*AP*AP*TP*AP*TP*TP*GP*TP*TP*TP*TP*G)-3')
Authors:Jin, C., Hu, Y., Ding, J., Zhang, Y.
Deposit date:2016-06-07
Release date:2017-02-22
Last modified:2017-05-24
Method:SOLUTION NMR
Cite:Sap1 is a replication-initiation factor essential for the assembly of pre-replicative complex in the fission yeast Schizosaccharomyces pombe
J. Biol. Chem., 292, 2017
3SX9
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CALCIUM-DEPENDENT PROTEIN KINASE 1 FROM TOXOPLASMA GONDII (TGCDPK1) IN COMPLEX WITH BUMPED KINASE INHIBITOR, RM-1-132
Descriptor:Calmodulin-domain protein kinase 1, 3-(6-ethoxynaphthalen-2-yl)-1-(piperidin-4-ylmethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Authors:Larson, E.T., Merritt, E.A.
Deposit date:2011-07-14
Release date:2012-03-14
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Multiple determinants for selective inhibition of apicomplexan calcium-dependent protein kinase CDPK1.
J.Med.Chem., 55, 2012