1GHE | | CRYSTAL STRUCTURE OF TABTOXIN RESISTANCE PROTEIN COMPLEXED WITH AN ACYL COENZYME A | | Descriptor: | ACETYLTRANSFERASE, ACETYL COENZYME *A | | Authors: | He, H., Ding, Y., Bartlam, M., Sun, F., Le, Y., Qin, X., Tang, H., Zhang, R., Joachimiak, A., Liu, Y., Zhao, N., Rao, Z. | | Deposit date: | 2000-12-13 | | Release date: | 2003-01-14 | | Last modified: | 2017-10-04 | | Method: | X-RAY DIFFRACTION (1.55 Å) | | Cite: | Crystal Structure of Tabtoxin Resistance Protein Complexed with Acetyl
Coenzyme A Reveals the Mechanism for beta-Lactam Acetylation
J.Mol.Biol., 325, 2003
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1J4J | | CRYSTAL STRUCTURE OF TABTOXIN RESISTANCE PROTEIN (FORM II) COMPLEXED WITH AN ACYL COENZYME A | | Descriptor: | TABTOXIN RESISTANCE PROTEIN, ACETYL COENZYME *A | | Authors: | He, H., Ding, Y., Bartlam, M., Zhang, R., Duke, N., Joachimiak, A., Shao, Y., Cao, Z., Tang, H., Liu, Y., Jiang, F., Liu, J., Zhao, N., Rao, Z. | | Deposit date: | 2001-10-02 | | Release date: | 2003-06-03 | | Last modified: | 2017-10-04 | | Method: | X-RAY DIFFRACTION (2.55 Å) | | Cite: | Crystal structure of tabtoxin resistance protein complexed with acetyl coenzyme A reveals the mechanism for beta-lactam acetylation.
J.Mol.Biol., 325, 2003
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3IG3 | | CRYSTAL STRUCTURE OF MOUSE PLEXIN A3 INTRACELLULAR DOMAIN | | Descriptor: | Plxna3 protein, GLYCEROL | | Authors: | He, H., Zhang, X. | | Deposit date: | 2009-07-27 | | Release date: | 2009-08-25 | | Last modified: | 2017-11-01 | | Method: | X-RAY DIFFRACTION (1.99 Å) | | Cite: | Crystal structure of the plexin A3 intracellular region reveals an autoinhibited conformation through active site sequestration.
Proc.Natl.Acad.Sci.USA, 106, 2009
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4OTM | |
4OTN | |
4QHD | | CRYSTAL STRUCTURE OF APO HUMAN APE1 | | Descriptor: | DNA-(apurinic or apyrimidinic site) lyase, 1,2-ETHANEDIOL | | Authors: | He, H., Chen, Q., Georgiadis, M.M. | | Deposit date: | 2014-05-28 | | Release date: | 2014-11-12 | | Method: | X-RAY DIFFRACTION (1.65 Å) | | Cite: | High-resolution crystal structures reveal plasticity in the metal binding site of apurinic/apyrimidinic endonuclease I.
Biochemistry, 53, 2014
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4QHE | | CRYSTAL STRUCTURE OF MG2+ BOUND HUMAN APE1 | | Descriptor: | DNA-(apurinic or apyrimidinic site) lyase, MAGNESIUM ION, 1,2-ETHANEDIOL | | Authors: | He, H., Chen, Q., Georgiadis, M.M. | | Deposit date: | 2014-05-28 | | Release date: | 2014-11-12 | | Last modified: | 2017-11-22 | | Method: | X-RAY DIFFRACTION (1.4 Å) | | Cite: | High-resolution crystal structures reveal plasticity in the metal binding site of apurinic/apyrimidinic endonuclease I.
Biochemistry, 53, 2014
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6LCC | |
6LCD | |
4QH9 | | CRYSTAL STRUCTURE OF MN2+ BOUND HUMAN APE1 | | Descriptor: | DNA-(apurinic or apyrimidinic site) lyase, 1,2-ETHANEDIOL, MANGANESE (II) ION | | Authors: | Chen, Q., He, H., Georgiadis, M.M. | | Deposit date: | 2014-05-27 | | Release date: | 2014-11-12 | | Last modified: | 2017-11-22 | | Method: | X-RAY DIFFRACTION (2.175 Å) | | Cite: | High-resolution crystal structures reveal plasticity in the metal binding site of apurinic/apyrimidinic endonuclease I.
Biochemistry, 53, 2014
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3NWN | | CRYSTAL STRUCTURE OF THE HUMAN KIF9 MOTOR DOMAIN IN COMPLEX WITH ADP | | Descriptor: | Kinesin-like protein KIF9, MAGNESIUM ION, CHLORIDE ION, ... | | Authors: | Zhu, H., Tempel, W., He, H., Shen, Y., Wang, J., Brothers, G., Landry, R., Arrowsmith, C.H., Edwards, A.M., Sundstrom, M., Weigelt, J., Bochkarev, A., Park, H., Structural Genomics Consortium (SGC) | | Deposit date: | 2010-07-09 | | Release date: | 2010-07-21 | | Last modified: | 2017-11-08 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Crystal structure of the human KIF9 motor domain in complex with ADP
To be Published
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4HC4 | | HUMAN HMT1 HNRNP METHYLTRANSFERASE-LIKE PROTEIN 6 (S. CEREVISIAE) | | Descriptor: | Protein arginine N-methyltransferase 6, S-ADENOSYL-L-HOMOCYSTEINE, 1,2-ETHANEDIOL, ... | | Authors: | Dong, A., Zeng, H., He, H., El Bakkouri, M., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Brown, P.J., Wu, H., Structural Genomics Consortium (SGC) | | Deposit date: | 2012-09-28 | | Release date: | 2012-10-17 | | Last modified: | 2018-05-16 | | Method: | X-RAY DIFFRACTION (1.97 Å) | | Cite: | Structural basis of arginine asymmetrical dimethylation by PRMT6.
Biochem. J., 473, 2016
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4MI0 | | HUMAN ENHANCER OF ZESTE (DROSOPHILA) HOMOLOG 2(EZH2) | | Descriptor: | Histone-lysine N-methyltransferase EZH2, ZINC ION, UNKNOWN ATOM OR ION | | Authors: | Dong, A., Zeng, H., He, H., Wernimont, A., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Brown, P.J., Wu, H., Structural Genomics Consortium (SGC) | | Deposit date: | 2013-08-30 | | Release date: | 2013-09-25 | | Last modified: | 2017-11-15 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structure of the catalytic domain of EZH2 reveals conformational plasticity in cofactor and substrate binding sites and explains oncogenic mutations.
Plos One, 8, 2013
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4QPP | | THE CRYSTAL STRUCTURE OF HUMAN HMT1 HNRNP METHYLTRANSFERASE-LIKE PROTEIN 6 IN COMPLEX WITH COMPOUND DS-421 (2-{4-[3-CHLORO-2-(2-METHOXYPHENYL)-1H-INDOL-5-YL]PIPERIDIN-1-YL}-N-METHYLETHANAMINE | | Descriptor: | Protein arginine N-methyltransferase 6, POLY-UNK, S-ADENOSYL-L-HOMOCYSTEINE, ... | | Authors: | Dong, A., Zeng, H., Smil, D., Walker, J.R., He, H., Eram, M., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Vedadi, M., Brown, P.J., Wu, H., Structural Genomics Consortium (SGC) | | Deposit date: | 2014-06-24 | | Release date: | 2014-08-20 | | Last modified: | 2017-11-22 | | Method: | X-RAY DIFFRACTION (2.52 Å) | | Cite: | The Crystal Structure of Human HMT1
hnRNP methyltransferase-like protein 6 in complex with compound DS-421
To be Published
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4QQK | | HUMAN HMT1 HNRNP METHYLTRANSFERASE-LIKE PROTEIN 6 (S. CEREVISIAE) WITH GMS | | Descriptor: | Protein arginine N-methyltransferase 6, (5S)-5-{[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl}-N~6~-carbamimidoyl-L-lysine, GLYCEROL, ... | | Authors: | Dong, A., Zeng, H., He, H., Wernimont, A., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Brown, P.J., Min, J., Luo, M., Wu, H., Structural Genomics Consortium (SGC) | | Deposit date: | 2014-06-27 | | Release date: | 2014-07-16 | | Last modified: | 2018-05-16 | | Method: | X-RAY DIFFRACTION (1.88 Å) | | Cite: | Structural basis of arginine asymmetrical dimethylation by PRMT6.
Biochem. J., 473, 2016
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4YVD | | CRYTSAL STRUCTURE OF HUMAN PLEIOTROPIC REGULATOR 1 (PRL1) | | Descriptor: | Pleiotropic regulator 1, SODIUM ION, CHLORIDE ION, ... | | Authors: | Dong, A., Zeng, H., Xu, C., Tempel, W., Li, Y., He, H., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Brown, P.J., Min, J., Wu, H., Structural Genomics Consortium (SGC) | | Deposit date: | 2015-03-19 | | Release date: | 2015-04-15 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Crytsal structure of human Pleiotropic Regulator 1 (PRL1).
to be published
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4IKP | | CRYSTAL STRUCTURE OF COACTIVATOR-ASSOCIATED ARGININE METHYLTRANSFERASE 1 WITH METHYLENESINEFUNGIN | | Descriptor: | Histone-arginine methyltransferase CARM1, (2S,5S)-2,6-diamino-5-{[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl}hexanoic acid, GLYCEROL, ... | | Authors: | Dong, A., Dombrovski, L., He, H., Ibanez, G., Wernimont, A., Zheng, W., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Brown, P.J., Min, J., Luo, M., Wu, H., Structural Genomics Consortium (SGC) | | Deposit date: | 2012-12-27 | | Release date: | 2013-02-13 | | Last modified: | 2018-04-18 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Crystal structure of coactivator-associated arginine methyltransferase 1 with methylenesinefungin
TO BE PUBLISHED
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3HM6 | | CRYSTAL STRUCTURE OF THE CYTOPLASMIC DOMAIN OF HUMAN PLEXIN B1 | | Descriptor: | Plexin-B1, Unknown peptide, UNKNOWN ATOM OR ION | | Authors: | Tong, Y., He, H., Shen, L., Tempel, W., MacKenzie, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Bochkarev, A., Park, H., Structural Genomics Consortium (SGC) | | Deposit date: | 2009-05-28 | | Release date: | 2009-06-09 | | Last modified: | 2017-11-01 | | Method: | X-RAY DIFFRACTION (2.402 Å) | | Cite: | Structure and function of the intracellular region of the plexin-b1 transmembrane receptor.
J.Biol.Chem., 284, 2009
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4LG8 | | CRYSTAL STRUCTURE OF PRPF19 WD40 REPEATS | | Descriptor: | Pre-mRNA-processing factor 19, SODIUM ION, UNKNOWN ATOM OR ION | | Authors: | Xu, C., Tempel, W., He, H., Dobrovetsky, E., Seitova, A., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC) | | Deposit date: | 2013-06-27 | | Release date: | 2013-08-07 | | Last modified: | 2018-01-03 | | Method: | X-RAY DIFFRACTION (1.89 Å) | | Cite: | Crystal structure of the WD40 domain of human PRPF19.
Biochem. Biophys. Res. Commun., 493, 2017
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4OA7 | | CRYSTAL STRUCTURE OF TANKYRASE1 IN COMPLEX WITH IWR1 | | Descriptor: | Tankyrase-1, ZINC ION, 4-[(3aR,4R,7S,7aS)-1,3-dioxo-1,3,3a,4,7,7a-hexahydro-2H-4,7-methanoisoindol-2-yl]-N-(quinolin-8-yl)benzamide | | Authors: | Zhang, X., He, H. | | Deposit date: | 2014-01-03 | | Release date: | 2015-01-07 | | Last modified: | 2017-11-22 | | Method: | X-RAY DIFFRACTION (2.301 Å) | | Cite: | Disruption of Wnt/ beta-Catenin Signaling and Telomeric Shortening Are Inextricable Consequences of Tankyrase Inhibition in Human Cells.
Mol.Cell.Biol., 35, 2015
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5GXH | | THE STRUCTURE OF THE GEMIN5 WD40 DOMAIN WITH AAUUUUUG | | Descriptor: | Gem-associated protein 5, RNA (5'-R(*A*AP*UP*UP*UP*UP*UP*G)-3'), UNKNOWN ATOM OR ION, ... | | Authors: | Xu, C., He, H., Li, Y., Dong, A., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC) | | Deposit date: | 2016-09-17 | | Release date: | 2016-10-26 | | Last modified: | 2018-10-17 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Structural insights into Gemin5-guided selection of pre-snRNAs for snRNP assembly
Genes Dev., 30, 2016
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5GXI | | STRUCUTRE OF THE GEMIN5 WD40 DOMAIN IN COMPLEX WITH AAUUUUUGAG | | Descriptor: | Gem-associated protein 5, RNA (5'-R(*A*AP*UP*UP*UP*UP*UP*GP*AP*G)-3'), UNKNOWN ATOM OR ION | | Authors: | Xu, C., He, H., Li, Y., Dong, A., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC) | | Deposit date: | 2016-09-18 | | Release date: | 2016-10-26 | | Last modified: | 2018-10-17 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | Structural insights into Gemin5-guided selection of pre-snRNAs for snRNP assembly
Genes Dev., 30, 2016
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5TEE | | CRYSTAL STRUCTURE OF GEMIN5 WD40 REPEATS IN APO FORM | | Descriptor: | Gem-associated protein 5, GLYCEROL, UNKNOWN ATOM OR ION, ... | | Authors: | Chao, X., Tempel, W., Bian, C., Cerovina, T., He, H., Walker, J.R., Seitova, A., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC) | | Deposit date: | 2016-09-21 | | Release date: | 2016-10-19 | | Last modified: | 2017-05-10 | | Method: | X-RAY DIFFRACTION (1.65 Å) | | Cite: | Structural insights into Gemin5-guided selection of pre-snRNAs for snRNP assembly.
Genes Dev., 30, 2016
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5TEF | | CRYSTAL STRUCTURE OF GEMIN5 WD40 REPEATS IN COMPLEX WITH M7GPPPG | | Descriptor: | Gem-associated protein 5, 7-METHYL-GUANOSINE-5'-TRIPHOSPHATE-5'-GUANOSINE, GLYCEROL, ... | | Authors: | Chao, X., Tempel, W., Bian, C., He, H., Cerovina, T., Seitova, A., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC) | | Deposit date: | 2016-09-21 | | Release date: | 2016-10-19 | | Last modified: | 2017-05-10 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Structural insights into Gemin5-guided selection of pre-snRNAs for snRNP assembly.
Genes Dev., 30, 2016
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5THA | | GEMIN5 WD40 REPEATS IN COMPLEX WITH A GUANOSYL MOIETY | | Descriptor: | Gem-associated protein 5, UNKNOWN ATOM OR ION, DIGUANOSINE-5'-TRIPHOSPHATE | | Authors: | Chao, X., Tempel, W., Bian, C., Cerovina, T., He, H., Seitova, A., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC) | | Deposit date: | 2016-09-29 | | Release date: | 2016-10-19 | | Last modified: | 2017-05-10 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Structural insights into Gemin5-guided selection of pre-snRNAs for snRNP assembly.
Genes Dev., 30, 2016
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