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2OAG
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CRYSTAL STRUCTURE OF HUMAN DIPEPTIDYL PEPTIDASE IV (DPPIV) WITH PYRROLIDINE-CONSTRAINED PHENETHYLAMINE 29G
Descriptor:Dipeptidyl peptidase 4, (3R,4S)-1-{6-[3-(METHYLSULFONYL)PHENYL]PYRIMIDIN-4-YL}-4-(2,4,5-TRIFLUOROPHENYL)PYRROLIDIN-3-AMINE
Authors:Backes, B.J., Longenecker, K.L., Hamilton, G.L., Stewart, K.D., Lai, C., Kopecka, H.
Deposit date:2006-12-15
Release date:2007-09-11
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Pyrrolidine-constrained phenethylamines: The design of potent, selective, and pharmacologically efficacious dipeptidyl peptidase IV (DPP4) inhibitors from a lead-like screening hit.
Bioorg.Med.Chem.Lett., 17, 2007
6NW2
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STRUCTURE OF HUMAN RIPK1 KINASE DOMAIN IN COMPLEX WITH COMPOUND 11
Descriptor:Receptor-interacting serine/threonine-protein kinase 1, (5R)-5-methyl-N-[(3S)-5-methyl-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepin-3-yl]-4,5,6,7-tetrahydro-2H-indazole-3-carboxamide
Authors:Fong, R., Lupardus, P.J.
Deposit date:2019-02-05
Release date:2019-05-01
Last modified:2019-05-15
Method:X-RAY DIFFRACTION (2 Å)
Cite:Potent and selective inhibitors of receptor-interacting protein kinase 1 that lack an aromatic back pocket group.
Bioorg.Med.Chem.Lett., 29, 2019
2OAE
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CRYSTAL STRUCTURE OF RAT DIPEPTIDYL PEPTIDASE (DPPIV) WITH THIAZOLE-BASED PEPTIDE MIMETIC #31
Descriptor:Dipeptidyl peptidase 4, SULFATE ION, N-{[(3S,5S)-5-(1,3-THIAZOLIDIN-3-YLCARBONYL)PYRROLIDIN-3-YL]METHYL}-1,3-THIAZOLE-4-CARBOXAMIDE
Authors:Longenecker, K.L., Shuai, Q., Patel, J., Wiedeman, P.
Deposit date:2006-12-15
Release date:2007-02-27
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (3 Å)
Cite:Pyrrolidine-constrained phenethylamines: The design of potent, selective, and pharmacologically efficacious dipeptidyl peptidase IV (DPP4) inhibitors from a lead-like screening hit.
Bioorg.Med.Chem.Lett., 17, 2007