Author results

6I6R
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NEW IRREVERSIBLE A-L-IDURONIDASE INHIBITORS AND ACTIVITY-BASED PROBES
Descriptor:Alpha-L-iduronidase, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Gloster, T.M., McMahon, S.A., Oehler, V.
Deposit date:2018-11-15
Release date:2018-12-05
Last modified:2019-03-06
Method:X-RAY DIFFRACTION (2.02 Å)
Cite:New Irreversible alpha-l-Iduronidase Inhibitors and Activity-Based Probes.
Chemistry, 24, 2018
6I6X
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NEW IRREVERSIBLE A-L-IDURONIDASE INHIBITORS AND ACTIVITY-BASED PROBES
Descriptor:Alpha-L-iduronidase, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Gloster, T.M., McMahon, S.A., Oehler, V.
Deposit date:2018-11-15
Release date:2018-12-05
Last modified:2018-12-26
Method:X-RAY DIFFRACTION (2.39 Å)
Cite:New Irreversible alpha-l-Iduronidase Inhibitors and Activity-Based Probes.
Chemistry, 24, 2018
6GX8
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ALPHA-GALACTOSIDASE FROM THERMOTOGA MARITIMA IN COMPLEX WITH HYDROLYSED CYCLOHEXENE-BASED CARBASUGAR MIMIC OF GALACTOSE
Descriptor:Alpha-galactosidase, SULFATE ION, (1~{S},2~{S},3~{S},4~{S})-3-fluoranyl-6-(hydroxymethyl)cyclohex-5-ene-1,2,4-triol, ...
Authors:Gloster, T.M., Oehler, V.
Deposit date:2018-06-26
Release date:2018-08-22
Method:X-RAY DIFFRACTION (1.42 Å)
Cite:Revealing the mechanism for covalent inhibition of glycoside hydrolases by carbasugars at an atomic level.
Nat Commun, 9, 2018
6GWF
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ALPHA-GALACTOSIDASE MUTANT D387A FROM THERMOTOGA MARITIMA IN COMPLEX WITH INTACT CYCLOHEXENE-BASED CARBASUGAR MIMIC OF GALACTOSE WITH 2,4-DINITRO LEAVING GROUP
Descriptor:Alpha-galactosidase, SULFATE ION, (1~{S},2~{S},5~{S},6~{R})-5-(2,4-dinitrophenoxy)-6-fluoranyl-3-(hydroxymethyl)cyclohex-3-ene-1,2-diol, ...
Authors:Gloster, T.M., Oehler, V.
Deposit date:2018-06-24
Release date:2018-08-22
Method:X-RAY DIFFRACTION (1.72 Å)
Cite:Revealing the mechanism for covalent inhibition of glycoside hydrolases by carbasugars at an atomic level.
Nat Commun, 9, 2018
6GWG
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ALPHA-GALACTOSIDASE FROM THERMOTOGA MARITIMA IN COMPLEX WITH CYCLOHEXENE-BASED CARBASUGAR MIMIC OF GALACTOSE COVALENTLY LINKED TO THE NUCLEOPHILE
Descriptor:Alpha-galactosidase, SULFATE ION, (1~{S},2~{S},3~{S})-3-fluoranyl-6-(hydroxymethyl)cyclohex-5-ene-1,2,4-triol, ...
Authors:Gloster, T.M., Oehler, V.
Deposit date:2018-06-24
Release date:2018-08-22
Method:X-RAY DIFFRACTION (1.77 Å)
Cite:Revealing the mechanism for covalent inhibition of glycoside hydrolases by carbasugars at an atomic level.
Nat Commun, 9, 2018
6GVD
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ALPHA-GALACTOSIDASE FROM THERMOTOGA MARITIMA IN COMPLEX WITH CYCLOHEXENE-BASED CARBASUGAR MIMIC OF GALACTOSE
Descriptor:Alpha-galactosidase, SULFATE ION, MAGNESIUM ION, ...
Authors:Gloster, T.M., Pengelly, R.J.
Deposit date:2018-06-20
Release date:2018-08-22
Method:X-RAY DIFFRACTION (1.22 Å)
Cite:Revealing the mechanism for covalent inhibition of glycoside hydrolases by carbasugars at an atomic level.
Nat Commun, 9, 2018
6GTA
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ALPHA-GALACTOSIDASE MUTANT D378A FROM THERMOTOGA MARITIMA IN COMPLEX WITH INTACT CYCLOHEXENE-BASED CARBASUGAR MIMIC OF GALACTOSE WITH 3,5 DIFLUOROPHENYL LEAVING GROUP
Descriptor:Alpha-galactosidase, SULFATE ION, MAGNESIUM ION, ...
Authors:Gloster, T.M., Pengelly, R.J.
Deposit date:2018-06-17
Release date:2018-08-22
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Revealing the mechanism for covalent inhibition of glycoside hydrolases by carbasugars at an atomic level.
Nat Commun, 9, 2018
5M12
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STRUCTURE OF GH36 ALPHA-GALACTOSIDASE FROM THERMOTOGA MARITIMA IN COMPLEX WITH INTACT CYCLOPROPYL-CARBASUGAR.
Descriptor:Alpha-galactosidase, SULFATE ION, MAGNESIUM ION, ...
Authors:Pengelly, R., Gloster, T.
Deposit date:2016-10-07
Release date:2016-11-09
Last modified:2016-11-30
Method:X-RAY DIFFRACTION (1.53 Å)
Cite:Structural Snapshots for Mechanism-Based Inactivation of a Glycoside Hydrolase by Cyclopropyl Carbasugars.
Angew.Chem.Int.Ed.Engl., 55, 2016
5M16
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STRUCTURE OF GH36 ALPHA-GALACTOSIDASE FROM THERMOTOGA MARITIMA IN COMPLEX WITH A HYDROLYSED CYCLOPROPYL CARBASUGAR.
Descriptor:Alpha-galactosidase, SULFATE ION, MAGNESIUM ION, ...
Authors:Pengelly, R., Gloster, T.
Deposit date:2016-10-07
Release date:2016-11-09
Last modified:2016-11-30
Method:X-RAY DIFFRACTION (1.62 Å)
Cite:Structural Snapshots for Mechanism-Based Inactivation of a Glycoside Hydrolase by Cyclopropyl Carbasugars.
Angew.Chem.Int.Ed.Engl., 55, 2016
5M1I
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STRUCTURE OF GH36 ALPHA-GALACTOSIDASE FROM THERMOTOGA MARITIMA IN A COVALENT COMPLEX WITH A CYCLOPROPYL CARBASUGAR.
Descriptor:Alpha-galactosidase, SULFATE ION, (1~{R},2~{S},3~{S},4~{S},6~{R})-4-fluoranyl-1-(hydroxymethyl)bicyclo[4.1.0]heptane-2,3-diol, ...
Authors:Pengelly, R., Gloster, T.
Deposit date:2016-10-07
Release date:2016-11-09
Last modified:2016-11-30
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Structural Snapshots for Mechanism-Based Inactivation of a Glycoside Hydrolase by Cyclopropyl Carbasugars.
Angew.Chem.Int.Ed.Engl., 55, 2016
5M0X
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STRUCTURE OF APO STRUCTURE OF GH36 ALPHA-GALACTOSIDASE FROM THERMOTOGA MARITIMA
Descriptor:Alpha-galactosidase, MAGNESIUM ION, SULFATE ION
Authors:Pengelly, R., Gloster, T.
Deposit date:2016-10-06
Release date:2016-11-09
Last modified:2016-11-30
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural Snapshots for Mechanism-Based Inactivation of a Glycoside Hydrolase by Cyclopropyl Carbasugars.
Angew.Chem.Int.Ed.Engl., 55, 2016
4HZM
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CRYSTAL STRUCTURE OF SALMONELLA TYPHIMURIUM FAMILY 3 GLYCOSIDE HYDROLASE (NAGZ) BOUND TO N-[(3S,4R,5R,6R)-4,5-DIHYDROXY-6-(HYDROXYMETHYL)PIPERIDIN-3-YL]BUTANAMIDE
Descriptor:Beta-hexosaminidase, N-[(3S,4R,5R,6R)-4,5-dihydroxy-6-(hydroxymethyl)piperidin-3-yl]butanamide, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID
Authors:Bacik, J.P., Mark, B.L.
Deposit date:2012-11-15
Release date:2013-06-19
Last modified:2013-11-13
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:The Development of Selective Inhibitors of NagZ: Increased Susceptibility of Gram-Negative Bacteria to beta-Lactams.
Chembiochem, 14, 2013
4GZ5
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CRYSTAL STRUCTURE OF HUMAN O-GLCNAC TRANSFERASE WITH UDP-GLCNAC
Descriptor:UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit, URIDINE-DIPHOSPHATE-N-ACETYLGLUCOSAMINE, SULFATE ION
Authors:Lazarus, M.B., Jiang, J., Gloster, T.M., Zandberg, W.F., Vocadlo, D.J., Walker, S.
Deposit date:2012-09-06
Release date:2012-10-31
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (3.075 Å)
Cite:Structural snapshots of the reaction coordinate for O-GlcNAc transferase.
Nat.Chem.Biol., 8, 2012
4GZ6
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CRYSTAL STRUCTURE OF HUMAN O-GLCNAC TRANSFERASE WITH UDP-5SGLCNAC
Descriptor:UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit, (2S,3R,4R,5S,6R)-3-(acetylamino)-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-thiopyran-2-yl [(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl dihydrogen diphosphate, SULFATE ION
Authors:Lazarus, M.B., Jiang, J., Gloster, T.M., Zandberg, W.F., Vocadlo, D.J., Walker, S.
Deposit date:2012-09-06
Release date:2012-10-31
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (2.98 Å)
Cite:Structural snapshots of the reaction coordinate for O-GlcNAc transferase.
Nat.Chem.Biol., 8, 2012
4GYW
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CRYSTAL STRUCTURE OF HUMAN O-GLCNAC TRANSFERASE IN COMPLEX WITH UDP AND A GLYCOPEPTIDE
Descriptor:UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit, Casein kinase II subunit alpha, URIDINE-5'-DIPHOSPHATE, ...
Authors:Lazarus, M.B., Jiang, J., Gloster, T.M., Zandberg, W.F., Vocadlo, D.J., Walker, S.
Deposit date:2012-09-05
Release date:2012-10-31
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural snapshots of the reaction coordinate for O-GlcNAc transferase.
Nat.Chem.Biol., 8, 2012
4GYY
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CRYSTAL STRUCTURE OF HUMAN O-GLCNAC TRANSFERASE WITH UDP-5SGLCNAC AND A PEPTIDE SUBSTRATE
Descriptor:UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit, Casein kinase II subunit alpha, (2S,3R,4R,5S,6R)-3-(acetylamino)-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-thiopyran-2-yl [(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl dihydrogen diphosphate, ...
Authors:Lazarus, M.B., Jiang, J., Gloster, T.M., Zandberg, W.F., Vocadlo, D.J., Walker, S.
Deposit date:2012-09-05
Release date:2012-10-31
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structural snapshots of the reaction coordinate for O-GlcNAc transferase.
Nat.Chem.Biol., 8, 2012
4GZ3
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CRYSTAL STRUCTURE OF HUMAN O-GLCNAC TRANSFERASE WITH UDP AND A THIOGLYCOPEPTIDE
Descriptor:UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit, Casein kinase II subunit alpha, URIDINE-5'-DIPHOSPHATE, ...
Authors:Lazarus, M.B., Jiang, J., Gloster, T.M., Zandberg, W.F., Vocadlo, D.J., Walker, S.
Deposit date:2012-09-05
Release date:2012-10-31
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural snapshots of the reaction coordinate for O-GlcNAc transferase.
Nat.Chem.Biol., 8, 2012
4B1L
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CARBOHYDRATE BINDING MODULE CBM66 FROM BACILLUS SUBTILIS
Descriptor:LEVANASE, FRUCTOSE, SODIUM ION
Authors:Cuskin, F., Flint, J.E., Morland, C., Basle, A., Henrissat, B., Countinho, P.M., Strazzulli, A., Solzehinkin, A., Davies, G.J., Gilbert, H.J., Gloster, T.M.
Deposit date:2012-07-11
Release date:2012-12-12
Last modified:2013-01-16
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:How Nature Can Exploit Nonspecific Catalytic and Carbohydrate Binding Modules to Create Enzymatic Specificity
Proc.Natl.Acad.Sci.USA, 109, 2012
4B1M
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CARBOHYDRATE BINDING MODULE CBM66 FROM BACILLUS SUBTILIS
Descriptor:LEVANASE, FRUCTOSE, SODIUM ION, ...
Authors:Cuskin, F., Flint, J.E., Morland, C., Basle, A., Henrissat, B., Countinho, P.M., Strazzulli, A., Solzehinkin, A., Davies, G.J., Gilbert, H.J., Gloster, T.M.
Deposit date:2012-07-11
Release date:2012-12-12
Last modified:2013-01-16
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:How Nature Can Exploit Nonspecific Catalytic and Carbohydrate Binding Modules to Create Enzymatic Specificity
Proc.Natl.Acad.Sci.USA, 109, 2012
4AZZ
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CARBOHYDRATE BINDING MODULE CBM66 FROM BACILLUS SUBTILIS
Descriptor:LEVANASE
Authors:Gloster, T.M., Flint, J.E., Gilbert, H.J., Davies, G.J.
Deposit date:2012-06-27
Release date:2012-07-25
Last modified:2013-01-09
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:How Nature Can Exploit Nonspecific Catalytic and Carbohydrate Binding Modules to Create Enzymatic Specificity.
Proc.Natl.Acad.Sci.USA, 109, 2012
4ACY
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SELENOMETHIONINE DERIVATIVE OF THE GH99 ENDO-ALPHA-MANNOSIDASE FROM BACTEROIDES THETAIOTAOMICRON
Descriptor:ENDO-ALPHA-MANNOSIDASE, GLYCEROL, FORMIC ACID
Authors:Thompson, A.J., Williams, R.J., Hakki, Z., Alonzi, D.S., Wennekes, T., Gloster, T.M., Songsrirote, K., Thomas-Oates, J.E., Wrodnigg, T.M., Spreitz, J., Stuetz, A.E., Butters, T.D., Williams, S.J., Davies, G.J.
Deposit date:2011-12-21
Release date:2012-02-01
Last modified:2017-06-28
Method:X-RAY DIFFRACTION (1.69 Å)
Cite:Structural and Mechanistic Insight Into N-Glycan Processing by Endo-Alpha-Mannosidase.
Proc.Natl.Acad.Sci.USA, 109, 2012
4ACZ
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STRUCTURE OF THE GH99 ENDO-ALPHA-MANNOSIDASE FROM BACTEROIDES THETAIOTAOMICRON
Descriptor:ENDO-ALPHA-MANNOSIDASE, GLYCEROL
Authors:Thompson, A.J., Williams, R.J., Hakki, Z., Alonzi, D.S., Wennekes, T., Gloster, T.M., Songsrirote, K., Thomas-Oates, J.E., Wrodnigg, T.M., Spreitz, J., Stuetz, A.E., Butters, T.D., Williams, S.J., Davies, G.J.
Deposit date:2011-12-21
Release date:2012-02-01
Last modified:2012-03-07
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:Structural and Mechanistic Insight Into N-Glycan Processing by Endo-Alpha-Mannosidase.
Proc.Natl.Acad.Sci.USA, 109, 2012
4AD0
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STRUCTURE OF THE GH99 ENDO-ALPHA-MANNOSIDASE FROM BACTERIODES THETAIOTAOMICRON IN COMPLEX WITH BIS-TRIS-PROPANE
Descriptor:ENDO-ALPHA-MANNOSIDASE, 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, GLYCEROL
Authors:Thompson, A.J., Williams, R.J., Hakki, Z., Alonzi, D.S., Wennekes, T., Gloster, T.M., Songsrirote, K., Thomas-Oates, J.E., Wrodnigg, T.M., Spreitz, J., Stuetz, A.E., Butters, T.D., Williams, S.J., Davies, G.J.
Deposit date:2011-12-21
Release date:2012-02-01
Last modified:2012-02-29
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:Structural and Mechanistic Insight Into N-Glycan Processing by Endo-Alpha-Mannosidase.
Proc.Natl.Acad.Sci.USA, 109, 2012
4AD1
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STRUCTURE OF THE GH99 ENDO-ALPHA-MANNOSIDASE FROM BACTEROIDES XYLANISOLVENS
Descriptor:GLYCOSYL HYDROLASE FAMILY 71
Authors:Thompson, A.J., Williams, R.J., Hakki, Z., Alonzi, D.S., Wennekes, T., Gloster, T.M., Songsrirote, K., Thomas-Oates, J.E., Wrodnigg, T.M., Spreitz, J., Stuetz, A.E., Butters, T.D., Williams, S.J., Davies, G.J.
Deposit date:2011-12-21
Release date:2012-02-01
Last modified:2012-02-29
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural and Mechanistic Insight Into N-Glycan Processing by Endo-Alpha-Mannosidase.
Proc.Natl.Acad.Sci.USA, 109, 2012
4AD2
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STRUCTURE OF THE GH99 ENDO-ALPHA-MANNOSIDASE FROM BACTEROIDES XYLANISOLVENS IN COMPLEX WITH GLUCOSE-1,3-ISOFAGOMINE
Descriptor:GLYCOSYL HYDROLASE FAMILY 71, ALPHA-D-GLUCOSE, 5-HYDROXYMETHYL-3,4-DIHYDROXYPIPERIDINE
Authors:Thompson, A.J., Williams, R.J., Hakki, Z., Alonzi, D.S., Wennekes, T., Gloster, T.M., Songsrirote, K., Thomas-Oates, J.E., Wrodnigg, T.M., Spreitz, J., Stuetz, A.E., Butters, T.D., Williams, S.J., Davies, G.J.
Deposit date:2011-12-21
Release date:2012-02-01
Last modified:2015-07-15
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural and Mechanistic Insight Into N-Glycan Processing by Endo-Alpha-Mannosidase.
Proc.Natl.Acad.Sci.USA, 109, 2012