7BST | | ECOR124I-OCR IN THE INTERMEDIATE STATE | | Descriptor: | Type I restriction enzyme R Protein, Type I restriction enzyme EcoR124II M protein, Overcome classical restriction gp0.3, ... | | Authors: | Gao, Y., Gao, P. | | Deposit date: | 2020-03-31 | | Release date: | 2020-05-27 | | Last modified: | 2020-06-24 | | Method: | ELECTRON MICROSCOPY (4.37 Å) | | Cite: | Structural insights into assembly, operation and inhibition of a type I restriction-modification system.
Nat Microbiol, 2020
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7BTO | | ECOR124I-ARDA IN THE TRANSLOCATION STATE | | Descriptor: | Type I restriction enzyme EcoR124II M protein, Antirestriction protein ArdA, Type I restriction enzyme R Protein, ... | | Authors: | Gao, Y., Gao, P. | | Deposit date: | 2020-04-02 | | Release date: | 2020-05-27 | | Last modified: | 2020-06-24 | | Method: | ELECTRON MICROSCOPY (3.97 Å) | | Cite: | Structural insights into assembly, operation and inhibition of a type I restriction-modification system.
Nat Microbiol, 2020
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7BTP | | ECOR124I-OCR IN RESTRICTION-ALLEVIATION STATE | | Descriptor: | Type-1 restriction enzyme EcoR124II specificity protein, Type I restriction enzyme R Protein, Type I restriction enzyme EcoR124II M protein, ... | | Authors: | Gao, Y., Gao, P. | | Deposit date: | 2020-04-02 | | Release date: | 2020-05-27 | | Last modified: | 2020-06-24 | | Method: | ELECTRON MICROSCOPY (4.01 Å) | | Cite: | Structural insights into assembly, operation and inhibition of a type I restriction-modification system.
Nat Microbiol, 2020
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7BTQ | | ECOR124I-DNA IN THE RESTRICTION-ALLEVIATION STATE | | Descriptor: | Type I restriction enzyme EcoR124II M protein, DNA (64-MER), Type-1 restriction enzyme EcoR124II specificity protein, ... | | Authors: | Gao, Y., Gao, P. | | Deposit date: | 2020-04-02 | | Release date: | 2020-05-27 | | Last modified: | 2020-06-24 | | Method: | ELECTRON MICROSCOPY (4.54 Å) | | Cite: | Structural insights into assembly, operation and inhibition of a type I restriction-modification system.
Nat Microbiol, 2020
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7BTR | | ECOR124I-ARDA IN THE RESTRICTION-ALLEVIATION STATE | | Descriptor: | Antirestriction protein ArdA, Type I restriction enzyme R Protein, Type I restriction enzyme EcoR124II M protein, ... | | Authors: | Gao, Y., Gao, P. | | Deposit date: | 2020-04-02 | | Release date: | 2020-05-27 | | Last modified: | 2020-06-24 | | Method: | ELECTRON MICROSCOPY (4.54 Å) | | Cite: | Structural insights into assembly, operation and inhibition of a type I restriction-modification system.
Nat Microbiol, 2020
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6M71 | | SARS-COV-2 RNA-DEPENDENT RNA POLYMERASE IN COMPLEX WITH COFACTORS | | Descriptor: | SARS-Cov-2 NSP 12, SARS-Cov-2 NSP 8, SARS-Cov-2 NSP 7 | | Authors: | Gao, Y., Yan, L., Huang, Y., Liu, F., Cao, L., Wang, T., Wang, Q., Lou, Z., Rao, Z. | | Deposit date: | 2020-03-16 | | Release date: | 2020-04-01 | | Last modified: | 2020-05-27 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | Structure of the RNA-dependent RNA polymerase from COVID-19 virus.
Science, 368, 2020
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7BTF | | SARS-COV-2 RNA-DEPENDENT RNA POLYMERASE IN COMPLEX WITH COFACTORS IN REDUCED CONDITION | | Descriptor: | NSP12, NSP7, NSP8, ... | | Authors: | Gao, Y., Yan, L., Huang, Y., Liu, F., Cao, L., Wang, T., Wang, Q., Lou, Z., Rao, Z. | | Deposit date: | 2020-04-01 | | Release date: | 2020-04-08 | | Last modified: | 2020-05-27 | | Method: | ELECTRON MICROSCOPY (2.95 Å) | | Cite: | Structure of the RNA-dependent RNA polymerase from COVID-19 virus.
Science, 368, 2020
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3UBU | | CRYSTAL STRUCTURE OF AGKISACUCETIN, A GPIB-BINDING SNACLEC (SNAKE C-TYPE LECTIN) THAT INHIBITS PLATELET | | Descriptor: | Agglucetin subunit alpha-1, Agglucetin subunit beta-2, SULFATE ION, ... | | Authors: | Gao, Y., Ge, H., Chen, H., Li, H., Liu, Y., Niu, L., Teng, M. | | Deposit date: | 2011-10-25 | | Release date: | 2012-04-11 | | Method: | X-RAY DIFFRACTION (1.91 Å) | | Cite: | Crystal structure of agkisacucetin, a Gpib-binding snake C-type lectin that inhibits platelet adhesion and aggregation.
Proteins, 2012
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5IRX | | STRUCTURE OF TRPV1 IN COMPLEX WITH DKTX AND RTX, DETERMINED IN LIPID NANODISC | | Descriptor: | Transient receptor potential cation channel subfamily V member 1, Tau-theraphotoxin-Hs1a, (4R,7S)-4-hydroxy-N,N,N-trimethyl-4,9-dioxo-7-[(pentanoyloxy)methyl]-3,5,8-trioxa-4lambda~5~-phosphatetradecan-1-aminium, ... | | Authors: | Gao, Y., Cao, E., Julius, D., Cheng, Y. | | Deposit date: | 2016-03-14 | | Release date: | 2016-05-25 | | Last modified: | 2019-12-18 | | Method: | ELECTRON MICROSCOPY (2.95 Å) | | Cite: | TRPV1 structures in nanodiscs reveal mechanisms of ligand and lipid action.
Nature, 534, 2016
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5IRZ | | STRUCTURE OF TRPV1 DETERMINED IN LIPID NANODISC | | Descriptor: | Transient receptor potential cation channel subfamily V member 1, (4R,7S)-4-hydroxy-N,N,N-trimethyl-4,9-dioxo-7-[(pentanoyloxy)methyl]-3,5,8-trioxa-4lambda~5~-phosphatetradecan-1-aminium, (2S)-1-{[(R)-hydroxy{[(1R,2R,3S,4S,5S,6S)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}-3-(pentanoyloxy)propan-2-yl decanoate, ... | | Authors: | Gao, Y., Cao, E., Julius, D., Cheng, Y. | | Deposit date: | 2016-03-15 | | Release date: | 2016-05-25 | | Last modified: | 2019-12-18 | | Method: | ELECTRON MICROSCOPY (3.28 Å) | | Cite: | TRPV1 structures in nanodiscs reveal mechanisms of ligand and lipid action.
Nature, 534, 2016
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5IS0 | | STRUCTURE OF TRPV1 IN COMPLEX WITH CAPSAZEPINE, DETERMINED IN LIPID NANODISC | | Descriptor: | Transient receptor potential cation channel subfamily V member 1, capsazepine | | Authors: | Gao, Y., Cao, E., Julius, D., Cheng, Y. | | Deposit date: | 2016-03-15 | | Release date: | 2016-05-25 | | Last modified: | 2019-12-18 | | Method: | ELECTRON MICROSCOPY (3.43 Å) | | Cite: | TRPV1 structures in nanodiscs reveal mechanisms of ligand and lipid action.
Nature, 534, 2016
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5WRV | | COMPLEX STRUCTURE OF HUMAN SRP72/SRP68 | | Descriptor: | Signal recognition particle subunit SRP68, Signal recognition particle subunit SRP72, ACETATE ION, ... | | Authors: | Gao, Y., Chen, Z. | | Deposit date: | 2016-12-04 | | Release date: | 2017-06-21 | | Last modified: | 2017-07-05 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Human apo-SRP72 and SRP68/72 complex structures reveal the molecular basis of protein translocation
J Mol Cell Biol, 9, 2017
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5WRW | | STRUCTURE OF HUMAN APO-SRP72 | | Descriptor: | Signal recognition particle subunit SRP72, SULFATE ION | | Authors: | Gao, Y., Chen, Z. | | Deposit date: | 2016-12-04 | | Release date: | 2017-06-21 | | Last modified: | 2017-07-05 | | Method: | X-RAY DIFFRACTION (2.91 Å) | | Cite: | Human apo-SRP72 and SRP68/72 complex structures reveal the molecular basis of protein translocation
J Mol Cell Biol, 9, 2017
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6LUM | | STRUCTURE OF MYCOBACTERIUM SMEGMATIS SUCCINATE DEHYDROGENASE 2 | | Descriptor: | Succinate dehydrogenase subunit C, Succinate dehydrogenase subunit D, Succinate dehydrogenase subunit F, ... | | Authors: | Gao, Y., Gong, H., Zhou, X., Xiao, Y., Wang, W., Ji, W., Wang, Q., Rao, Z. | | Deposit date: | 2020-01-29 | | Release date: | 2020-05-27 | | Method: | ELECTRON MICROSCOPY (2.84 Å) | | Cite: | Structure of Mycobacterium smegmatis succinate dehydrogenase 2
To Be Published
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6N7I | | STRUCTURE OF BACTERIOPHAGE T7 E343Q MUTANT GP4 HELICASE-PRIMASE IN COMPLEX WITH SSDNA, DTTP, AC DINUCLEOTIDE AND CTP (GP4(5)-DNA) | | Descriptor: | DNA primase/helicase, DNA (25-MER), THYMIDINE-5'-TRIPHOSPHATE, ... | | Authors: | Gao, Y., Cui, Y., Zhou, Z., Yang, W. | | Deposit date: | 2018-11-27 | | Release date: | 2019-03-06 | | Last modified: | 2019-12-18 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Structures and operating principles of the replisome.
Science, 363, 2019
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6N7N | | STRUCTURE OF BACTERIOPHAGE T7 E343Q MUTANT GP4 HELICASE-PRIMASE IN COMPLEX WITH SSDNA, DTTP, AC DINUCLEOTIDE AND CTP (FORM I) | | Descriptor: | DNA primase/helicase, DNA (5'-D(P*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*T)-3'), THYMIDINE-5'-TRIPHOSPHATE, ... | | Authors: | Gao, Y., Cui, Y., Zhou, Z., Yang, W. | | Deposit date: | 2018-11-27 | | Release date: | 2019-03-06 | | Last modified: | 2019-12-18 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | Structures and operating principles of the replisome.
Science, 363, 2019
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6N7S | | STRUCTURE OF BACTERIOPHAGE T7 E343Q MUTANT GP4 HELICASE-PRIMASE IN COMPLEX WITH SSDNA, DTTP, AC DINUCLEOTIDE AND CTP (FORM II) | | Descriptor: | DNA primase/helicase, DNA (25-MER), THYMIDINE-5'-TRIPHOSPHATE, ... | | Authors: | Gao, Y., Cui, Y., Zhou, Z., Yang, W. | | Deposit date: | 2018-11-28 | | Release date: | 2019-03-06 | | Last modified: | 2019-12-18 | | Method: | ELECTRON MICROSCOPY (4.6 Å) | | Cite: | Structures and operating principles of the replisome.
Science, 363, 2019
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6N7T | | STRUCTURE OF BACTERIOPHAGE T7 E343Q MUTANT GP4 HELICASE-PRIMASE IN COMPLEX WITH SSDNA, DTTP, AC DINUCLEOTIDE AND CTP (FORM III) | | Descriptor: | DNA primase/helicase, DNA (25-MER), THYMIDINE-5'-TRIPHOSPHATE, ... | | Authors: | Gao, Y., Cui, Y., Zhou, Z., Yang, W. | | Deposit date: | 2018-11-28 | | Release date: | 2019-03-06 | | Last modified: | 2019-12-18 | | Method: | ELECTRON MICROSCOPY (3.9 Å) | | Cite: | Structures and operating principles of the replisome.
Science, 363, 2019
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6N9W | | STRUCTURE OF BACTERIOPHAGE T7 LAGGING-STRAND DNA POLYMERASE (D5A/E7A) AND GP4 (HELICASE/PRIMASE) BOUND TO DNA INCLUDING RNA/DNA HYBRID, AND AN INCOMING DTTP (LAGS2) | | Descriptor: | DNA primase/helicase, DNA-directed DNA polymerase, Primer, ... | | Authors: | Gao, Y., Cui, Y., Zhou, Z., Yang, W. | | Deposit date: | 2018-12-04 | | Release date: | 2019-03-06 | | Last modified: | 2019-12-18 | | Method: | ELECTRON MICROSCOPY (4 Å) | | Cite: | Structures and operating principles of the replisome.
Science, 363, 2019
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2DU9 | | CRYSTAL STRUCTURE OF THE TRANSCRIPTIONAL FACTOR FROM C.GLUTAMICUM | | Descriptor: | Predicted transcriptional regulators, (4S)-2-METHYL-2,4-PENTANEDIOL | | Authors: | Gao, Y., Yao, M., Tanaka, I. | | Deposit date: | 2006-07-20 | | Release date: | 2007-07-24 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.28 Å) | | Cite: | The structures of transcription factor CGL2947 from Corynebacterium glutamicum in two crystal forms: A novel homodimer assembling and the implication for effector-binding mode
Protein Sci., 16, 2007
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6N7V | | STRUCTURE OF BACTERIOPHAGE T7 GP4 (HELICASE-PRIMASE, E343Q MUTANT) IN COMPLEX WITH SSDNA, DTTP, AC DINUCLEOTIDE, AND CTP (FROM MULTIPLE LEAD COMPLEXES) | | Descriptor: | DNA primase/helicase, DNA (93-MER), THYMIDINE-5'-TRIPHOSPHATE, ... | | Authors: | Gao, Y., Fox, T., Val, N., Yang, W. | | Deposit date: | 2018-11-28 | | Release date: | 2019-03-06 | | Last modified: | 2019-12-18 | | Method: | ELECTRON MICROSCOPY (3.8 Å) | | Cite: | Structures and operating principles of the replisome.
Science, 363, 2019
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6N7W | | STRUCTURE OF BACTERIOPHAGE T7 LEADING-STRAND DNA POLYMERASE (D5A/E7A)/TRX IN COMPLEX WITH A DNA FORK AND INCOMING DTTP (FROM MULTIPLE LEAD COMPLEXES) | | Descriptor: | DNA-directed DNA polymerase, TrxA, DNA (25-MER), ... | | Authors: | Gao, Y., Fox, T., Val, N., Yang, W. | | Deposit date: | 2018-11-28 | | Release date: | 2019-03-06 | | Last modified: | 2019-12-18 | | Method: | ELECTRON MICROSCOPY (4.5 Å) | | Cite: | Structures and operating principles of the replisome.
Science, 363, 2019
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6N9U | | STRUCTURE OF BACTERIOPHAGE T7 LAGGING-STRAND DNA POLYMERASE (D5A/E7A) INTERACTING WITH PRIMASE DOMAINS OF TWO GP4 SUBUNITS BOUND TO AN RNA/DNA HYBRID AND DTTP (FROM LAGS1) | | Descriptor: | DNA primase/helicase, DNA-directed DNA polymerase, RNA (5'-R(*AP*CP*CP*AP*G)-D(P*(DOC))-3'), ... | | Authors: | Gao, Y., Fox, T., Val, N., Yang, W. | | Deposit date: | 2018-12-04 | | Release date: | 2019-03-06 | | Last modified: | 2019-12-18 | | Method: | ELECTRON MICROSCOPY (3.7 Å) | | Cite: | Structures and operating principles of the replisome.
Science, 363, 2019
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6N9V | | STRUCTURE OF BACTERIOPHAGE T7 LAGGING-STRAND DNA POLYMERASE (D5A/E7A) AND GP4 (HELICASE/PRIMASE) BOUND TO DNA INCLUDING RNA/DNA HYBRID, AND AN INCOMING DTTP (LAGS1) | | Descriptor: | DNA primase/helicase, DNA-directed DNA polymerase, Primer, ... | | Authors: | Gao, Y., Fox, T., Val, N., Yang, W. | | Deposit date: | 2018-12-04 | | Release date: | 2019-03-06 | | Last modified: | 2019-12-18 | | Method: | ELECTRON MICROSCOPY (4 Å) | | Cite: | Structures and operating principles of the replisome.
Science, 363, 2019
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6N9X | | STRUCTURE OF BACTERIOPHAGE T7 LAGGING-STRAND DNA POLYMERASE (D5A/E7A) AND GP4 (HELICASE/PRIMASE) BOUND TO DNA INCLUDING RNA/DNA HYBRID, AND AN INCOMING DTTP (LAGS3) | | Descriptor: | DNA primase/helicase, DNA-directed DNA polymerase, Primer, ... | | Authors: | Gao, Y., Fox, T., Val, N., Yang, W. | | Deposit date: | 2018-12-04 | | Release date: | 2019-03-06 | | Last modified: | 2019-12-18 | | Method: | ELECTRON MICROSCOPY (4.1 Å) | | Cite: | Structures and operating principles of the replisome.
Science, 363, 2019
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