Author results

7BST
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ECOR124I-OCR IN THE INTERMEDIATE STATE
Descriptor:Type I restriction enzyme R Protein, Type I restriction enzyme EcoR124II M protein, Overcome classical restriction gp0.3, ...
Authors:Gao, Y., Gao, P.
Deposit date:2020-03-31
Release date:2020-05-27
Last modified:2020-06-24
Method:ELECTRON MICROSCOPY (4.37 Å)
Cite:Structural insights into assembly, operation and inhibition of a type I restriction-modification system.
Nat Microbiol, 2020
7BTO
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ECOR124I-ARDA IN THE TRANSLOCATION STATE
Descriptor:Type I restriction enzyme EcoR124II M protein, Antirestriction protein ArdA, Type I restriction enzyme R Protein, ...
Authors:Gao, Y., Gao, P.
Deposit date:2020-04-02
Release date:2020-05-27
Last modified:2020-06-24
Method:ELECTRON MICROSCOPY (3.97 Å)
Cite:Structural insights into assembly, operation and inhibition of a type I restriction-modification system.
Nat Microbiol, 2020
7BTP
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ECOR124I-OCR IN RESTRICTION-ALLEVIATION STATE
Descriptor:Type-1 restriction enzyme EcoR124II specificity protein, Type I restriction enzyme R Protein, Type I restriction enzyme EcoR124II M protein, ...
Authors:Gao, Y., Gao, P.
Deposit date:2020-04-02
Release date:2020-05-27
Last modified:2020-06-24
Method:ELECTRON MICROSCOPY (4.01 Å)
Cite:Structural insights into assembly, operation and inhibition of a type I restriction-modification system.
Nat Microbiol, 2020
7BTQ
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ECOR124I-DNA IN THE RESTRICTION-ALLEVIATION STATE
Descriptor:Type I restriction enzyme EcoR124II M protein, DNA (64-MER), Type-1 restriction enzyme EcoR124II specificity protein, ...
Authors:Gao, Y., Gao, P.
Deposit date:2020-04-02
Release date:2020-05-27
Last modified:2020-06-24
Method:ELECTRON MICROSCOPY (4.54 Å)
Cite:Structural insights into assembly, operation and inhibition of a type I restriction-modification system.
Nat Microbiol, 2020
7BTR
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ECOR124I-ARDA IN THE RESTRICTION-ALLEVIATION STATE
Descriptor:Antirestriction protein ArdA, Type I restriction enzyme R Protein, Type I restriction enzyme EcoR124II M protein, ...
Authors:Gao, Y., Gao, P.
Deposit date:2020-04-02
Release date:2020-05-27
Last modified:2020-06-24
Method:ELECTRON MICROSCOPY (4.54 Å)
Cite:Structural insights into assembly, operation and inhibition of a type I restriction-modification system.
Nat Microbiol, 2020
6M71
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SARS-COV-2 RNA-DEPENDENT RNA POLYMERASE IN COMPLEX WITH COFACTORS
Descriptor:SARS-Cov-2 NSP 12, SARS-Cov-2 NSP 8, SARS-Cov-2 NSP 7
Authors:Gao, Y., Yan, L., Huang, Y., Liu, F., Cao, L., Wang, T., Wang, Q., Lou, Z., Rao, Z.
Deposit date:2020-03-16
Release date:2020-04-01
Last modified:2020-05-27
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Structure of the RNA-dependent RNA polymerase from COVID-19 virus.
Science, 368, 2020
7BTF
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SARS-COV-2 RNA-DEPENDENT RNA POLYMERASE IN COMPLEX WITH COFACTORS IN REDUCED CONDITION
Descriptor:NSP12, NSP7, NSP8, ...
Authors:Gao, Y., Yan, L., Huang, Y., Liu, F., Cao, L., Wang, T., Wang, Q., Lou, Z., Rao, Z.
Deposit date:2020-04-01
Release date:2020-04-08
Last modified:2020-05-27
Method:ELECTRON MICROSCOPY (2.95 Å)
Cite:Structure of the RNA-dependent RNA polymerase from COVID-19 virus.
Science, 368, 2020
3UBU
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CRYSTAL STRUCTURE OF AGKISACUCETIN, A GPIB-BINDING SNACLEC (SNAKE C-TYPE LECTIN) THAT INHIBITS PLATELET
Descriptor:Agglucetin subunit alpha-1, Agglucetin subunit beta-2, SULFATE ION, ...
Authors:Gao, Y., Ge, H., Chen, H., Li, H., Liu, Y., Niu, L., Teng, M.
Deposit date:2011-10-25
Release date:2012-04-11
Method:X-RAY DIFFRACTION (1.91 Å)
Cite:Crystal structure of agkisacucetin, a Gpib-binding snake C-type lectin that inhibits platelet adhesion and aggregation.
Proteins, 2012
5IRX
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STRUCTURE OF TRPV1 IN COMPLEX WITH DKTX AND RTX, DETERMINED IN LIPID NANODISC
Descriptor:Transient receptor potential cation channel subfamily V member 1, Tau-theraphotoxin-Hs1a, (4R,7S)-4-hydroxy-N,N,N-trimethyl-4,9-dioxo-7-[(pentanoyloxy)methyl]-3,5,8-trioxa-4lambda~5~-phosphatetradecan-1-aminium, ...
Authors:Gao, Y., Cao, E., Julius, D., Cheng, Y.
Deposit date:2016-03-14
Release date:2016-05-25
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (2.95 Å)
Cite:TRPV1 structures in nanodiscs reveal mechanisms of ligand and lipid action.
Nature, 534, 2016
5IRZ
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STRUCTURE OF TRPV1 DETERMINED IN LIPID NANODISC
Descriptor:Transient receptor potential cation channel subfamily V member 1, (4R,7S)-4-hydroxy-N,N,N-trimethyl-4,9-dioxo-7-[(pentanoyloxy)methyl]-3,5,8-trioxa-4lambda~5~-phosphatetradecan-1-aminium, (2S)-1-{[(R)-hydroxy{[(1R,2R,3S,4S,5S,6S)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}-3-(pentanoyloxy)propan-2-yl decanoate, ...
Authors:Gao, Y., Cao, E., Julius, D., Cheng, Y.
Deposit date:2016-03-15
Release date:2016-05-25
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (3.28 Å)
Cite:TRPV1 structures in nanodiscs reveal mechanisms of ligand and lipid action.
Nature, 534, 2016
5IS0
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STRUCTURE OF TRPV1 IN COMPLEX WITH CAPSAZEPINE, DETERMINED IN LIPID NANODISC
Descriptor:Transient receptor potential cation channel subfamily V member 1, capsazepine
Authors:Gao, Y., Cao, E., Julius, D., Cheng, Y.
Deposit date:2016-03-15
Release date:2016-05-25
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (3.43 Å)
Cite:TRPV1 structures in nanodiscs reveal mechanisms of ligand and lipid action.
Nature, 534, 2016
5WRV
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COMPLEX STRUCTURE OF HUMAN SRP72/SRP68
Descriptor:Signal recognition particle subunit SRP68, Signal recognition particle subunit SRP72, ACETATE ION, ...
Authors:Gao, Y., Chen, Z.
Deposit date:2016-12-04
Release date:2017-06-21
Last modified:2017-07-05
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Human apo-SRP72 and SRP68/72 complex structures reveal the molecular basis of protein translocation
J Mol Cell Biol, 9, 2017
5WRW
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STRUCTURE OF HUMAN APO-SRP72
Descriptor:Signal recognition particle subunit SRP72, SULFATE ION
Authors:Gao, Y., Chen, Z.
Deposit date:2016-12-04
Release date:2017-06-21
Last modified:2017-07-05
Method:X-RAY DIFFRACTION (2.91 Å)
Cite:Human apo-SRP72 and SRP68/72 complex structures reveal the molecular basis of protein translocation
J Mol Cell Biol, 9, 2017
6LUM
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STRUCTURE OF MYCOBACTERIUM SMEGMATIS SUCCINATE DEHYDROGENASE 2
Descriptor:Succinate dehydrogenase subunit C, Succinate dehydrogenase subunit D, Succinate dehydrogenase subunit F, ...
Authors:Gao, Y., Gong, H., Zhou, X., Xiao, Y., Wang, W., Ji, W., Wang, Q., Rao, Z.
Deposit date:2020-01-29
Release date:2020-05-27
Method:ELECTRON MICROSCOPY (2.84 Å)
Cite:Structure of Mycobacterium smegmatis succinate dehydrogenase 2
To Be Published
6N7I
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STRUCTURE OF BACTERIOPHAGE T7 E343Q MUTANT GP4 HELICASE-PRIMASE IN COMPLEX WITH SSDNA, DTTP, AC DINUCLEOTIDE AND CTP (GP4(5)-DNA)
Descriptor:DNA primase/helicase, DNA (25-MER), THYMIDINE-5'-TRIPHOSPHATE, ...
Authors:Gao, Y., Cui, Y., Zhou, Z., Yang, W.
Deposit date:2018-11-27
Release date:2019-03-06
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Structures and operating principles of the replisome.
Science, 363, 2019
6N7N
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STRUCTURE OF BACTERIOPHAGE T7 E343Q MUTANT GP4 HELICASE-PRIMASE IN COMPLEX WITH SSDNA, DTTP, AC DINUCLEOTIDE AND CTP (FORM I)
Descriptor:DNA primase/helicase, DNA (5'-D(P*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*T)-3'), THYMIDINE-5'-TRIPHOSPHATE, ...
Authors:Gao, Y., Cui, Y., Zhou, Z., Yang, W.
Deposit date:2018-11-27
Release date:2019-03-06
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Structures and operating principles of the replisome.
Science, 363, 2019
6N7S
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STRUCTURE OF BACTERIOPHAGE T7 E343Q MUTANT GP4 HELICASE-PRIMASE IN COMPLEX WITH SSDNA, DTTP, AC DINUCLEOTIDE AND CTP (FORM II)
Descriptor:DNA primase/helicase, DNA (25-MER), THYMIDINE-5'-TRIPHOSPHATE, ...
Authors:Gao, Y., Cui, Y., Zhou, Z., Yang, W.
Deposit date:2018-11-28
Release date:2019-03-06
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (4.6 Å)
Cite:Structures and operating principles of the replisome.
Science, 363, 2019
6N7T
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STRUCTURE OF BACTERIOPHAGE T7 E343Q MUTANT GP4 HELICASE-PRIMASE IN COMPLEX WITH SSDNA, DTTP, AC DINUCLEOTIDE AND CTP (FORM III)
Descriptor:DNA primase/helicase, DNA (25-MER), THYMIDINE-5'-TRIPHOSPHATE, ...
Authors:Gao, Y., Cui, Y., Zhou, Z., Yang, W.
Deposit date:2018-11-28
Release date:2019-03-06
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Structures and operating principles of the replisome.
Science, 363, 2019
6N9W
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STRUCTURE OF BACTERIOPHAGE T7 LAGGING-STRAND DNA POLYMERASE (D5A/E7A) AND GP4 (HELICASE/PRIMASE) BOUND TO DNA INCLUDING RNA/DNA HYBRID, AND AN INCOMING DTTP (LAGS2)
Descriptor:DNA primase/helicase, DNA-directed DNA polymerase, Primer, ...
Authors:Gao, Y., Cui, Y., Zhou, Z., Yang, W.
Deposit date:2018-12-04
Release date:2019-03-06
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Structures and operating principles of the replisome.
Science, 363, 2019
2DU9
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CRYSTAL STRUCTURE OF THE TRANSCRIPTIONAL FACTOR FROM C.GLUTAMICUM
Descriptor:Predicted transcriptional regulators, (4S)-2-METHYL-2,4-PENTANEDIOL
Authors:Gao, Y., Yao, M., Tanaka, I.
Deposit date:2006-07-20
Release date:2007-07-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.28 Å)
Cite:The structures of transcription factor CGL2947 from Corynebacterium glutamicum in two crystal forms: A novel homodimer assembling and the implication for effector-binding mode
Protein Sci., 16, 2007
6N7V
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STRUCTURE OF BACTERIOPHAGE T7 GP4 (HELICASE-PRIMASE, E343Q MUTANT) IN COMPLEX WITH SSDNA, DTTP, AC DINUCLEOTIDE, AND CTP (FROM MULTIPLE LEAD COMPLEXES)
Descriptor:DNA primase/helicase, DNA (93-MER), THYMIDINE-5'-TRIPHOSPHATE, ...
Authors:Gao, Y., Fox, T., Val, N., Yang, W.
Deposit date:2018-11-28
Release date:2019-03-06
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Structures and operating principles of the replisome.
Science, 363, 2019
6N7W
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STRUCTURE OF BACTERIOPHAGE T7 LEADING-STRAND DNA POLYMERASE (D5A/E7A)/TRX IN COMPLEX WITH A DNA FORK AND INCOMING DTTP (FROM MULTIPLE LEAD COMPLEXES)
Descriptor:DNA-directed DNA polymerase, TrxA, DNA (25-MER), ...
Authors:Gao, Y., Fox, T., Val, N., Yang, W.
Deposit date:2018-11-28
Release date:2019-03-06
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (4.5 Å)
Cite:Structures and operating principles of the replisome.
Science, 363, 2019
6N9U
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STRUCTURE OF BACTERIOPHAGE T7 LAGGING-STRAND DNA POLYMERASE (D5A/E7A) INTERACTING WITH PRIMASE DOMAINS OF TWO GP4 SUBUNITS BOUND TO AN RNA/DNA HYBRID AND DTTP (FROM LAGS1)
Descriptor:DNA primase/helicase, DNA-directed DNA polymerase, RNA (5'-R(*AP*CP*CP*AP*G)-D(P*(DOC))-3'), ...
Authors:Gao, Y., Fox, T., Val, N., Yang, W.
Deposit date:2018-12-04
Release date:2019-03-06
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Structures and operating principles of the replisome.
Science, 363, 2019
6N9V
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STRUCTURE OF BACTERIOPHAGE T7 LAGGING-STRAND DNA POLYMERASE (D5A/E7A) AND GP4 (HELICASE/PRIMASE) BOUND TO DNA INCLUDING RNA/DNA HYBRID, AND AN INCOMING DTTP (LAGS1)
Descriptor:DNA primase/helicase, DNA-directed DNA polymerase, Primer, ...
Authors:Gao, Y., Fox, T., Val, N., Yang, W.
Deposit date:2018-12-04
Release date:2019-03-06
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Structures and operating principles of the replisome.
Science, 363, 2019
6N9X
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STRUCTURE OF BACTERIOPHAGE T7 LAGGING-STRAND DNA POLYMERASE (D5A/E7A) AND GP4 (HELICASE/PRIMASE) BOUND TO DNA INCLUDING RNA/DNA HYBRID, AND AN INCOMING DTTP (LAGS3)
Descriptor:DNA primase/helicase, DNA-directed DNA polymerase, Primer, ...
Authors:Gao, Y., Fox, T., Val, N., Yang, W.
Deposit date:2018-12-04
Release date:2019-03-06
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Structures and operating principles of the replisome.
Science, 363, 2019