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1YA4
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CRYSTAL STRUCTURE OF HUMAN LIVER CARBOXYLESTERASE 1 IN COMPLEX WITH TAMOXIFEN
Descriptor:CES1 protein, N-ACETYL-D-GLUCOSAMINE, O-SIALIC ACID, ...
Authors:Fleming, C.D., Bencharit, S., Edwards, C.C., Hyatt, J.L., Morton, C.L., Howard-Williams, E.L., Potter, P.M., Redinbo, M.R.
Deposit date:2004-12-17
Release date:2005-08-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structural insights into drug processing by human carboxylesterase 1: tamoxifen, mevastatin, and inhibition by benzil.
J.Mol.Biol., 352, 2005
1YA8
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CRYSTAL STRUCTURE OF HUMAN LIVER CARBOXYLESTERASE IN COMPLEX WITH CLEAVAGE PRODUCTS OF MEVASTATIN
Descriptor:CES1 protein, N-ACETYL-D-GLUCOSAMINE, O-SIALIC ACID, ...
Authors:Fleming, C.D., Bencharit, S., Edwards, C.C., Hyatt, J.L., Morton, C.L., Howard-Williams, E.L., Potter, P.M., Redinbo, M.R.
Deposit date:2004-12-17
Release date:2005-08-02
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural insights into drug processing by human carboxylesterase 1: tamoxifen, mevastatin, and inhibition by benzil.
J.Mol.Biol., 352, 2005
1YAH
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CRYSTAL STRUCTURE OF HUMAN LIVER CARBOXYLESTERASE COMPLEXED TO ETYL ACETATE; A FATTY ACID ETHYL ESTER ANALOGUE
Descriptor:CES1 protein, N-ACETYL-D-GLUCOSAMINE, O-SIALIC ACID, ...
Authors:Fleming, C.D., Bencahrit, S., Edwards, C.C., Hyatt, J.L., Morton, C.L., Howard-Williams, E.L., Potter, P.M., Redinbo, M.R.
Deposit date:2004-12-17
Release date:2005-08-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural insights into drug processing by human carboxylesterase 1: tamoxifen, mevastatin, and inhibition by benzil.
J.Mol.Biol., 352, 2005
1YAJ
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CRYSTAL STRUCTURE OF HUMAN LIVER CARBOXYLESTERASE IN COMPLEX WITH BENZIL
Descriptor:CES1 protein, N-ACETYL-D-GLUCOSAMINE, O-SIALIC ACID, ...
Authors:Fleming, C.D., Bencharit, S., Edwards, C.C., Hyatt, J.L., Morton, C.M., Howard-Williams, E.L., Potter, P.M., Redinbo, M.R.
Deposit date:2004-12-17
Release date:2005-08-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structural insights into drug processing by human carboxylesterase 1: tamoxifen, mevastatin, and inhibition by benzil.
J.Mol.Biol., 352, 2005
2HRQ
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CRYSTAL STRUCTURE OF HUMAN LIVER CARBOXYLESTERASE 1 (HCE1) IN COVALENT COMPLEX WITH THE NERVE AGENT SOMAN (GD)
Descriptor:Liver carboxylesterase 1, N-ACETYL-D-GLUCOSAMINE, O-SIALIC ACID, ...
Authors:Fleming, C.D., Redinbo, M.R.
Deposit date:2006-07-20
Release date:2007-05-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal Structures of Human Carboxylesterase 1 in Covalent Complexes with the Chemical Warfare Agents Soman and Tabun.
Biochemistry, 46, 2007
2HRR
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CRYSTAL STRUCTURE OF HUMAN LIVER CARBOXYLESTERASE 1 (HCE1) IN COVALENT COMPLEX WITH THE NERVE AGENT TABUN (GA)
Descriptor:Liver carboxylesterase 1, N-ACETYL-D-GLUCOSAMINE, O-SIALIC ACID, ...
Authors:Fleming, C.D., Redinbo, M.R.
Deposit date:2006-07-20
Release date:2007-05-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal Structures of Human Carboxylesterase 1 in Covalent Complexes with the Chemical Warfare Agents Soman and Tabun.
Biochemistry, 46, 2007
3MB2
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KINETIC AND STRUCTURAL CHARACTERIZATION OF A HETEROHEXAMER 4-OXALOCROTONATE TAUTOMERASE FROM CHLOROFLEXUS AURANTIACUS J-10-FL: IMPLICATIONS FOR FUNCTIONAL AND STRUCTURAL DIVERSITY IN THE TAUTOMERASE SUPERFAMILY
Descriptor:4-oxalocrotonate tautomerase family enzyme - alpha subunit, 4-oxalocrotonate tautomerase family enzyme - beta subunit, SULFATE ION
Authors:Burks, E.A., Fleming, C.D., Mesecar, A.D., Whitman, C.P., Pegan, S.D.
Deposit date:2010-03-24
Release date:2010-06-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.41 Å)
Cite:Kinetic and structural characterization of a heterohexamer 4-oxalocrotonate tautomerase from Chloroflexus aurantiacus J-10-fl: implications for functional and structural diversity in the tautomerase superfamily
Biochemistry, 49, 2010
5T25
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KINETIC, SPECTRAL AND STRUCTURAL CHARACTERIZATION OF THE SLOW BINDING INHIBITOR ACETOPYRUVATE WITH DIHYDRODIPICOLINATE SYNTHASE FROM ESCHERICHIA COLI.
Descriptor:4-hydroxy-tetrahydrodipicolinate synthase, LYSINE, SODIUM ION
Authors:Chooback, L., Thomas, L.M., Karsten, W.E., Fleming, C.D., Seabourn, P.
Deposit date:2016-08-23
Release date:2017-03-01
Last modified:2018-11-07
Method:X-RAY DIFFRACTION (1.991 Å)
Cite:Kinetic, Spectral and Structural Characterization of the Slow Binding Inhibitor Acetopyruvate with Dihydrodipicolinate Synthase from Escherichia coli.
To Be Published
5T26
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KINETIC, SPECTRAL AND STRUCTURAL CHARACTERIZATION OF THE SLOW BINDING INHIBITOR ACETOPYRUVATE WITH DIHYDRODIPICOLINATE SYNTHASE FROM ESCHERICHIA COLI.
Descriptor:4-hydroxy-tetrahydrodipicolinate synthase, SODIUM ION, L(+)-TARTARIC ACID, ...
Authors:Chooback, L., Thomas, L.M., Karsten, W.E., Fleming, C.D., Seabourn, P.
Deposit date:2016-08-23
Release date:2016-10-05
Last modified:2019-10-02
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Kinetic, Spectral and Structural Characterization of the Slow Binding Inhibitor Acetopyruvate with Dihydrodipicolinate Synthase from Escherichia coli.
To Be Published
3K9B
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CRYSTAL STRUCTURE OF HUMAN LIVER CARBOXYLESTERASE 1 (HCE1) IN COVALENT COMPLEX WITH THE NERVE AGENT CYCLOSARIN (GF)
Descriptor:Liver carboxylesterase 1, cyclohexyl (S)-methylphosphonofluoridoate
Authors:Hemmert, A.C., Redinbo, M.R.
Deposit date:2009-10-15
Release date:2010-01-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Human carboxylesterase 1 stereoselectively binds the nerve agent cyclosarin and spontaneously hydrolyzes the nerve agent sarin.
Mol.Pharmacol., 77, 2010