Author results

2JJI
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ENDOTHIAPEPSIN IN COMPLEX WITH A GEM-DIOL INHIBITOR.
Descriptor:ENDOTHIAPEPSIN, N~2~-[(2R)-2-benzyl-3-(tert-butylsulfonyl)propanoyl]-N-{(1R)-1-(cyclohexylmethyl)-3,3-difluoro-2,2-dihydroxy-4-[(2-morpholin-4-ylethyl)amino]-4-oxobutyl}-3-(1H-imidazol-3-ium-4-yl)-L-alaninamide, SULFATE ION
Authors:Coates, L., Tuan, H.-F., Tomanicek, S.J., Kovalevsky, A., Mustyakimov, M., Erskine, P., Cooper, J.
Deposit date:2008-04-09
Release date:2008-05-27
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (1.57 Å)
Cite:The Catalytic Mechanism of an Aspartic Proteinase Explored with Neutron and X-Ray Diffraction
J.Am.Chem.Soc., 130, 2008
2JJJ
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ENDOTHIAPEPSIN IN COMPLEX WITH A GEM-DIOL INHIBITOR.
Descriptor:ENDOTHIAPEPSIN, N~2~-[(2R)-2-benzyl-3-(tert-butylsulfonyl)propanoyl]-N-{(1R)-1-(cyclohexylmethyl)-3,3-difluoro-2,2-dihydroxy-4-[(2-morpholin-4-ylethyl)amino]-4-oxobutyl}-3-(1H-imidazol-3-ium-4-yl)-L-alaninamide, SULFATE ION
Authors:Coates, L., Tuan, H.-F., Tomanicek, S.J., Kovalevsky, A., Mustyakimov, M., Erskine, P., Cooper, J.
Deposit date:2008-04-09
Release date:2008-05-27
Last modified:2013-09-25
Method:X-RAY DIFFRACTION (1 Å)
Cite:The Catalytic Mechanism of an Aspartic Proteinase Explored with Neutron and X-Ray Diffraction
J.Am.Chem.Soc., 130, 2008
2VS2
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NEUTRON DIFFRACTION STRUCTURE OF ENDOTHIAPEPSIN IN COMPLEX WITH A GEM- DIOL INHIBITOR.
Descriptor:ENDOTHIAPEPSIN, N~2~-[(2R)-2-benzyl-3-(tert-butylsulfonyl)propanoyl]-N-{(1R)-1-(cyclohexylmethyl)-3,3-difluoro-2,2-dihydroxy-4-[(2-morpholin-4-ylethyl)amino]-4-oxobutyl}-3-(1H-imidazol-3-ium-4-yl)-L-alaninamide
Authors:Coates, L., Tuan, H.-F., Tomanicek, S., Kovalevsky, A., Mustyakimov, M., Erskine, P., Cooper, J.
Deposit date:2008-04-17
Release date:2008-05-27
Last modified:2018-11-14
Method:NEUTRON DIFFRACTION (2 Å)
Cite:The Catalytic Mechanism of an Aspartic Proteinase Explored with Neutron and X-Ray Diffraction
J.Am.Chem.Soc., 130, 2008
2BJI
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HIGH RESOLUTION STRUCTURE OF MYO-INOSITOL MONOPHOSPHATASE, THE TARGET OF LITHIUM THERAPY
Descriptor:INOSITOL-1(OR 4)-MONOPHOSPHATASE, MAGNESIUM ION
Authors:Gill, R., Mohammed, F., Badyal, R., Coates, L., Erskine, P., Thompson, D., Cooper, J., Gore, M., Wood, S.
Deposit date:2005-02-03
Release date:2005-02-11
Last modified:2018-02-28
Method:X-RAY DIFFRACTION (1.24 Å)
Cite:High-resolution structure of myo-inositol monophosphatase, the putative target of lithium therapy.
Acta Crystallogr. D Biol. Crystallogr., 61, 2005
4MLQ
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CRYSTAL STRUCTURE OF BACILLUS MEGATERIUM PORPHOBILINOGEN DEAMINASE
Descriptor:Porphobilinogen deaminase, 3-[5-{[3-(2-carboxyethyl)-4-(carboxymethyl)-5-methyl-1H-pyrrol-2-yl]methyl}-4-(carboxymethyl)-1H-pyrrol-3-yl]propanoic acid, 3-[(5S)-5-{[3-(2-carboxyethyl)-4-(carboxymethyl)-5-methyl-1H-pyrrol-2-yl]methyl}-4-(carboxymethyl)-2-oxo-2,5-dihydro-1H-pyrrol-3-yl]propanoic acid, ...
Authors:Azim, N., Deery, E., Warren, M.J., Erskine, P., Cooper, J.B., Coker, A., Wood, S.P., Akhtar, M.
Deposit date:2013-09-06
Release date:2014-04-02
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structural evidence for the partially oxidized dipyrromethene and dipyrromethanone forms of the cofactor of porphobilinogen deaminase: structures of the Bacillus megaterium enzyme at near-atomic resolution.
Acta Crystallogr.,Sect.D, 70, 2014
4MLV
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CRYSTAL STRUCTURE OF BACILLUS MEGATERIUM PORPHOBILINOGEN DEAMINASE
Descriptor:Porphobilinogen deaminase, 3-[5-{[3-(2-carboxyethyl)-4-(carboxymethyl)-5-methyl-1H-pyrrol-2-yl]methyl}-4-(carboxymethyl)-1H-pyrrol-3-yl]propanoic acid, 3-[(5S)-5-{[3-(2-carboxyethyl)-4-(carboxymethyl)-5-methyl-1H-pyrrol-2-yl]methyl}-4-(carboxymethyl)-2-oxo-2,5-dihydro-1H-pyrrol-3-yl]propanoic acid, ...
Authors:Azim, N., Deery, E., Warren, M.J., Erskine, P., Cooper, J.B., Coker, A., Wood, S.P., Akhtar, M.
Deposit date:2013-09-06
Release date:2014-04-02
Method:X-RAY DIFFRACTION (1.455 Å)
Cite:Structural evidence for the partially oxidized dipyrromethene and dipyrromethanone forms of the cofactor of porphobilinogen deaminase: structures of the Bacillus megaterium enzyme at near-atomic resolution.
Acta Crystallogr.,Sect.D, 70, 2014
4P9G
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STRUCTURE OF THE 2,4'-DIHYDROXYACETOPHENONE DIOXYGENASE FROM ALCALIGENES SP.
Descriptor:2,4'-dihydroxyacetophenone dioxygenase, FE (III) ION, CARBONATE ION, ...
Authors:Keegan, R., Lebedev, A., Erskine, P., Guo, J., Wood, S.P., Hopper, D.J., Cooper, J.B.
Deposit date:2014-04-03
Release date:2014-09-10
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure of the 2,4'-dihydroxyacetophenone dioxygenase from Alcaligenes sp. 4HAP
Acta Crystallogr.,Sect.D, 70, 2014
5BPX
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STRUCTURE OF THE 2,4'-DIHYDROXYACETOPHENONE DIOXYGENASE FROM ALCALIGENES SP. 4HAP.
Descriptor:2,4'-dihydroxyacetophenone dioxygenase, FE (III) ION, ACETATE ION, ...
Authors:Guo, J., Erskine, P., Wood, S.P., Cooper, J.B.
Deposit date:2015-05-28
Release date:2015-06-10
Last modified:2015-10-21
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:Extension of resolution and oligomerization-state studies of 2,4'-dihydroxyacetophenone dioxygenase from Alcaligenes sp. 4HAP.
Acta Crystallogr.,Sect.F, 71, 2015
5OV4
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BACILLUS MEGATERIUM PORPHOBILINOGEN DEAMINASE D82A MUTANT
Descriptor:Porphobilinogen deaminase
Authors:Guo, J., Erskine, P., Coker, A.R., Wood, S.P., Cooper, J.B.
Deposit date:2017-08-28
Release date:2017-10-11
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.692 Å)
Cite:Structural studies of domain movement in active-site mutants of porphobilinogen deaminase from Bacillus megaterium.
Acta Crystallogr F Struct Biol Commun, 73, 2017
5OV5
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BACILLUS MEGATERIUM PORPHOBILINOGEN DEAMINASE D82E MUTANT
Descriptor:Porphobilinogen deaminase, 3-[5-{[3-(2-carboxyethyl)-4-(carboxymethyl)-5-methyl-1H-pyrrol-2-yl]methyl}-4-(carboxymethyl)-1H-pyrrol-3-yl]propanoic acid
Authors:Guo, J., Erskine, P., Coker, A.R., Wood, S.P., Cooper, J.B.
Deposit date:2017-08-28
Release date:2017-09-06
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (1.81 Å)
Cite:Structural studies of domain movement in active-site mutants of porphobilinogen deaminase from Bacillus megaterium.
Acta Crystallogr F Struct Biol Commun, 73, 2017
5OV6
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BACILLUS MEGATERIUM PORPHOBILINOGEN DEAMINASE D82N MUTANT
Descriptor:Porphobilinogen deaminase, 3-[4-(2-hydroxy-2-oxoethyl)-2,5-dimethyl-1~{H}-pyrrol-3-yl]propanoic acid
Authors:Guo, J., Erskine, P., Coker, A.R., Wood, S.P., Cooper, J.B.
Deposit date:2017-08-28
Release date:2017-09-06
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (1.87 Å)
Cite:Structural studies of domain movement in active-site mutants of porphobilinogen deaminase from Bacillus megaterium.
Acta Crystallogr F Struct Biol Commun, 73, 2017
5DZU
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STRUCTURE OF POTATO CATHEPSIN D INHIBITOR
Descriptor:Aspartic protease inhibitor 11, GLYCEROL, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Guo, J., Erskine, P., Coker, A.R., Wood, S.P., Cooper, J.B.
Deposit date:2015-09-26
Release date:2015-10-21
Last modified:2018-04-25
Method:X-RAY DIFFRACTION (2.12 Å)
Cite:Structure of a Kunitz-type potato cathepsin D inhibitor.
J.Struct.Biol., 192, 2015
5K4Q
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THREE-DIMENSIONAL STRUCTURE OF L-THREONINE 3-DEHYDROGENASE FROM TRYPANOSOMA BRUCEI BOUND TO NAD+ REFINED TO 2.3 ANGSTROMS
Descriptor:L-threonine 3-dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, GLYCEROL, ...
Authors:Adjogatse, E.K., Cooper, J.B., Erskine, P.T.
Deposit date:2016-05-21
Release date:2017-11-15
Last modified:2018-10-10
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure and function of L-threonine-3-dehydrogenase from the parasitic protozoan Trypanosoma brucei revealed by X-ray crystallography and geometric simulations.
Acta Crystallogr D Struct Biol, 74, 2018
5K4T
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THREE-DIMENSIONAL STRUCTURE OF L-THREONINE 3-DEHYDROGENASE FROM TRYPANOSOMA BRUCEI REFINED TO 2.1 ANGSTROMS
Descriptor:L-threonine 3-dehydrogenase, GLYCEROL
Authors:Adjogatse, E.K., Cooper, J.B., Erskine, P.T.
Deposit date:2016-05-22
Release date:2017-11-15
Last modified:2018-10-10
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure and function of L-threonine-3-dehydrogenase from the parasitic protozoan Trypanosoma brucei revealed by X-ray crystallography and geometric simulations.
Acta Crystallogr D Struct Biol, 74, 2018
5K4U
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THREE-DIMENSIONAL STRUCTURE OF L-THREONINE 3-DEHYDROGENASE FROM TRYPANOSOMA BRUCEI SHOWING DIFFERENT ACTIVE SITE LOOP CONFORMATIONS BETWEEN DIMER SUBUNITS, REFINED TO 1.9 ANGSTROMS
Descriptor:L-threonine 3-dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, GLYCEROL, ...
Authors:Adjogatse, E.K., Cooper, J.B., Erskine, P.T.
Deposit date:2016-05-22
Release date:2017-11-15
Last modified:2018-10-10
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure and function of L-threonine-3-dehydrogenase from the parasitic protozoan Trypanosoma brucei revealed by X-ray crystallography and geometric simulations.
Acta Crystallogr D Struct Biol, 74, 2018
5K4V
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THREE-DIMENSIONAL STRUCTURE OF L-THREONINE 3-DEHYDROGENASE FROM TRYPANOSOMA BRUCEI BOUND TO NAD+ REFINED TO 2.2 ANGSTROMS
Descriptor:L-threonine 3-dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ACETATE ION, ...
Authors:Adjogatse, E.A., Erskine, P.T., Cooper, J.B.
Deposit date:2016-05-22
Release date:2017-11-15
Last modified:2018-10-10
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure and function of L-threonine-3-dehydrogenase from the parasitic protozoan Trypanosoma brucei revealed by X-ray crystallography and geometric simulations.
Acta Crystallogr D Struct Biol, 74, 2018
5K4W
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THREE-DIMENSIONAL STRUCTURE OF L-THREONINE 3-DEHYDROGENASE FROM TRYPANOSOMA BRUCEI BOUND TO NADH AND L-THREONINE REFINED TO 1.72 ANGSTROMS
Descriptor:L-threonine 3-dehydrogenase, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, THREONINE, ...
Authors:Adjogatse, E.A., Erskine, P.T., Cooper, J.B.
Deposit date:2016-05-22
Release date:2018-01-10
Last modified:2018-10-10
Method:X-RAY DIFFRACTION (1.72 Å)
Cite:Structure and function of L-threonine-3-dehydrogenase from the parasitic protozoan Trypanosoma brucei revealed by X-ray crystallography and geometric simulations.
Acta Crystallogr D Struct Biol, 74, 2018
5K4Y
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THREE-DIMENSIONAL STRUCTURE OF L-THREONINE 3-DEHYDROGENASE FROM TRYPANOSOMA BRUCEI REFINED TO 1.77 ANGSTROMS
Descriptor:L-threonine 3-dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ACETATE ION, ...
Authors:Adjogatse, E.A., Erskine, P.T., Cooper, J.B.
Deposit date:2016-05-22
Release date:2018-01-17
Last modified:2018-10-10
Method:X-RAY DIFFRACTION (1.77 Å)
Cite:Structure and function of L-threonine-3-dehydrogenase from the parasitic protozoan Trypanosoma brucei revealed by X-ray crystallography and geometric simulations.
Acta Crystallogr D Struct Biol, 74, 2018
5K50
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THREE-DIMENSIONAL STRUCTURE OF L-THREONINE 3-DEHYDROGENASE FROM TRYPANOSOMA BRUCEI BOUND TO NAD+ AND L-ALLO-THREONINE REFINED TO 2.23 ANGSTROMS
Descriptor:L-threonine 3-dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, GLYCEROL, ...
Authors:Adjogatse, E.A., Erskine, P.T., Cooper, J.B.
Deposit date:2016-05-22
Release date:2017-11-15
Last modified:2018-10-10
Method:X-RAY DIFFRACTION (2.26 Å)
Cite:Structure and function of L-threonine-3-dehydrogenase from the parasitic protozoan Trypanosoma brucei revealed by X-ray crystallography and geometric simulations.
Acta Crystallogr D Struct Biol, 74, 2018
5L9A
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L-THREONINE DEHYDROGENASE FROM TRYPANOSOMA BRUCEI.
Descriptor:L-threonine 3-dehydrogenase, ACETATE ION
Authors:Erskine, P.T., Cooper, J.B., Adjogatse, E., Kelly, J., Wood, S.P.
Deposit date:2016-06-09
Release date:2016-06-22
Last modified:2018-10-10
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Structure and function of L-threonine-3-dehydrogenase from the parasitic protozoan Trypanosoma brucei revealed by X-ray crystallography and geometric simulations.
Acta Crystallogr D Struct Biol, 74, 2018
5LC1
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L-THREONINE DEHYDROGENASE FROM TRYPANOSOMA BRUCEI WITH NAD AND THE INHIBITOR PYRUVATE BOUND.
Descriptor:L-threonine 3-dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, PYRUVIC ACID, ...
Authors:Erskine, P.T., Adjogatse, E., Wood, S.P., Cooper, J.B.
Deposit date:2016-06-18
Release date:2016-07-27
Last modified:2018-10-10
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure and function of L-threonine-3-dehydrogenase from the parasitic protozoan Trypanosoma brucei revealed by X-ray crystallography and geometric simulations.
Acta Crystallogr D Struct Biol, 74, 2018
3URI
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ENDOTHIAPEPSIN-DB5 COMPLEX.
Descriptor:Endothiapepsin, DB5 peptide
Authors:Bailey, D., Sanz-Aparicio, J., Albert, A., Cooper, J.B.
Deposit date:2011-11-22
Release date:2012-04-18
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:An analysis of subdomain orientation, conformational change and disorder in relation to crystal packing of aspartic proteinases.
Acta Crystallogr.,Sect.D, 68, 2012
3URJ
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TYPE IV NATIVE ENDOTHIAPEPSIN
Descriptor:Endothiapepsin, SULFATE ION
Authors:Bailey, D., Cooper, J.B.
Deposit date:2011-11-22
Release date:2012-04-04
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:An analysis of subdomain orientation, conformational change and disorder in relation to crystal packing of aspartic proteinases.
Acta Crystallogr.,Sect.D, 68, 2012
3URL
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ENDOTHIAPEPSIN-DB6 COMPLEX.
Descriptor:Endothiapepsin, DB6 peptide, SULFATE ION
Authors:Bailey, D., Sanz-Aparicio, J., Albert, A., Cooper, J.B.
Deposit date:2011-11-22
Release date:2012-04-18
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (2 Å)
Cite:An analysis of subdomain orientation, conformational change and disorder in relation to crystal packing of aspartic proteinases.
Acta Crystallogr.,Sect.D, 68, 2012
3UTL
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HUMAN PEPSIN 3B
Descriptor:Pepsin A
Authors:Coker, A., Cooper, J.B.
Deposit date:2011-11-25
Release date:2011-12-14
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.61 Å)
Cite:An analysis of subdomain orientation, conformational change and disorder in relation to crystal packing of aspartic proteinases.
Acta Crystallogr.,Sect.D, 68, 2012